bufuralol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
aromatic ring -CH(-OH)-CH2-NH-R 424 54340-62-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bufuralol
  • dl-Bufuralol
  • (+/-)-Bufuralol
  • Molecular weight: 261.37
  • Formula: C16H23NO2
  • CLOGP: 3.40
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 45.40
  • ALOGS: -3.87
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 46 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.19 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.89 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR Ki 8.20 WOMBAT-PK
Beta-2 adrenergic receptor GPCR Ki 8.80 WOMBAT-PK
Multidrug resistance protein 1 Transporter WOMBAT-PK
Cytochrome P450 2D6 Enzyme Ks 4.59 WOMBAT-PK

External reference:

IDSource
C0054212 UMLSCUI
CHEBI:34593 CHEBI
CHEMBL296035 ChEMBL_ID
CHEMBL251642 ChEMBL_ID
CHEMBL399261 ChEMBL_ID
DB06726 DRUGBANK_ID
C010831 MESH_SUPPLEMENTAL_RECORD_UI
71733 PUBCHEM_CID
9834 IUPHAR_LIGAND_ID
3539 INN_ID
891H89GFT4 UNII

Pharmaceutical products:

None