dibutylphthalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4414 84-74-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dibutylphthalate
  • dibutyl phthalate
  • butyl phthalate
  • phthalate dibutyl
A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.
  • Molecular weight: 278.35
  • Formula: C16H22O4
  • CLOGP: 4.73
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 52.60
  • ALOGS: -4.67
  • ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P03BX03 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
INSECTICIDES AND REPELLENTS
Other insecticides and repellents
MeSH PA D010968 Plasticizers
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:50905 teratogeno
CHEBI has role CHEBI:67239 glucosidoinvertase inhibitor
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:79056 plasticizer

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transient receptor potential cation channel subfamily A member 1 Ion channel ACTIVATOR EC50 4.60 IUPHAR

External reference:

IDSource
N0000166643 NUI
C0012052 UMLSCUI
CHEBI:34687 CHEBI
DB7 PDB_CHEM_ID
CHEMBL272485 ChEMBL_ID
DB13716 DRUGBANK_ID
6295 IUPHAR_LIGAND_ID
2286E5R2KE UNII
3026 PUBCHEM_CID
1362873 RXNORM
NOCODE MMSL
006320 NDDF
411442007 SNOMEDCT_US
4353000 SNOMEDCT_US
D003993 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None