phenol indications/contra

Stem definitionDrug idCAS RN
4266 108-95-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phenol
  • hydroxybenzene
An antiseptic and disinfectant aromatic alcohol.
  • Molecular weight: 94.11
  • Formula: C6H6O
  • CLOGP: 1.47
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -0.31
  • ROTB: 0

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C05BB05 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Sclerosing agents for local injection
ATC D08AE03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Phenol and derivatives
ATC N01BX03 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Other local anesthetics
ATC R02AA19 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004202 Disinfectants
MeSH PA D019999 Pharmaceutical Solutions
MeSH PA D012597 Sclerosing Solutions
CHEBI has role CHEBI:48218 antiseptic drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Skin irritation indication 367466007
Itching of skin indication 418363000
Minor Skin Wound Pain indication
Mouth Irritation indication
Herpes zoster contraindication 4740000 DOID:8536
Bacterial septicemia contraindication 10001005
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Shock contraindication 27942005
Cytomegalovirus infection contraindication 28944009
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Gastrointestinal ulcer contraindication 40845000
Conduction disorder of the heart contraindication 44808001
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Incontinence of feces contraindication 72042002
Diabetes mellitus contraindication 73211009 DOID:9351
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal hemorrhage contraindication 74474003
Decreased respiratory function contraindication 80954004
Herpes simplex contraindication 88594005 DOID:8566
Malignant lymphoma contraindication 118600007 DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase contraindication 124275001 DOID:1919
Open wound contraindication 125643001
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002 DOID:1826
Heart block contraindication 233916004
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Primary malignant neoplasm contraindication 372087000
Malignant neoplasm of skin contraindication 372130007 DOID:4159
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007 DOID:2723
Opportunistic Fungal Infection contraindication
BK Polyomavirus Reactivation Nephropathy contraindication

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.68 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 5.26 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.04 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 5.02 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.57 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 4.94 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 5.06 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5 CHEMBL
Endolysin Enzyme Kd 4.04 CHEMBL
Carbonic anhydrase 2 Unclassified Ki 4.59 CHEMBL
Carbonic anhydrase Unclassified Ki 4.86 CHEMBL
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase Enzyme Ki 4.10 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 4.19 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 4.98 CHEMBL
Carbonic anhydrase Enzyme Ki 4.76 CHEMBL

External reference:

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IDSource
4017412 VUID
N0000145800 NUI
C0070570 UMLSCUI
D00033 KEGG_DRUG
CHEMBL14060 ChEMBL_ID
339NCG44TV UNII
DB03255 DRUGBANK_ID
4017412 VANDF
N0000005762 NDFRT
N0000145800 NDFRT
5274 MMSL
33290 RXNORM
11515 MMSL
116613007 SNOMEDCT_US
003199 NDDF
003172 NDDF
354036003 SNOMEDCT_US
996 PUBCHEM_CID
D019800 MESH_DESCRIPTOR_UI
CHEBI:15882 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Major Camphor and Phenol HUMAN OTC DRUG LABEL 2 00904-7851 LIQUID 4.70 g TOPICAL OTC monograph final 12 sections
Campho-Phenique Pain Relieving Antiseptic HUMAN OTC DRUG LABEL 2 0280-0210 LIQUID 4.70 mg TOPICAL OTC monograph not final 14 sections
Campho Phenique Cold Sore Treatment HUMAN OTC DRUG LABEL 2 0280-0220 GEL 4.70 g TOPICAL OTC monograph not final 14 sections
CAMPHO-PHENIQUE ANTISEPTIC HUMAN OTC DRUG LABEL 2 0280-0230 GEL 4.70 g TOPICAL OTC monograph not final 14 sections
Chloraseptic Warming Sore Throat HUMAN OTC DRUG LABEL 1 0295-1026 SPRAY 3.50 mg ORAL OTC MONOGRAPH NOT FINAL 9 sections
Chloraseptic Sore Throat Menthol HUMAN OTC DRUG LABEL 1 0295-1046 SPRAY 3.50 mg ORAL OTC MONOGRAPH NOT FINAL 9 sections
Chloraseptic Sore Throat Citrus HUMAN OTC DRUG LABEL 1 0295-1588 SPRAY 3.50 mg ORAL OTC MONOGRAPH NOT FINAL 9 sections
Chloraseptic Sore Throat Max HUMAN OTC DRUG LABEL 2 0295-1749 SPRAY 15 mg ORAL OTC MONOGRAPH NOT FINAL 8 sections
Chloraseptic Sore Throat Cherry HUMAN OTC DRUG LABEL 1 0295-9513 SPRAY 3.50 mg ORAL OTC MONOGRAPH NOT FINAL 9 sections
Sore throat HUMAN OTC DRUG LABEL 1 0363-0376 SPRAY 1.40 g ORAL OTC MONOGRAPH NOT FINAL 9 sections
Sore Throat HUMAN OTC DRUG LABEL 1 0363-1640 LIQUID 1.50 g ORAL OTC MONOGRAPH NOT FINAL 12 sections
Oral Relief HUMAN OTC DRUG LABEL 1 0363-1650 SPRAY 1.40 g ORAL OTC MONOGRAPH NOT FINAL 9 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6040 SALVE 0.40 mg TOPICAL OTC monograph not final 9 sections
Medicated Lip Balm HUMAN OTC DRUG LABEL 3 0363-6080 STICK 0.40 mg TOPICAL OTC monograph not final 9 sections
Walgreens Camphor Phenol Gel HUMAN OTC DRUG LABEL 2 0363-9425 GEL 4.70 mg TOPICAL OTC monograph not final 8 sections
Calamine Phenolated Topical Suspension HUMAN OTC DRUG LABEL 2 0395-0407 LOTION 10 mg TOPICAL OTC monograph final 11 sections
CHAPSTICK MEDICATED HUMAN OTC DRUG LABEL 3 0573-1920 STICK 5 mg TOPICAL OTC MONOGRAPH FINAL 9 sections
Castellani Paint HUMAN OTC DRUG LABEL 1 0884-2893 LIQUID 15 mg TOPICAL OTC monograph not final 10 sections
Castellani Paint HUMAN OTC DRUG LABEL 1 0884-2993 LIQUID 15 mg TOPICAL OTC monograph not final 10 sections
Sore Throat Cherry HUMAN OTC DRUG LABEL 1 0904-6305 LIQUID 1.50 g ORAL OTC MONOGRAPH NOT FINAL 12 sections
Ambix First Aid HUMAN OTC DRUG LABEL 2 10038-250 CREAM 0.01 g TOPICAL OTC monograph not final 11 sections
Blistex Lip Medex HUMAN OTC DRUG LABEL 2 10157-8407 PASTE 0.60 g TOPICAL OTC MONOGRAPH NOT FINAL 7 sections
Blistex con Medicacion Crema Labial HUMAN OTC DRUG LABEL 2 10157-9926 STICK 0.45 g TOPICAL EXPORT ONLY 1 sections
Blistex HUMAN OTC DRUG LABEL 4 10157-9951 OINTMENT 0.50 g TOPICAL OTC MONOGRAPH NOT FINAL 7 sections
Sore throat HUMAN OTC DRUG LABEL 1 11673-376 SPRAY 1.40 g ORAL OTC MONOGRAPH NOT FINAL 9 sections
Yat Tip Xiao HUMAN OTC DRUG LABEL 2 17429-010 PLASTER 40 mg TOPICAL OTC monograph final 11 sections
Sore Throat HUMAN OTC DRUG LABEL 1 21130-376 SPRAY 1.40 g ORAL OTC MONOGRAPH NOT FINAL 9 sections
Calamine Phenolated Topical Suspension HUMAN OTC DRUG LABEL 2 24385-407 LOTION 10 mg TOPICAL OTC monograph final 12 sections
Budpak First Aid HUMAN OTC DRUG LABEL 1 27293-016 CREAM 0.01 g TOPICAL OTC monograph not final 10 sections
Sore Throat HUMAN OTC DRUG LABEL 1 36800-065 SPRAY 1.50 g ORAL OTC MONOGRAPH NOT FINAL 9 sections