bufuralol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| aromatic ring -CH(-OH)-CH2-NH-R | 424 | 54340-62-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 46 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.70 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 8.90 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.19 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.30 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018674 | Adrenergic Antagonists |
| MeSH PA | D000319 | Adrenergic beta-Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.89 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | Ki | 8.20 | WOMBAT-PK | |||||
| Beta-2 adrenergic receptor | GPCR | Ki | 8.80 | WOMBAT-PK | |||||
| Multidrug resistance protein 1 | Transporter | WOMBAT-PK | |||||||
| Cytochrome P450 2D6 | Enzyme | Ks | 4.59 | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| C0054212 | UMLSCUI |
| CHEBI:34593 | CHEBI |
| CHEMBL296035 | ChEMBL_ID |
| CHEMBL251642 | ChEMBL_ID |
| CHEMBL399261 | ChEMBL_ID |
| DB06726 | DRUGBANK_ID |
| C010831 | MESH_SUPPLEMENTAL_RECORD_UI |
| 71733 | PUBCHEM_CID |
| 9834 | IUPHAR_LIGAND_ID |
| 3539 | INN_ID |
| 891H89GFT4 | UNII |
Pharmaceutical products:
None