clopenthixol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4397 982-24-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clopenthixol hydrochloride
  • clopenthixol HCl
  • clopenthixol
  • chlorpenthixol
  • sordinol
A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.
  • Molecular weight: 400.97
  • Formula: C22H25ClN2OS
  • CLOGP: 4.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 26.71
  • ALOGS: -5.19
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.10 g O
0.10 g P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AF02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Thioxanthene derivatives
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:37890 alpha-adrenergic receptor blockaders
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:65190 typical antipsychotic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Psychotic disorder indication 69322001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.19 Basic
pKa2 4.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 6 GPCR Ki 6.77 CHEMBL

External reference:

IDSource
D02613 KEGG_DRUG
633-59-0 SECONDARY_CAS_RN
C0009026 UMLSCUI
CHEBI:59115 CHEBI
CHEMBL53904 ChEMBL_ID
CHEMBL87385 ChEMBL_ID
CHEMBL3989892 ChEMBL_ID
DB13841 DRUGBANK_ID
1315 INN_ID
0A432D932A UNII
5311507 PUBCHEM_CID
387566002 SNOMEDCT_US
427940003 SNOMEDCT_US
D003006 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None