calcitonin human 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 4427 21215-62-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • calcitonin (human)
  • cibacalcin
  • calcitonin (human synthetic)
  • calcitonin human
  • Molecular weight: 3417.88
  • Formula: C151H226N40O45S3
  • CLOGP: -8.49
  • LIPINSKI: 3
  • HAC: 85
  • HDO: 45
  • TPSA: 1359.60
  • ALOGS: -4.71
  • ROTB: 91

Drug dosage:

DoseUnitRoute
100 U P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.23 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 10 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.82 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 31, 1986 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H05BA03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CALCIUM HOMEOSTASIS
ANTI-PARATHYROID AGENTS
Calcitonin preparations
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:50646 antiosteoporotic

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.79 acidic
pKa2 9.65 acidic
pKa3 11.96 acidic
pKa4 12.29 acidic
pKa5 12.42 acidic
pKa6 12.62 acidic
pKa7 12.8 acidic
pKa8 12.81 acidic
pKa9 12.86 acidic
pKa10 12.98 acidic
pKa11 13.17 acidic
pKa12 13.29 acidic
pKa13 13.33 acidic
pKa14 13.41 acidic
pKa15 13.41 acidic
pKa16 13.46 acidic
pKa17 13.67 acidic
pKa18 13.68 acidic
pKa19 13.78 acidic
pKa20 13.86 acidic
pKa21 13.97 acidic
pKa22 10.81 Basic
pKa23 7.14 Basic
pKa24 6.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Calcitonin receptor GPCR AGONIST IC50 7.81 SCIENTIFIC LITERATURE CHEMBL
Amylin receptor AMY1 GPCR AGONIST IC50 7.53 SCIENTIFIC LITERATURE
Amylin receptor AMY2 GPCR AGONIST IC50 8.08 SCIENTIFIC LITERATURE
Amylin receptor AMY3 GPCR AGONIST IC50 7.71 SCIENTIFIC LITERATURE

External reference:

IDSource
C0770558 UMLSCUI
CHEBI:135973 CHEBI
CHEMBL4594248 ChEMBL_ID
CHEMBL4594242 ChEMBL_ID
DB06773 DRUGBANK_ID
I0IO929019 UNII
235481 RXNORM
002145 NDDF
127383000 SNOMEDCT_US
16129616 PUBCHEM_CID

Pharmaceutical products:

None