buflomedil indications/contra

Stem definitionDrug idCAS RN
vasodilators 422 55837-25-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • buflomedil hydrochloride
  • buflomedil
  • buflomedil HCl
  • Molecular weight: 307.39
  • Formula: C17H25NO4
  • CLOGP: 2.93
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 48
  • ALOGS: -2.80
  • ROTB: 8

Drug dosage:

DoseUnitRoute
0.60 g O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1976 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC C04AX20 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Other peripheral vasodilators
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 7.22 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.89 CHEMBL
Voltage-dependent calcium channel gamma-1 subunit Ion channel WOMBAT-PK
Alpha-1B adrenergic receptor GPCR WOMBAT-PK
Alpha-1D adrenergic receptor GPCR WOMBAT-PK
Alpha-2C adrenergic receptor GPCR WOMBAT-PK
Alpha-1A adrenergic receptor GPCR WOMBAT-PK
Alpha-2A adrenergic receptor GPCR WOMBAT-PK
C-8 sterol isomerase Enzyme Ki 5.15 CHEMBL

External reference:

scroll-->
IDSource
C0771138 UMLSCUI
D07176 KEGG_DRUG
3J944AFS8S UNII
35543-24-9 SECONDARY_CAS_RN
19836 RXNORM
004291 NDDF
703405005 SNOMEDCT_US
CHEMBL188921 ChEMBL_ID
2467 PUBCHEM_CID
CHEBI:94538 CHEBI
3735 INN_ID
C010651 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None