bunazosin indications/contra

Stem definitionDrug idCAS RN
antihypertensive substances, prazosin derivatives 429 80755-51-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bunazosin hydrochloride
  • detantol
  • bunazosin
  • bunazosin HCl
  • Molecular weight: 373.46
  • Formula: C19H27N5O3
  • CLOGP: 2.10
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 93.81
  • ALOGS: -2.81
  • ROTB: 5

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D058668 Adrenergic alpha-1 Receptor Antagonists
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Essential hypertension indication 59621000 DOID:10825

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.22 Basic
pKa2 0.87 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-1B adrenergic receptor GPCR ANTAGONIST WOMBAT-PK KEGG DRUG
Alpha-1A adrenergic receptor GPCR ANTAGONIST WOMBAT-PK KEGG DRUG
Ribosyldihydronicotinamide dehydrogenase [quinone] Enzyme WOMBAT-PK
Alpha-2B adrenergic receptor GPCR WOMBAT-PK

External reference:

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IDSource
C0772213 UMLSCUI
D01887 KEGG_DRUG
18V54TZ7U6 UNII
52712-76-2 SECONDARY_CAS_RN
19850 RXNORM
007091 NDDF
5466 INN_ID
CHEMBL188185 ChEMBL_ID
2472 PUBCHEM_CID
C018176 MESH_SUPPLEMENTAL_RECORD_UI
DB12230 DRUGBANK_ID
CHEBI:135576 CHEBI

Pharmaceutical products:

None