etybenzatropine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 4423 524-83-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ethybenztropine
  • tropethydryline
  • etybenzatropine chlorhydrate
  • ponalide
  • etybenzatropine
  • ethylbenztropine
minor descriptor (65-66); major descriptor (66-79); on-line search ETHYBENZTROPINE (65-79); Index Medicus search ETHYBENZTROPINE (66-79); RN given refers to (endo)-isomer of parent cpd
  • Molecular weight: 321.46
  • Formula: C22H27NO
  • CLOGP: 4.05
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -5.45
  • ROTB: 5

Drug dosage:

DoseUnitRoute
9 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1 39
kinase-selectivity-class AXL,EIF2AK3,GRK2,PDK4 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 Moderate 0.72

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04AC30 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
ANTICHOLINERGIC AGENTS
Ethers of tropine or tropine derivatives
CHEBI has role CHEBI:48407 antiparkinson drug

Related Drugs by ATC class:

N04AC Ethers of tropine or tropine derivatives 1 drug
benzatropine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04087 KEGG_DRUG
C3652692 UMLSCUI
CHEBI:750737 CHEBI
CHEMBL2104273 ChEMBL_ID
DB13468 DRUGBANK_ID
C027641 MESH_SUPPLEMENTAL_RECORD_UI
20055089 PUBCHEM_CID
1358000 RXNORM
1247 INN_ID
G1X2X9N95N UNII

Pharmaceutical products:

None