cobamamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4404 13870-90-1

Description:

MoleculeDescription

Synonyms:

  • cobamamide
  • adenosylcobalamin
  • cobalamin coenzyme
  • Vitamin B12 coenzyme
  • Molecular weight: 1579.61
  • Formula: C72H100CoN18O17P
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 608.02
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ejection fraction abnormal 66.06 40.49 13 1052 1772 63486185
Sensitisation 57.77 40.49 13 1052 3373 63484584
Polycystic ovaries 54.17 40.49 13 1052 4458 63483499
Carpal tunnel syndrome 49.53 40.49 17 1048 20800 63467157
Dementia 43.35 40.49 15 1050 18779 63469178
Rhinitis allergic 41.76 40.49 13 1052 11714 63476243
Sleep disorder due to a general medical condition 41.26 40.49 13 1052 12175 63475782

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ultrasound antenatal screen 96.65 79.37 15 545 541 34955830
Trisomy 18 91.75 79.37 15 545 756 34955615
Hydrops foetalis 89.99 79.37 15 545 852 34955519
Cleft lip and palate 89.23 79.37 15 545 897 34955474

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hydrops foetalis 102.11 38.72 17 1572 761 79742038
Trisomy 18 99.04 38.72 16 1573 593 79742206
Ultrasound antenatal screen 96.98 38.72 16 1573 677 79742122
Cleft lip and palate 96.86 38.72 16 1573 682 79742117
Ejection fraction abnormal 59.75 38.72 13 1576 2427 79740372
Sensitisation 55.80 38.72 13 1576 3298 79739501
Polycystic ovaries 54.09 38.72 13 1576 3766 79739033
Foetal exposure during pregnancy 48.59 38.72 13 1576 5777 79737022
Needle fatigue 46.99 38.72 9 1580 893 79741906
Gait spastic 44.45 38.72 9 1580 1188 79741611
Relapsing-remitting multiple sclerosis 42.31 38.72 9 1580 1510 79741289
Rhinitis allergic 38.95 38.72 13 1576 12256 79730543

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03BA04 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
VITAMIN B12 AND FOLIC ACID
Vitamin B12 (cyanocobalamin and analogues)
CHEBI has role CHEBI:23354 coenzymes
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:26348 prosthetic groups
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of Vitamin B12 Deficiency indication
Hypokalemia contraindication 43339004
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Atrophic gastritis contraindication 84568007 DOID:8929




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00042 KEGG_DRUG
C0056039 UMLSCUI
CHEBI:18408 CHEBI
B1Z PDB_CHEM_ID
CHEMBL3833359 ChEMBL_ID
DB11191 DRUGBANK_ID
C000913 MESH_SUPPLEMENTAL_RECORD_UI
1915 INN_ID
F0R1QK73KB UNII
131635025 PUBCHEM_CID
21373 RXNORM
NOCODE MMSL
004345 NDDF
259509008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
EnBrace HR HUMAN PRESCRIPTION DRUG LABEL 16 64661-650 CAPSULE, DELAYED RELEASE PELLETS 50 ug ORAL UNAPPROVED DRUG OTHER 11 sections
EnBrace HR HUMAN PRESCRIPTION DRUG LABEL 16 64661-650 CAPSULE, DELAYED RELEASE PELLETS 50 ug ORAL UNAPPROVED DRUG OTHER 11 sections
EnBrace HR HUMAN PRESCRIPTION DRUG LABEL 16 64661-650 CAPSULE, DELAYED RELEASE PELLETS 50 ug ORAL UNAPPROVED DRUG OTHER 11 sections
EnLyte HUMAN PRESCRIPTION DRUG LABEL 18 64661-711 CAPSULE, DELAYED RELEASE PELLETS 50 ug ORAL unapproved drug other 12 sections
Biopar delta-FORTE HUMAN PRESCRIPTION DRUG LABEL 6 64661-793 CAPSULE 50 ug ORAL unapproved drug other 11 sections
Biopar delta-FORTE HUMAN PRESCRIPTION DRUG LABEL 6 64661-793 CAPSULE 50 ug ORAL unapproved drug other 11 sections
Biopar delta-FORTE HUMAN PRESCRIPTION DRUG LABEL 6 64661-793 CAPSULE 50 ug ORAL unapproved drug other 11 sections