secbutabarbital indications/contra

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 439 125-40-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butabarbital
  • butabarb
  • butabarbitone
  • butatab
  • secbubarbital
  • secbutabarbital
  • secbutobarbitone
  • butabarbital sodium
Butabarbital (a synonym for Secbutabarbital) should be distinguished from Butobarbital
  • Molecular weight: 212.25
  • Formula: C10H16N2O3
  • CLOGP: 1.58
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -2.18
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
June 5, 1939 FDA MEDA PHARMS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives

Drug Use (View source of the data)

scroll-->
DiseaseRelationSNOMED_IDDOID
Dysuria indication 49650001
Severe anxiety (panic) indication 80583007
Insomnia indication 193462001
Urinary Tract Irritation indication
Gilles de la Tourette's syndrome contraindication 5158005 DOID:11119
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Bipolar disorder contraindication 13746004 DOID:3312
Hepatic encephalopathy contraindication 13920009 DOID:13413
Severe chronic ulcerative colitis contraindication 14311001
Disorder of autonomic nervous system contraindication 15241006
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Feeling agitated contraindication 24199005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007 DOID:2848
Glomerulonephritis contraindication 36171008 DOID:2921
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypovolemic shock contraindication 39419009
Hyperactive behavior contraindication 44548000
Uremia contraindication 44730006 DOID:4676
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Paralytic ileus contraindication 55525008 DOID:8442
Anorexia nervosa contraindication 56882008 DOID:8689
Hepatic failure contraindication 59927004
Aggressive behavior contraindication 61372001
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Arteriosclerotic vascular disease contraindication 72092001 DOID:2349
Hepatic coma contraindication 72836002 DOID:12550
Sleep apnea contraindication 73430006 DOID:0050848
Hiatal hernia contraindication 84089009 DOID:12642
Cardiomyopathy contraindication 85898001 DOID:0050700
Weight loss contraindication 89362005
Kidney disease contraindication 90708001 DOID:2527
Myasthenia gravis contraindication 91637004 DOID:437
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Structural disorder of heart contraindication 128599005
Seizure disorder contraindication 128613002 DOID:1826
Motor tic disorder contraindication 230337001
Cerebrovascular accident contraindication 230690007 DOID:6713
Mania contraindication 231494001
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007 DOID:3122
Sleep automatism contraindication 247962006
Benign prostatic hyperplasia contraindication 266569009 DOID:2883
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Cardiovascular event risk contraindication 395112001
Visual impairment contraindication 397540003
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Porphyria contraindication 418470004 DOID:13268
Fever greater than 100.4 Fahrenheit contraindication 426000000
Hypertensive urgency contraindication 443482000
Acute exacerbation of asthma contraindication 708038006
General anesthesia off-label use 50697003

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.93 acidic
pKa2 9.62 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR WOMBAT-PK CHEMBL

External reference:

scroll-->
IDSource
DB00237 DRUGBANK_ID
4019647 VUID
N0000147740 NUI
C0006464 UMLSCUI
7137 IUPHAR_LIGAND_ID
D00699 KEGG_DRUG
CHEMBL449 ChEMBL_ID
2479 PUBCHEM_CID
4019647 VANDF
N0000147740 NDFRT
N0000006092 NDFRT
477631 RXNORM
004582 NDDF
d00923 MMSL
3794 MMSL
372901004 SNOMEDCT_US
9268004 SNOMEDCT_US
9WTD50I918 UNII
143-81-7 SECONDARY_CAS_RN
CHEBI:3228 CHEBI
CHEMBL1200982 ChEMBL_ID
1152 INN_ID
C084833 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

scroll-->
ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Butisol Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0037-0113 TABLET 30 mg ORAL NDA 12 sections