sodium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4477 68-04-2

Description:

MoleculeDescription

Synonyms:

  • sodium citrate
  • trisodium citrate
Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES.
  • Molecular weight: 258.07
  • Formula: C6H5Na3O7
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 140.62
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 3, 1980 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Paraesthesia 12943.57 199.11 3835 17864 153131 63314192
Feeling hot 7743.08 199.11 2025 19674 48329 63418994
Pallor 7659.76 199.11 1820 19879 28748 63438575
Hyperhidrosis 4203.46 199.11 1515 20184 106321 63361002
Thirst 4024.82 199.11 936 20763 13105 63454218
Dizziness 3542.92 199.11 2034 19665 427891 63039432
Nausea 2360.12 199.11 2074 19625 852397 62614926
Dysgeusia 2030.73 199.11 715 20984 45995 63421328
Vision blurred 2006.95 199.11 852 20847 91072 63376251
Asthenia 1133.20 199.11 977 20722 382627 63084696
Dyspepsia 921.96 199.11 519 21180 101677 63365646
Restlessness 915.51 199.11 353 21346 29100 63438223
Chills 751.04 199.11 472 21227 112906 63354417
Injection site haematoma 506.58 199.11 157 21542 6675 63460648
Toxic anterior segment syndrome 258.51 199.11 69 21630 1702 63465621
Fatigue 225.61 199.11 22 21677 888006 62579317
Drug ineffective 223.24 199.11 44 21655 1044721 62422602

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Paraesthesia 5094.07 177.73 1496 9330 62676 34883429
Feeling hot 2468.56 177.73 660 10166 18712 34927393
Pallor 2258.07 177.73 653 10173 24827 34921278
Thirst 1480.80 177.73 367 10459 7528 34938577
Hyperhidrosis 1411.00 177.73 608 10218 75084 34871021
Dizziness 1000.58 177.73 691 10135 217830 34728275
Nausea 927.80 177.73 789 10037 339119 34606986
Dysgeusia 876.14 177.73 323 10503 26174 34919931
Vision blurred 568.68 177.73 279 10547 45684 34900421
Appendicolith 378.83 177.73 130 10696 8471 34937634
Restlessness 361.01 177.73 170 10656 25312 34920793
Dyspepsia 352.16 177.73 188 10638 36544 34909561
Injection site haematoma 333.83 177.73 83 10743 1702 34944403
Appendicitis 310.11 177.73 130 10696 14677 34931428
Chills 291.04 177.73 223 10603 80820 34865285
Toxic anterior segment syndrome 252.27 177.73 61 10765 1108 34944997
Cardiogenic shock 240.26 177.73 131 10695 26487 34919618
Asthenia 235.24 177.73 331 10495 244920 34701185
Stress 226.88 177.73 132 10694 30215 34915890

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Paraesthesia 18162.07 137.21 5331 27105 170992 79540960
Feeling hot 10084.80 137.21 2685 29751 57049 79654903
Pallor 9506.82 137.21 2472 29964 47590 79664362
Hyperhidrosis 5516.67 137.21 2122 30314 149370 79562582
Thirst 5433.19 137.21 1302 31134 17317 79694635
Dizziness 4518.40 137.21 2724 29712 523717 79188235
Nausea 3336.55 137.21 2863 29573 954333 78757619
Dysgeusia 2940.28 137.21 1037 31399 56140 79655812
Vision blurred 2619.99 137.21 1129 31307 104769 79607183
Asthenia 1321.47 137.21 1307 31129 510382 79201570
Dyspepsia 1303.92 137.21 707 31729 107980 79603972
Restlessness 1236.14 137.21 523 31913 45969 79665983
Chills 1021.29 137.21 695 31741 159539 79552413
Injection site haematoma 916.27 137.21 240 32196 4587 79707365
Toxic anterior segment syndrome 413.90 137.21 114 32322 2650 79709302
Appendicolith 340.84 137.21 129 32307 8422 79703530
Tetany 311.26 137.21 91 32345 2637 79709315
Drug ineffective 292.23 137.21 46 32390 1080867 78631085
Diarrhoea 291.14 137.21 17 32419 880472 78831480
Fatigue 279.18 137.21 28 32408 929699 78782253
Pyrexia 237.36 137.21 9 32427 678700 79033252
Neck pain 232.89 137.21 214 32222 75203 79636749
Appendicitis 231.17 137.21 129 32307 20665 79691287
Palpitations 193.92 137.21 248 32188 126362 79585590
Dyspnoea 186.09 137.21 59 32377 856966 78854986
Arthralgia 179.98 137.21 14 32422 571789 79140163
Abdominal pain 179.47 137.21 450 31986 389119 79322833
Rash 176.98 137.21 16 32420 578342 79133610
Pneumonia 169.35 137.21 32 32404 660214 79051738
Cardiogenic shock 151.34 137.21 130 32306 41784 79670168
Fall 150.45 137.21 13 32423 487616 79224336
Malaise 145.98 137.21 15 32421 489854 79222098
Toxicity to various agents 139.36 137.21 8 32428 421532 79290420

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05CB02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Salt solutions
MeSH PA D000925 Anticoagulants
MeSH PA D002021 Buffers
MeSH PA D005503 Food Additives
MeSH PA D005520 Food Preservatives
MeSH PA D006401 Hematologic Agents
CHEBI has role CHEBI:50249 anticoagulants
CHEBI has role CHEBI:35617 flavouring agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Heartburn indication 16331000
Cough indication 49727002
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Common cold indication 82272006 DOID:10459
Indigestion indication 162031009
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric Hypersecretory Conditions indication
Hiatal Hernia with Reflux Esophagitis indication
Renal tubular acidosis off-label use 1776003 DOID:14219
Multiple endocrine adenomas off-label use 60549007
Cystinuria off-label use 85020001 DOID:9266
Systemic mast cell disease off-label use 397016004 DOID:349
Calcium renal calculus off-label use 427649000
Calcium Oxalate Renal Calculi off-label use
Stress-Related GI Mucosal Bleeding Prevention off-label use
Cystine Renal Calculi off-label use
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Ocular hypertension contraindication 4210003 DOID:9282
Hypocalcemia contraindication 5291005
Hyperkalemia contraindication 14140009
Pulmonary edema contraindication 19242006 DOID:11396
Myocardial infarction contraindication 22298006 DOID:5844
Ventricular tachycardia contraindication 25569003
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Arterial thrombosis contraindication 65198009
Arteriosclerotic vascular disease contraindication 72092001
Gastrointestinal hemorrhage contraindication 74474003
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Gastrointestinal obstruction contraindication 126765001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Gastroparesis contraindication 235675006
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Rhabdomyolysis contraindication 240131006
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Peripheral edema contraindication 271809000
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Primary adrenocortical insufficiency contraindication 373662000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Traumatic injury contraindication 417746004
Ketoacidosis in diabetes mellitus contraindication 420422005 DOID:1837
Hypertensive urgency contraindication 443482000
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Genitourinary Tract Infections contraindication
Esophageal Compression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 4 Enzyme Ki 7 CHEMBL
Carbonic anhydrase Enzyme Ki 4.41 CHEMBL

External reference:

IDSource
D05855 KEGG_DRUG
4017463 VUID
N0000145851 NUI
4017463 VANDF
CHEBI:32142 CHEBI
CHEMBL1355 ChEMBL_ID
C514290 MESH_SUPPLEMENTAL_RECORD_UI
DB09154 DRUGBANK_ID
253204 RXNORM
5226 MMSL
5479 MMSL
d03098 MMSL
000732 NDDF
000758 NDDF
002077 NDDF
002078 NDDF
002332 NDDF
412546005 SNOMEDCT_US
412547001 SNOMEDCT_US
C0142825 UMLSCUI
D000077559 MESH_DESCRIPTOR_UI
6224 PUBCHEM_CID

Pharmaceutical products:

None