sulfur 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4260	7704-34-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sulfur	An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine. Molecular weight: 32.06 Formula: S CLOGP: LIPINSKI: None HAC: 0 HDO: 0 TPSA: ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sulfur

An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.

Molecular weight: 32.06
Formula: S
CLOGP:
LIPINSKI: None
HAC: 0
HDO: 0
TPSA:
ALOGS:
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 17, 1940	FDA	POYTHRESS

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	95.05	13.92	145	7131	310542	63171204
Broncholithiasis	72.56	13.92	14	7262	239	63481507
Lymph node calcification	68.76	13.92	14	7262	318	63481428
Bronchial wall thickening	47.79	13.92	14	7262	1485	63480261
Lower respiratory tract infection viral	40.23	13.92	11	7265	910	63480836
Lichen nitidus	38.35	13.92	7	7269	87	63481659
Exposure to toxic agent	29.84	13.92	14	7262	5573	63476173
Oesophagitis	28.38	13.92	19	7257	14989	63466757
Sexual abuse	21.39	13.92	5	7271	219	63481527
Soft tissue necrosis	21.01	13.92	6	7270	581	63481165

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Choroiditis	55.12	17.25	15	4057	1200	34951659
Endophthalmitis	46.82	17.25	17	4055	3491	34949368
Visual acuity reduced	34.03	17.25	22	4050	16127	34936732
Intraocular pressure increased	30.13	17.25	14	4058	5369	34947490
Eye pain	22.76	17.25	16	4056	13446	34939413
Chondritis	22.68	17.25	5	4067	165	34952694
Post inflammatory pigmentation change	19.91	17.25	5	4067	292	34952567
Dysphagia	19.87	17.25	30	4042	62351	34890508
Completed suicide	19.16	17.25	38	4034	98130	34854729
Exposure to toxic agent	18.85	17.25	9	4063	3666	34949193

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	87.10	13.62	134	8692	298782	79436780
Broncholithiasis	67.44	13.62	13	8813	229	79735333
Lymph node calcification	60.45	13.62	13	8813	402	79735160
Exposure to toxic agent	49.85	13.62	23	8803	9135	79726427
Choroiditis	49.41	13.62	14	8812	1367	79734195
Lichen nitidus	38.37	13.62	7	8819	90	79735472
Bronchial wall thickening	36.64	13.62	13	8813	2628	79732934
Endophthalmitis	34.53	13.62	16	8810	6412	79729150
Lower respiratory tract infection viral	33.19	13.62	10	8816	1210	79734352
Soft tissue necrosis	31.49	13.62	9	8817	906	79734656

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D10AB02	DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Preparations containing sulfur
CHEBI has role	CHEBI:33286	agricultural chemicals
CHEBI has role	CHEBI:35718	antifungal agents
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:33937	macronutrients

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Greasy skin	indication	42273000
Seborrheic dermatitis	indication	50563003	DOID:8741
Acne vulgaris	indication	88616000
Pityriasis simplex	indication	200767005
Acute necrotizing ulcerative gingivitis	indication	399050001
Acneiform eruption	indication	402644006
Aphthous ulcer of mouth	indication	426965005	DOID:9663
Rosacea	off-label use	398909004	DOID:8881
Itching of skin	off-label use	418363000
Infection of skin AND/OR subcutaneous tissue	contraindication	19824006

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	4.40		CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	6.22		CHEMBL

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External reference:

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ID	Source
002558	NDDF
002997	NDDF
10223	RXNORM
10544-50-0	SECONDARY_CAS_RN
332304007	SNOMEDCT_US
4018870	VUID
4018870	VANDF
43735007	SNOMEDCT_US
5362487	PUBCHEM_CID
5415	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Adult Acnomel Tinted	HUMAN OTC DRUG LABEL	2	0295-9116	CREAM	8 g	TOPICAL	OTC monograph final	12 sections
AVAR	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0480	EMULSION	50 mg	TOPICAL	unapproved drug other	12 sections
AVAR	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0480	EMULSION	50 mg	TOPICAL	unapproved drug other	12 sections
AVAR LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0475	EMULSION	20 mg	TOPICAL	unapproved drug other	12 sections
AVAR LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0475	EMULSION	20 mg	TOPICAL	unapproved drug other	12 sections
Avar-e	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0470	CREAM	50 mg	TOPICAL	unapproved drug other	12 sections
Avar-e Green	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0460	CREAM	50 mg	TOPICAL	unapproved drug other	13 sections
Avar-e LS	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0465	CREAM	20 mg	TOPICAL	unapproved drug other	12 sections
GRANDPAS THYLOX ACNE TREATMENT WITH SULFUR	HUMAN OTC DRUG LABEL	1	11118-1006	SOAP	3 g	TOPICAL	OTC monograph final	9 sections
GRANDPAS THYLOX ACNE TREATMENT WITH SULFUR	HUMAN OTC DRUG LABEL	1	11118-1006	SOAP	3 g	TOPICAL	OTC monograph final	9 sections

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