buformin indications/contra

Stem definitionDrug idCAS RN
antihyperglycaemics, phenformin derivatives 423 692-13-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • buformin
  • buformine
  • butformin
  • butylbiguanide
  • butyldiguanide
  • buformin hydrochloride
  • buformin HCl
An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.
  • Molecular weight: 157.22
  • Formula: C6H15N5
  • CLOGP: -1.54
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 5
  • TPSA: 97.78
  • ALOGS: -2.32
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.20 g O

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatitis toxic 27.86 0 3 1 991 3384864

Pharmacologic Action:

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SourceCodeDescription
ATC A10BA03 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Biguanides
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.6 Basic
pKa2 3.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
CHEBI:3209 CHEBI
D00595 KEGG_DRUG
CHEMBL39736 ChEMBL_ID
N0000166588 NDFRT
D002026 MESH_DESCRIPTOR_UI
D947SXO87P UNII
1190-53-0 SECONDARY_CAS_RN
DB04830 DRUGBANK_ID
2004 INN_ID
2468 PUBCHEM_CID

Pharmaceutical products:

None