carbamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4264	57-13-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: urea carbamide carbamimidic acid	A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. Molecular weight: 60.06 Formula: CH4N2O CLOGP: -1.66 LIPINSKI: 0 HAC: 3 HDO: 2 TPSA: 69.11 ALOGS: 0.84 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

urea
carbamide
carbamimidic acid

A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

Molecular weight: 60.06
Formula: CH4N2O
CLOGP: -1.66
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 69.11
ALOGS: 0.84
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 5, 1966	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome	94.91	23.45	35	2401	22980	63463606
Hypertension	42.81	23.45	53	2383	279250	63207336
Hypercholesterolaemia	35.44	23.45	17	2419	21317	63465269
Decreased appetite	31.19	23.45	43	2393	251009	63235577

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome	127.56	23.56	44	1872	16751	34938264
Decreased appetite	42.93	23.56	49	1867	166343	34788672
Hepatic encephalopathy	32.70	23.56	16	1900	14669	34940346
Hepatic function abnormal	28.99	23.56	22	1894	44341	34910674
Hepatocellular carcinoma	28.92	23.56	12	1904	7497	34947518
Blood bilirubin increased	25.03	23.56	19	1897	38277	34916738

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome	223.64	20.84	77	3773	33057	79707481
Hepatic function abnormal	48.96	20.84	35	3815	73072	79667466
Decreased appetite	47.93	20.84	70	3780	342348	79398190
Platelet count decreased	46.59	20.84	52	3798	194612	79545926
Hypertension	39.69	20.84	63	3787	330929	79409609
Hepatic encephalopathy	35.22	20.84	19	3831	24147	79716391
Diarrhoea	30.25	20.84	102	3748	880387	78860151
Hepatocellular carcinoma	28.25	20.84	12	3838	9009	79731529
Blood bilirubin increased	27.63	20.84	24	3826	66208	79674330
Dermatitis exfoliative	26.14	20.84	12	3838	10817	79729721

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	B05BC02	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTIONS Solutions producing osmotic diuresis
ATC	D02AE01	DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES EMOLLIENTS AND PROTECTIVES Carbamide products
ATC	D02AE51	DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES EMOLLIENTS AND PROTECTIVES Carbamide products
CHEBI has role	CHEBI:33287	fertilizers
CHEBI has role	CHEBI:64577	dough improvers
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:83056	Daphnia magna metabolites

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Impacted cerumen	indication	18070006
Atopic dermatitis	indication	24079001	DOID:3310
Contact dermatitis	indication	40275004	DOID:2773
Seborrheic dermatitis	indication	50563003	DOID:8741
Pityriasis versicolor	indication	56454009	DOID:9060
Pityriasis simplex	indication	200767005
Eruption of skin	indication	271807003	DOID:0050486
Acne vulgaris	off-label use	88616000
Hyperkeratosis	off-label use	396228006
Rosacea	off-label use	398909004	DOID:8881

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.96	acidic
pKa2	13.39	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Olfactory receptor 51E2	GPCR	Q9H255	O51E2_HUMAN		EC50	7.64		CHEMBL

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External reference:

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ID	Source
URE	PDB_CHEM_ID
002015	NDDF
002273	NDDF
11002	RXNORM
1176	PUBCHEM_CID
16858004	SNOMEDCT_US
387092000	SNOMEDCT_US
4018430	VUID
4018430	VANDF
4539	IUPHAR_LIGAND_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CEM-Urea	HUMAN PRESCRIPTION DRUG LABEL	1	42546-100	SOLUTION	0.45 mL	TOPICAL	unapproved drug other	13 sections
UREA	HUMAN PRESCRIPTION DRUG LABEL	1	42192-101	EMULSION	50 g	TOPICAL	unapproved drug other	14 sections
UREA	HUMAN PRESCRIPTION DRUG LABEL	1	42291-849	CREAM	40 g	TOPICAL	unapproved drug other	13 sections
UREA	HUMAN PRESCRIPTION DRUG LABEL	1	42291-849	CREAM	40 g	TOPICAL	unapproved drug other	13 sections
UREA	HUMAN PRESCRIPTION DRUG LABEL	1	42792-101	CREAM	390 mg	TOPICAL	unapproved drug other	12 sections
UREA	HUMAN PRESCRIPTION DRUG LABEL	1	42792-101	CREAM	390 mg	TOPICAL	unapproved drug other	12 sections
UREA	HUMAN PRESCRIPTION DRUG LABEL	1	42808-202	CREAM	450 mg	TOPICAL	unapproved drug other	15 sections
UREA	HUMAN PRESCRIPTION DRUG LABEL	1	42808-202	CREAM	450 mg	TOPICAL	unapproved drug other	15 sections
UREA	HUMAN PRESCRIPTION DRUG LABEL	1	42808-202	CREAM	450 mg	TOPICAL	unapproved drug other	15 sections
Urea	HUMAN PRESCRIPTION DRUG LABEL	1	42808-204	GEL	450 mg	TOPICAL	unapproved drug other	16 sections

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