acediasulfone indications/contra

Stem definitionDrug idCAS RN
44 80-03-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acediasulfone
antibacterial drug for treatment of ear infections
  • Molecular weight: 306.34
  • Formula: C14H14N2O4S
  • CLOGP: 1.13
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 109.49
  • ALOGS: -3.23
  • ROTB: 5

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.36 acidic
pKa2 2.03 Basic
pKa3 1.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydropteroate synthetase, putative Unclassified IC50 4.75 CHEMBL
Aldose reductase Enzyme IC50 4.70 CHEMBL

External reference:

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IDSource
30YP2YHH8W UNII
CHEMBL48396 ChEMBL_ID
66451 PUBCHEM_CID
C521214 MESH_SUPPLEMENTAL_RECORD_UI
DB08926 DRUGBANK_ID

Pharmaceutical products:

None