phosphoric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4478 7664-38-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phosphoric acid
concise etchant is 37% H3PO4
  • Molecular weight: 97.99
  • Formula: H3O4P
  • CLOGP: -2.17
  • LIPINSKI: None
  • HAC: 4
  • HDO: 3
  • TPSA: 77.76
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 24, 1971 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Skin candida 115.92 19.61 27 5218 1628 63482149
Creatinine renal clearance decreased 114.42 19.61 45 5200 16263 63467514
Sedation complication 107.11 19.61 41 5204 13781 63469996
Balance disorder 103.46 19.61 72 5173 84350 63399427
Blood calcium decreased 102.68 19.61 48 5197 26403 63457374
Orthostatic hypotension 96.92 19.61 51 5194 36109 63447668
Constipation 80.80 19.61 96 5149 224847 63258930
Cognitive disorder 76.39 19.61 51 5194 55764 63428013
Sedation 71.99 19.61 43 5202 38766 63445011
Depressed level of consciousness 71.48 19.61 51 5194 62027 63421750
Neutropenic sepsis 58.16 19.61 28 5217 16410 63467367
Nervous system disorder 46.11 19.61 25 5220 18741 63465036
Mobility decreased 43.86 19.61 52 5193 121107 63362670
Hypomagnesaemia 43.53 19.61 28 5217 28709 63455068
Dehydration 41.93 19.61 61 5184 173293 63310484
Dysphagia 40.59 19.61 43 5202 88542 63395235
Mouth ulceration 40.02 19.61 28 5217 32956 63450821
Mucosal inflammation 39.50 19.61 32 5213 46896 63436881
Gait disturbance 39.37 19.61 61 5184 183117 63300660
Hypokalaemia 36.65 19.61 44 5201 103760 63380017
Candida infection 36.59 19.61 25 5220 28326 63455451
Oesophagitis 31.42 19.61 18 5227 14990 63468787
Productive cough 31.30 19.61 32 5213 63176 63420601
Hypotension 28.76 19.61 67 5178 272537 63211240
Neutrophil count decreased 28.74 19.61 29 5216 56377 63427400
Fall 27.71 19.61 83 5162 392251 63091526
Multiple drug therapy 25.34 19.61 10 5235 3636 63480141
Vomiting 22.12 19.61 98 5147 559519 62924258
Anaemia 20.60 19.61 62 5183 293368 63190409

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Periarthritis 30.37 21.26 8 2144 1076 34953703
Dehydration 27.86 21.26 37 2115 129932 34824847

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Creatinine renal clearance decreased 134.30 17.68 51 5786 18951 79719600
Sedation complication 125.13 17.68 46 5791 15623 79722928
Blood calcium decreased 121.47 17.68 55 5782 31764 79706787
Balance disorder 117.52 17.68 79 5758 98778 79639773
Skin candida 107.77 17.68 26 5811 2061 79736490
Orthostatic hypotension 94.60 17.68 56 5781 56108 79682443
Cognitive disorder 85.73 17.68 57 5780 69869 79668682
Constipation 80.27 17.68 101 5736 282949 79455602
Sedation 75.19 17.68 47 5790 51848 79686703
Depressed level of consciousness 58.97 17.68 52 5785 96600 79641951
Mobility decreased 55.87 17.68 56 5781 122119 79616432
Neutropenic sepsis 48.20 17.68 28 5809 27036 79711515
Nervous system disorder 43.15 17.68 26 5811 26830 79711721
Dehydration 42.82 17.68 70 5767 248117 79490434
Mouth ulceration 36.95 17.68 27 5810 38367 79700184
Dysphagia 35.17 17.68 44 5793 122092 79616459
Fall 34.99 17.68 96 5741 487533 79251018
Candida infection 34.81 17.68 26 5811 38188 79700363
Hypomagnesaemia 34.25 17.68 28 5809 46883 79691668
Mucosal inflammation 29.76 17.68 32 5805 75548 79663003
Hypotension 28.93 17.68 84 5753 440233 79298318
Gait disturbance 28.55 17.68 53 5784 207453 79531098
Multiple drug therapy 25.42 17.68 10 5827 4068 79734483
Hypokalaemia 25.31 17.68 41 5796 143999 79594552
Pain 24.49 17.68 109 5728 703693 79034858
Productive cough 22.56 17.68 30 5807 88301 79650250
Neutrophil count decreased 21.11 17.68 30 5807 93929 79644622
Bladder disorder 17.70 17.68 10 5827 9155 79729396

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003764 Dental Materials
CHEBI has role CHEBI:33287 fertilizers
CHEBI has role CHEBI:46787 solvents
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:84735 algal metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nutritional support indication 278906000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.0 acidic
pKa2 6.06 acidic
pKa3 11.11 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05467 KEGG_DRUG
4018718 VUID
N0000178952 NUI
4018718 VANDF
CHEBI:26078 CHEBI
2HP PDB_CHEM_ID
IPS PDB_CHEM_ID
PI PDB_CHEM_ID
PO4 PDB_CHEM_ID
CHEMBL1187 ChEMBL_ID
C030242 MESH_SUPPLEMENTAL_RECORD_UI
DB09394 DRUGBANK_ID
E4GA8884NN UNII
8259 RXNORM
NOCODE MMSL
006128 NDDF
C0031700 UMLSCUI
1004 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense nausea relief HUMAN OTC DRUG LABEL 3 0113-0112 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 0.04 g INTRAVENOUS NDA 24 sections
FreAmine III HUMAN PRESCRIPTION DRUG LABEL 16 0264-9010 INJECTION, SOLUTION 0.12 g INTRAVENOUS NDA 24 sections
FreAmine III HUMAN PRESCRIPTION DRUG LABEL 16 0264-9011 INJECTION, SOLUTION 0.12 g INTRAVENOUS NDA 24 sections
HepatAmine HUMAN PRESCRIPTION DRUG LABEL 16 0264-9371 INJECTION, SOLUTION 0.12 g INTRAVENOUS NDA 23 sections
Nausea Relief HUMAN OTC DRUG LABEL 3 0363-0056 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
Nausea Relief HUMAN OTC DRUG LABEL 3 0363-0056 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
Anti Nausea HUMAN OTC DRUG LABEL 3 0536-1302 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Anti Nausea HUMAN OTC DRUG LABEL 3 0536-1302 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
formula em HUMAN OTC DRUG LABEL 3 0904-0049 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
nausea relief HUMAN OTC DRUG LABEL 3 11822-0401 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
Select Brand Anti-Nausea HUMAN OTC DRUG LABEL 2 15127-291 SOLUTION 21.50 mg ORAL unapproved drug other 11 sections
signature care anti nausea HUMAN OTC DRUG LABEL 3 21130-694 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
Kroger Anti NauseaCherry Flavor HUMAN OTC DRUG LABEL 3 30142-708 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Kroger Anti NauseaCherry Flavor HUMAN OTC DRUG LABEL 3 30142-708 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Kroger Anti NauseaCherry Flavor HUMAN OTC DRUG LABEL 3 30142-708 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
nausea relief HUMAN OTC DRUG LABEL 3 30142-709 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
Anti Nausea Liquid HUMAN OTC DRUG LABEL 3 36800-708 SOLUTION 21.50 mg ORAL Unapproved drug other 13 sections
Anti Nausea Liquid HUMAN OTC DRUG LABEL 3 36800-708 SOLUTION 21.50 mg ORAL Unapproved drug other 13 sections
nausea relief HUMAN OTC DRUG LABEL 3 37808-501 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
HEB Anti Nausea HUMAN OTC DRUG LABEL 3 37808-883 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
HEB Anti Nausea HUMAN OTC DRUG LABEL 3 37808-883 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
equaline anti nausea HUMAN OTC DRUG LABEL 3 41163-630 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
Meijer Anti Nausea HUMAN OTC DRUG LABEL 3 41250-495 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Meijer Anti Nausea HUMAN OTC DRUG LABEL 3 41250-495 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Nausea Relief HUMAN OTC DRUG LABEL 3 41250-502 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
Good Neighbor Pharmacy Nausea Relief HUMAN OTC DRUG LABEL 3 46122-296 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections
Good Neighbor Anti NauseaCherry Flavor HUMAN OTC DRUG LABEL 3 46122-729 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Good Neighbor Anti NauseaCherry Flavor HUMAN OTC DRUG LABEL 3 46122-729 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
sunmark anti nausea HUMAN OTC DRUG LABEL 3 49348-576 SOLUTION 21.50 mg ORAL Unapproved drug other 14 sections