epanolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 4467 86880-51-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • epanolol
  • ICI-141,292
  • Molecular weight: 369.42
  • Formula: C20H23N3O4
  • CLOGP: 1.04
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 114.61
  • ALOGS: -3.78
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 8 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AB10 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.91 acidic
pKa2 13.35 acidic
pKa3 7.48 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06646 KEGG_DRUG
CHEBI:4800 CHEBI
CHEMBL87697 ChEMBL_ID
C038616 MESH_SUPPLEMENTAL_RECORD_UI
5654 INN_ID
DB13757 DRUGBANK_ID
9KGC55KP6A UNII
008150 NDDF
C0116294 UMLSCUI
72014 PUBCHEM_CID

Pharmaceutical products:

None