bunaftine indications/contra

Stem definitionDrug idCAS RN
428 32421-46-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bunaftine
  • bunaftide
  • bunaphtide
N-Butyl-N-(2-(diethylamino)ethyl)-1-naphthamide. A proposed antiarrhythmic that prolongs myocardial refractory period and stabilizes cell membranes.
  • Molecular weight: 326.48
  • Formula: C21H30N2O
  • CLOGP: 5.10
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -4.35
  • ROTB: 9

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C01BD03 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class III
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
D07428 KEGG_DRUG
N0000167382 NDFRT
36131 PUBCHEM_CID
D002035 MESH_DESCRIPTOR_UI
CHEMBL2104200 ChEMBL_ID
GH09PRQ3FU UNII
3387 INN_ID
CHEBI:135392 CHEBI

Pharmaceutical products:

None