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stannous fluoride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4273 | 7783-47-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Inorganic fluorides of tin. They include both stannic fluoride (tin tetrafluoride) and stannous fluoride (tin difluoride). The latter is used in the prevention of dental caries.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,JAK1,MAP2K6,MAP3K21,MAPK7,MARK4,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK,ULK1 | 39 | |||
| kinase-selectivity-class | PDK1 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Vertebral lateral recess stenosis | 44.43 | 34.70 | 6 | 419 | 346 | 110588528 |
| Ligamentum flavum hypertrophy | 44.05 | 34.70 | 6 | 419 | 369 | 110588505 |
| Osteoarthropathy | 43.99 | 34.70 | 6 | 419 | 373 | 110588501 |
| Toe operation | 38.08 | 34.70 | 6 | 419 | 1008 | 110587866 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A01AA04 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Caries prophylactic agents |
| MeSH PA | D002327 | Cariostatic Agents |
| MeSH PA | D020011 | Protective Agents |
Related Drugs by ATC class:
A01AA Caries prophylactic agents 3 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Prevention of dental caries | indication | 426482000 | |
| Gingivitis | off-label use | 66383009 | DOID:3087 |
| Dental Plaque Prevention | off-label use | ||
| Dental fluorosis | contraindication | 30265004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018970 | VUID |
| N0000178988 | NUI |
| D05919 | KEGG_DRUG |
| 4018970 | VANDF |
| C0038143 | UMLSCUI |
| CHEBI:135933 | CHEBI |
| CHEMBL1909079 | ChEMBL_ID |
| DB11092 | DRUGBANK_ID |
| 3FTR44B32Q | UNII |
| 24550 | PUBCHEM_CID |
| 10030 | RXNORM |
| 21815 | MMSL |
| 5509 | MMSL |
| 001104 | NDDF |
| 329224004 | SNOMEDCT_US |
| 42193003 | SNOMEDCT_US |
| D014002 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Gel-Kam Fruit and Berry | HUMAN OTC DRUG LABEL | 1 | 0126-0165 | GEL, DENTIFRICE | 1 mg | DENTAL | OTC MONOGRAPH DRUG | 13 sections |
| Gel-Kam Mint | HUMAN OTC DRUG LABEL | 1 | 0126-0192 | GEL, DENTIFRICE | 1 mg | DENTAL | OTC MONOGRAPH DRUG | 13 sections |
| SENSODYNE Repair and Protect Extra Fresh | HUMAN OTC DRUG LABEL | 1 | 0135-0547 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| SENSODYNE Repair and Protect | HUMAN OTC DRUG LABEL | 1 | 0135-0548 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| Sensodyne Complete ProtectionExtra Fresh | HUMAN OTC DRUG LABEL | 1 | 0135-0572 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 11 sections |
| Sensodyne Complete Protection | HUMAN OTC DRUG LABEL | 1 | 0135-0573 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 11 sections |
| SENSODYNE Repair and Protect Whitening | HUMAN OTC DRUG LABEL | 1 | 0135-0575 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| parodontax | HUMAN OTC DRUG LABEL | 1 | 0135-0598 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 12 sections |
| parodontax | HUMAN OTC DRUG LABEL | 1 | 0135-0599 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 12 sections |
| parodontax | HUMAN OTC DRUG LABEL | 1 | 0135-0601 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 12 sections |
| SENSODYNE Rapid Relief | HUMAN OTC DRUG LABEL | 1 | 0135-0621 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| SENSODYNE Rapid Relief | HUMAN OTC DRUG LABEL | 1 | 0135-0622 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| parodontaxComplete Protection | HUMAN OTC DRUG LABEL | 1 | 0135-0627 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 12 sections |
| SENSODYNE Rapid Relief | HUMAN OTC DRUG LABEL | 1 | 0135-0632 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| parodontaxComplete Protection | HUMAN OTC DRUG LABEL | 1 | 0135-0634 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 12 sections |
| parodontaxActive Gum Repair | HUMAN OTC DRUG LABEL | 1 | 0135-0637 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 12 sections |
| parodontaxActive Gum Repair Whitening | HUMAN OTC DRUG LABEL | 1 | 0135-0638 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 12 sections |
| Parodontax Gum Strengthen and Protect | HUMAN OTC DRUG LABEL | 1 | 0135-0655 | PASTE, DENTIFRICE | 1.50 mg | DENTAL | OTC Monograph Drug | 11 sections |
| Polident ProPartial | HUMAN OTC DRUG LABEL | 1 | 0135-0710 | PASTE | 1.50 mg | DENTAL | OTC Monograph Drug | 12 sections |
| parodontaxActive Gum Repair Breath Freshener | HUMAN OTC DRUG LABEL | 1 | 0135-0737 | PASTE | 1.10 mg | DENTAL | OTC Monograph Drug | 12 sections |
| SENSODYNE Sensitivity Gum and Enamel Mint | HUMAN OTC DRUG LABEL | 1 | 0135-5022 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| SENSODYNE Sensitivity and Gum Mint | HUMAN OTC DRUG LABEL | 1 | 0135-5023 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| SENSODYNE Sensitivity and Gum Whitening | HUMAN OTC DRUG LABEL | 1 | 0135-5024 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| SENSODYNE SENSITIVITY AND GUM CLEAN AND FRESH | HUMAN OTC DRUG LABEL | 1 | 0135-5025 | PASTE | 1.10 mg | ORAL | OTC Monograph Drug | 11 sections |
| Sensodyne Fresh Clean | HUMAN OTC DRUG LABEL | 1 | 0135-5912 | PASTE, DENTIFRICE | 15 mg | ORAL | OTC Monograph Drug | 11 sections |
| Sensodyne Whiten and Shine | HUMAN OTC DRUG LABEL | 1 | 0135-5913 | PASTE, DENTIFRICE | 15 mg | ORAL | OTC Monograph Drug | 11 sections |
| Walgreens Restore and Defend | HUMAN OTC DRUG LABEL | 1 | 0363-1599 | PASTE, DENTIFRICE | 0.15 g | DENTAL | OTC Monograph Drug | 8 sections |
| TherabreathDeep Clean | HUMAN OTC DRUG LABEL | 1 | 10237-270 | PASTE, DENTIFRICE | 0.45 g | ORAL | OTC Monograph Drug | 11 sections |
| TherabreathHealthy Gums | HUMAN OTC DRUG LABEL | 1 | 10237-271 | PASTE, DENTIFRICE | 0.45 g | ORAL | OTC Monograph Drug | 11 sections |
| Stangard | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10866-0271 | GEL | 3.80 mg | DENTAL | Export only | 6 sections |