sennosides 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4307	104428-88-8

Description:

Molecule	Description
Synonyms: sennosides a&b sennosides a and b sennosides	Medications derived from SENNA EXTRACT that are used to treat CONSTIPATION. Molecular weight: 1725.49 Formula: C84H76O40 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

sennosides a&b
sennosides a and b
sennosides

Medications derived from SENNA EXTRACT that are used to treat CONSTIPATION.

Molecular weight: 1725.49
Formula: C84H76O40
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Constipation	398.50	9.89	968	93255	223975	63170824
Drug ineffective	380.95	9.89	605	93618	1044160	62350639
Pemphigus	244.14	9.89	6	94217	183720	63211079
Systemic lupus erythematosus	241.27	9.89	18	94205	208900	63185899
Temperature regulation disorder	235.58	9.89	134	94089	5998	63388801
Hand deformity	212.65	9.89	5	94218	159452	63235347
Pneumonia aspiration	208.81	9.89	257	93966	34283	63360516
Synovitis	192.58	9.89	25	94198	186893	63207906
Maternal exposure during pregnancy	183.16	9.89	50	94173	220012	63174787
Glossodynia	181.71	9.89	25	94198	178851	63215948
Arthropathy	173.06	9.89	66	94157	234726	63160073
Food allergy	172.84	9.89	140	94083	11261	63383538
Therapeutic product effect decreased	164.35	9.89	42	94181	193145	63201654
Drug intolerance	150.30	9.89	142	94081	308519	63086280
Coeliac disease	148.83	9.89	135	94088	12662	63382137
Alopecia	142.45	9.89	175	94048	337361	63057438
Discomfort	137.42	9.89	39	94184	167335	63227464
Plasma cell myeloma	131.42	9.89	210	94013	35695	63359104
Joint swelling	130.91	9.89	177	94046	327489	63067310
Gastrooesophageal reflux disease	130.58	9.89	374	93849	95265	63299534
Immunodeficiency	126.11	9.89	153	94070	20101	63374698
Wound	123.44	9.89	44	94179	163219	63231580
Pulmonary embolism	122.95	9.89	417	93806	116267	63278532
Treatment failure	122.02	9.89	72	94151	198971	63195828
Fluid retention	118.56	9.89	269	93954	59417	63335382
Helicobacter infection	112.99	9.89	6	94217	92779	63302020
Completed suicide	112.29	9.89	38	94185	145635	63249164
Duodenal ulcer perforation	111.60	9.89	4	94219	87205	63307594
Dehydration	110.00	9.89	529	93694	172825	63221974
Pericarditis	107.37	9.89	31	94192	131548	63263251
Swelling	101.82	9.89	157	94066	275221	63119578
Mental status changes	98.95	9.89	196	94027	39403	63355396
Deep vein thrombosis	96.77	9.89	309	93914	83491	63311308
Back pain	94.90	9.89	694	93529	263451	63131348
Pleural effusion	94.57	9.89	329	93894	92881	63301918
Off label use	93.21	9.89	603	93620	673859	62720940
Upper respiratory tract infection	90.64	9.89	298	93925	81749	63313050
Abdominal discomfort	90.61	9.89	215	94008	320670	63074129
Psoriatic arthropathy	90.09	9.89	14	94209	91506	63303293
Contraindicated product administered	87.42	9.89	117	94106	217531	63177268
Folliculitis	87.36	9.89	4	94219	70313	63324486
Muscle injury	83.60	9.89	3	94220	65342	63329457
Hyperhidrosis	82.55	9.89	348	93875	107488	63287311
Arthralgia	82.42	9.89	502	93721	569208	62825591
Rash erythematous	81.55	9.89	189	94034	42321	63352478
Salpingo-oophorectomy unilateral	81.37	9.89	35	94188	846	63393953
Condition aggravated	79.72	9.89	317	93906	401900	62992899
Oedema peripheral	77.47	9.89	514	93709	188997	63205802
Sinusitis fungal	75.72	9.89	42	94181	1789	63393010
Drug interaction	75.13	9.89	141	94082	228990	63165809
Haemoglobin decreased	73.60	9.89	417	93806	145068	63249731
Coma	72.18	9.89	235	93988	64129	63330670
Pneumonia	71.19	9.89	1010	93213	455757	62939042
Bursitis	70.29	9.89	164	94059	36877	63357922
Sputum increased	69.20	9.89	44	94179	2415	63392384
Platelet count decreased	65.57	9.89	343	93880	115779	63279020
Product use issue	65.23	9.89	144	94079	220376	63174423
Liver injury	64.99	9.89	7	94216	60513	63334286
Embolism venous	63.81	9.89	46	94177	3108	63391691
Toxicity to various agents	61.82	9.89	176	94047	247074	63147725
Infection	59.63	9.89	160	94063	229013	63165786
Diastolic dysfunction	59.55	9.89	60	94163	6411	63388388
Irritable bowel syndrome	59.27	9.89	24	94199	82388	63312411
Exposure during pregnancy	59.06	9.89	87	94136	155460	63239339
Febrile neutropenia	58.90	9.89	338	93885	118111	63276688
Therapeutic product effect incomplete	57.92	9.89	60	94163	124996	63269803
Oesophageal spasm	57.43	9.89	43	94180	3080	63391719
Musculoskeletal stiffness	56.72	9.89	118	94105	184500	63210299
Failure to thrive	55.98	9.89	61	94162	7137	63387662
Oesophageal pain	55.15	9.89	45	94178	3656	63391143
Respiratory symptom	54.78	9.89	43	94180	3304	63391495
Asthma	53.92	9.89	349	93874	127212	63267587
Diverticulum	52.15	9.89	76	94147	11915	63382884
Asthenia	51.08	9.89	826	93397	382778	63012021
Anaemia	51.01	9.89	662	93561	292768	63102031
Small intestinal obstruction	51.00	9.89	95	94128	18242	63376557
Sleep apnoea syndrome	50.98	9.89	125	94098	29008	63365791
Hiatus hernia	50.50	9.89	104	94119	21490	63373309
Intentional overdose	49.54	9.89	24	94199	74128	63320671
Urinary tract infection	49.35	9.89	605	93618	264079	63130720
Abdominal pain	46.45	9.89	651	93572	292805	63101994
Total lung capacity decreased	44.53	9.89	32	94191	2151	63392648
Iron deficiency anaemia	44.16	9.89	94	94129	19875	63374924
Cardiac failure congestive	44.15	9.89	261	93962	92172	63302627
Product use in unapproved indication	43.63	9.89	129	94094	178951	63215848
Ileus	43.11	9.89	78	94145	14647	63380152
Somnolence	42.69	9.89	429	93794	178256	63216543
Blister	42.41	9.89	80	94143	129734	63265065
Chronic sinusitis	41.45	9.89	71	94152	12772	63382027
Gastrointestinal disorder	41.04	9.89	83	94140	131156	63263643
Eosinophil percentage increased	40.91	9.89	23	94200	1006	63393793
Intentional product use issue	40.75	9.89	80	94143	127812	63266987
Blood uric acid decreased	40.50	9.89	21	94202	780	63394019
Knee arthroplasty	40.28	9.89	15	94208	54191	63340608
White blood cell count decreased	40.27	9.89	348	93875	138756	63256043
Neutrophil count decreased	40.04	9.89	178	94045	56228	63338571
Fungal infection	39.87	9.89	133	94090	36741	63358058
Nasal polyps	39.85	9.89	47	94176	5992	63388807
Blood cholesterol increased	39.31	9.89	49	94174	93983	63300816
Impaired healing	39.25	9.89	57	94166	102485	63292314
Cestode infection	38.85	9.89	15	94208	272	63394527
Tricuspid valve incompetence	38.50	9.89	74	94149	14547	63380252
Lung opacity	37.97	9.89	34	94189	3134	63391665
Aspiration	37.70	9.89	62	94161	10789	63384010
Inflammation	37.50	9.89	40	94183	82233	63312566
Female genital tract fistula	37.46	9.89	51	94172	7508	63387291
Peritonitis bacterial	37.33	9.89	41	94182	4838	63389961
Bronchopulmonary aspergillosis allergic	36.94	9.89	29	94194	2229	63392570
Rheumatoid arthritis	36.38	9.89	224	93999	253595	63141204
Hypoxia	35.39	9.89	179	94044	59613	63335186
Carbohydrate antigen 125 increased	35.30	9.89	31	94192	2785	63392014
Malignant neoplasm progression	34.27	9.89	224	93999	81897	63312902
General physical health deterioration	32.49	9.89	171	94052	201231	63193568
Abortion spontaneous	31.94	9.89	15	94208	47180	63347619
Blood calcium increased	31.91	9.89	53	94170	9297	63385502
Blood creatinine decreased	31.48	9.89	40	94183	5505	63389294
Type 2 diabetes mellitus	31.46	9.89	29	94194	63839	63330960
Magnesium deficiency	31.31	9.89	16	94207	576	63394223
Red blood cell sedimentation rate increased	31.31	9.89	13	94210	43969	63350830
Foetal exposure during pregnancy	31.19	9.89	5	94218	31957	63362842
Lymphoedema	30.57	9.89	59	94164	11633	63383166
Respiratory failure	29.04	9.89	254	93969	101604	63293195
Decreased appetite	28.79	9.89	528	93695	250524	63144275
Haemorrhoids	28.64	9.89	85	94138	22065	63372734
Disease progression	28.47	9.89	293	93930	122465	63272334
Premenstrual syndrome	28.39	9.89	16	94207	703	63394096
Emphysema	28.36	9.89	55	94168	10883	63383916
Obstructive airways disorder	28.27	9.89	81	94142	20618	63374181
Mobility decreased	27.57	9.89	90	94133	121069	63273730
Accidental exposure to product	27.40	9.89	4	94219	27401	63367398
Hepatocellular injury	27.37	9.89	4	94219	27377	63367422
Therapy non-responder	27.31	9.89	44	94179	75857	63318942
Device expulsion	27.08	9.89	9	94214	34913	63359886
Vomiting	27.00	9.89	1050	93173	558567	62836232
Fall	26.25	9.89	765	93458	391569	63003230
Suicide attempt	26.25	9.89	31	94192	60887	63333912
Granulocytopenia	26.20	9.89	37	94186	5635	63389164
Dental restoration failure	26.14	9.89	17	94206	970	63393829
Hallucination	25.66	9.89	154	94069	54663	63340136
Peripheral swelling	25.42	9.89	262	93961	265680	63129119
International normalised ratio increased	25.41	9.89	136	94087	46289	63348510
Adverse drug reaction	25.27	9.89	50	94173	79664	63315135
Live birth	25.03	9.89	4	94219	25626	63369173
Blood sodium decreased	24.92	9.89	86	94137	24166	63370633
Abdominal distension	24.69	9.89	216	94007	86399	63308400
Death	24.50	9.89	728	93495	373653	63021146
Loss of personal independence in daily activities	24.47	9.89	69	94154	97221	63297578
Ill-defined disorder	24.46	9.89	53	94170	81702	63313097
Lichen sclerosus	24.34	9.89	17	94206	1092	63393707
Lip pruritus	24.32	9.89	16	94207	931	63393868
Drug abuse	24.29	9.89	44	94179	72474	63322325
Hip arthroplasty	24.23	9.89	21	94202	47625	63347174
Cellulitis	24.21	9.89	206	94017	81752	63313047
Drug reaction with eosinophilia and systemic symptoms	24.09	9.89	10	94213	33826	63360973
Chronic obstructive pulmonary disease	23.77	9.89	167	94056	62519	63332280
Dysphagia	23.76	9.89	218	94005	88367	63306432
Drug resistance	23.75	9.89	3	94220	22930	63371869
Hysterectomy	23.70	9.89	47	94176	9452	63385347
Spinal compression fracture	23.63	9.89	60	94163	14223	63380576
Tinnitus	23.47	9.89	110	94113	35518	63359281
Hypophagia	23.21	9.89	100	94123	31159	63363640
C-reactive protein increased	23.21	9.89	68	94155	94639	63300160
Injection site erythema	23.20	9.89	56	94167	83118	63311681
Injection site reaction	22.92	9.89	32	94191	58492	63336307
Polymenorrhoea	22.87	9.89	17	94206	1204	63393595
Therapeutic response decreased	22.76	9.89	35	94188	61490	63333309
Hepatotoxicity	21.83	9.89	14	94209	37027	63357772
Nausea	21.69	9.89	1508	92715	852963	62541836
Pregnancy	21.61	9.89	14	94209	36822	63357977
Injection site pain	21.60	9.89	109	94114	129691	63265108
Drug hypersensitivity	21.47	9.89	328	93895	310359	63084440
Sinusitis	21.37	9.89	224	93999	226429	63168370
Rash	21.06	9.89	653	93570	560218	62834581
Intentional self-injury	21.03	9.89	6	94217	25681	63369118
Atelectasis	20.20	9.89	74	94149	21409	63373390
Hip fracture	20.16	9.89	92	94131	29382	63365417
Rales	19.63	9.89	52	94171	12645	63382154
Hospice care	19.49	9.89	39	94184	7893	63386906
Haematocrit decreased	19.36	9.89	112	94111	39228	63355571
Gastrointestinal haemorrhage	18.93	9.89	194	94029	80982	63313817
Ecchymosis	18.77	9.89	47	94176	11047	63383752
Grip strength decreased	18.63	9.89	5	94218	22282	63372517
Anxiety	18.53	9.89	438	93785	217103	63177696
Adverse event	18.44	9.89	46	94177	67513	63327286
Blood potassium decreased	18.36	9.89	116	94107	41910	63352889
Injection site pruritus	18.34	9.89	24	94199	45092	63349707
Dyspnoea	18.33	9.89	1176	93047	660137	62734662
Candida infection	18.29	9.89	87	94136	28264	63366535
Cystitis	18.28	9.89	142	94081	54849	63339950
Decubitus ulcer	18.25	9.89	45	94178	10475	63384324
Infusion related reaction	18.07	9.89	256	93967	245265	63149534
Menstruation delayed	17.71	9.89	17	94206	1712	63393087
Injection site swelling	17.66	9.89	27	94196	47545	63347254
Malignant neoplasm of thorax	17.36	9.89	4	94219	9	63394790
Lower gastrointestinal haemorrhage	17.28	9.89	37	94186	7853	63386946
Hyperaesthesia	17.28	9.89	41	94182	9317	63385482
Intestinal obstruction	17.23	9.89	91	94132	30808	63363991
Sepsis	17.17	9.89	321	93902	152802	63241997
Hypersensitivity	16.96	9.89	319	93904	292366	63102433
Blood creatinine increased	16.85	9.89	202	94021	87642	63307157
Bone erosion	16.78	9.89	3	94220	17714	63377085
Cholinergic syndrome	16.43	9.89	10	94213	508	63394291
Blood urea increased	16.33	9.89	80	94143	26299	63368500
Acute respiratory failure	16.21	9.89	97	94126	34388	63360411
Compression fracture	16.20	9.89	32	94191	6416	63388383
Cholestasis	16.18	9.89	12	94211	29422	63365377
Cardiac murmur	16.18	9.89	53	94170	14499	63380300
Drug ineffective for unapproved indication	16.15	9.89	16	94207	34047	63360752
Non-small cell lung cancer	15.94	9.89	23	94200	3572	63391227
Heart rate increased	15.66	9.89	211	94012	94027	63300772
Erythema	15.62	9.89	356	93867	175395	63219404
Body temperature fluctuation	15.44	9.89	18	94205	2267	63392532
Blood alkaline phosphatase increased	15.43	9.89	113	94110	42854	63351945
Hypervolaemia	15.38	9.89	83	94140	28330	63366469
Pyrexia	15.14	9.89	848	93375	469630	62925169
Ascites	15.14	9.89	108	94115	40620	63354179
Breath sounds abnormal	15.04	9.89	43	94180	10930	63383869
Pneumonia viral	14.94	9.89	35	94188	7887	63386912
Blood test abnormal	14.83	9.89	54	94169	15575	63379224
Arthritis	14.73	9.89	106	94117	115815	63278984
Cholecystitis chronic	14.59	9.89	41	94182	10320	63384479
Unresponsive to stimuli	14.56	9.89	93	94130	33723	63361076
Injection site rash	14.32	9.89	5	94218	18804	63375995
Haemoptysis	14.28	9.89	82	94141	28644	63366155
Tremor	14.06	9.89	275	93948	131964	63262835
Enterocolitis	14.05	9.89	34	94189	7824	63386975
Malnutrition	13.80	9.89	52	94171	15246	63379553
Lymphocyte count decreased	13.52	9.89	84	94139	30173	63364626
Premature baby	13.41	9.89	7	94216	20728	63374071
Full blood count decreased	13.40	9.89	75	94148	25949	63368850
Pruritus	13.01	9.89	423	93800	361030	63033769
Bronchial artery embolisation	12.94	9.89	3	94220	7	63394792
Atrial fibrillation	12.89	9.89	244	93979	116392	63278407
Neuralgia	12.88	9.89	74	94149	25852	63368947
Hepatic enzyme increased	12.83	9.89	217	94006	202111	63192688
Thrombocytopenia	12.75	9.89	304	93919	150853	63243946
Colitis ulcerative	12.67	9.89	12	94211	26079	63368720
Radiation associated pain	12.64	9.89	5	94218	97	63394702
Vision blurred	12.58	9.89	199	94024	91725	63303074
Parkinson's disease	12.52	9.89	12	94211	1207	63393592
Joint range of motion decreased	12.43	9.89	18	94205	32410	63362389
Premature delivery	12.42	9.89	16	94207	30265	63364534
Fatigue	12.35	9.89	1501	92722	886527	62508272
Basal cell carcinoma	12.32	9.89	14	94209	27977	63366822
Onychoclasis	12.30	9.89	28	94195	6194	63388605
Nasal discharge discolouration	12.29	9.89	16	94207	2255	63392544
Gingival pain	12.19	9.89	33	94190	8129	63386670
Blood loss anaemia	12.07	9.89	35	94188	8966	63385833
Sputum discoloured	11.91	9.89	52	94171	16295	63378504
Injection site bruising	11.86	9.89	28	94195	41882	63352917
Medication error	11.77	9.89	39	94184	52245	63342554
Chest pain	11.76	9.89	411	93812	215548	63179251
Small cell lung cancer extensive stage	11.73	9.89	3	94220	12	63394787
Arteriovenous graft site infection	11.73	9.89	3	94220	12	63394787
Postural tremor	11.71	9.89	7	94216	344	63394455
Injection site warmth	11.64	9.89	4	94219	15191	63379608
Postmenopausal haemorrhage	11.45	9.89	15	94208	2127	63392672
Hypoalbuminaemia	11.38	9.89	41	94182	11764	63383035
Product dose omission issue	11.32	9.89	263	93960	234050	63160749
Acquired epidermolysis bullosa	11.31	9.89	4	94219	56	63394743
Catheter site pain	11.30	9.89	23	94200	4712	63390087
Nasopharyngitis	11.30	9.89	289	93934	253968	63140831
Anaphylactic reaction	11.28	9.89	55	94168	66045	63328754
Cholecystitis	11.27	9.89	49	94174	15328	63379471
Heart rate decreased	11.16	9.89	110	94113	45450	63349349
Impaired work ability	11.15	9.89	6	94217	17469	63377330
Wrong technique in product usage process	11.15	9.89	51	94172	62289	63332510
Sleep disorder	11.14	9.89	73	94150	81493	63313306
Urinary tract obstruction	11.10	9.89	15	94208	2193	63392606
Flank pain	11.05	9.89	51	94172	16359	63378440
Embolic stroke	11.05	9.89	20	94203	3756	63391043
Joint stiffness	11.04	9.89	29	94194	41840	63352959
Non-Hodgkin's lymphoma	11.04	9.89	12	94211	1400	63393399
Cystocele	10.86	9.89	11	94212	1183	63393616
Gastrointestinal injury	10.80	9.89	8	94215	564	63394235
Product prescribing error	10.67	9.89	14	94209	26275	63368524
Blood thyroid stimulating hormone increased	10.66	9.89	29	94194	7165	63387634
Limb crushing injury	10.60	9.89	6	94217	266	63394533
COVID-19	10.56	9.89	112	94111	112991	63281808
Large intestinal obstruction	10.52	9.89	15	94208	2304	63392495
Insulin C-peptide increased	10.49	9.89	4	94219	70	63394729
Rubber sensitivity	10.46	9.89	15	94208	2316	63392483
Pruritus genital	10.37	9.89	16	94207	2638	63392161
White blood cell count increased	10.36	9.89	114	94109	48447	63346352
Muscular weakness	10.30	9.89	246	93977	122107	63272692
Wound infection bacterial	10.29	9.89	8	94215	606	63394193
Gastric ulcer	10.29	9.89	66	94157	23971	63370828
Pulmonary hypertension	10.27	9.89	92	94131	37031	63357768
Urinary retention postoperative	10.24	9.89	4	94219	75	63394724
Retching	10.23	9.89	46	94177	14599	63380200
Hypokalaemia	10.08	9.89	213	94010	103591	63291208
Intracranial hypotension	9.98	9.89	6	94217	298	63394501
Pharyngeal mass	9.96	9.89	6	94217	299	63394500

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	226.35	10.44	295	62548	456456	34437632
Off label use	163.10	10.44	318	62525	419206	34474882
Constipation	143.01	10.44	555	62288	136427	34757661
Drug abuse	108.26	10.44	23	62820	99073	34795015
Completed suicide	106.80	10.44	23	62820	98145	34795943
Plasma cell myeloma	86.57	10.44	216	62627	41821	34852267
Pneumonia	80.74	10.44	1000	61843	361627	34532461
Dehydration	79.63	10.44	451	62392	129518	34764570
Drug interaction	76.88	10.44	184	62659	225762	34668326
Product use in unapproved indication	65.19	10.44	69	62774	117430	34776658
Toxicity to various agents	57.71	10.44	177	62666	200185	34693903
Mental status changes	56.85	10.44	174	62669	37909	34856179
Soft tissue mass	47.48	10.44	27	62816	992	34893096
Multimorbidity	46.71	10.44	26	62817	916	34893172
Febrile neutropenia	46.67	10.44	412	62431	136437	34757651
Oesophageal perforation	45.96	10.44	28	62815	1171	34892917
Pleural effusion	44.73	10.44	275	62568	81271	34812817
Intentional overdose	44.01	10.44	12	62831	43662	34850426
Dysphagia	43.22	10.44	224	62619	62157	34831931
Urinary tract infection	42.67	10.44	278	62565	83803	34810285
Fall	42.17	10.44	553	62290	202332	34691756
Decreased appetite	41.74	10.44	470	62373	165922	34728166
Platelet count decreased	41.11	10.44	361	62482	119356	34774732
Condition aggravated	40.90	10.44	192	62651	192004	34702084
Haemoglobin decreased	38.31	10.44	358	62485	120414	34773674
White blood cell count increased	38.24	10.44	161	62682	40990	34853098
Confusional state	36.04	10.44	407	62436	143753	34750335
Foetal exposure during pregnancy	35.62	10.44	12	62831	38089	34855999
Malignant neoplasm progression	35.30	10.44	275	62568	87771	34806317
Superinfection	35.11	10.44	32	62811	2487	34891601
Treatment failure	33.88	10.44	21	62822	46676	34847412
Failure to thrive	32.84	10.44	57	62786	8544	34885544
Pneumonia aspiration	30.79	10.44	153	62690	41750	34852338
Haematocrit decreased	30.67	10.44	127	62716	32089	34861999
Muscular weakness	30.50	10.44	230	62613	72667	34821421
Disease progression	29.70	10.44	311	62532	107766	34786322
Overdose	27.94	10.44	78	62765	90981	34803107
Cholestasis	27.92	10.44	7	62836	26941	34867147
Transplant failure	25.96	10.44	32	62811	3521	34890567
Deep vein thrombosis	25.70	10.44	203	62640	65045	34829043
Contraindicated product administered	25.56	10.44	4	62839	21477	34872611
Product dose omission issue	25.19	10.44	120	62723	119591	34774497
Urinary retention	24.91	10.44	130	62713	36158	34857930
Hepatocellular injury	24.55	10.44	5	62838	22206	34871882
Metastatic renal cell carcinoma	24.55	10.44	24	62819	2037	34892051
Ileus	24.25	10.44	75	62768	16424	34877664
Neutrophil count decreased	24.12	10.44	166	62677	50938	34843150
White blood cell count decreased	23.61	10.44	269	62574	95176	34798912
Lung consolidation	23.53	10.44	40	62803	5896	34888192
Pneumonitis	23.00	10.44	121	62722	33757	34860331
Hallucination	22.97	10.44	165	62678	51333	34842755
Drug hypersensitivity	22.52	10.44	72	62771	80457	34813631
Drug reaction with eosinophilia and systemic symptoms	22.39	10.44	16	62827	32996	34861092
Hypoxia	22.02	10.44	172	62671	54923	34839165
Neurogenic bladder	21.39	10.44	21	62822	1792	34892296
Red blood cell count decreased	21.21	10.44	106	62737	28984	34865104
Cardiac failure congestive	20.73	10.44	235	62608	83035	34811053
Asthenia	20.66	10.44	582	62261	244669	34649419
Therapeutic product effect incomplete	20.64	10.44	37	62806	50504	34843584
Rheumatoid arthritis	20.58	10.44	23	62820	38215	34855873
Suicide attempt	20.54	10.44	24	62819	39092	34854996
Pulmonary vasculitis	20.46	10.44	13	62830	586	34893502
Burkholderia test positive	20.45	10.44	16	62827	1007	34893081
Intentional product misuse	19.91	10.44	32	62811	45579	34848509
Neuritis	19.53	10.44	15	62828	919	34893169
Granulocytopenia	19.42	10.44	39	62804	6528	34887560
Atelectasis	19.39	10.44	73	62770	17654	34876434
Pathological fracture	19.30	10.44	31	62812	4360	34889728
Premature baby	18.67	10.44	6	62837	19627	34874461
Hypophagia	18.56	10.44	89	62754	23933	34870155
Decubitus ulcer	18.52	10.44	46	62797	8875	34885213
Intentional product use issue	18.51	10.44	51	62792	59765	34834323
Sepsis	18.38	10.44	410	62433	166151	34727937
Multiple organ dysfunction syndrome	18.38	10.44	73	62770	76493	34817595
Back pain	17.52	10.44	312	62531	121477	34772611
Subacute endocarditis	17.15	10.44	6	62837	66	34894022
Pulmonary embolism	17.10	10.44	241	62602	89505	34804583
Immunosuppressant drug level increased	16.77	10.44	35	62808	6020	34888068
Drug ineffective for unapproved indication	16.74	10.44	11	62832	23704	34870384
Eosinophil percentage increased	16.38	10.44	11	62832	545	34893543
Neutrophil count increased	15.85	10.44	67	62776	17079	34877009
Disturbance in attention	15.80	10.44	14	62829	25931	34868157
Injection site pain	15.53	10.44	29	62814	38976	34855112
Oral pustule	15.45	10.44	8	62835	243	34893845
Blood sodium decreased	15.41	10.44	64	62779	16187	34877901
Death	15.38	10.44	868	61975	397181	34496907
Lumbar spinal stenosis	15.34	10.44	21	62822	2561	34891527
Toxic epidermal necrolysis	15.33	10.44	10	62833	21636	34872452
Metabolic acidosis	15.26	10.44	35	62808	43645	34850443
Dyspnoea paroxysmal nocturnal	15.20	10.44	16	62827	1483	34892605
Stupor	14.94	10.44	22	62821	2869	34891219
Myelosuppression	14.92	10.44	8	62835	19257	34874831
Delirium	14.73	10.44	132	62711	43859	34850229
Product use issue	14.71	10.44	61	62782	63155	34830933
Angioedema	14.69	10.44	28	62815	37346	34856742
Hospice care	14.63	10.44	36	62807	6904	34887184
Fatigue	14.45	10.44	809	62034	369844	34524244
Streptococcus test positive	14.35	10.44	13	62830	1002	34893086
Biliary obstruction	14.35	10.44	21	62822	2724	34891364
Wrong technique in product usage process	14.11	10.44	27	62816	35959	34858129
Synovitis	13.91	10.44	4	62839	14062	34880026
Water intoxication	13.90	10.44	9	62834	419	34893669
Cancer pain	13.33	10.44	20	62823	2652	34891436
Cholangitis	13.24	10.44	40	62803	8649	34885439
Psoriatic arthropathy	12.90	10.44	10	62833	19788	34874300
Lactic acidosis	12.85	10.44	27	62816	34745	34859343
Eosinophilia	12.81	10.44	17	62826	26205	34867883
Cellulitis	12.53	10.44	148	62695	52803	34841285
Calculus bladder	12.46	10.44	12	62831	1000	34893088
Cardiogenic shock	12.26	10.44	18	62825	26600	34867488
Peritonitis bacterial	12.15	10.44	31	62812	6079	34888009
Spinal compression fracture	12.03	10.44	34	62809	7082	34887006
Polyneuropathy	11.81	10.44	6	62837	14890	34879198
Oesophageal carcinoma	11.61	10.44	40	62803	9264	34884824
Unresponsive to stimuli	11.53	10.44	87	62756	27482	34866606
Withdrawal syndrome	11.50	10.44	4	62839	12451	34881637
Faecaloma	11.45	10.44	28	62815	5349	34888739
Radiation skin injury	11.44	10.44	10	62833	735	34893353
Small intestinal obstruction	11.43	10.44	55	62788	14811	34879277
Band neutrophil percentage increased	11.31	10.44	5	62838	106	34893982
Full blood count decreased	11.19	10.44	63	62780	18025	34876063
Haemoptysis	11.19	10.44	104	62739	34902	34859186
Paratracheal lymphadenopathy	11.18	10.44	5	62838	109	34893979
Urticaria	11.17	10.44	66	62777	62311	34831777
Monocyte percentage increased	11.01	10.44	11	62832	958	34893130
COVID-19	10.95	10.44	88	62755	77462	34816626
Vomiting	10.94	10.44	547	62296	247074	34647014
Dextrocardia	10.85	10.44	5	62838	117	34893971
Muscle spasticity	10.82	10.44	29	62814	5859	34888229
Incorrect dose administered	10.79	10.44	37	62806	40478	34853610
Radiation pneumonitis	10.74	10.44	18	62825	2622	34891466
Coma	10.67	10.44	44	62799	45634	34848454
Blood calcium decreased	10.59	10.44	41	62802	10043	34884045
Pyrexia	10.57	10.44	714	62129	332299	34561789
Inflammatory marker increased	10.51	10.44	26	62817	5002	34889086

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	420.71	9.93	674	126434	1080239	78537041
Constipation	371.63	9.93	1142	125966	281908	79335372
Completed suicide	221.49	9.93	59	127049	245708	79371572
Temperature regulation disorder	216.60	9.93	128	126980	5725	79611555
Off label use	212.27	9.93	740	126368	906475	78710805
Plasma cell myeloma	177.90	9.93	311	126797	52948	79564332
Pneumonia aspiration	176.19	9.93	353	126755	66614	79550666
Synovitis	170.73	9.93	20	127088	150714	79466566
Food allergy	164.17	9.93	137	126971	10687	79606593
Systemic lupus erythematosus	147.89	9.93	12	127096	121137	79496143
Hand deformity	146.85	9.93	4	127104	103915	79513365
Toxicity to various agents	146.55	9.93	281	126827	421259	79196021
Coeliac disease	140.57	9.93	128	126980	11223	79606057
Dehydration	136.97	9.93	767	126341	247420	79369860
Pemphigus	129.97	9.93	7	127101	99575	79517705
Drug interaction	129.78	9.93	294	126814	414889	79202391
Pneumonia	124.31	9.93	1601	125507	658645	78958635
Mental status changes	123.19	9.93	306	126802	66653	79550627
Therapeutic product effect decreased	117.59	9.93	57	127051	163806	79453474
Febrile neutropenia	117.07	9.93	698	126410	230301	79386979
Drug intolerance	116.48	9.93	150	126958	263969	79353311
Arthropathy	112.10	9.93	72	127036	177039	79440241
Drug abuse	111.65	9.93	60	127048	162631	79454649
Pulmonary embolism	110.75	9.93	554	126554	171100	79446180
Immunodeficiency	107.29	9.93	152	126956	21616	79595664
Condition aggravated	104.89	9.93	427	126681	500697	79116583
Maternal exposure during pregnancy	103.41	9.93	44	127064	136494	79480786
Joint swelling	103.23	9.93	189	126919	288457	79328823
Fluid retention	103.06	9.93	294	126814	69515	79547765
Pleural effusion	102.45	9.93	481	126627	144781	79472499
Platelet count decreased	99.10	9.93	589	126519	194075	79423205
Discomfort	97.53	9.93	39	127069	125578	79491702
Gastrooesophageal reflux disease	96.57	9.93	375	126733	103871	79513409
Treatment failure	94.06	9.93	80	127028	170406	79446874
Deep vein thrombosis	93.16	9.93	411	126697	120508	79496772
Back pain	92.51	9.93	813	126295	303367	79313913
Alopecia	86.76	9.93	147	126961	231208	79386072
Haemoglobin decreased	85.68	9.93	627	126481	221492	79395788
Duodenal ulcer perforation	85.33	9.93	5	127103	66206	79551074
Helicobacter infection	84.80	9.93	7	127101	69697	79547583
Product use in unapproved indication	80.83	9.93	174	126934	250185	79367095
Intentional overdose	80.47	9.93	34	127074	105926	79511354
Glossodynia	80.35	9.93	32	127076	103305	79513975
Salpingo-oophorectomy unilateral	74.32	9.93	33	127075	801	79616479
Arthralgia	73.87	9.93	571	126537	571232	79046048
Psoriatic arthropathy	73.55	9.93	17	127091	77982	79539298
Failure to thrive	72.61	9.93	92	127016	11752	79605528
Malignant neoplasm progression	72.10	9.93	416	126692	135574	79481706
Upper respiratory tract infection	71.06	9.93	311	126797	90857	79526423
Ileus	68.71	9.93	138	126970	26073	79591207
Pericarditis	67.84	9.93	41	127067	104195	79513085
Oesophageal spasm	63.61	9.93	49	127059	3407	79613873
Neutrophil count decreased	63.22	9.93	307	126801	93652	79523628
Folliculitis	61.09	9.93	8	127100	55372	79561908
Respiratory symptom	59.27	9.93	54	127054	4737	79612543
Bursitis	58.88	9.93	157	126951	35687	79581593
Urinary tract infection	58.48	9.93	682	126426	273830	79343450
Eosinophil percentage increased	58.28	9.93	34	127074	1484	79615796
Hyperhidrosis	56.31	9.93	424	126684	151068	79466212
Rash erythematous	56.10	9.93	211	126897	57558	79559722
Muscle injury	56.08	9.93	6	127102	48555	79568725
Sinusitis fungal	55.77	9.93	39	127069	2335	79614945
Intentional product use issue	55.77	9.93	98	127010	152014	79465266
Oesophageal pain	54.45	9.93	49	127059	4230	79613050
Hypoxia	52.88	9.93	313	126795	102930	79514350
Decreased appetite	52.72	9.93	802	126306	341616	79275664
White blood cell count decreased	51.96	9.93	493	126615	187795	79429485
Dysphagia	51.86	9.93	353	126755	121783	79495497
Granulocytopenia	50.78	9.93	76	127032	11355	79605925
Oedema peripheral	50.74	9.93	620	126488	251668	79365612
Irritable bowel syndrome	50.51	9.93	18	127090	62223	79555057
Inflammation	50.47	9.93	45	127063	93708	79523572
Wound	50.12	9.93	67	127041	116112	79501168
Hepatocellular injury	49.88	9.93	8	127100	47585	79569695
Drug resistance	49.30	9.93	5	127103	42208	79575072
Therapeutic product effect incomplete	48.60	9.93	95	127013	141550	79475730
Therapeutic response decreased	46.81	9.93	24	127084	66829	79550451
Hiatus hernia	46.56	9.93	110	126998	23202	79594078
Contraindicated product administered	46.37	9.93	115	126993	157423	79459857
Peritonitis bacterial	45.96	9.93	66	127042	9501	79607779
Soft tissue mass	44.62	9.93	27	127081	1261	79616019
Oesophageal perforation	44.54	9.93	29	127079	1542	79615738
Hallucination	43.94	9.93	260	126848	85485	79531795
Sputum increased	43.88	9.93	45	127063	4568	79612712
Embolism venous	43.34	9.93	43	127065	4196	79613084
White blood cell count increased	42.65	9.93	233	126875	74400	79542880
Haematocrit decreased	42.44	9.93	202	126906	61110	79556170
Cholestasis	42.41	9.93	15	127093	52094	79565186
Suicide attempt	42.07	9.93	42	127066	82890	79534390
Drug reaction with eosinophilia and systemic symptoms	40.78	9.93	26	127082	64218	79553062
Disease progression	40.10	9.93	460	126648	183902	79433378
Product use issue	39.99	9.93	185	126923	209637	79407643
Musculoskeletal stiffness	39.81	9.93	144	126964	174864	79442416
Multimorbidity	39.42	9.93	26	127082	1413	79615867
Exposure during pregnancy	39.05	9.93	63	127045	101069	79516211
Abdominal discomfort	38.39	9.93	238	126870	250489	79366791
Cestode infection	38.27	9.93	15	127093	263	79617017
Fall	38.07	9.93	1032	126076	486597	79130683
Gastrointestinal disorder	37.71	9.93	87	127021	122118	79495162
Female genital tract fistula	37.56	9.93	47	127061	5928	79611352
Blood cholesterol increased	36.39	9.93	48	127060	83672	79533608
Carbohydrate antigen 125 increased	35.96	9.93	29	127079	2155	79615125
Cardiac failure congestive	35.92	9.93	366	126742	142036	79475244
Small intestinal obstruction	35.61	9.93	110	126998	27162	79590118
Asthma	35.42	9.93	350	126758	134745	79482535
General physical health deterioration	35.37	9.93	275	126833	274963	79342317
Blood sodium decreased	35.26	9.93	125	126983	33130	79584150
Diverticulum	35.02	9.93	75	127033	14821	79602459
Blood uric acid decreased	34.63	9.93	23	127085	1265	79616015
Diastolic dysfunction	34.62	9.93	62	127046	10749	79606531
Death	34.55	9.93	1163	125945	565351	79051929
Total lung capacity decreased	34.49	9.93	32	127076	2873	79614407
Impaired healing	34.41	9.93	54	127054	87601	79529679
Sepsis	34.01	9.93	611	126497	268817	79348463
Asthenia	33.66	9.93	1060	126048	510629	79106651
Anaemia	33.36	9.93	937	126171	444078	79173202
Iron deficiency anaemia	33.02	9.93	103	127005	25569	79591711
Lung opacity	33.00	9.93	41	127067	5133	79612147
Red blood cell sedimentation rate increased	32.91	9.93	16	127092	45926	79571354
Hypophagia	32.52	9.93	151	126957	45216	79572064
Infection	32.24	9.93	239	126869	241473	79375807
Liver injury	31.90	9.93	26	127082	56588	79560692
Sleep apnoea syndrome	31.17	9.93	128	126980	36350	79580930
Chronic sinusitis	31.10	9.93	66	127042	12960	79604320
Injection site reaction	31.07	9.93	25	127083	54760	79562520
Knee arthroplasty	31.07	9.93	15	127093	43233	79574047
Premenstrual syndrome	30.91	9.93	16	127092	550	79616730
Injection site pain	30.75	9.93	105	127003	129733	79487547
Spinal compression fracture	30.65	9.93	77	127031	16881	79600399
Swelling	30.49	9.93	211	126897	216500	79400780
Fungal infection	29.95	9.93	139	126969	41609	79575671
Red blood cell count decreased	29.85	9.93	175	126933	57338	79559942
Muscular weakness	29.73	9.93	389	126719	160340	79456940
Pneumonitis	29.55	9.93	182	126926	60678	79556602
Bronchopulmonary aspergillosis allergic	29.37	9.93	30	127078	3031	79614249
Cellulitis	29.29	9.93	284	126824	108776	79508504
Rheumatoid arthritis	28.83	9.93	204	126904	208266	79409014
Drug ineffective for unapproved indication	28.29	9.93	24	127084	51214	79566066
Drug hypersensitivity	27.99	9.93	323	126785	298593	79318687
Respiratory failure	27.89	9.93	424	126684	180487	79436793
Blood creatinine decreased	27.83	9.93	47	127061	7778	79609502
International normalised ratio increased	27.55	9.93	230	126878	84491	79532789
Blood calcium increased	27.55	9.93	55	127053	10345	79606935
Accidental exposure to product	27.28	9.93	8	127100	31314	79585966
Intentional self-injury	26.95	9.93	9	127099	32410	79584870
Haemoptysis	26.90	9.93	167	126941	55832	79561448
Magnesium deficiency	26.70	9.93	15	127093	609	79616671
Therapy non-responder	26.67	9.93	68	127040	92237	79525043
Urinary retention	26.65	9.93	168	126940	56462	79560818
Injection site erythema	26.34	9.93	53	127055	78144	79539136
Nasal polyps	26.05	9.93	44	127064	7283	79609997
Haemorrhoids	25.51	9.93	103	127005	29025	79588255
Emphysema	25.37	9.93	70	127038	16230	79601050
Abdominal distension	25.32	9.93	297	126811	119353	79497927
Aspiration	25.12	9.93	80	127028	20078	79597202
Lichen sclerosus	24.93	9.93	17	127091	977	79616303
Mobility decreased	24.91	9.93	105	127003	122070	79495210
Polymenorrhoea	24.80	9.93	17	127091	985	79616295
Neurogenic bladder	24.69	9.93	32	127076	4180	79613100
Myelosuppression	24.64	9.93	17	127091	40279	79577001
Metabolic acidosis	24.47	9.93	60	127048	82469	79534811
Decubitus ulcer	24.05	9.93	67	127041	15620	79601660
Rales	23.68	9.93	78	127030	19923	79597357
Product dose omission issue	22.97	9.93	268	126840	247269	79370011
Somnolence	22.84	9.93	520	126588	238461	79378819
Hepatotoxicity	22.77	9.93	29	127079	51323	79565957
Obstructive airways disorder	22.76	9.93	105	127003	31354	79585926
Cystitis	22.72	9.93	153	126955	52579	79564701
Injection site swelling	22.63	9.93	25	127083	47107	79570173
Metastatic renal cell carcinoma	22.45	9.93	23	127085	2332	79614948
Lung consolidation	22.14	9.93	46	127062	8901	79608379
Vomiting	22.08	9.93	1284	125824	664544	78952736
Injection site pruritus	21.92	9.93	21	127087	42262	79575018
Abdominal pain	21.52	9.93	791	126317	388778	79228502
Lip pruritus	21.46	9.93	15	127093	897	79616383
Pulmonary vasculitis	21.46	9.93	14	127094	747	79616533
Hysterectomy	21.42	9.93	37	127071	6235	79611045
Pregnancy	21.39	9.93	8	127100	26843	79590437
Chronic obstructive pulmonary disease	21.27	9.93	219	126889	85200	79532080
Lymphoedema	21.02	9.93	55	127053	12358	79604922
Hospice care	20.93	9.93	49	127059	10275	79607005
Pyrexia	20.84	9.93	1300	125808	677409	78939871
Transplant failure	20.82	9.93	31	127077	4610	79612670
Atelectasis	20.69	9.93	104	127004	32153	79585127
Ecchymosis	20.48	9.93	62	127046	15144	79602136
Dental restoration failure	20.44	9.93	15	127093	969	79616311
Gastrointestinal haemorrhage	20.42	9.93	340	126768	147379	79469901
Fatigue	20.41	9.93	1733	125375	927994	78689286
Lymphocyte count decreased	20.25	9.93	137	126971	47152	79570128
Grip strength decreased	20.15	9.93	5	127103	21864	79595416
Adverse drug reaction	19.89	9.93	48	127060	66344	79550936
Interstitial lung disease	19.77	9.93	270	126838	112330	79504950
Superinfection	19.54	9.93	31	127077	4871	79612409
Multiple organ dysfunction syndrome	19.52	9.93	112	126996	120134	79497146
Menstruation delayed	19.48	9.93	17	127091	1409	79615871
Wrong technique in product usage process	19.41	9.93	57	127051	73818	79543462
Tricuspid valve incompetence	19.13	9.93	72	127036	19640	79597640
Unresponsive to stimuli	18.97	9.93	153	126955	55635	79561645
C-reactive protein increased	18.95	9.93	124	126984	128903	79488377
Hip fracture	18.91	9.93	98	127010	30663	79586617
Nausea	18.83	9.93	1770	125338	955426	78661854
Medication error	18.74	9.93	52	127056	68590	79548690
Radiation pneumonitis	18.70	9.93	27	127081	3906	79613374
Arthritis	18.65	9.93	107	127001	114773	79502507
Abortion spontaneous	18.65	9.93	12	127096	29495	79587785
Device expulsion	18.53	9.93	9	127099	25852	79591428
Blister	18.48	9.93	113	126995	119363	79497917
Sputum discoloured	18.34	9.93	76	127032	21667	79595613
Colitis ulcerative	18.31	9.93	17	127091	34725	79582555
Cancer pain	17.99	9.93	31	127077	5214	79612066
Lactic acidosis	17.97	9.93	55	127053	70304	79546976
Live birth	17.84	9.93	4	127104	18740	79598540
COVID-19	17.78	9.93	163	126945	157511	79459769
Neutrophil count increased	17.62	9.93	93	127015	29303	79587977
Neuralgia	17.59	9.93	102	127006	33282	79583998
Type 2 diabetes mellitus	17.35	9.93	41	127067	57081	79560199
Injection site bruising	17.32	9.93	24	127084	40978	79576302
Acute respiratory failure	16.95	9.93	157	126951	59384	79557896
Enterocolitis	16.65	9.93	56	127052	14456	79602824
Malignant neoplasm of thorax	16.50	9.93	4	127104	11	79617269
Postmenopausal haemorrhage	16.34	9.93	16	127092	1536	79615744
Hepatic function abnormal	16.14	9.93	183	126925	72924	79544356
Sleep disorder	16.04	9.93	76	127032	85601	79531679
Ill-defined disorder	15.78	9.93	53	127055	65822	79551458
Hyperaesthesia	15.68	9.93	49	127059	12173	79605107
Hypervolaemia	15.57	9.93	119	126989	42571	79574709
Coma	15.54	9.93	236	126872	100413	79516867
Agitation	15.47	9.93	234	126874	99481	79517799
Malnutrition	15.47	9.93	74	127034	22428	79594852
Product prescribing error	15.41	9.93	30	127078	44783	79572497
Nasopharyngitis	15.23	9.93	299	126809	253582	79363698
Polyneuropathy	15.02	9.93	10	127098	24141	79593139
Blood creatinine increased	14.99	9.93	338	126770	154719	79462561
Retching	14.69	9.93	61	127047	17406	79599874
Basal cell carcinoma	14.69	9.93	23	127085	37352	79579928
Hypokalaemia	14.56	9.93	316	126792	143724	79473556
Haemorrhage intracranial	14.44	9.93	81	127027	26112	79591168
Ascites	14.43	9.93	184	126924	75378	79541902
Toxic epidermal necrolysis	14.35	9.93	31	127077	44550	79572730
Water intoxication	14.30	9.93	11	127097	763	79616517
Lethargy	14.30	9.93	195	126913	81097	79536183
Anaphylactic shock	14.29	9.93	22	127086	35974	79581306
Poriomania	14.25	9.93	7	127101	215	79617065
Adverse event	14.04	9.93	49	127059	60165	79557115
Upper respiratory tract inflammation	14.04	9.93	24	127084	4011	79613269
Sinusitis	14.03	9.93	223	126885	195278	79422002
Blood potassium decreased	13.93	9.93	124	126984	46388	79570892
Loss of personal independence in daily activities	13.87	9.93	101	127007	102479	79514801
Eosinophil count increased	13.81	9.93	59	127049	17046	79600234
Poisoning	13.75	9.93	12	127096	25260	79592020
Myalgia	13.58	9.93	211	126897	185430	79431850
Blood urea increased	13.56	9.93	128	126980	48662	79568618
Haematotoxicity	13.45	9.93	4	127104	15515	79601765
Urticaria	13.38	9.93	211	126897	184990	79432290
Joint effusion	13.32	9.93	6	127102	18008	79599272
Lip dry	13.32	9.93	4	127104	15414	79601866
Delirium	13.29	9.93	199	126909	84428	79532852
Stupor	13.26	9.93	32	127076	6840	79610440
Dyspnoea paroxysmal nocturnal	13.17	9.93	17	127091	2211	79615069
Serotonin syndrome	13.14	9.93	33	127075	44994	79572286
Hip arthroplasty	13.13	9.93	23	127085	35733	79581547
Rubber sensitivity	13.03	9.93	15	127093	1734	79615546
Neuritis	12.97	9.93	15	127093	1743	79615537
Pneumonia viral	12.96	9.93	38	127070	9120	79608160
Heart rate increased	12.90	9.93	267	126841	120457	79496823
Lumbar spinal stenosis	12.88	9.93	27	127081	5255	79612025
Perirectal abscess	12.74	9.93	16	127092	2025	79615255
Oral pustule	12.69	9.93	7	127101	274	79617006
Spinal cord compression	12.64	9.93	30	127078	6347	79610933
Posterior reversible encephalopathy syndrome	12.55	9.93	14	127094	26267	79591013
Intestinal obstruction	12.53	9.93	114	126994	42906	79574374
Blood thyroid stimulating hormone increased	12.53	9.93	39	127069	9669	79607611
Injection site warmth	12.50	9.93	4	127104	14803	79602477
Acute generalised exanthematous pustulosis	12.37	9.93	6	127102	17248	79600032
Calculus bladder	12.36	9.93	13	127095	1359	79615921
Cardiomegaly	12.29	9.93	78	127030	26274	79591006
Airway burns	12.19	9.93	3	127105	9	79617271
Monocyte percentage increased	12.14	9.93	16	127092	2125	79615155
Tremor	12.12	9.93	356	126752	169727	79447553
Pruritus	12.11	9.93	510	126598	394138	79223142
Blood creatine phosphokinase decreased	12.10	9.93	11	127097	962	79616318
Impaired quality of life	11.95	9.93	4	127104	14382	79602898
Anxiety	11.92	9.93	497	126611	248015	79369265
Faecaloma	11.86	9.93	43	127065	11521	79605759
Faecal volume increased	11.78	9.93	7	127101	316	79616964
Intentional product misuse	11.78	9.93	96	127012	95069	79522211
Angioedema	11.71	9.93	72	127036	75963	79541317
Tinnitus	11.68	9.93	115	126993	44218	79573062
Bronchopulmonary aspergillosis	11.64	9.93	11	127097	22283	79594997
Non-small cell lung cancer	11.62	9.93	29	127079	6331	79610949
Dyspnoea	11.62	9.93	1547	125561	855478	78761802
Dyspnoea exertional	11.51	9.93	199	126909	86874	79530406
Pneumothorax	11.50	9.93	81	127027	28242	79589038
Illness	11.43	9.93	37	127071	46474	79570806
Otorrhoea	11.41	9.93	14	127094	1731	79615549
Compression fracture	11.33	9.93	29	127079	6431	79610849
Cardiogenic shock	11.26	9.93	32	127076	41882	79575398
Lupus-like syndrome	11.25	9.93	4	127104	13853	79603427
Radiation associated pain	11.20	9.93	5	127103	123	79617157
Cholecystitis chronic	11.16	9.93	38	127070	9868	79607412
Impaired work ability	11.14	9.93	9	127099	19672	79597608
Peripheral swelling	11.10	9.93	336	126772	269281	79347999
Lower gastrointestinal haemorrhage	11.06	9.93	53	127055	16072	79601208
Cholangitis	11.05	9.93	45	127063	12731	79604549
Foetal death	11.02	9.93	33	127075	8011	79609269
Malignant neoplasm of renal pelvis	10.98	9.93	5	127103	129	79617151
Ankylosing spondylitis	10.85	9.93	3	127105	12202	79605078
Accidental overdose	10.79	9.93	30	127078	39551	79577729
Productive cough	10.66	9.93	199	126909	88132	79529148
Pathological fracture	10.65	9.93	39	127069	10498	79606782
Bladder catheterisation	10.63	9.93	10	127098	914	79616366
Embolic stroke	10.62	9.93	32	127076	7794	79609486
Blood test abnormal	10.59	9.93	56	127052	17654	79599626
Immunosuppressant drug level increased	10.50	9.93	35	127073	8992	79608288
Cytomegalovirus infection	10.42	9.93	34	127074	42610	79574670
Bronchial artery embolisation	10.38	9.93	3	127105	19	79617261
Phlebosclerosis	10.35	9.93	5	127103	148	79617132
Dementia	10.29	9.93	71	127037	24588	79592692
Catheter site pain	10.28	9.93	25	127083	5371	79611909
Venoocclusive liver disease	10.26	9.93	3	127105	11768	79605512
Hyponatraemia	10.26	9.93	363	126745	177485	79439795
Small cell lung cancer extensive stage	10.25	9.93	3	127105	20	79617260
Respiratory tract congestion	10.24	9.93	10	127098	19944	79597336
Ear infection	10.23	9.93	25	127083	34407	79582873
Gastrointestinal perforation	10.20	9.93	27	127081	6110	79611170
Nasal discharge discolouration	10.13	9.93	16	127092	2505	79614775
Gastrointestinal injury	10.10	9.93	10	127098	973	79616307
Bacteraemia	10.08	9.93	88	127020	32736	79584544
Feeling hot	10.04	9.93	55	127053	59679	79557601
Hiccups	10.04	9.93	37	127071	9994	79607286

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D054368	Laxatives

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089
Irritable bowel syndrome	off-label use	10743008	DOID:9778
Incomplete passage of stool	off-label use	249515001
Incontinence of feces	contraindication	72042002
Appendicitis	contraindication	74400008	DOID:8337
Intestinal obstruction	contraindication	81060008	DOID:8437
Gastrointestinal obstruction	contraindication	126765001
Intestinal Impaction	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4021246	VUID
N0000179238	NUI
62211-03-4	SECONDARY_CAS_RN
4019930	VANDF
4021246	VANDF
C3489575	UMLSCUI
CHEMBL2108559	ChEMBL_ID
DB11365	DRUGBANK_ID
3FYP5M0IJX	UNII
5199	PUBCHEM_CID
36387	RXNORM
5149	MMSL
5452	MMSL
5455	MMSL
84266	MMSL
d01013	MMSL
001169	NDDF
001170	NDDF
003868	NDDF
30125007	SNOMEDCT_US
387162007	SNOMEDCT_US
412302003	SNOMEDCT_US
420709001	SNOMEDCT_US
D000081226	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
EX-LAXREGULAR STRENGTH STIMULANT LAXATIVE	HUMAN OTC DRUG LABEL	1	0067-0003	PILL	15 mg	ORAL	OTC monograph not final	16 sections
EX-LAXREGULAR STRENGTH CHOCOLATED STIMULANT LAXATIVE	HUMAN OTC DRUG LABEL	1	0067-8140	TABLET, CHEWABLE	15 mg	ORAL	OTC monograph not final	15 sections
EX-LAXREGULAR STRENGTH STIMULANT LAXATIVE	HUMAN OTC DRUG LABEL	1	0067-8141	TABLET	15 mg	ORAL	OTC monograph not final	16 sections
EX-LAXMAXIMUM STRENGTH STIMULANT LAXATIVE	HUMAN OTC DRUG LABEL	1	0067-8142	PILL	25 mg	ORAL	OTC monograph not final	16 sections
Perdiem	HUMAN OTC DRUG LABEL	1	0067-8143	TABLET	15 mg	ORAL	OTC monograph not final	15 sections
Senna Syrup	HUMAN OTC DRUG LABEL	1	0121-4967	LIQUID	8.80 mg	ORAL	OTC monograph not final	11 sections
Senna Syrup	HUMAN OTC DRUG LABEL	1	0121-4967	LIQUID	8.80 mg	ORAL	OTC monograph not final	11 sections
Senna laxative	HUMAN OTC DRUG LABEL	1	0363-0138	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Senna laxative	HUMAN OTC DRUG LABEL	1	0363-0138	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
LaxativeRegular Strength	HUMAN OTC DRUG LABEL	1	0363-0347	TABLET, COATED	15 mg	ORAL	OTC monograph not final	16 sections
Senna laxative	HUMAN OTC DRUG LABEL	1	0363-0486	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Senna laxative	HUMAN OTC DRUG LABEL	1	0363-0486	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Stool SoftenerPlus Stimulant Laxative	HUMAN OTC DRUG LABEL	2	0363-0584	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Stool SoftenerPlus Stimulant Laxative	HUMAN OTC DRUG LABEL	2	0363-0584	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Senna S	HUMAN OTC DRUG LABEL	2	0363-0785	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Senna S	HUMAN OTC DRUG LABEL	2	0363-0785	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Stool Softener LaxativePlus Stimulant	HUMAN OTC DRUG LABEL	2	0363-0827	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Stool Softener LaxativePlus Stimulant	HUMAN OTC DRUG LABEL	2	0363-0827	TABLET	8.60 mg	ORAL	OTC MONOGRAPH NOT FINAL	14 sections
Senna S	HUMAN OTC DRUG LABEL	2	0363-0883	TABLET	8.60 mg	ORAL	OTC monograph not final	14 sections
Senna S	HUMAN OTC DRUG LABEL	2	0363-0883	TABLET	8.60 mg	ORAL	OTC monograph not final	14 sections
SENNA-S	HUMAN OTC DRUG LABEL	2	0363-3010	CAPSULE, GELATIN COATED	8.60 mg	ORAL	OTC monograph not final	15 sections
SENNA-S	HUMAN OTC DRUG LABEL	2	0363-3010	CAPSULE, GELATIN COATED	8.60 mg	ORAL	OTC monograph not final	15 sections
Laxative	HUMAN OTC DRUG LABEL	1	0363-3480	TABLET, SUGAR COATED	25 mg	ORAL	OTC monograph not final	16 sections
Laxative	HUMAN OTC DRUG LABEL	1	0363-3480	TABLET, SUGAR COATED	25 mg	ORAL	OTC monograph not final	16 sections
Chocolated Laxative	HUMAN OTC DRUG LABEL	1	0363-5000	TABLET, CHEWABLE	15 mg	ORAL	OTC monograph not final	17 sections
Chocolated Laxative	HUMAN OTC DRUG LABEL	1	0363-5000	TABLET, CHEWABLE	15 mg	ORAL	OTC monograph not final	17 sections
Walgreens Senna Laxative	HUMAN OTC DRUG LABEL	1	0363-7120	LIQUID	25 mg	ORAL	OTC monograph not final	13 sections
Walgreens Senna Laxative	HUMAN OTC DRUG LABEL	1	0363-7120	LIQUID	25 mg	ORAL	OTC monograph not final	13 sections
Stool Softener Laxative	HUMAN OTC DRUG LABEL	2	0363-8550	TABLET	8.60 mg	ORAL	OTC monograph not final	14 sections
Stool Softener Laxative	HUMAN OTC DRUG LABEL	2	0363-8550	TABLET	8.60 mg	ORAL	OTC monograph not final	14 sections