bumadizone indications/contra

Stem definitionDrug idCAS RN
anti-inflammatory analgesics, phenylbutazone derivatives 426 3583-64-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bumadizone
  • bumadizon
  • bumazidone
  • bumadizone calcium
  • bumadizone calcium hydrate
  • bumadizone calcium dihydrate
  • eumotol
  • desflam
an anlgesic, antipyretic and anti-inflammatory agent; minor descriptor (75-86); on line & INDEX MEDICUS search MALONATES (75-86); RN given refers to parent cpd
  • Molecular weight: 326.40
  • Formula: C19H22N2O3
  • CLOGP: 4.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 69.64
  • ALOGS: -3.78
  • ROTB: 8

Drug dosage:

DoseUnitRoute
0.40 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC M01AB07 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35493 antipyretic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.54 acidic
pKa2 1.3 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
C0054219 UMLSCUI
D07264 KEGG_DRUG
7PSH384AJD UNII
69365-73-7 SECONDARY_CAS_RN
19847 RXNORM
005444 NDDF
2847 INN_ID
19161 PUBCHEM_CID
C100233 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2105456 ChEMBL_ID
CHEBI:76119 CHEBI

Pharmaceutical products:

None