candicidin indications/contra

Stem definitionDrug idCAS RN
antibiotics, polyene derivatives 4424 1403-17-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • candicidin
  • Candicidin D
Mixture of antifungal heptaene macrolides from Streptomyces griseus or Actinomyces levoris used topically in candidiasis. The antibiotic complex is composed of candicidins A, B, C, and D, of which D is the major component.
  • Molecular weight: 1109.32
  • Formula: C59H84N2O18
  • CLOGP: -1.46
  • LIPINSKI: 3
  • HAC: 20
  • HDO: 11
  • TPSA: 356.38
  • ALOGS: -5.07
  • ROTB: 10

Drug dosage:

DoseUnitRoute
6 mg V

Approvals:

DateAgencyCompanyOrphan
None FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC G01AA04 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Candidiasis of vagina indication 72934000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.46 acidic
pKa2 10.11 acidic
pKa3 11.12 acidic
pKa4 12.11 acidic
pKa5 12.74 acidic
pKa6 13.88 acidic
pKa7 8.62 Basic
pKa8 2.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
D03347 KEGG_DRUG
48N2IYJ202 UNII
2013 INN_ID
39372-30-0 SECONDARY_CAS_RN
CHEMBL1200647 ChEMBL_ID
D002174 MESH_DESCRIPTOR_UI
DB01152 DRUGBANK_ID
N0000168429 NDFRT
002890 NDDF
81816007 SNOMEDCT_US
CHEBI:354984 CHEBI

Pharmaceutical products:

None