titanium dioxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4237 13463-67-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • titanium dioxide
  • titanium oxide
used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure
  • Molecular weight: 79.87
  • Formula: O2Ti
  • CLOGP: -1.32
  • LIPINSKI: None
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 5, 2006 FDA LOREAL USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 901.62 22.43 224 3747 24152 63460899
Chronic sinusitis 280.47 22.43 78 3893 12765 63472286
Paraesthesia oral 245.09 22.43 77 3894 19179 63465872
Procedural pain 236.49 22.43 77 3894 21492 63463559
Drug ineffective 162.23 22.43 255 3716 1044510 62440541
Therapeutic product effect incomplete 136.08 22.43 89 3882 124967 63360084
Vaginal flatulence 134.87 22.43 33 3938 3260 63481791
Dyspepsia 126.70 22.43 79 3892 102117 63382934
Proctitis 118.43 22.43 33 3938 5408 63479643
Female genital tract fistula 116.28 22.43 35 3936 7524 63477527
Radiculopathy 103.48 22.43 33 3938 8578 63476473
Vaginal discharge 101.34 22.43 33 3938 9165 63475886
Colitis ulcerative 74.07 22.43 35 3936 26056 63458995
Oral candidiasis 72.23 22.43 33 3938 22765 63462286
Pyrexia 72.11 22.43 115 3856 470363 63014688
Frequent bowel movements 71.92 22.43 33 3938 22989 63462062
Weight decreased 69.76 22.43 86 3885 276712 63208339
Infusion related reaction 62.98 22.43 77 3894 245444 63239607
Colitis 56.21 22.43 36 3935 48492 63436559
Rectal haemorrhage 55.87 22.43 36 3935 48994 63436057
Haematochezia 52.98 22.43 36 3935 53508 63431543
Malaise 38.55 22.43 82 3889 415872 63069179
Nausea 34.45 22.43 124 3847 854347 62630704
Constipation 25.12 22.43 48 3923 224895 63260156

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 94.12 26.72 20 1785 1280 34953846
SARS-CoV-2 test negative 81.34 26.72 17 1788 1003 34954123
Accident 67.18 26.72 20 1785 5027 34950099
Proctalgia 64.70 26.72 20 1785 5703 34949423
Haemorrhoids 49.77 26.72 21 1784 14554 34940572
Body temperature increased 46.23 26.72 21 1784 17347 34937779
Appendicolith 41.86 26.72 16 1789 8585 34946541
Ascites 33.75 26.72 24 1781 46547 34908579
Appendicitis 33.49 26.72 16 1789 14791 34940335
Ventricular fibrillation 29.53 26.72 17 1788 22937 34932189
Febrile neutropenia 28.29 26.72 35 1770 136814 34818312
Cardiogenic shock 27.20 26.72 17 1788 26601 34928525

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 266.93 21.61 74 5229 11222 79727863
Chronic sinusitis 260.97 21.61 75 5228 12951 79726134
Paraesthesia oral 223.54 21.61 74 5229 20397 79718688
Procedural pain 214.82 21.61 74 5229 23010 79716075
Vaginal flatulence 135.64 21.61 32 5271 2543 79736542
Therapeutic product effect incomplete 120.90 21.61 89 5214 141556 79597529
Female genital tract fistula 117.78 21.61 34 5269 5941 79733144
Dyspepsia 112.86 21.61 77 5226 108610 79630475
Proctitis 106.60 21.61 32 5271 6400 79732685
Vaginal discharge 101.91 21.61 32 5271 7431 79731654
Radiculopathy 96.64 21.61 32 5271 8792 79730293
Anal inflammation 81.78 21.61 19 5284 1411 79737674
Pyrexia 76.34 21.61 150 5153 678559 79060526
SARS-CoV-2 test negative 66.80 21.61 16 5287 1355 79737730
Infusion related reaction 63.05 21.61 77 5226 230160 79508925
Frequent bowel movements 62.16 21.61 33 5270 29506 79709579
Colitis ulcerative 59.83 21.61 34 5269 34708 79704377
Oral candidiasis 59.26 21.61 32 5271 29596 79709489
Weight decreased 58.53 21.61 93 5210 355105 79383980
Proctalgia 48.77 21.61 20 5283 9981 79729104
Malaise 48.62 21.61 103 5200 489766 79249319
Accident 47.68 21.61 19 5284 8812 79730273
Rectal haemorrhage 43.69 21.61 38 5265 76262 79662823
Constipation 43.69 21.61 72 5231 282978 79456107
Colitis 42.97 21.61 37 5266 73270 79665815
Haematochezia 39.17 21.61 38 5265 87607 79651478
Appendicolith 37.99 21.61 16 5287 8535 79730550
Nausea 36.18 21.61 142 5161 957054 78782031
Pain 33.83 21.61 113 5190 703689 79035396
Haemorrhoids 28.66 21.61 20 5283 29108 79709977
Off label use 24.61 21.61 122 5181 907093 78831992
Appendicitis 24.58 21.61 16 5287 20778 79718307
Body temperature increased 23.17 21.61 21 5282 44399 79694686
Abdominal pain 22.73 21.61 67 5236 389502 79349583
Febrile neutropenia 22.15 21.61 48 5255 230951 79508134
Ascites 21.80 21.61 26 5277 75536 79663549

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D001672 Biocompatible Materials
MeSH PA D004396 Coloring Agents
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D017319 Photosensitizing Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D013473 Sunscreening Agents
CHEBI has role CHEBI:77182 food coloring

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
15FIX9V2JP UNII
4019139 VUID
N0000179267 NUI
D01931 KEGG_DRUG
4019139 VANDF
C0076733 UMLSCUI
CHEBI:32234 CHEBI
CHEMBL1201136 ChEMBL_ID
26042 PUBCHEM_CID
DB09536 DRUGBANK_ID
C009495 MESH_SUPPLEMENTAL_RECORD_UI
38323 RXNORM
NOCODE MMSL
001911 NDDF
432929006 SNOMEDCT_US
62036000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 35 mg TOPICAL OTC monograph not final 12 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 35 mg TOPICAL OTC monograph not final 12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 50 mg TOPICAL OTC monograph not final 12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 32 TINTED Sunscreen HUMAN OTC DRUG LABEL 2 0023-5675 LOTION 50 mg TOPICAL OTC monograph not final 12 sections
Essential Defense Mineral Shield Broad Spectrum SPF 35 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5703 LOTION 50 mg TOPICAL OTC monograph not final 7 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.05 g TOPICAL OTC monograph final 8 sections
Solbar Shield SPF40 HUMAN OTC DRUG LABEL 2 0096-0682 CREAM 0.05 g TOPICAL OTC monograph final 8 sections
Cetaphil Sheer Mineral Sunscreen Stick SPF 50 HUMAN OTC DRUG LABEL 2 0299-4108 STICK 60 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen Stick SPF 50 HUMAN OTC DRUG LABEL 2 0299-4108 STICK 60 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 30 HUMAN OTC DRUG LABEL 2 0299-4111 LOTION 30 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 30 HUMAN OTC DRUG LABEL 2 0299-4111 LOTION 30 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50 HUMAN OTC DRUG LABEL 2 0299-4112 LOTION 49 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50 HUMAN OTC DRUG LABEL 2 0299-4122 LOTION 90 mg TOPICAL OTC monograph final 11 sections
Cetaphil Sheer Mineral Sunscreen SPF 50 HUMAN OTC DRUG LABEL 2 0299-4122 LOTION 90 mg TOPICAL OTC monograph final 11 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 40 HUMAN OTC DRUG LABEL 2 0299-4138 CREAM 101 mg TOPICAL OTC monograph final 9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 57 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 57 mg TOPICAL OTC monograph final 11 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 20 HUMAN OTC DRUG LABEL 2 0299-5889 CREAM 101 mg TOPICAL OTC monograph final 9 sections
Cetaphil Redness Relieving Daily Facial Moisturizer with sunscreen SPF 20 HUMAN OTC DRUG LABEL 2 0299-5889 CREAM 101 mg TOPICAL OTC monograph final 9 sections
Almay Line Smoothing Liquid Make-Up for Dry Skin HUMAN OTC DRUG LABEL 2 0311-0700 LIQUID 4.70 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Skintone Matching Makeup HUMAN OTC DRUG LABEL 2 0311-0701 LIQUID 4.80 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Skintone Anti- Aging Make-Up HUMAN OTC DRUG LABEL 2 0311-0702 LIQUID 3.90 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade Smart Balance Make-Up HUMAN OTC DRUG LABEL 2 0311-0703 LIQUID 3.80 mg TOPICAL OTC monograph final 8 sections
Almay Wake-Up Liquid Make-Up HUMAN OTC DRUG LABEL 2 0311-0704 LIQUID 9 mg TOPICAL OTC monograph final 8 sections
Almay Smart Shade CC Cream HUMAN OTC DRUG LABEL 3 0311-0705 LIQUID 5.10 mg TOPICAL OTC monograph final 6 sections
Almay Age Smart Shade CC Luminous Primer SPF 15 HUMAN OTC DRUG LABEL 2 0311-0706 LIQUID 4.30 mg TOPICAL OTC monograph final 8 sections
Almay Age Essentials Makeup SPF 15 HUMAN OTC DRUG LABEL 2 0311-0707 LIQUID 4.30 mg TOPICAL OTC monograph final 8 sections
ALMAY SMART SHADE ANTI-AGING SKINTONE MATCHING MAKEUP SPF 20 HUMAN OTC DRUG LABEL 2 0311-0710 LIQUID 5.50 mg TOPICAL OTC monograph final 8 sections
Almay Best Blend Forever Makeup HUMAN OTC DRUG LABEL 4 0311-0719 LOTION 5.30 mg TOPICAL OTC monograph final 5 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5.80 mg TOPICAL OTC monograph final 7 sections