bosutinib Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
tyrosine kinase inhibitors 4359 380843-75-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • WAY-173606
  • bosutinib
  • bosulif
  • bosutinib monohydrate
  • bosutinib hydrate
  • SKI-606
  • SKI 606
a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases
  • Molecular weight: 530.45
  • Formula: C26H29Cl2N5O3
  • CLOGP: 4.94
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 1
  • TPSA: 82.88
  • ALOGS: -4.75
  • ROTB: 9

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 4, 2012 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 2355.56 43.10 733 1813 149452 4486994
Nausea 782.55 43.10 349 2197 176984 4459462
Rash 417.75 43.10 196 2350 108192 4528254
Fatigue 408.85 43.10 212 2334 145354 4491092
Pleural effusion 403.74 43.10 128 2418 24270 4612176
Vomiting 372.20 43.10 187 2359 119512 4516934
Chronic myeloid leukaemia 300.58 43.10 58 2488 1357 4635089
Neoplasm progression 294.54 43.10 80 2466 8775 4627671
Cytogenetic analysis abnormal 244.45 43.10 37 2509 179 4636267
Abdominal pain 221.75 43.10 106 2440 59918 4576528
Drug intolerance 168.44 43.10 65 2481 21681 4614765
Dyspnoea 137.05 43.10 105 2441 138880 4497566
Abdominal pain upper 135.32 43.10 64 2482 35051 4601395
Disease progression 134.73 43.10 67 2479 40944 4595502
Death 129.64 43.10 118 2428 198045 4438401
Headache 126.15 43.10 95 2451 122278 4514168
Fluid retention 124.74 43.10 44 2502 11377 4625069
Abdominal discomfort 116.25 43.10 54 2492 28354 4608092
Cardiac failure 99.73 43.10 48 2498 27240 4609206
Second primary malignancy 95.90 43.10 26 2520 2802 4633644
Hepatic enzyme increased 95.30 43.10 41 2505 17950 4618496
Constipation 93.38 43.10 53 2493 42101 4594345
Arthralgia 89.47 43.10 66 2480 81928 4554518
Decreased appetite 88.95 43.10 57 2489 56340 4580106
Pyrexia 86.16 43.10 72 2474 107072 4529374
Malaise 86.07 43.10 67 2479 90090 4546356
Pericardial effusion 76.33 43.10 28 2518 8070 4628376
Cytopenia 76.18 43.10 21 2525 2405 4634041
Pain 75.82 43.10 63 2483 92807 4543639
Bone pain 75.57 43.10 32 2514 13454 4622992
Pulmonary oedema 75.57 43.10 33 2513 14953 4621493
Alanine aminotransferase increased 71.87 43.10 39 2507 28334 4608112
Pruritus 71.51 43.10 55 2491 72517 4563929
Acquired gene mutation 69.64 43.10 14 2532 403 4636043
Drug resistance 68.88 43.10 26 2520 8110 4628336
Asthenia 65.25 43.10 56 2490 86107 4550339
Weight decreased 61.91 43.10 45 2501 54419 4582027
Pulmonary hypertension 57.04 43.10 23 2523 8540 4627906
Pneumonia 56.75 43.10 56 2490 102759 4533687
White blood cell count increased 56.13 43.10 27 2519 15240 4621206
Gastrointestinal disorder 54.83 43.10 27 2519 16034 4620412
Oedema 53.73 43.10 28 2518 18723 4617723
Back pain 53.41 43.10 40 2506 50559 4585887
Peripheral swelling 52.21 43.10 31 2515 26661 4609785
Cardiac failure congestive 51.12 43.10 33 2513 32889 4603557
Anaemia 51.07 43.10 45 2501 71515 4564931
Dizziness 50.70 43.10 52 2494 99819 4536627
Myalgia 50.63 43.10 36 2510 42012 4594434
Atrial fibrillation 47.75 43.10 31 2515 31184 4605262
Chest pain 46.76 43.10 37 2509 50663 4585783
Abdominal distension 46.27 43.10 25 2521 17964 4618482
Dehydration 45.88 43.10 34 2512 42256 4594190
Renal impairment 45.86 43.10 28 2518 25310 4611136
Liver function test increased 45.27 43.10 17 2529 5217 4631229
Haemoglobin decreased 44.76 43.10 32 2514 37625 4598821
Blood creatinine increased 44.32 43.10 28 2518 26872 4609574
Cough 43.77 43.10 37 2509 55550 4580896
Dyspepsia 43.22 43.10 23 2523 16031 4620415

Pharmacologic Action:

SourceCodeDescription
ATC L01XE14 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Protein kinase inhibitors
CHEBI has role CHEBI:35610 antineoplastic agent
FDA EPC N0000175605 Kinase Inhibitor
FDA MoA N0000175076 Protein Kinase Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Blastic phase chronic myeloid leukemia indication 413656006
Chronic Myelocytic Leukemia Accelerated Phase indication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.74 Basic
pKa2 6.69 Basic
pKa3 4.74 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 100MG BASE BOSULIF PF PRISM CV N203341 Sept. 4, 2012 RX TABLET ORAL 7417148 Dec. 11, 2025 A METHOD OF TREATING CHRONIC MYELOGENOUS LEUKEMIA
EQ 400MG BASE BOSULIF PF PRISM CV N203341 Oct. 27, 2017 RX TABLET ORAL 7417148 Dec. 11, 2025 A METHOD OF TREATING CHRONIC MYELOGENOUS LEUKEMIA
EQ 500MG BASE BOSULIF PF PRISM CV N203341 Sept. 4, 2012 RX TABLET ORAL 7417148 Dec. 11, 2025 A METHOD OF TREATING CHRONIC MYELOGENOUS LEUKEMIA

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 100MG BASE BOSULIF PF PRISM CV N203341 Sept. 4, 2012 RX TABLET ORAL Dec. 19, 2020 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+CML)
EQ 400MG BASE BOSULIF PF PRISM CV N203341 Oct. 27, 2017 RX TABLET ORAL Dec. 19, 2020 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+CML)
EQ 500MG BASE BOSULIF PF PRISM CV N203341 Sept. 4, 2012 RX TABLET ORAL Dec. 19, 2020 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+CML)
EQ 100MG BASE BOSULIF PF PRISM CV N203341 Sept. 4, 2012 RX TABLET ORAL Dec. 19, 2024 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+ CML)
EQ 400MG BASE BOSULIF PF PRISM CV N203341 Oct. 27, 2017 RX TABLET ORAL Dec. 19, 2024 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+ CML)
EQ 500MG BASE BOSULIF PF PRISM CV N203341 Sept. 4, 2012 RX TABLET ORAL Dec. 19, 2024 TREATMENT OF ADULT PATIENTS WITH NEWLY-DIAGNOSED CHRONIC PHASE (CP) PHILADELPHIA CHROMOSOME-POSITIVE CHRONIC MYELOGENOUS LEUKEMIA (PH+ CML)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Proto-oncogene tyrosine-protein kinase Src Kinase INHIBITOR Kd 9 CHEMBL CHEMBL
Tyrosine-protein kinase ABL1 Kinase INHIBITOR Kd 10.54 CHEMBL CHEMBL
Tyrosine-protein kinase HCK Kinase INHIBITOR Kd 8.47 CHEMBL CHEMBL
Tyrosine-protein kinase Lyn Kinase INHIBITOR Kd 8.38 CHEMBL CHEMBL
Serine/threonine-protein kinase 35 Kinase Kd 8.70 CHEMBL
Platelet-derived growth factor receptor alpha Kinase Kd 5.29 CHEMBL
Serine/threonine-protein kinase RIO3 Kinase Kd 5.80 CHEMBL
Hepatocyte growth factor receptor Kinase Kd 5.66 CHEMBL
Casein kinase I isoform epsilon Kinase Kd 6.96 CHEMBL
Myosin-IIIb Kinase Kd 5.64 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 3 Kinase Kd 5.59 CHEMBL
Serine/threonine-protein kinase PAK 3 Kinase Kd 5.24 CHEMBL
Cyclin-dependent kinase 15 Kinase Kd 5.80 CHEMBL
Receptor-interacting serine/threonine-protein kinase 2 Kinase Kd 5.43 CHEMBL
Ephrin type-B receptor 4 Kinase Kd 8.04 CHEMBL
Tyrosine-protein kinase JAK2 Kinase Kd 5.96 CHEMBL
Ribosomal protein S6 kinase alpha-6 Kinase Kd 5.57 CHEMBL
Serine/threonine-protein kinase NIM1 Kinase Kd 5.82 CHEMBL
Cyclin-G-associated kinase Kinase Kd 8.89 CHEMBL
Microtubule-associated serine/threonine-protein kinase 1 Kinase Kd 6.46 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 5 Kinase Kd 8.09 CHEMBL
Casein kinase I isoform delta Kinase Kd 6.62 CHEMBL
Tyrosine-protein kinase ITK/TSK Kinase Kd 5.77 CHEMBL
Mitogen-activated protein kinase kinase kinase MLT Kinase Kd 7.10 CHEMBL
Homeodomain-interacting protein kinase 3 Kinase Kd 5.49 CHEMBL
Homeodomain-interacting protein kinase 2 Kinase Kd 5.72 CHEMBL
Tyrosine-protein kinase SYK Kinase Kd 6.54 CHEMBL
Serine/threonine-protein kinase PLK1 Kinase Kd 5.74 CHEMBL
Wee1-like protein kinase Kinase Kd 6.29 CHEMBL
Tyrosine-protein kinase BTK Kinase Kd 8.32 CHEMBL
NUAK family SNF1-like kinase 1 Kinase Kd 5.23 CHEMBL
Mitogen-activated protein kinase kinase kinase 13 Kinase Kd 6.32 CHEMBL
Serine/threonine-protein kinase TBK1 Kinase Kd 6.60 CHEMBL
Ephrin type-A receptor 1 Kinase Kd 5.64 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 1 Kinase Kd 7.82 CHEMBL
Serine/threonine-protein kinase Nek11 Kinase Kd 6.19 CHEMBL
Tyrosine-protein kinase Fgr Kinase Kd 8.20 CHEMBL
Serine/threonine-protein kinase D3 Kinase Kd 5.34 CHEMBL
STE20/SPS1-related proline-alanine-rich protein kinase Kinase Kd 5.43 CHEMBL
Mitogen-activated protein kinase kinase kinase 7 Kinase Kd 7 CHEMBL
Dual specificity protein kinase CLK2 Kinase Kd 5.77 CHEMBL
Dual specificity protein kinase CLK3 Kinase Kd 6.52 CHEMBL
G protein-coupled receptor kinase 7 Kinase Kd 5.77 CHEMBL
Tyrosine-protein kinase FRK Kinase Kd 8.85 CHEMBL
Homeodomain-interacting protein kinase 1 Kinase Kd 6.28 CHEMBL
Dual specificity protein kinase CLK1 Kinase Kd 6.22 CHEMBL
Ephrin type-A receptor 8 Kinase Kd 8.05 CHEMBL
Ephrin type-A receptor 2 Kinase Kd 7.74 CHEMBL
Ephrin type-A receptor 3 Kinase Kd 8.24 CHEMBL
Serine/threonine-protein kinase tousled-like 2 Kinase Kd 5.68 CHEMBL
Serine/threonine-protein kinase 10 Kinase Kd 8.15 CHEMBL
Tyrosine-protein kinase Fer Kinase Kd 6.44 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit gamma Kinase Kd 5.44 CHEMBL
AP2-associated protein kinase 1 Kinase Kd 5.64 CHEMBL
Protein kinase C epsilon type Kinase Kd 5.62 CHEMBL
Tyrosine-protein kinase JAK3 Kinase Kd 5.92 CHEMBL
Tyrosine-protein kinase Yes Kinase Kd 8.40 CHEMBL
Serine/threonine-protein kinase N2 Kinase Kd 5.49 CHEMBL
Tyrosine-protein kinase CSK Kinase Kd 7.49 CHEMBL
Serine/threonine-protein kinase TAO1 Kinase Kd 5.89 CHEMBL
Serine/threonine-protein kinase TNNI3K Kinase Kd 6.77 CHEMBL
Receptor tyrosine-protein kinase erbB-2 Kinase Kd 5.60 CHEMBL
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Kinase Kd 5.89 CHEMBL
High affinity nerve growth factor receptor Kinase Kd 5.51 CHEMBL
Platelet-derived growth factor receptor beta Kinase Kd 6.70 CHEMBL
Rho-associated protein kinase 1 Kinase Kd 6.06 CHEMBL
Citron Rho-interacting kinase Kinase Kd 5.62 CHEMBL
Ribosomal protein S6 kinase alpha-3 Kinase Kd 5.92 CHEMBL
Myosin-IIIa Kinase Kd 5.21 CHEMBL
Ankyrin repeat and protein kinase domain-containing protein 1 Kinase Kd 5.68 CHEMBL
Homeodomain-interacting protein kinase 4 Kinase Kd 6.89 CHEMBL
Serine/threonine-protein kinase 25 Kinase Kd 6.05 CHEMBL
Myosin light chain kinase, smooth muscle Kinase Kd 6.31 CHEMBL
Mitogen-activated protein kinase kinase kinase 4 Kinase Kd 6.96 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 5 Kinase Kd 9.30 CHEMBL
Misshapen-like kinase 1 Kinase Kd 8.49 CHEMBL
Casein kinase I isoform alpha-like Kinase Kd 5.59 CHEMBL
Leucine-rich repeat serine/threonine-protein kinase 2 Kinase Kd 6.30 CHEMBL
Serine/threonine-protein kinase 36 Kinase Kd 6.24 CHEMBL
Interleukin-1 receptor-associated kinase 4 Kinase Kd 6.44 CHEMBL
Mast/stem cell growth factor receptor Kit Kinase Kd 7.14 CHEMBL
BMP-2-inducible protein kinase Kinase Kd 6.46 CHEMBL
Receptor tyrosine-protein kinase erbB-4 Kinase Kd 7.59 CHEMBL
Mitogen-activated protein kinase kinase kinase 11 Kinase Kd 5.57 CHEMBL
Ephrin type-A receptor 6 Kinase Kd 5.96 CHEMBL
TRAF2 and NCK-interacting protein kinase Kinase Kd 7.51 CHEMBL
Megakaryocyte-associated tyrosine-protein kinase Kinase Kd 5.24 CHEMBL
Calcium/calmodulin-dependent protein kinase kinase 2 Kinase Kd 6.11 CHEMBL
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase Kinase Kd 6.46 CHEMBL
STE20-like serine/threonine-protein kinase Kinase Kd 8.33 CHEMBL
Dual specificity protein kinase CLK4 Kinase Kd 5.49 CHEMBL
Macrophage-stimulating protein receptor Kinase Kd 5.20 CHEMBL
Non-receptor tyrosine-protein kinase TYK2 Kinase Kd 5.35 CHEMBL
Serine/threonine-protein kinase PAK 1 Kinase Kd 5.64 CHEMBL
Interleukin-1 receptor-associated kinase 1 Kinase Kd 6.22 CHEMBL
Serine/threonine-protein kinase 4 Kinase Kd 6.72 CHEMBL
Serine/threonine-protein kinase 3 Kinase Kd 6.43 CHEMBL
Calcium/calmodulin-dependent protein kinase type 1D Kinase Kd 6.26 CHEMBL
Serine/threonine-protein kinase TAO2 Kinase Kd 5.72 CHEMBL
Serine/threonine-protein kinase Nek2 Kinase Kd 5.80 CHEMBL
5'-AMP-activated protein kinase catalytic subunit alpha-1 Kinase Kd 5.41 CHEMBL
Ribosomal protein S6 kinase alpha-2 Kinase Kd 5.49 CHEMBL
Cytoplasmic tyrosine-protein kinase BMX Kinase Kd 6.70 CHEMBL
Ephrin type-A receptor 5 Kinase Kd 7.57 CHEMBL
Serine/threonine-protein kinase ULK2 Kinase Kd 6.35 CHEMBL
Ephrin type-A receptor 4 Kinase Kd 7.74 CHEMBL
NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Kinase IC50 6.82 CHEMBL
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Kinase Kd 6.47 CHEMBL
Ephrin type-B receptor 1 Kinase Kd 7.48 CHEMBL
Activated CDC42 kinase 1 Kinase Kd 7.54 CHEMBL
Cyclin-dependent kinase 16 Kinase Kd 5.62 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 3 Kinase Kd 8.29 CHEMBL
Focal adhesion kinase 1 Kinase Kd 6.24 CHEMBL
NT-3 growth factor receptor Kinase Kd 5.47 CHEMBL
Tyrosine-protein kinase ZAP-70 Kinase Kd 5.80 CHEMBL
Calcium/calmodulin-dependent protein kinase type II subunit alpha Kinase Kd 5.35 CHEMBL
G protein-coupled receptor kinase 4 Kinase Kd 5.31 CHEMBL
Mitogen-activated protein kinase kinase kinase 2 Kinase Kd 7.52 CHEMBL
Serine/threonine-protein kinase ULK3 Kinase Kd 6.34 CHEMBL
Abelson tyrosine-protein kinase 2 Kinase Kd 8.82 CHEMBL
Eukaryotic translation initiation factor 2-alpha kinase 1 Kinase Kd 6.20 CHEMBL
Serine/threonine-protein kinase 26 Kinase Kd 7.43 CHEMBL
Serine/threonine-protein kinase PLK2 Kinase Kd 6.02 CHEMBL
Bone morphogenetic protein receptor type-2 Kinase Kd 6.24 CHEMBL
Protein-tyrosine kinase 2-beta Kinase Kd 6.41 CHEMBL
Tyrosine-protein kinase Blk Kinase Kd 8.48 CHEMBL
Angiopoietin-1 receptor Kinase Kd 5.41 CHEMBL
Inhibitor of nuclear factor kappa-B kinase subunit epsilon Kinase Kd 7.28 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 7 Kinase Kd 5.28 CHEMBL
Peripheral plasma membrane protein CASK Kinase Kd 6.08 CHEMBL
Dual serine/threonine and tyrosine protein kinase Kinase Kd 6.42 CHEMBL
Receptor tyrosine-protein kinase erbB-3 Kinase Kd 9.11 CHEMBL
Ephrin type-B receptor 6 Kinase Kd 5.52 CHEMBL
Serine/threonine-protein kinase SIK2 Kinase Kd 7.54 CHEMBL
Serine/threonine-protein kinase TAO3 Kinase Kd 6.47 CHEMBL
Tyrosine-protein kinase Srms Kinase Kd 7 CHEMBL
Casein kinase I isoform alpha Kinase Kd 6.55 CHEMBL
Mitogen-activated protein kinase kinase kinase 1 Kinase Kd 5.36 CHEMBL
Cyclin-dependent kinase 7 Kinase Kd 5.92 CHEMBL
Serine/threonine-protein kinase 32A Kinase Kd 5.74 CHEMBL
Serine/threonine-protein kinase SIK3 Kinase Kd 7.19 CHEMBL
Rho-associated protein kinase 2 Kinase Kd 6.44 CHEMBL
Serine/threonine-protein kinase 24 Kinase Kd 6.42 CHEMBL
Tyrosine-protein kinase Fyn Kinase Kd 7.96 CHEMBL
Tyrosine-protein kinase ABL Kinase IC50 8.96 CHEMBL
Wee1-like protein kinase 2 Kinase Kd 7.03 CHEMBL
Macrophage colony-stimulating factor 1 receptor Kinase Kd 6.42 CHEMBL
Hormonally up-regulated neu tumor-associated kinase Kinase Kd 5.30 CHEMBL
Discoidin domain-containing receptor 2 Kinase Kd 6.85 CHEMBL
Protein kinase C delta type Kinase Kd 5.80 CHEMBL
Tyrosine-protein kinase receptor Tie-1 Kinase Kd 5.54 CHEMBL
Serine/threonine-protein kinase DCLK3 Kinase Kd 5.27 CHEMBL
Cyclin-dependent kinase 14 Kinase Kd 5.85 CHEMBL
Eukaryotic translation initiation factor 2-alpha kinase 4 Kinase Kd 6.57 CHEMBL
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase Kd 5.42 CHEMBL
Myotonin-protein kinase Kinase Kd 7.04 CHEMBL
Epithelial discoidin domain-containing receptor 1 Kinase Kd 6.92 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 4 Kinase Kd 8.09 CHEMBL
Serine/threonine-protein kinase PAK 2 Kinase Kd 5.72 CHEMBL
Tyrosine-protein kinase receptor TYRO3 Kinase Kd 7.21 CHEMBL
Tyrosine-protein kinase Fes/Fps Kinase Kd 6.48 CHEMBL
Tyrosine-protein kinase Lck Kinase Kd 9.23 CHEMBL
Mitogen-activated protein kinase kinase kinase 9 Kinase Kd 5.57 CHEMBL
Leukocyte tyrosine kinase receptor Kinase Kd 5.52 CHEMBL
Mitogen-activated protein kinase kinase kinase 19 Kinase Kd 7.80 CHEMBL
Tyrosine-protein kinase receptor UFO Kinase Kd 7.28 CHEMBL
BDNF/NT-3 growth factors receptor Kinase Kd 5.92 CHEMBL
NUAK family SNF1-like kinase 2 Kinase Kd 6.66 CHEMBL
Ephrin type-B receptor 2 Kinase Kd 8.08 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 2 Kinase Kd 8 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 4 Kinase Kd 5.59 CHEMBL
Serine/threonine-protein kinase tousled-like 1 Kinase Kd 6.24 CHEMBL
SRSF protein kinase 3 Kinase Kd 5.41 CHEMBL
Tyrosine-protein kinase TXK Kinase Kd 7.14 CHEMBL
Serine/threonine-protein kinase VRK2 Kinase Kd 6.15 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 6 Kinase Kd 5.89 CHEMBL
ALK tyrosine kinase receptor Kinase Kd 6.16 CHEMBL
Ephrin type-B receptor 3 Kinase Kd 6.68 CHEMBL
Mitogen-activated protein kinase kinase kinase 12 Kinase Kd 6.17 CHEMBL
Tyrosine-protein kinase Tec Kinase Kd 5.49 CHEMBL
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Kinase Kd 5.48 CHEMBL
Mitogen-activated protein kinase kinase kinase 3 Kinase Kd 7.27 CHEMBL
Bcr/Abl fusion protein Kinase IC50 7.70 CHEMBL
Serine/threonine-protein kinase RIO1 Kinase Kd 5.66 CHEMBL
Ribosomal protein S6 kinase beta-1 Kinase Kd 6.18 CHEMBL
Serine/threonine-protein kinase ULK1 Kinase Kd 5.92 CHEMBL
Serine/threonine-protein kinase 33 Kinase Kd 7.43 CHEMBL
Serine/threonine-protein kinase Chk2 Kinase Kd 6.92 CHEMBL
Testis-specific serine/threonine-protein kinase 1 Kinase Kd 5.34 CHEMBL
Serine/threonine-protein kinase NLK Kinase Kd 5.66 CHEMBL
Serine/threonine-protein kinase Chk1 Kinase Kd 5.52 CHEMBL
Serine/threonine-protein kinase N1 Kinase Kd 5.54 CHEMBL
Serine/threonine-protein kinase SIK1 Kinase Kd 7.52 CHEMBL
Mitogen-activated protein kinase kinase kinase kinase 2 Kinase Kd 8.51 CHEMBL
Tyrosine-protein kinase Mer Kinase Kd 6.96 CHEMBL
Dual specificity mitogen-activated protein kinase kinase 1 Kinase Kd 7.72 CHEMBL
Mitogen-activated protein kinase 7 Kinase Kd 5.64 CHEMBL
Receptor-type tyrosine-protein kinase FLT3 Kinase Kd 6 CHEMBL
Epidermal growth factor receptor Kinase Kd 7.74 CHEMBL
Protein kinase C theta type Kinase Kd 6.04 CHEMBL
Tyrosine-protein kinase Blk Kinase IC50 8.14 CHEMBL
Serine/threonine-protein kinase PknB Kinase Kd 5.26 CHEMBL

External reference:

IDSource
4031718 VUID
N0000185728 NUI
C1831731 UMLSCUI
D03252 KEGG_DRUG
5018V4AEZ0 UNII
8715 INN_ID
703586005 SNOMEDCT_US
1307619 RXNORM
28803 MMSL
d07901 MMSL
014636 NDDF
4031718 VANDF
703128001 SNOMEDCT_US
918639-08-4 SECONDARY_CAS_RN
CHEMBL288441 ChEMBL_ID
DB8 PDB_CHEM_ID
DB06616 DRUGBANK_ID
CHEBI:39112 CHEBI
5710 IUPHAR_LIGAND_ID
5328940 PUBCHEM_CID
C471992 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BOSULIF HUMAN PRESCRIPTION DRUG LABEL 1 0069-0135 TABLET, FILM COATED 100 mg ORAL NDA 19 sections
BOSULIF HUMAN PRESCRIPTION DRUG LABEL 1 0069-0136 TABLET, FILM COATED 500 mg ORAL NDA 19 sections
BOSULIF HUMAN PRESCRIPTION DRUG LABEL 1 0069-0193 TABLET, FILM COATED 400 mg ORAL NDA 19 sections
BOSULIF HUMAN PRESCRIPTION DRUG LABEL 1 63539-117 TABLET, FILM COATED 100 mg ORAL NDA 18 sections