methyl salicylate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4245 119-36-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methyl salicylate
  • analgit
  • methyl 2-hydroxybenzoate
  • methyl ester 2-hydroxy benzoic acid
used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990
  • Molecular weight: 152.15
  • Formula: C8H8O3
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -1.42
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 2008 FDA HISAMITSU PHARM CO

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food intolerance 99.67 24.46 25 3269 3300 63482428
Injection site inflammation 96.08 24.46 25 3269 3818 63481910
Urosepsis 60.80 24.46 26 3268 18498 63467230
Urticaria thermal 57.02 24.46 11 3283 428 63485300
Administration site erythema 45.35 24.46 10 3284 755 63484973
Hypercholesterolaemia 44.94 24.46 22 3272 21312 63464416
Angioedema 37.58 24.46 26 3268 47939 63437789
Pruritus 33.63 24.46 64 3230 361389 63124339
Nail bed tenderness 33.62 24.46 7 3287 402 63485326
Hypertension 33.10 24.46 55 3239 279248 63206480
Hepatic enzyme increased 32.66 24.46 46 3248 202282 63283446
Pigmentation disorder 31.30 24.46 11 3283 4628 63481100
Vitamin B12 deficiency 29.87 24.46 11 3283 5292 63480436
Scratch 27.58 24.46 11 3283 6554 63479174
Dyspepsia 27.39 24.46 30 3264 102166 63383562
Secretion discharge 26.91 24.46 13 3281 12218 63473510
Autonomic neuropathy 26.37 24.46 7 3287 1152 63484576
Dizziness postural 26.34 24.46 11 3283 7365 63478363
Anticipatory anxiety 25.84 24.46 7 3287 1244 63484484
Skin plaque 25.07 24.46 11 3283 8309 63477419

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anticholinergic syndrome 34.08 26.05 7 543 1262 34955119
Erythema multiforme 33.20 26.05 10 540 8639 34947742
Dermatitis exfoliative 31.28 26.05 9 541 6630 34949751
Bronchospasm 27.03 26.05 9 541 10722 34945659

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Food intolerance 104.13 24.86 25 2964 3823 79737576
Injection site inflammation 103.32 24.86 25 2964 3951 79737448
Pruritus 65.47 24.86 77 2912 394571 79346828
Urticaria thermal 60.44 24.86 11 2978 434 79740965
Urosepsis 59.99 24.86 26 2963 26469 79714930
Administration site erythema 55.81 24.86 10 2979 361 79741038
Angioedema 36.66 24.86 27 2962 76008 79665391
Nail bed tenderness 35.81 24.86 7 2982 407 79740992
Dyspepsia 34.09 24.86 30 2959 108657 79632742
Pigmentation disorder 32.74 24.86 11 2978 5607 79735792
Vitamin B12 deficiency 30.01 24.86 11 2978 7230 79734169
Pulmonary fibrosis 29.09 24.86 19 2970 44093 79697306
Scratch 28.47 24.86 11 2978 8352 79733047
Anticipatory anxiety 28.36 24.86 7 2982 1197 79740202
Septic shock 27.25 24.86 28 2961 122773 79618626
Asthma 26.77 24.86 29 2960 135066 79606333
Skin plaque 25.80 24.86 11 2978 10734 79730665
Secretion discharge 25.30 24.86 12 2977 15010 79726389
Autonomic neuropathy 25.21 24.86 7 2982 1888 79739511
Dizziness postural 25.04 24.86 11 2978 11538 79729861

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018501 Antirheumatic Agents
MeSH PA D005404 Fixatives
CHEBI has role CHEBI:24850 insect attractants
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35617 flavouring agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Backache indication 161891005
Sprains and Strains indication
Arthritic Pain indication
Gastritis contraindication 4556007 DOID:4029
Bacterial septicemia contraindication 10001005 DOID:0040085
Shock contraindication 27942005
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Disorder of skin contraindication 95320005 DOID:37
Anemia due to enzyme deficiency contraindication 111577008
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Heart block contraindication 233916004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019432 VUID
N0000147562 NUI
D01087 KEGG_DRUG
4019432 VANDF
C0066282 UMLSCUI
CHEBI:88839 CHEBI
CHEMBL108545 ChEMBL_ID
DB09543 DRUGBANK_ID
C033069 MESH_SUPPLEMENTAL_RECORD_UI
2431 IUPHAR_LIGAND_ID
LAV5U5022Y UNII
4133 PUBCHEM_CID
29787 RXNORM
5086 MMSL
6316 MMSL
001588 NDDF
001990 NDDF
111141006 SNOMEDCT_US
386988003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Theragesic Creme HUMAN OTC DRUG LABEL 2 0178-0320 GEL 150 mg TOPICAL OTC monograph not final 16 sections
Theragesic Creme HUMAN OTC DRUG LABEL 2 0178-0320 GEL 150 mg TOPICAL OTC monograph not final 16 sections
Theragesic Plus HUMAN OTC DRUG LABEL 2 0178-0350 GEL 250 mg TOPICAL OTC monograph not final 15 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0363-0072 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0363-0072 MOUTHWASH 0.06 kg ORAL OTC monograph not final 12 sections
WALGREENS COOL AND HEAT MUSCLE AND JOINT RELIEF HUMAN OTC DRUG LABEL 2 0363-0147 CREAM 30 g TOPICAL OTC monograph not final 11 sections
WALGREENS MEDICATED PAIN RELIEVING HUMAN OTC DRUG LABEL 3 0363-0149 PATCH 36 mg TOPICAL OTC monograph not final 14 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 14 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 14 sections
Rinse HUMAN OTC DRUG LABEL 4 0363-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 14 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 15 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 15 sections
Antispetic HUMAN OTC DRUG LABEL 4 0363-0664 MOUTHWASH 0.60 mg ORAL OTC monograph not final 15 sections
Tartar control plus HUMAN OTC DRUG LABEL 4 0363-0855 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 10 g TOPICAL OTC monograph not final 11 sections
Pain Relief Patches HUMAN OTC DRUG LABEL 3 0363-0907 PATCH 10 g TOPICAL OTC monograph not final 11 sections
Walgreens Pain Relieving Analgesic HUMAN OTC DRUG LABEL 3 0363-1199 CREAM 300 mg TOPICAL OTC MONOGRAPH NOT FINAL 15 sections
Walgreens Cool n Heat HUMAN OTC DRUG LABEL 2 0363-9901 CREAM 300 mg TOPICAL OTC monograph not final 11 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 6.30 g TOPICAL OTC monograph not final 12 sections
Pain Relieving Patches HUMAN OTC DRUG LABEL 3 0363-9903 PATCH 6.30 1 TOPICAL OTC monograph not final 12 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 10 g TOPICAL OTC monograph not final 13 sections
Large Pain Relieving HUMAN OTC DRUG LABEL 3 0363-9904 PATCH 10 g TOPICAL OTC monograph not final 13 sections
Castiva Cooling HUMAN OTC DRUG LABEL 2 0395-0129 CREAM 140 mg TOPICAL OTC monograph not final 14 sections
Rugby Pain Relieving Analgesic HUMAN OTC DRUG LABEL 2 0536-1101 CREAM 150 mg TOPICAL OTC monograph not final 15 sections
Rugby Muscle Rub Cream HUMAN OTC DRUG LABEL 2 0536-1349 CREAM 150 mg TOPICAL OTC monograph not final 9 sections
Antiseptic HUMAN OTC DRUG LABEL 4 0869-0072 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antiseptic HUMAN OTC DRUG LABEL 4 0869-0072 MOUTHWASH 0.60 mg ORAL OTC monograph not final 12 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0869-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0869-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections
Antiseptic Mouth Rinse HUMAN OTC DRUG LABEL 4 0869-0318 MOUTHWASH 0.60 mg ORAL OTC monograph not final 13 sections