peginesatide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
peptides and glycopeptides 4234 1350810-60-4

Description:

MoleculeDescription

Synonyms:

  • hematide
  • omontys
  • peginesatide
  • peginesatide acetate
  • AF-37702
an erythropoiesis stimulating agent
  • Molecular weight:
  • Formula: C233H354N62O58S6(CH2O)a(CH2O)b
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 27, 2012 FDA TAKEDA PHARMS USA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03XA04 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
OTHER ANTIANEMIC PREPARATIONS
Other antianemic preparations
FDA PE N0000009319 Increased Erythroid Cell Production
FDA EPC N0000175665 Erythropoiesis-stimulating Agent
CHEBI has role CHEBI:66894 erythropoiesis-stimulating agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anemia in chronic kidney disease indication 707323002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 10MG BASE/ML (EQ 10MG BASE/ML) OMONTYS TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7084245 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 10MG BASE/ML (EQ 10MG BASE/ML) OMONTYS TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7414105 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 1MG BASE/0.5ML (EQ 1MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7084245 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 1MG BASE/0.5ML (EQ 1MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7414105 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 20MG BASE/2ML (EQ 10MG BASE/ML) OMONTYS TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7084245 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 20MG BASE/2ML (EQ 10MG BASE/ML) OMONTYS TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7414105 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 2MG BASE/0.5ML (EQ 2MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7084245 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 2MG BASE/0.5ML (EQ 2MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7414105 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 3MG BASE/0.5ML (EQ 3MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7084245 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 3MG BASE/0.5ML (EQ 3MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7414105 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 4MG BASE/0.5ML (EQ 4MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7084245 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 4MG BASE/0.5ML (EQ 4MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7414105 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 5MG BASE/0.5ML (EQ 5MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7084245 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 5MG BASE/0.5ML (EQ 5MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7414105 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 6MG BASE/0.5ML (EQ 6MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7084245 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 6MG BASE/0.5ML (EQ 6MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7414105 May 12, 2024 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 10MG BASE/ML (EQ 10MG BASE/ML) OMONTYS TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7550433 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 10MG BASE/ML (EQ 10MG BASE/ML) OMONTYS TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7919461 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 1MG BASE/0.5ML (EQ 1MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7550433 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 1MG BASE/0.5ML (EQ 1MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7919461 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 20MG BASE/2ML (EQ 10MG BASE/ML) OMONTYS TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7550433 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 20MG BASE/2ML (EQ 10MG BASE/ML) OMONTYS TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7919461 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 2MG BASE/0.5ML (EQ 2MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7550433 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 2MG BASE/0.5ML (EQ 2MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7919461 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 3MG BASE/0.5ML (EQ 3MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7550433 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 3MG BASE/0.5ML (EQ 3MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7919461 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 4MG BASE/0.5ML (EQ 4MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7550433 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 4MG BASE/0.5ML (EQ 4MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7919461 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 5MG BASE/0.5ML (EQ 5MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7550433 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 5MG BASE/0.5ML (EQ 5MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7919461 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 6MG BASE/0.5ML (EQ 6MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7550433 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE
EQ 6MG BASE/0.5ML (EQ 6MG BASE/0.5ML) OMONTYS PRESERVATIVE FREE TAKEDA PHARMS USA N202799 March 27, 2012 DISCN SOLUTION INTRAVENOUS, SUBCUTANEOUS 7919461 June 2, 2026 TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Erythropoietin receptor Membrane receptor AGONIST IC50 10.43 IUPHAR DRUG LABEL

External reference:

IDSource
D09946 KEGG_DRUG
913976-27-9 SECONDARY_CAS_RN
4031520 VANDF
CHEBI:66889 CHEBI
CHEMBL2107866 ChEMBL_ID
CHEMBL1963684 ChEMBL_ID
C556270 MESH_SUPPLEMENTAL_RECORD_UI
C514771 MESH_SUPPLEMENTAL_RECORD_UI
7447 IUPHAR_LIGAND_ID
9304 INN_ID
1185870-58-9 SECONDARY_CAS_RN
DB08894 DRUGBANK_ID
JX56W9N61Q UNII
1248797 RXNORM
188373 MMSL
28476 MMSL
d07857 MMSL
014268 NDDF
C3179929 UMLSCUI

Pharmaceutical products:

None