carbamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4264 57-13-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • urea
  • carbamide
  • carbamimidic acid
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
  • Molecular weight: 60.06
  • Formula: CH4N2O
  • CLOGP: -1.66
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 69.11
  • ALOGS: 0.84
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 5, 1966 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 94.91 23.45 35 2401 22980 63463606
Hypertension 42.81 23.45 53 2383 279250 63207336
Hypercholesterolaemia 35.44 23.45 17 2419 21317 63465269
Decreased appetite 31.19 23.45 43 2393 251009 63235577

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 127.56 23.56 44 1872 16751 34938264
Decreased appetite 42.93 23.56 49 1867 166343 34788672
Hepatic encephalopathy 32.70 23.56 16 1900 14669 34940346
Hepatic function abnormal 28.99 23.56 22 1894 44341 34910674
Hepatocellular carcinoma 28.92 23.56 12 1904 7497 34947518
Blood bilirubin increased 25.03 23.56 19 1897 38277 34916738

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Palmar-plantar erythrodysaesthesia syndrome 223.64 20.84 77 3773 33057 79707481
Hepatic function abnormal 48.96 20.84 35 3815 73072 79667466
Decreased appetite 47.93 20.84 70 3780 342348 79398190
Platelet count decreased 46.59 20.84 52 3798 194612 79545926
Hypertension 39.69 20.84 63 3787 330929 79409609
Hepatic encephalopathy 35.22 20.84 19 3831 24147 79716391
Diarrhoea 30.25 20.84 102 3748 880387 78860151
Hepatocellular carcinoma 28.25 20.84 12 3838 9009 79731529
Blood bilirubin increased 27.63 20.84 24 3826 66208 79674330
Dermatitis exfoliative 26.14 20.84 12 3838 10817 79729721
Colon cancer 25.68 20.84 13 3837 14510 79726028
Enterocolitis 22.81 20.84 12 3838 14500 79726038
Malignant neoplasm progression 22.22 20.84 30 3820 135960 79604578

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05BC02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTIONS
Solutions producing osmotic diuresis
ATC D02AE01 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
EMOLLIENTS AND PROTECTIVES
Carbamide products
ATC D02AE51 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
EMOLLIENTS AND PROTECTIVES
Carbamide products
CHEBI has role CHEBI:33287 fertilizers
CHEBI has role CHEBI:64577 dough improvers
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83056 Daphnia magna metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Impacted cerumen indication 18070006
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Pityriasis versicolor indication 56454009 DOID:9060
Pityriasis simplex indication 200767005
Eruption of skin indication 271807003 DOID:0050486
Acne vulgaris off-label use 88616000
Hyperkeratosis off-label use 396228006
Rosacea off-label use 398909004 DOID:8881
Injury of ear contraindication 2999009
Otalgia contraindication 16001004
Chronic purulent otitis media contraindication 38394007 DOID:14247
Perforation of tympanic membrane contraindication 60442001
Procedure on ear contraindication 118891001
Infection of ear contraindication 129127001
Irritation of ear contraindication 162360008
Itching of ear contraindication 699392007
Ear Redness contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.96 acidic
pKa2 13.39 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Olfactory receptor 51E2 GPCR EC50 7.64 CHEMBL

External reference:

IDSource
4018430 VUID
N0000146756 NUI
D00023 KEGG_DRUG
4018430 VANDF
C0041942 UMLSCUI
CHEBI:16199 CHEBI
URE PDB_CHEM_ID
CHEMBL985 ChEMBL_ID
DB03904 DRUGBANK_ID
4539 IUPHAR_LIGAND_ID
1176 PUBCHEM_CID
11002 RXNORM
5656 MMSL
9476 MMSL
d04207 MMSL
002015 NDDF
002273 NDDF
16858004 SNOMEDCT_US
387092000 SNOMEDCT_US
D014508 MESH_DESCRIPTOR_UI
8W8T17847W UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Urea Cream 40% HUMAN PRESCRIPTION DRUG LABEL 1 0904-7167 CREAM 400 mg TOPICAL unapproved drug other 16 sections
Urea Cream 40% HUMAN PRESCRIPTION DRUG LABEL 1 0904-7167 CREAM 400 mg TOPICAL unapproved drug other 16 sections
Urea Cream 40% HUMAN PRESCRIPTION DRUG LABEL 1 16477-340 CREAM 400 mg TOPICAL unapproved drug other 15 sections
Urea Cream 41% HUMAN PRESCRIPTION DRUG LABEL 1 16477-341 CREAM 410 mg TOPICAL unapproved drug other 15 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42192-101 EMULSION 50 g TOPICAL unapproved drug other 14 sections
UREA HYDRATING TOPICAL HUMAN PRESCRIPTION DRUG LABEL 1 42192-115 AEROSOL, FOAM 35 g TOPICAL unapproved drug other 14 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42291-849 CREAM 40 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42291-849 CREAM 40 g TOPICAL unapproved drug other 13 sections
YouGreen F HUMAN OTC DRUG LABEL 1 42361-043 OINTMENT 7.50 g TOPICAL unapproved drug other 9 sections
CEM-Urea HUMAN PRESCRIPTION DRUG LABEL 1 42546-100 SOLUTION 0.45 mL TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42792-101 CREAM 390 mg TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42792-101 CREAM 390 mg TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42808-202 CREAM 450 mg TOPICAL unapproved drug other 15 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42808-202 CREAM 450 mg TOPICAL unapproved drug other 15 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 42808-202 CREAM 450 mg TOPICAL unapproved drug other 15 sections
Urea HUMAN PRESCRIPTION DRUG LABEL 1 42808-204 GEL 450 mg TOPICAL unapproved drug other 16 sections
Urea HUMAN PRESCRIPTION DRUG LABEL 1 42808-204 GEL 450 mg TOPICAL unapproved drug other 16 sections
Urea HUMAN PRESCRIPTION DRUG LABEL 1 42808-204 GEL 450 mg TOPICAL unapproved drug other 16 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 44523-617 CREAM 400 mg TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 44523-617 CREAM 400 mg TOPICAL unapproved drug other 12 sections
Urea 39% Cream HUMAN PRESCRIPTION DRUG LABEL 1 44523-801 CREAM 390 mg TOPICAL unapproved drug other 16 sections
Urea 47% Cream HUMAN PRESCRIPTION DRUG LABEL 1 50096-501 CREAM 470 mg TOPICAL unapproved drug other 11 sections
Urea 20 HUMAN OTC DRUG LABEL 1 50268-820 GEL 200 mg TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 50268-872 CREAM 40 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 50268-872 CREAM 40 g TOPICAL unapproved drug other 13 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 52187-549 CREAM 470 mg TOPICAL unapproved drug other 11 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-308 CREAM 40 g TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-308 CREAM 40 g TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-311 CREAM 39 g TOPICAL unapproved drug other 12 sections
UREA HUMAN PRESCRIPTION DRUG LABEL 1 54295-311 CREAM 39 g TOPICAL unapproved drug other 12 sections