hydrocortisone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 4213 50-03-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortisone acetate
  • cortisol acetate
  • hydroxycorticosterone acetate
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions
  • Molecular weight: 404.50
  • Formula: C23H32O6
  • CLOGP: 2.42
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -3.84
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.23 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 16
kinase-selectivity-class GRK2,MAP2K6 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 4.140 Moderate 0.77
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.048 % Moderate 0.77

Approvals:

DateAgencyCompanyOrphan
Dec. 21, 1951 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pericarditis 749.82 10.24 2267 295443 267884 90062853
Anti-cyclic citrullinated peptide antibody positive 685.27 10.24 2015 295695 234418 90096319
Duodenal ulcer perforation 673.17 10.24 1919 295791 219369 90111368
Infusion related reaction 666.39 10.24 2922 294788 413858 89916879
Wound 661.34 10.24 2343 295367 300637 90030100
Rheumatoid factor positive 645.94 10.24 1611 296099 170039 90160698
Helicobacter infection 615.47 10.24 1889 295821 224961 90105776
Hand deformity 603.67 10.24 2241 295469 294121 90036616
Rheumatic fever 579.09 10.24 1440 296270 151681 90179056
Glossodynia 571.41 10.24 2330 295380 319449 90011288
Pemphigus 551.51 10.24 2330 295380 324534 90006203
Discomfort 547.40 10.24 2061 295649 272274 90058463
Systemic lupus erythematosus 538.15 10.24 2484 295226 359412 89971325
Type 2 diabetes mellitus 535.96 10.24 1676 296034 201568 90129169
Intentional product use issue 481.20 10.24 1687 296023 215205 90115532
Synovitis 476.58 10.24 2245 295465 327507 90003230
Hepatic enzyme increased 447.65 10.24 2352 295358 358384 89972353
Completed suicide 440.34 10.24 7 297703 145051 90185686
Fall 425.20 10.24 577 297133 481233 89849504
Blister 420.72 10.24 1806 295904 253192 90077545
Swollen joint count increased 420.47 10.24 1046 296664 110160 90220577
Toxicity to various agents 418.99 10.24 211 297499 287635 90043102
Blood cholesterol increased 412.37 10.24 1560 296150 206452 90124285
Death 406.63 10.24 543 297167 456008 89874729
Injury 386.19 10.24 1474 296236 195875 90134862
Arthropathy 352.27 10.24 2232 295478 364010 89966727
Folliculitis 345.19 10.24 1458 296252 202895 90127842
Swelling 339.75 10.24 2448 295262 416610 89914127
Product dose omission issue 305.90 10.24 304 297406 291383 90039354
Fibromyalgia 303.96 10.24 1413 296297 204856 90125881
Adrenocortical insufficiency acute 299.90 10.24 154 297556 2447 90328290
Drug interaction 297 10.24 282 297428 276171 90054566
Psoriatic arthropathy 296.19 10.24 1508 296202 226827 90103910
Irritable bowel syndrome 294.67 10.24 1406 296304 206042 90124695
Abdominal discomfort 292.33 10.24 2615 295095 474713 89856024
Maternal exposure during pregnancy 289.74 10.24 2100 295610 357963 89972774
Liver injury 283.36 10.24 1211 296499 169356 90161381
Ill-defined disorder 264.64 10.24 1256 296454 183635 90147102
Muscle injury 262.33 10.24 1213 296497 175441 90155296
Deep vein thrombosis postoperative 260.18 10.24 659 297051 70150 90260587
Facet joint syndrome 256.87 10.24 809 296901 97580 90233157
General physical health deterioration 250.28 10.24 2008 295702 353107 89977630
Acute kidney injury 245.47 10.24 422 297288 319965 90010772
Impaired healing 243.59 10.24 1457 296253 232742 90097995
Sleep disorder due to general medical condition, insomnia type 239.98 10.24 947 296763 127747 90202990
Alopecia 236.15 10.24 2575 295135 492496 89838241
Grip strength decreased 231.46 10.24 750 296960 91826 90238911
Hypersensitivity 231.36 10.24 2396 295314 452281 89878456
Condition aggravated 230.13 10.24 2975 294735 592570 89738167
Joint range of motion decreased 225.19 10.24 963 296747 134680 90196057
Anaemia 224.49 10.24 518 297192 352284 89978453
Lip dry 219.94 10.24 781 296929 100174 90230563
Adjustment disorder with depressed mood 216.69 10.24 536 297174 56217 90274520
Drug abuse 209.37 10.24 16 297694 82331 90248406
Lower respiratory tract infection 209.00 10.24 1475 296235 249184 90081553
Product use issue 205.04 10.24 1814 295896 328105 90002632
Autoimmune disorder 199.35 10.24 630 297080 76114 90254623
Dislocation of vertebra 197.45 10.24 513 297197 55455 90275282
C-reactive protein abnormal 194.30 10.24 882 296828 126547 90204190
Hypercholesterolaemia 194.22 10.24 750 296960 100142 90230595
Breast cancer stage III 192.33 10.24 663 297047 83784 90246953
Live birth 191.56 10.24 634 297076 78473 90252264
Mobility decreased 190.44 10.24 1443 296267 249291 90081446
Treatment failure 183.63 10.24 1661 296049 302267 90028470
Sleep disorder 180.30 10.24 1191 296519 196839 90133898
Injection site pain 179.74 10.24 183 297527 173516 90157221
Intentional overdose 178.70 10.24 44 297666 93790 90236947
Cerebrovascular accident 175.95 10.24 93 297617 123440 90207297
Cough 175.67 10.24 622 297088 368340 89962397
Lupus vulgaris 174.60 10.24 428 297282 44631 90286106
White blood cell count decreased 172.98 10.24 176 297534 166933 90163804
Cardiac failure congestive 171.75 10.24 55 297655 98639 90232098
Musculoskeletal stiffness 170.76 10.24 1604 296106 294928 90035809
Steroid withdrawal syndrome 170.33 10.24 69 297641 607 90330130
Myocardial infarction 169.20 10.24 68 297642 105904 90224833
Hip arthroplasty 168.06 10.24 592 297118 75616 90255121
Atrial fibrillation 167.39 10.24 117 297593 133494 90197243
Peripheral venous disease 165.75 10.24 629 297081 83292 90247445
Neutropenia 165.17 10.24 304 297406 224600 90106137
Prescribed overdose 165.01 10.24 697 297013 96928 90233809
Urinary tract infection 162.94 10.24 490 297220 305142 90025595
Dyspepsia 162.73 10.24 1162 296548 196998 90133739
Lower limb fracture 161.20 10.24 629 297081 84384 90246353
Gait inability 159.81 10.24 923 296787 145533 90185204
Contraindicated product administered 159.76 10.24 1681 296029 318458 90012279
Road traffic accident 157.44 10.24 736 296974 106890 90223847
Stomatitis 156.69 10.24 1483 296227 273215 90057522
Platelet count decreased 156.23 10.24 132 297578 136837 90193900
Wheezing 155.07 10.24 1323 296387 236757 90093980
X-ray abnormal 152.73 10.24 409 297301 45015 90285722
Wound infection 151.53 10.24 722 296988 105680 90225057
Pulmonary fibrosis 149.87 10.24 725 296985 106778 90223959
Drug intolerance 148.96 10.24 2178 295532 445413 89885324
Overdose 144.82 10.24 183 297527 157526 90173211
Back pain 144.80 10.24 544 297166 316631 90014106
Balance disorder 142.86 10.24 70 297640 97010 90233727
Nausea 142.38 10.24 2682 295028 1107634 89223103
Dehydration 139.96 10.24 266 297444 194181 90136556
Tremor 139.34 10.24 179 297531 152994 90177743
Joint swelling 138.73 10.24 2373 295337 500927 89829810
Malignant neoplasm progression 138.67 10.24 90 297620 106780 90223957
Somnolence 135.30 10.24 304 297406 208780 90121957
Haemoglobin decreased 134.58 10.24 202 297508 161754 90168983
Cardiac failure 134.38 10.24 98 297612 109398 90221339
Bursitis 132.89 10.24 813 296897 130841 90199896
Therapeutic product effect decreased 132.62 10.24 1445 296265 276126 90054611
Urticaria 131.46 10.24 1588 296122 311146 90019591
Suicide attempt 131.23 10.24 42 297668 75357 90255380
Feeling abnormal 130.98 10.24 217 297493 167018 90163719
Syncope 130.27 10.24 146 297564 132517 90198220
Adrenal insufficiency 128.68 10.24 296 297414 29625 90301112
Renal impairment 128.53 10.24 95 297615 105326 90225411
Colitis ulcerative 127.61 10.24 462 297248 59804 90270933
Prescribed underdose 125.52 10.24 534 297176 74485 90256252
Adverse event 125.48 10.24 736 296974 116682 90214055
Knee arthroplasty 122.49 10.24 570 297140 82612 90248125
Gastrointestinal disorder 121.55 10.24 1334 296376 255353 90075384
Wrong technique in product usage process 120.83 10.24 42 297668 71529 90259208
Injection site erythema 119.79 10.24 89 297621 98413 90232324
Sedation 117.95 10.24 11 297699 48160 90282577
Onychomycosis 116.17 10.24 327 297383 37049 90293688
Multiple sclerosis relapse 115.54 10.24 17 297693 52288 90278449
Cognitive disorder 113.33 10.24 43 297667 69364 90261373
Disease progression 112.91 10.24 214 297496 156401 90174336
Hypotension 112.65 10.24 618 297092 324779 90005958
Coma 112.09 10.24 49 297661 72583 90258154
Sciatica 110.60 10.24 639 297071 100743 90229994
Chronic obstructive pulmonary disease 110.51 10.24 52 297658 73777 90256960
Migraine 109.55 10.24 1030 296680 189362 90141375
Constipation 109.30 10.24 511 297199 279884 90050853
Device expulsion 106.66 10.24 7 297703 40879 90289858
Onychomadesis 106.33 10.24 363 297347 45635 90285102
Oedema 105.16 10.24 1063 296647 199232 90131505
Renal failure 104.44 10.24 168 297542 130839 90199898
Myelosuppression 104.26 10.24 24 297686 53567 90277170
Anti-cyclic citrullinated peptide antibody 103.79 10.24 257 297453 26964 90303773
Dry mouth 103.54 10.24 991 296719 183068 90147669
Myalgia 103.49 10.24 267 297443 174858 90155879
Obesity 102.36 10.24 645 297065 104862 90225875
Interstitial lung disease 102.35 10.24 62 297648 76343 90254394
Alanine aminotransferase increased 101.83 10.24 144 297566 118194 90212543
Blood creatinine increased 100.17 10.24 111 297599 101275 90229462
Hyperhidrosis 98.47 10.24 186 297524 136119 90194618
Contusion 97.94 10.24 1258 296452 249958 90080779
Night sweats 97.04 10.24 740 296970 128026 90202711
Suicidal ideation 96.08 10.24 62 297648 73793 90256944
Depressed level of consciousness 94.82 10.24 61 297649 72723 90258014
Influenza 94.61 10.24 197 297513 139067 90191670
Ulcer haemorrhage 94.61 10.24 243 297467 26078 90304659
Cataract 94.49 10.24 60 297650 72032 90258705
C-reactive protein 93.18 10.24 270 297440 31097 90299640
Therapy interrupted 90.65 10.24 26 297684 50082 90280655
Breast cancer stage II 89.84 10.24 288 297422 35046 90295691
Product label confusion 89.53 10.24 218 297492 22632 90308105
Thrombocytopenia 89.45 10.24 367 297343 208358 90122379
Drug tolerance decreased 89.20 10.24 270 297440 31860 90298877
Electrocardiogram QT prolonged 88.70 10.24 65 297645 72391 90258346
Retinitis 88.45 10.24 303 297407 38155 90292582
Aspartate aminotransferase increased 86.85 10.24 127 297583 102810 90227927
Delirium 86.78 10.24 614 297096 103745 90226992
Frequent bowel movements 86.67 10.24 394 297316 56541 90274196
Blood glucose increased 85.89 10.24 112 297598 95134 90235603
Rash 85.42 10.24 3308 294402 792792 89537945
Blepharospasm 83.14 10.24 382 297328 55063 90275674
Full blood count abnormal 82.93 10.24 11 297699 36586 90294151
Seizure 82.49 10.24 243 297467 152386 90178351
Vision blurred 81.88 10.24 148 297562 110145 90220592
Breast cancer 81.81 10.24 37 297673 53724 90277013
Hypoaesthesia 80.87 10.24 1466 296244 312744 90017993
Gastrointestinal haemorrhage 80.48 10.24 107 297603 90141 90240596
Loss of consciousness 78.18 10.24 220 297490 140018 90190719
Exposure during pregnancy 77.91 10.24 1157 296553 237253 90093484
Palpitations 77.33 10.24 213 297497 136515 90194222
Unevaluable event 77.04 10.24 42 297668 54806 90275931
Accidental exposure to product 74.79 10.24 23 297687 42343 90288394
Product use in unapproved indication 74.70 10.24 1534 296176 334702 89996035
Femur fracture 74.48 10.24 29 297681 46053 90284684
Diarrhoea 74.39 10.24 2436 295274 936754 89393983
Lung disorder 73.69 10.24 785 296925 149098 90181639
Hypertension 73.37 10.24 1995 295715 455537 89875200
Herpes zoster 72.98 10.24 124 297586 94520 90236217
Pleural effusion 72.27 10.24 163 297547 111828 90218909
Inflammation 71.55 10.24 899 296811 177693 90153044
Intentional self-injury 71.02 10.24 7 297703 29327 90301410
COVID-19 71.01 10.24 299 297411 168544 90162193
Epistaxis 70.86 10.24 106 297604 85019 90245718
Secondary adrenocortical insufficiency 69.42 10.24 59 297651 2259 90328478
Therapy cessation 69.32 10.24 17 297693 36344 90294393
Neutrophil count decreased 68.82 10.24 80 297630 71452 90259285
Cardiac disorder 68.35 10.24 52 297658 56820 90273917
Confusional state 67.98 10.24 1705 296005 384500 89946237
Osteonecrosis of jaw 67.65 10.24 22 297688 39081 90291656
Lupus-like syndrome 66.31 10.24 327 297383 48519 90282218
Thrombosis 66.18 10.24 86 297624 73165 90257572
Eye injury 66.12 10.24 125 297585 10895 90319842
Febrile bone marrow aplasia 65.43 10.24 116 297594 9622 90321115
Hypofibrinogenaemia 65.43 10.24 46 297664 1324 90329413
Adverse drug reaction 65.42 10.24 628 297082 116073 90214664
Hyperadrenocorticism 65.28 10.24 32 297678 458 90330279
Respiratory arrest 64.63 10.24 15 297695 33296 90297441
Injection site swelling 64.22 10.24 61 297649 59778 90270959
Drug level below therapeutic 64.02 10.24 87 297623 5727 90325010
Liver disorder 63.80 10.24 644 297066 120625 90210112
Porphyria acute 63.62 10.24 165 297545 17810 90312927
Cardio-respiratory arrest 63.61 10.24 68 297642 63072 90267665
Bronchitis 63.57 10.24 272 297438 152655 90178082
Agitation 63.53 10.24 76 297634 67022 90263715
Dysarthria 62.73 10.24 52 297658 54430 90276307
Pneumonia 62.22 10.24 1608 296102 636451 89694286
Hallucination 62.14 10.24 75 297635 65884 90264853
Orthostatic hypotension 60.26 10.24 31 297679 41796 90288941
Chronic kidney disease 60.18 10.24 46 297664 50145 90280592
Leukopenia 59.89 10.24 153 297557 100557 90230180
Aphasia 59.82 10.24 33 297677 42779 90287958
Cardiac arrest 58.94 10.24 164 297546 104771 90225966
Epilepsy 58.91 10.24 467 297243 81739 90248998
Liver function test abnormal 57.96 10.24 49 297661 50796 90279941
Metastases to liver 57.86 10.24 12 297698 28795 90301942
Off label use 57.74 10.24 4282 293428 1097970 89232767
Device dislocation 57.57 10.24 16 297694 31466 90299271
Diverticulitis 57.33 10.24 39 297671 45148 90285589
Amnesia 56.97 10.24 576 297134 107929 90222808
Dysphagia 56.93 10.24 184 297526 112094 90218643
Walking aid user 56.51 10.24 249 297461 35257 90295480
Craniopharyngioma 56.34 10.24 21 297689 144 90330593
Renal disorder 56.14 10.24 27 297683 37832 90292905
Maternal exposure timing unspecified 56.02 10.24 182 297528 22301 90308436
Arrhythmia 55.79 10.24 35 297675 42297 90288440
Weight increased 55.43 10.24 1780 295930 416147 89914590
Bradycardia 54.94 10.24 121 297589 83726 90247011
Plasma cell myeloma 54.86 10.24 33 297677 40795 90289942
Hepatic function abnormal 54.76 10.24 43 297667 46245 90284492
Dyspnoea exertional 54.55 10.24 96 297614 72192 90258545
Injection site bruising 54.20 10.24 55 297655 52252 90278485
Cystitis 53.69 10.24 85 297625 66633 90264104
Lung neoplasm malignant 53.35 10.24 8 297702 24265 90306472
Vertigo 53.33 10.24 92 297618 69719 90261018
Serotonin syndrome 53.23 10.24 29 297681 37858 90292879
Nail disorder 52.93 10.24 354 297356 58713 90272024
Intentional product misuse 51.85 10.24 138 297572 89466 90241271
Exostosis 51.62 10.24 325 297385 52809 90277928
Cholelithiasis 51.29 10.24 58 297652 52448 90278289
Osteoarthritis 51.29 10.24 916 296794 194814 90135923
Asthenia 51.23 10.24 1348 296362 532403 89798334
Red blood cell sedimentation rate abnormal 50.91 10.24 9 297701 24195 90306542
Therapy non-responder 50.48 10.24 678 297032 136026 90194711
Metastases to bone 50.46 10.24 11 297699 25494 90305243
Haematuria 50.18 10.24 26 297684 34911 90295826
Drug withdrawal syndrome 49.97 10.24 16 297694 28707 90302030
Dyskinesia 49.84 10.24 29 297681 36505 90294232
Blood creatine phosphokinase increased 49.34 10.24 25 297685 33998 90296739
Influenza like illness 49.07 10.24 121 297589 80490 90250247
Cellulitis 48.91 10.24 146 297564 91191 90239546
Blood pressure systolic abnormal 48.90 10.24 4 297706 19474 90311263
International normalised ratio increased 48.74 10.24 50 297660 47266 90283471
Acute myocardial infarction 48.59 10.24 27 297683 34863 90295874
Blood potassium decreased 48.53 10.24 51 297659 47676 90283061
Neuropathy peripheral 48.51 10.24 258 297452 136712 90194025
Coronary artery disease 48.32 10.24 25 297685 33598 90297139
Abortion spontaneous 48.28 10.24 64 297646 53992 90276745
Blood alkaline phosphatase increased 48.19 10.24 52 297658 48027 90282710
Drug eruption 47.04 10.24 29 297681 35378 90295359
Pancytopenia 46.91 10.24 219 297491 120044 90210693
Angina pectoris 46.81 10.24 36 297674 39124 90291613
Pulmonary embolism 46.57 10.24 246 297464 130574 90200163
Disability 46.51 10.24 260 297450 40485 90290252
Skin ulcer 46.05 10.24 58 297652 50017 90280720
Pulmonary hypertension 46.04 10.24 43 297667 42480 90288257
Rheumatoid nodule 45.84 10.24 6 297704 20160 90310577
Bone disorder 45.68 10.24 10 297700 23110 90307627
Dysphonia 45.62 10.24 86 297624 62998 90267739
Blood calcium decreased 45.56 10.24 21 297689 30161 90300576
Transient ischaemic attack 45.19 10.24 45 297665 43131 90287606
Abdominal pain upper 44.89 10.24 1420 296290 331254 89999483
Adverse reaction 44.75 10.24 205 297505 29507 90301230
Hepatic cirrhosis 44.59 10.24 358 297352 62895 90267842
Red blood cell count decreased 44.41 10.24 52 297658 46299 90284438
Hip fracture 44.07 10.24 27 297683 33050 90297687
Blood pressure fluctuation 43.92 10.24 309 297401 52104 90278633
Incorrect route of product administration 43.92 10.24 301 297409 50325 90280412
Finger deformity 43.77 10.24 219 297491 32678 90298059
Drug-induced liver injury 42.96 10.24 470 297240 89848 90240889
Injection site pruritus 42.92 10.24 69 297641 53765 90276972
Device difficult to use 42.91 10.24 4 297706 17521 90313216
Hepatic steatosis 42.86 10.24 35 297675 36910 90293827
Normal newborn 42.76 10.24 171 297539 23191 90307546
Cerebral infarction 42.55 10.24 17 297693 26579 90304158
Neoplasm progression 42.53 10.24 50 297660 44436 90286301
Hypoxia 42.27 10.24 111 297599 72288 90258449
Dysgeusia 42.25 10.24 67 297643 52493 90278244
Taste disorder 42.12 10.24 346 297364 61200 90269537
Respiratory failure 41.97 10.24 223 297487 118195 90212542
Hypothalamic pituitary adrenal axis suppression 41.85 10.24 21 297689 317 90330420
Sepsis 41.82 10.24 383 297327 179431 90151306
Melaena 41.58 10.24 32 297678 34765 90295972
Complication associated with device 41.42 10.24 7 297703 19442 90311295
Upper gastrointestinal haemorrhage 41.42 10.24 12 297698 22964 90307773
Urinary retention 41.06 10.24 38 297672 37706 90293031
Product prescribing error 41.02 10.24 24 297686 30121 90300616
Coeliac disease 40.96 10.24 269 297441 44341 90286396
Laryngitis 40.66 10.24 296 297414 50457 90280280
Blood pressure diastolic abnormal 40.52 10.24 8 297702 19873 90310864
Pituitary tumour benign 40.24 10.24 42 297668 2090 90328647
Eating disorder 40.16 10.24 21 297689 28052 90302685
Sinus congestion 39.99 10.24 20 297690 27404 90303333
Respiratory tract infection 39.75 10.24 84 297626 58994 90271743
Vaginal haemorrhage 39.66 10.24 27 297683 31244 90299493
Affect lability 39.59 10.24 6 297704 18057 90312680
Basal cell carcinoma 39.52 10.24 31 297679 33358 90297379
Hyponatraemia 39.15 10.24 267 297443 133271 90197466
Mental status changes 38.79 10.24 54 297656 44625 90286112
Back injury 38.56 10.24 274 297436 46348 90284389
Poisoning 38.55 10.24 3 297707 15214 90315523
Dysstasia 38.49 10.24 17 297693 25035 90305702
Rheumatoid arthritis 38.49 10.24 902 296808 361712 89969025
Dry eye 38.45 10.24 83 297627 57848 90272889
Bone erosion 38.42 10.24 302 297408 52719 90278018
Pulmonary arterial hypertension 38.34 10.24 19 297691 26168 90304569
Surgery 38.23 10.24 55 297655 44832 90285905
Neuroleptic malignant syndrome 38.18 10.24 3 297707 15093 90315644
Rhabdomyolysis 37.84 10.24 69 297641 51187 90279550
Restlessness 37.65 10.24 37 297673 35683 90295054
Adrenal suppression 37.22 10.24 29 297681 980 90329757
Full blood count decreased 37.16 10.24 26 297684 29663 90301074
Hypophagia 36.99 10.24 38 297672 35899 90294838
Bone pain 36.98 10.24 94 297616 61889 90268848
Blood pressure increased 36.92 10.24 442 297268 196775 90133962
Blood pressure systolic increased 36.76 10.24 86 297624 58259 90272478
Tooth disorder 36.63 10.24 29 297681 31061 90299676
Blood urea increased 36.30 10.24 28 297682 30385 90300352
Nervousness 36.21 10.24 35 297675 34021 90296716
Hyperkalaemia 36.13 10.24 102 297608 64862 90265875
Creatinine renal clearance decreased 35.71 10.24 9 297701 18890 90311847
Food allergy 35.07 10.24 20 297690 25458 90305279
Parkinsonism 35.00 10.24 3 297707 14062 90316675
Poisoning deliberate 34.96 10.24 6 297704 16480 90314257
Immunodeficiency 34.86 10.24 55 297655 43179 90287558
Gastric disorder 34.70 10.24 35 297675 33349 90297388
Neoplasm malignant 34.67 10.24 36 297674 33844 90296893
Palmar-plantar erythrodysaesthesia syndrome 34.47 10.24 25 297685 27998 90302739
Visual acuity reduced 34.25 10.24 17 297693 23393 90307344
Hypomagnesaemia 34.02 10.24 40 297670 35548 90295189
Productive cough 33.93 10.24 134 297576 76929 90253808
Lymphocyte count decreased 33.93 10.24 39 297671 35011 90295726
Panniculitis 33.60 10.24 4 297706 14454 90316283
Blood bilirubin increased 33.46 10.24 57 297653 43413 90287324
Subcutaneous drug absorption impaired 33.16 10.24 109 297601 13436 90317301
Rash vesicular 33.15 10.24 133 297577 18064 90312673
Eosinophilia 33.13 10.24 27 297683 28506 90302231
Haematoma 33.10 10.24 48 297662 39000 90291737
Musculoskeletal disorder 33.09 10.24 15 297695 21754 90308983
Motor dysfunction 32.95 10.24 11 297699 19219 90311518
Human bocavirus infection 32.69 10.24 20 297690 452 90330285
Breast cancer female 32.50 10.24 5 297705 14881 90315856
Ulcer 32.47 10.24 36 297674 32846 90297891
Hypoglycaemia 32.34 10.24 119 297591 69729 90261008
Head injury 32.07 10.24 33 297677 31155 90299582
Urinary incontinence 32.02 10.24 46 297664 37520 90293217
Coordination abnormal 32.02 10.24 15 297695 21341 90309396
Mitral valve incompetence 31.99 10.24 17 297693 22507 90308230
Foetal death 31.94 10.24 14 297696 20709 90310028
Tinnitus 31.84 10.24 58 297652 43044 90287693
Device issue 31.82 10.24 30 297680 29507 90301230
Disturbance in attention 31.68 10.24 67 297643 47042 90283695
Jaundice 31.67 10.24 36 297674 32481 90298256
Depressed mood 31.66 10.24 74 297636 50148 90280589
Sinus disorder 31.57 10.24 40 297670 34407 90296330
General symptom 31.51 10.24 113 297597 14555 90316182
Diabetes mellitus inadequate control 31.47 10.24 11 297699 18673 90312064
Nasal congestion 31.30 10.24 154 297556 83260 90247477
Psychotic disorder 31.05 10.24 34 297676 31196 90299541
Myelodysplastic syndrome 30.85 10.24 15 297695 20888 90309849
Platelet count increased 30.74 10.24 15 297695 20844 90309893
Localised infection 30.73 10.24 39 297671 33523 90297214
Seronegative arthritis 30.64 10.24 130 297580 18104 90312633
Female genital tract fistula 30.50 10.24 128 297582 17740 90312997
Ventricular tachycardia 30.45 10.24 22 297688 24686 90306051
Hypocalcaemia 30.42 10.24 58 297652 42310 90288427
Dermatitis atopic 30.35 10.24 155 297555 23317 90307420
Injection site haemorrhage 30.23 10.24 29 297681 28289 90302448
Hospitalisation 29.71 10.24 273 297437 127827 90202910
Haemorrhage 29.67 10.24 122 297588 69247 90261490
Device related bacteraemia 29.65 10.24 18 297692 401 90330336
Rib fracture 29.49 10.24 26 297684 26409 90304328
Chills 29.45 10.24 284 297426 131697 90199040
Disorientation 29.45 10.24 63 297647 44051 90286686
Pain in jaw 29.22 10.24 72 297638 47913 90282824
Perfume sensitivity 29.13 10.24 25 297685 970 90329767
Hemiparesis 29.11 10.24 37 297673 31782 90298955
Metabolic acidosis 29.09 10.24 90 297620 55586 90275151
Breast cancer metastatic 28.99 10.24 7 297703 15125 90315612
Blood potassium increased 28.98 10.24 16 297694 20733 90310004
Nasopharyngitis 28.88 10.24 1624 296086 405480 89925257
Inappropriate schedule of product administration 28.76 10.24 670 297040 149263 90181474
Overlap syndrome 28.76 10.24 77 297633 8471 90322266
Diaphragm muscle weakness 28.74 10.24 9 297701 33 90330704
Muscle rigidity 28.66 10.24 6 297704 14303 90316434
Musculoskeletal pain 28.59 10.24 751 296959 170500 90160237
Limb injury 28.45 10.24 37 297673 31471 90299266
Metastases to central nervous system 28.41 10.24 11 297699 17531 90313206
Dyspnoea 28.23 10.24 2501 295209 878454 89452283
Stenotrophomonas bacteraemia 28.19 10.24 12 297698 121 90330616
Respiratory tract congestion 28.19 10.24 29 297681 27381 90303356
Memory impairment 28.19 10.24 848 296862 196396 90134341
Pregnancy 28.19 10.24 320 297390 61727 90269010
Dystonia 28.16 10.24 10 297700 16809 90313928
Burning sensation 28.15 10.24 110 297600 63342 90267395
Gamma-glutamyltransferase increased 28.09 10.24 51 297659 37901 90292836
Rhinitis allergic 28.07 10.24 10 297700 16775 90313962
Ascites 28.02 10.24 73 297637 47667 90283070
Geotrichum infection 27.84 10.24 20 297690 596 90330141
Metastases to lung 27.66 10.24 9 297701 15982 90314755
Rectal haemorrhage 27.55 10.24 403 297307 82341 90248396
Foot fracture 27.53 10.24 28 297682 26578 90304159
Speech disorder 27.29 10.24 69 297641 45516 90285221
Drug resistance 27.24 10.24 36 297674 30413 90300324
Myocardial ischaemia 27.24 10.24 6 297704 13808 90316929
Torsade de pointes 27.24 10.24 8 297702 15174 90315563
Drug level decreased 27.22 10.24 82 297628 9648 90321089
Hypervolaemia 27.05 10.24 41 297669 32716 90298021
Joint dislocation 27.02 10.24 244 297466 44338 90286399
Haematocrit decreased 26.89 10.24 61 297649 41771 90288966
Injection site mass 26.79 10.24 20 297690 22070 90308667
Muscle twitching 26.76 10.24 24 297686 24178 90306559
Therapy partial responder 26.68 10.24 20 297690 22023 90308714
Sputum discoloured 26.68 10.24 17 297693 20374 90310363
Intervertebral disc protrusion 26.61 10.24 30 297680 27166 90303571
Nodule 26.59 10.24 29 297681 26657 90304080
Diabetes insipidus 26.57 10.24 42 297668 3170 90327567
Respiratory depression 26.53 10.24 9 297701 15566 90315171
Altered state of consciousness 26.49 10.24 39 297671 31493 90299244
Myoclonus 26.45 10.24 15 297695 19153 90311584
Deep vein thrombosis 26.45 10.24 184 297526 91436 90239301
No adverse event 26.38 10.24 124 297586 67858 90262879
Akathisia 26.15 10.24 3 297707 11156 90319581
Intervertebral disc degeneration 26.10 10.24 12 297698 17262 90313475
Agranulocytosis 25.94 10.24 47 297663 34955 90295782
Osteomyelitis 25.87 10.24 32 297678 27814 90302923
Pulmonary mass 25.76 10.24 34 297676 28738 90301999
Rotator cuff syndrome 25.75 10.24 10 297700 15909 90314828
Pustular psoriasis 25.73 10.24 125 297585 18431 90312306
Ischaemic stroke 25.71 10.24 21 297689 22145 90308592
Vasculitis 25.70 10.24 22 297688 22671 90308066
Salpingo-oophorectomy unilateral 25.69 10.24 23 297687 945 90329792
Hypokalaemia 25.64 10.24 291 297419 130825 90199912
Hepatotoxicity 25.47 10.24 72 297638 45770 90284967
Tardive dyskinesia 25.46 10.24 3 297707 10927 90319810
Oxygen saturation decreased 25.39 10.24 228 297482 107255 90223482
Angioedema 25.38 10.24 118 297592 64758 90265979
Lactic acidosis 25.37 10.24 83 297627 50380 90280357
Cytopenia 25.04 10.24 13 297697 17436 90313301
Bone marrow failure 25.03 10.24 42 297668 32179 90298558
Product storage error 24.97 10.24 18 297692 20223 90310514
Dementia 24.82 10.24 25 297685 23836 90306901
Bone density decreased 24.77 10.24 13 297697 17332 90313405
Schizophrenia 24.75 10.24 9 297701 14905 90315832
Hypercalcaemia 24.47 10.24 47 297663 34193 90296544
Illness 24.47 10.24 163 297547 81806 90248931
Normal tension glaucoma 24.44 10.24 8 297702 35 90330702
Hypertensive crisis 24.42 10.24 14 297696 17770 90312967
Gastritis 24.38 10.24 64 297646 41689 90289048
Fracture 24.28 10.24 22 297688 22054 90308683
Cerebral haemorrhage 24.14 10.24 48 297662 34474 90296263
Deafness 24.10 10.24 23 297687 22491 90308246
Natural killer-cell leukaemia 24.02 10.24 10 297700 95 90330642
Heart rate increased 23.91 10.24 246 297464 112656 90218081
Infection 23.86 10.24 1435 296275 360659 89970078
Carpal tunnel syndrome 23.84 10.24 26 297684 23902 90306835
Stress 23.73 10.24 163 297547 81232 90249505
Pneumonia aspiration 23.72 10.24 63 297647 40877 90289860
Nerve injury 23.64 10.24 4 297706 11102 90319635
Haematotoxicity 23.62 10.24 6 297704 12529 90318208
Insulin-like growth factor increased 23.62 10.24 22 297688 952 90329785
Fusarium infection 23.50 10.24 23 297687 1059 90329678
Urticaria thermal 23.39 10.24 17 297693 516 90330221
Arterial occlusive disease 23.37 10.24 6 297704 12440 90318297
Congenital anomaly 23.22 10.24 59 297651 6288 90324449
Joint injury 23.20 10.24 45 297665 32619 90298118
Hypersomnia 23.04 10.24 22 297688 21509 90309228
Pollakiuria 22.99 10.24 46 297664 32959 90297778
Fear 22.95 10.24 13 297697 16609 90314128
Irritability 22.92 10.24 52 297658 35610 90295127
Multiple sclerosis 22.84 10.24 35 297675 27805 90302932
Sensory disturbance 22.84 10.24 11 297699 15402 90315335
Hallucination, auditory 22.77 10.24 12 297698 15963 90314774
Breath sounds abnormal 22.77 10.24 11 297699 15375 90315362
Grip strength 22.72 10.24 73 297637 8892 90321845
Cardiovascular disorder 22.63 10.24 8 297702 13484 90317253
Pruritus 22.61 10.24 2069 295641 539456 89791281
Mental disorder 22.55 10.24 45 297665 32273 90298464
Antithrombin III 22.53 10.24 11 297699 156 90330581
Diabetes mellitus 22.52 10.24 123 297587 64752 90265985
Right ventricular failure 22.52 10.24 18 297692 19187 90311550
Pulmonary oedema 22.50 10.24 116 297594 61964 90268773
Insulin-like growth factor decreased 22.44 10.24 15 297695 397 90330340
Aggression 22.39 10.24 33 297677 26635 90304102
Injection site warmth 22.37 10.24 15 297695 17500 90313237
Hypothyroidism 22.37 10.24 94 297616 53033 90277704
Skin necrosis 22.33 10.24 14 297696 16927 90313810
Ligament sprain 22.28 10.24 10 297700 14589 90316148
Extrapyramidal disorder 22.15 10.24 13 297697 16290 90314447
Steroid dependence 22.08 10.24 32 297678 2237 90328500
Drug dependence 22.08 10.24 39 297671 29288 90301449
Gastric ulcer 22.05 10.24 35 297675 27413 90303324
Upper limb fracture 22.00 10.24 23 297687 21555 90309182
Body height decreased 21.98 10.24 6 297704 11943 90318794
Ventricular extrasystoles 21.98 10.24 8 297702 13242 90317495
Pulmonary congestion 21.81 10.24 19 297691 19414 90311323
Hemiplegia 21.80 10.24 13 297697 16147 90314590
Glycosylated haemoglobin increased 21.73 10.24 12 297698 15550 90315187
Complication of device insertion 21.69 10.24 4 297706 10432 90320305
Blood glucose decreased 21.69 10.24 27 297683 23402 90307335
Generalised tonic-clonic seizure 21.55 10.24 52 297658 34851 90295886
Personality disorder 21.53 10.24 7 297703 12437 90318300
Mood altered 21.48 10.24 15 297695 17129 90313608
Movement disorder 21.48 10.24 39 297671 28980 90301757
Synovial cyst 21.44 10.24 6 297704 11746 90318991
COVID-19 pneumonia 21.36 10.24 17 297693 18160 90312577
Infective pulmonary exacerbation of cystic fibrosis 21.24 10.24 4 297706 10275 90320462
Faecal calprotectin increased 21.22 10.24 43 297667 3944 90326793
Renal cyst 21.17 10.24 8 297702 12942 90317795
Splenomegaly 21.11 10.24 8 297702 12916 90317821
Unresponsive to stimuli 21.09 10.24 60 297650 38061 90292676
Abnormal behaviour 21.02 10.24 26 297684 22602 90308135
Sedation complication 21.00 10.24 15 297695 16929 90313808
Transaminases increased 20.97 10.24 58 297652 37134 90293603
Pelvic fracture 20.87 10.24 12 297698 15207 90315530
Toxic skin eruption 20.84 10.24 13 297697 15761 90314976
Sinusitis 20.82 10.24 1350 296360 341738 89988999
Heavy menstrual bleeding 20.80 10.24 22 297688 20508 90310229
Vaginal discharge 20.77 10.24 122 297588 19342 90311395
Musculoskeletal discomfort 20.71 10.24 23 297687 20968 90309769
Multiple allergies 20.69 10.24 12 297698 15134 90315603
Swollen joint count 20.62 10.24 69 297641 8584 90322153
Lymphadenopathy 20.53 10.24 79 297631 45696 90285041
Wrist fracture 20.48 10.24 13 297697 15611 90315126
Mental impairment 20.46 10.24 15 297695 16705 90314032
Hyperaesthesia 20.41 10.24 5 297705 10697 90320040
Nephropathy 20.40 10.24 3 297707 9232 90321505
Herpes simplex oesophagitis 20.35 10.24 11 297699 195 90330542
Subdural haematoma 20.28 10.24 15 297695 16630 90314107
Ear infection 20.23 10.24 332 297378 69443 90261294
Haematemesis 20.23 10.24 51 297659 33675 90297062
Drug level above therapeutic 20.23 10.24 53 297657 5756 90324981
Urosepsis 20.15 10.24 24 297686 21208 90309529
Blood pressure abnormal 19.96 10.24 21 297689 19624 90311113
Pneumonitis 19.96 10.24 76 297634 44094 90286643
Proctitis 19.89 10.24 101 297609 15158 90315579
Colitis microscopic 19.80 10.24 6 297704 11153 90319584
Medication error 19.68 10.24 389 297321 84263 90246474
Restless legs syndrome 19.66 10.24 27 297683 22443 90308294
Faecaloma 19.64 10.24 5 297705 10426 90320311
Vaginal flatulence 19.63 10.24 88 297622 12550 90318187
Metastases to lymph nodes 19.49 10.24 7 297703 11682 90319055
Hot flush 19.45 10.24 115 297595 59373 90271364
Therapeutic response unexpected 19.44 10.24 26 297684 21854 90308883
Gangrene 19.37 10.24 9 297701 12867 90317870
Hypogonadism 19.34 10.24 9 297701 114 90330623
Spondylitis 19.30 10.24 95 297615 14083 90316654
Injection site rash 19.25 10.24 31 297679 24142 90306595
Groin pain 19.22 10.24 8 297702 12205 90318532
Upper respiratory tract infection 19.18 10.24 301 297409 128017 90202720
Eye irritation 19.15 10.24 53 297657 33925 90296812
Renal injury 19.12 10.24 5 297705 10238 90320499
Deformity 19.11 10.24 8 297702 12162 90318575
Small intestinal obstruction 19.10 10.24 25 297685 21209 90309528
Femoral neck fracture 19.09 10.24 5 297705 10228 90320509
Excessive eye blinking 19.00 10.24 23 297687 1349 90329388
Mydriasis 18.98 10.24 13 297697 14999 90315738
Weaning failure 18.95 10.24 15 297695 519 90330218
Acute hepatic failure 18.86 10.24 28 297682 22533 90308204
Eye pain 18.69 10.24 78 297632 44090 90286647
Headache 18.61 10.24 2517 295193 860229 89470508
Device malfunction 18.56 10.24 25 297685 20952 90309785
Jaundice cholestatic 18.56 10.24 5 297705 10038 90320699
Allergy test positive 18.46 10.24 17 297693 725 90330012
Purpura 18.42 10.24 13 297697 14765 90315972
Spinal stenosis 18.42 10.24 18 297692 17406 90313331
Abnormal dreams 18.33 10.24 7 297703 11250 90319487
Thirst 18.21 10.24 16 297694 16279 90314458
Intermenstrual bleeding 18.20 10.24 4 297706 9219 90321518
Toothache 18.19 10.24 28 297682 22202 90308535
Blood lactate dehydrogenase increased 18.18 10.24 36 297674 25896 90304841
Inflammatory marker increased 18.17 10.24 4 297706 9210 90321527
Spinal compression fracture 18.08 10.24 14 297696 15164 90315573
Cholestasis 18.04 10.24 60 297650 36239 90294498
Cardiomyopathy 17.96 10.24 24 297686 20182 90310555
Ecchymosis 17.95 10.24 9 297701 12314 90318423
Joint effusion 17.95 10.24 23 297687 19687 90311050
Diabetic ketoacidosis 17.89 10.24 33 297677 24374 90306363
Post procedural infection 17.84 10.24 7 297703 11067 90319670
C-reactive protein increased 17.77 10.24 747 296963 180642 90150095
Apathy 17.75 10.24 7 297703 11033 90319704
Therapy change 17.71 10.24 3 297707 8319 90322418
Ageusia 17.71 10.24 16 297694 16060 90314677
Strongyloidiasis 17.68 10.24 24 297686 1578 90329159
Dysuria 17.67 10.24 68 297642 39333 90291404
Sensory loss 17.62 10.24 20 297690 18055 90312682
Transplant rejection 17.58 10.24 10 297700 12748 90317989
Dizziness 17.52 10.24 1682 296028 587602 89743135
Blood test abnormal 17.52 10.24 26 297684 20926 90309811
Colon cancer 17.50 10.24 7 297703 10937 90319800
Hypopituitarism 17.46 10.24 25 297685 1728 90329009
Meniscus injury 17.46 10.24 3 297707 8234 90322503
Product administration error 17.41 10.24 38 297672 26385 90304352
Faecal volume decreased 17.36 10.24 11 297699 265 90330472
Haemoptysis 17.31 10.24 54 297656 33266 90297471
Tongue disorder 17.28 10.24 7 297703 10853 90319884
Multiple fractures 17.22 10.24 5 297705 9557 90321180
Anhedonia 17.18 10.24 8 297702 11423 90319314
Acute generalised exanthematous pustulosis 17.15 10.24 12 297698 13691 90317046
Rash maculo-papular 16.88 10.24 73 297637 40860 90289877
Gastroenteritis norovirus 16.87 10.24 29 297681 2347 90328390
Sleep apnoea syndrome 16.81 10.24 51 297659 31696 90299041
Crying 16.80 10.24 37 297673 25608 90305129
Eczema herpeticum 16.79 10.24 10 297700 215 90330522
Upper-airway cough syndrome 16.75 10.24 15 297695 15120 90315617
Major depression 16.74 10.24 6 297704 10029 90320708
Genital haemorrhage 16.72 10.24 4 297706 8698 90322039
Sinusitis fungal 16.69 10.24 26 297684 1938 90328799
Labelled drug-drug interaction medication error 16.68 10.24 14 297696 14568 90316169
Hereditary angioedema 16.68 10.24 5 297705 9360 90321377
Temperature regulation disorder 16.68 10.24 14 297696 14565 90316172
Intracranial infection 16.63 10.24 10 297700 219 90330518
Anal fissure 16.62 10.24 47 297663 5338 90325399
Diffuse large B-cell lymphoma 16.56 10.24 4 297706 8641 90322096
Tendonitis 16.47 10.24 28 297682 21344 90309393
Body temperature fluctuation 16.46 10.24 28 297682 2247 90328490
Rhinovirus infection 16.45 10.24 50 297660 5913 90324824
Hiatus hernia 16.28 10.24 37 297673 25324 90305413
Tubulointerstitial nephritis 16.25 10.24 37 297673 25306 90305431
Glomerular filtration rate decreased 16.22 10.24 19 297691 16913 90313824
Atrioventricular block complete 16.14 10.24 6 297704 9805 90320932
Death neonatal 16.13 10.24 27 297683 2138 90328599
Peritoneal tuberculosis 16.12 10.24 14 297696 552 90330185
Fatigue 16.01 10.24 3450 294260 1150573 89180164
Back disorder 15.90 10.24 141 297569 25490 90305247
Chromaturia 15.86 10.24 24 297686 19163 90311574
Chronic sinusitis 15.85 10.24 133 297577 23669 90307068
Catarrh 15.84 10.24 23 297687 1611 90329126
Pancreatic carcinoma 15.81 10.24 4 297706 8373 90322364
Electrocardiogram abnormal 15.80 10.24 7 297703 10291 90320446
Hepatitis acute 15.79 10.24 8 297702 10879 90319858
Sinus tachycardia 15.68 10.24 45 297665 28468 90302269
Eosinophil count increased 15.67 10.24 12 297698 13069 90317668
Limb discomfort 15.62 10.24 68 297642 37992 90292745
Lymphoma 15.61 10.24 13 297697 13578 90317159
Blood pressure decreased 15.52 10.24 164 297546 74731 90256006
Actinomycotic sepsis 15.46 10.24 10 297700 250 90330487
Tenosynovitis 15.45 10.24 15 297695 14552 90316185
Nightmare 15.37 10.24 30 297680 21695 90309042
Rhinorrhoea 15.37 10.24 201 297509 88115 90242622
White blood cell count abnormal 15.33 10.24 3 297707 7501 90323236
Blindness 15.30 10.24 41 297669 26527 90304210
Miosis 15.27 10.24 6 297704 9478 90321259
Paranoia 15.26 10.24 12 297698 12896 90317841
Gastrointestinal toxicity 15.23 10.24 6 297704 9461 90321276
Withdrawal syndrome 15.17 10.24 32 297678 22492 90308245
Vomiting 15.11 10.24 2316 295394 785977 89544760
Sneezing 15.10 10.24 49 297661 29820 90300917
Gingival bleeding 15.06 10.24 16 297694 14887 90315850
Psychomotor hyperactivity 15.03 10.24 12 297698 12801 90317936
Amenorrhoea 15.03 10.24 10 297700 11712 90319025
Lymphopenia 15.00 10.24 33 297677 22848 90307889
SARS-CoV-2 test positive 14.94 10.24 9 297701 11119 90319618
Proteinuria 14.94 10.24 34 297676 23257 90307480
Electrocardiogram QRS complex prolonged 14.88 10.24 3 297707 7345 90323392
Concussion 14.85 10.24 9 297701 11082 90319655
Foot deformity 14.85 10.24 277 297433 59374 90271363
Varicose vein 14.82 10.24 3 297707 7324 90323413
Initial insomnia 14.81 10.24 6 297704 9304 90321433
Spinal pain 14.77 10.24 18 297692 15749 90314988
Bedridden 14.73 10.24 11 297699 12137 90318600
Blood pressure systolic decreased 14.71 10.24 6 297704 9264 90321473
Viral upper respiratory tract infection 14.69 10.24 5 297705 8629 90322108
Unmasking of previously unidentified disease 14.63 10.24 21 297689 1455 90329282
Pyelonephritis 14.60 10.24 30 297680 21286 90309451
Atelectasis 14.57 10.24 37 297673 24372 90306365
Cortisol decreased 14.55 10.24 23 297687 1736 90329001
Ankylosing spondylitis 14.55 10.24 13 297697 13120 90317617
Progressive multifocal leukoencephalopathy 14.53 10.24 18 297692 15637 90315100
Gastroenteritis viral 14.52 10.24 51 297659 30304 90300433
Ankle fracture 14.52 10.24 28 297682 20342 90310395
Herpes zoster infection neurological 14.52 10.24 13 297697 534 90330203
Pulmonary thrombosis 14.47 10.24 7 297703 9775 90320962
Fluid retention 14.42 10.24 203 297507 87888 90242849
Hypophysitis 14.40 10.24 28 297682 2492 90328245
Feeding disorder 14.38 10.24 22 297688 17490 90313247
Dental caries 14.24 10.24 10 297700 11387 90319350
Nocturia 14.19 10.24 8 297702 10247 90320490
Acute myeloid leukaemia 14.18 10.24 29 297681 20611 90310126
Wheelchair user 14.15 10.24 4 297706 7781 90322956
Increased tendency to bruise 14.12 10.24 11 297699 11879 90318858
Abortion induced 14.12 10.24 11 297699 11877 90318860
Pharyngitis 14.11 10.24 32 297678 21915 90308822
Spinal operation 14.04 10.24 8 297702 10188 90320549
Atrial flutter 14.03 10.24 9 297701 10749 90319988
Osteonecrosis 14.01 10.24 42 297668 26199 90304538
Bipolar disorder 13.96 10.24 6 297704 8979 90321758
Drug use disorder 13.90 10.24 5 297705 8338 90322399
Pelvic pain 13.90 10.24 18 297692 15339 90315398
Aortic arteriosclerosis 13.87 10.24 4 297706 7680 90323057
Oesophagitis 13.85 10.24 22 297688 17227 90313510
Delusion 13.83 10.24 15 297695 13825 90316912
Sarcoidosis 13.82 10.24 9 297701 10664 90320073
Faeces discoloured 13.77 10.24 31 297679 21289 90309448
Oral herpes 13.69 10.24 60 297650 33464 90297273
Injection site haematoma 13.66 10.24 3 297707 6919 90323818
Perioral dermatitis 13.66 10.24 13 297697 578 90330159
Gestational diabetes 13.60 10.24 9 297701 10573 90320164
Leukocytosis 13.57 10.24 54 297656 30936 90299801
Nephropathy toxic 13.54 10.24 13 297697 12675 90318062
Respiratory disorder 13.47 10.24 293 297417 64523 90266214
Nervous system disorder 13.46 10.24 32 297678 21561 90309176
Musculoskeletal chest pain 13.42 10.24 37 297673 23713 90307024
Post-traumatic stress disorder 13.40 10.24 3 297707 6825 90323912
Malignant melanoma 13.28 10.24 13 297697 12563 90318174
Bradykinesia 13.28 10.24 3 297707 6785 90323952
Drug reaction with eosinophilia and systemic symptoms 13.28 10.24 84 297626 42674 90288063
Airway peak pressure increased 13.26 10.24 11 297699 407 90330330
Ovarian cancer 13.22 10.24 3 297707 6764 90323973
Toxic encephalopathy 13.21 10.24 6 297704 8693 90322044
Bronchiectasis 13.21 10.24 34 297676 22296 90308441
Device breakage 13.19 10.24 16 297694 14028 90316709
Mastocytosis 13.19 10.24 16 297694 940 90329797
Cholecystitis chronic 13.12 10.24 8 297702 9818 90320919
Myositis 13.10 10.24 129 297581 23999 90306738
Tendon rupture 13.09 10.24 7 297703 9236 90321501
Intentional dose omission 13.07 10.24 24 297686 17759 90312978
Left ventricular failure 13.03 10.24 3 297707 6697 90324040
Emotional distress 13.01 10.24 69 297641 36593 90294144
Small intestine gangrene 12.97 10.24 5 297705 38 90330699
Skin laceration 12.96 10.24 43 297667 25992 90304745
Muscle tightness 12.96 10.24 15 297695 13424 90317313
Seasonal allergy 12.84 10.24 36 297674 22947 90307790
Hospice care 12.82 10.24 8 297702 9696 90321041
Premature labour 12.82 10.24 15 297695 13361 90317376
Panic attack 12.81 10.24 44 297666 26321 90304416
Sickle cell anaemia with crisis 12.81 10.24 4 297706 7293 90323444
Hepatomegaly 12.71 10.24 15 297695 13311 90317426
Nasal oedema 12.70 10.24 3 297707 6581 90324156
Ataxia 12.69 10.24 25 297685 18017 90312720
Electrolyte imbalance 12.68 10.24 38 297672 23707 90307030
Blood corticotrophin decreased 12.68 10.24 12 297698 530 90330207
Cardiomegaly 12.65 10.24 27 297683 18898 90311839
Vitamin D deficiency 12.63 10.24 24 297686 17532 90313205
Device use error 12.60 10.24 4 297706 7217 90323520
Mucous stools 12.53 10.24 42 297668 5229 90325508
Hypoacusis 12.53 10.24 48 297662 27802 90302935
Foot operation 12.48 10.24 7 297703 8994 90321743
Spinal fusion surgery 12.47 10.24 76 297634 12207 90318530
Dyslipidaemia 12.45 10.24 9 297701 10098 90320639
Lethargy 12.39 10.24 140 297570 62999 90267738
Mass 12.38 10.24 20 297690 15557 90315180
Hyperemesis gravidarum 12.37 10.24 14 297696 764 90329973
Central nervous system lesion 12.35 10.24 12 297698 11634 90319103
Mania 12.33 10.24 17 297693 14107 90316630
Osteopenia 12.14 10.24 37 297673 22965 90307772
Swelling face 12.10 10.24 191 297519 81161 90249576
Cholecystitis acute 12.08 10.24 8 297702 9396 90321341
Glucocorticoid deficiency 12.08 10.24 12 297698 563 90330174
Oral discomfort 12.07 10.24 10 297700 10473 90320264
Blood albumin decreased 12.06 10.24 23 297687 16780 90313957
Large intestine polyp 12.04 10.24 8 297702 9378 90321359
Obstructive airways disorder 12.02 10.24 44 297666 25825 90304912
Malnutrition 11.98 10.24 27 297683 18531 90312206
Diplopia 11.97 10.24 51 297659 28663 90302074
Protein urine present 11.96 10.24 4 297706 6980 90323757
Brachycephaly 11.95 10.24 4 297706 19 90330718
Proctalgia 11.93 10.24 56 297654 8142 90322595
Spinal fracture 11.92 10.24 35 297675 21981 90308756
Breast pain 11.92 10.24 10 297700 10408 90320329
Large intestinal ulcer 11.91 10.24 34 297676 3883 90326854
Postoperative wound infection 11.88 10.24 16 297694 13410 90317327
Enterococcal sepsis 11.84 10.24 20 297690 1596 90329141
Uterine perforation 11.81 10.24 5 297705 7549 90323188
Tooth loss 11.81 10.24 5 297705 7549 90323188
Thrombotic microangiopathy 11.79 10.24 21 297689 15722 90315015
Eructation 11.78 10.24 11 297699 10871 90319866
Complication of device removal 11.78 10.24 3 297707 6252 90324485
Cerebral microangiopathy 11.76 10.24 9 297701 296 90330441
Cellulitis staphylococcal 11.76 10.24 15 297695 928 90329809
Somnambulism 11.70 10.24 3 297707 6225 90324512
Blood pressure inadequately controlled 11.69 10.24 3 297707 6221 90324516
Hypothalamo-pituitary disorder 11.64 10.24 24 297686 2228 90328509
17-hydroxyprogesterone decreased 11.64 10.24 3 297707 4 90330733
Shared psychotic disorder 11.63 10.24 4 297706 21 90330716
Neoplasm recurrence 11.62 10.24 30 297680 3229 90327508
Pseudohypoaldosteronism 11.61 10.24 5 297705 52 90330685
Decubitus ulcer 11.59 10.24 13 297697 11800 90318937
Embolism venous 11.57 10.24 32 297678 3588 90327149
Blood sodium decreased 11.54 10.24 49 297661 27564 90303173
Pre-existing condition improved 11.52 10.24 8 297702 9161 90321576
Stress fracture 11.51 10.24 7 297703 8604 90322133
Anger 11.50 10.24 17 297693 13703 90317034
Spinal osteoarthritis 11.45 10.24 29 297681 19119 90311618
Asphyxia 11.44 10.24 50 297660 7053 90323684
Secondary immunodeficiency 11.40 10.24 23 297687 2103 90328634
Exposure via skin contact 11.38 10.24 11 297699 10694 90320043
Eye haemorrhage 11.37 10.24 10 297700 10170 90320567
Adrenocortical carcinoma 11.37 10.24 5 297705 55 90330682
Burns second degree 11.31 10.24 22 297688 1958 90328779
Inappropriate antidiuretic hormone secretion 11.31 10.24 30 297680 19475 90311262
Norovirus test positive 11.24 10.24 8 297702 235 90330502
Nephrolithiasis 11.21 10.24 105 297605 48980 90281757
Fungal infection 11.20 10.24 88 297622 42573 90288164
Pneumonia adenoviral 11.12 10.24 8 297702 239 90330498
Hyperreflexia 11.07 10.24 4 297706 6653 90324084
Vaccination site inflammation 11.06 10.24 5 297705 59 90330678
Tenderness 11.03 10.24 48 297662 26820 90303917
Drug ineffective 11.00 10.24 4237 293473 1380061 88950676
Sulphaemoglobinaemia 10.97 10.24 11 297699 522 90330215
Petechiae 10.91 10.24 22 297688 15719 90315018
Blood cholesterol 10.90 10.24 15 297695 999 90329738
Skin haemorrhage 10.86 10.24 35 297675 21345 90309392
Secondary hypogonadism 10.86 10.24 7 297703 174 90330563
Hypokinesia 10.83 10.24 22 297688 15675 90315062
Subarachnoid haemorrhage 10.80 10.24 27 297683 17877 90312860
Vulval haemorrhage 10.79 10.24 4 297706 27 90330710
Oedema peripheral 10.76 10.24 716 296994 257199 90073538
Brain injury 10.76 10.24 6 297704 7732 90323005
Pneumonia viral 10.69 10.24 8 297702 8815 90321922
Atrioventricular block 10.67 10.24 8 297702 8807 90321930
Haemoglobin abnormal 10.62 10.24 5 297705 7095 90323642
Anosmia 10.61 10.24 10 297700 9838 90320899
Drug specific antibody present 10.61 10.24 41 297669 5473 90325264
Radiculopathy 10.57 10.24 100 297610 18405 90312332
Sleep disorder due to general medical condition, hypersomnia type 10.57 10.24 22 297688 2057 90328680
Neonatal infection 10.54 10.24 8 297702 260 90330477
Polyp 10.52 10.24 6 297704 7638 90323099
Infusion site erythema 10.45 10.24 18 297692 13652 90317085
Peripheral sensory neuropathy 10.44 10.24 9 297701 9241 90321496
Bladder disorder 10.41 10.24 12 297698 10760 90319977
Poor venous access 10.41 10.24 104 297606 19423 90311314
Hepatic failure 10.40 10.24 82 297628 39646 90291091
Neutrophil count increased 10.37 10.24 31 297679 19359 90311378
Peroneal nerve palsy 10.36 10.24 3 297707 5745 90324992
Emotional disorder 10.36 10.24 21 297689 14976 90315761
Demyelination 10.36 10.24 7 297703 8133 90322604
Eczema 10.36 10.24 237 297473 52633 90278104
Refusal of treatment by patient 10.34 10.24 3 297707 5735 90325002
Blood corticotrophin increased 10.24 10.24 6 297704 125 90330612

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional product use issue 368.59 10.38 579 85490 71254 42464012
Adrenal insufficiency 280.89 10.38 262 85807 18662 42516604
Blood pressure fluctuation 255.36 10.38 293 85776 26615 42508651
Condition aggravated 216.25 10.38 1069 85000 259685 42275581
Adrenocortical insufficiency acute 209.04 10.38 98 85971 2117 42533149
Off label use 189.78 10.38 2042 84027 636293 41898973
Bronchiectasis 187.69 10.38 206 85863 17813 42517453
Inappropriate schedule of product administration 179.05 10.38 511 85558 95391 42439875
Drug abuse 177.61 10.38 8 86061 104763 42430503
Death 176.02 10.38 437 85632 470748 42064518
Infusion related reaction 172.46 10.38 380 85689 60426 42474840
Completed suicide 168.13 10.38 6 86063 96459 42438807
Toxicity to various agents 162.04 10.38 135 85934 229001 42306265
Frequent bowel movements 159.02 10.38 206 85863 21201 42514065
Adrenal suppression 147.60 10.38 60 86009 905 42534361
Graft loss 143.76 10.38 58 86011 857 42534409
Impaired quality of life 128.81 10.38 151 85918 14026 42521240
Steroid dependence 123.43 10.38 105 85964 6617 42528649
Febrile bone marrow aplasia 119.45 10.38 124 85945 10057 42525209
Craniopharyngioma 115.92 10.38 36 86033 230 42535036
Eczema 115.25 10.38 229 85840 33857 42501409
Serum sickness 107.87 10.38 63 86006 2162 42533104
Febrile neutropenia 105.70 10.38 689 85380 185014 42350252
Drug ineffective 102.98 10.38 1813 84256 628384 41906882
Diabetes insipidus 102.94 10.38 74 85995 3639 42531627
Aplastic anaemia 102.82 10.38 126 85943 12258 42523008
Drug level below therapeutic 92.08 10.38 88 85981 6457 42528809
Heart rate decreased 87.80 10.38 214 85855 36318 42498948
Burns second degree 85.83 10.38 82 85987 6014 42529252
Catarrh 85.20 10.38 81 85988 5905 42529361
Leukoencephalopathy 82.11 10.38 73 85996 4881 42530385
Dermatitis atopic 80.83 10.38 112 85957 12292 42522974
Hypofibrinogenaemia 78.10 10.38 49 86020 1918 42533348
Gingival pain 78.04 10.38 91 85978 8403 42526863
Mucosal inflammation 76.90 10.38 247 85822 49127 42486139
Heart rate irregular 73.50 10.38 123 85946 15927 42519339
Parosmia 73.35 10.38 84 85985 7607 42527659
Hypopnoea 73.34 10.38 85 85984 7797 42527469
Systemic lupus erythematosus 71.23 10.38 91 85978 9233 42526033
Impaired work ability 68.28 10.38 102 85967 11989 42523277
Pituitary tumour benign 66.80 10.38 35 86034 967 42534299
Fall 65.45 10.38 248 85821 234272 42300994
Interstitial lung disease 64.86 10.38 39 86030 78423 42456843
Steroid withdrawal syndrome 64.22 10.38 24 86045 285 42534981
Drug interaction 63.63 10.38 300 85769 266699 42268567
Stress 58.98 10.38 210 85859 44002 42491264
Gingival disorder 57.00 10.38 37 86032 1537 42533729
Erythema 56.60 10.38 395 85674 108398 42426868
Overdose 56.48 10.38 78 85991 105186 42430080
Intentional overdose 56.18 10.38 17 86052 51439 42483827
Hypertriglyceridaemia 55.16 10.38 84 85985 10042 42525224
Flushing 53.85 10.38 181 85888 36847 42498419
Rhinitis 53.79 10.38 91 85978 11886 42523380
Body temperature fluctuation 53.08 10.38 36 86033 1611 42533655
Soft tissue mass 52.64 10.38 30 86039 982 42534284
Anal inflammation 51.89 10.38 40 86029 2189 42533077
Myocardial infarction 51.71 10.38 108 85961 123901 42411365
Drug specific antibody present 51.00 10.38 51 86018 3955 42531311
Hypopituitarism 50.02 10.38 43 86026 2748 42532518
Multimorbidity 49.34 10.38 28 86041 909 42534357
Cardiac murmur 48.28 10.38 90 85979 12685 42522581
Faecal calprotectin increased 48.14 10.38 44 86025 3050 42532216
Colitis ulcerative 47.33 10.38 138 85931 26037 42509229
Suicide attempt 47.22 10.38 17 86052 46083 42489183
Product use in unapproved indication 46.94 10.38 574 85495 183882 42351384
Swollen tongue 46.42 10.38 120 85949 21111 42514155
Hallucination 45.57 10.38 30 86039 57477 42477789
Rash 44.91 10.38 797 85272 276157 42259109
Oesophageal perforation 44.69 10.38 29 86040 1204 42534062
Cortisol decreased 44.12 10.38 30 86039 1348 42533918
SARS-CoV-2 test negative 43.85 10.38 33 86036 1742 42533524
Gastrointestinal haemorrhage 43.41 10.38 82 85987 97644 42437622
Septic shock 43.15 10.38 325 85744 91347 42443919
Oral disorder 41.63 10.38 50 86019 4762 42530504
Atrial fibrillation 41.28 10.38 144 85925 139449 42395817
Hospitalisation 40.95 10.38 54 86015 74276 42460990
Rectal haemorrhage 40.61 10.38 203 85866 49403 42485863
Sedation 39.34 10.38 7 86062 30468 42504798
Posterior reversible encephalopathy syndrome 38.44 10.38 82 85987 12739 42522527
Transplant failure 38.28 10.38 44 86025 4000 42531266
Multiple organ dysfunction syndrome 38.06 10.38 330 85739 96705 42438561
Pseudostroke 36.53 10.38 12 86057 94 42535172
Cardiac failure 35.95 10.38 104 85965 106752 42428514
Pituitary haemorrhage 35.19 10.38 14 86055 199 42535067
Platelet count decreased 35.17 10.38 152 85917 138429 42396837
Alcohol poisoning 34.62 10.38 58 86011 7516 42527750
Hypophysitis 34.11 10.38 36 86033 2975 42532291
Analgesic therapy 33.96 10.38 53 86016 6471 42528795
Poor venous access 33.77 10.38 56 86013 7196 42528070
Rash erythematous 33.45 10.38 141 85928 31950 42503316
Loss of personal independence in daily activities 33.40 10.38 193 85876 49623 42485643
Haematochezia 33.25 10.38 217 85852 58219 42477047
Secondary adrenocortical insufficiency 32.95 10.38 30 86039 2069 42533197
Superinfection 32.93 10.38 35 86034 2916 42532350
Hypogonadism 32.87 10.38 32 86037 2402 42532864
Skin exfoliation 32.58 10.38 168 85901 41385 42493881
Drug level decreased 32.47 10.38 66 86003 9911 42525355
Bronchopulmonary aspergillosis allergic 32.20 10.38 43 86026 4555 42530711
Therapeutic response shortened 32.12 10.38 79 85990 13475 42521791
Congenital hiatus hernia 31.92 10.38 50 86019 6124 42529142
Acute kidney injury 31.88 10.38 536 85533 366801 42168465
Body temperature increased 31.82 10.38 102 85967 20256 42515010
Pneumoretroperitoneum 31.77 10.38 12 86057 147 42535119
Blood pressure increased 31.69 10.38 330 85739 101598 42433668
Malignant neoplasm progression 31.25 10.38 113 85956 108287 42426979
White blood cell count decreased 31.22 10.38 116 85953 110280 42424986
Hypophosphataemia 30.99 10.38 103 85966 20842 42514424
Migraine 30.76 10.38 117 85952 25297 42509969
Chorioretinopathy 30.35 10.38 25 86044 1506 42533760
Symptom masked 30.17 10.38 20 86049 861 42534405
Cerebellar tumour 29.95 10.38 11 86058 124 42535142
Hyponatraemia 29.91 10.38 325 85744 101137 42434129
Suicidal ideation 29.71 10.38 32 86037 48129 42487137
Chills 29.46 10.38 305 85764 93761 42441505
Neuralgia 29.35 10.38 116 85953 25531 42509735
Thermophobia 28.78 10.38 9 86060 59 42535207
Renal impairment 28.51 10.38 120 85949 110108 42425158
Insulin-like growth factor decreased 28.46 10.38 13 86056 264 42535002
Anaemia 28.37 10.38 397 85672 279881 42255385
Myelopathy 28.29 10.38 32 86037 2859 42532407
Sleep disorder therapy 27.86 10.38 50 86019 6844 42528422
Kounis syndrome 27.52 10.38 34 86035 3334 42531932
Cardiac disorder 27.51 10.38 35 86034 48897 42486369
Renal failure 27.29 10.38 174 85895 143552 42391714
Cerebral candidiasis 27.23 10.38 9 86060 72 42535194
Prostate cancer 27.16 10.38 30 86039 44613 42490653
Hypertrophic cardiomyopathy 27.13 10.38 23 86046 1442 42533824
Strongyloidiasis 27.02 10.38 34 86035 3397 42531869
Skin irritation 26.94 10.38 52 86017 7522 42527744
Asthenia 26.57 10.38 403 85666 280390 42254876
Product use issue 26.52 10.38 254 85815 76497 42458769
Thyrotoxic periodic paralysis 26.30 10.38 11 86058 179 42535087
Respiratory disorder 26.18 10.38 101 85968 21984 42513282
Lichen planus 25.62 10.38 21 86048 1256 42534010
Proctalgia 25.60 10.38 49 86020 7044 42528222
Respiratory moniliasis 24.75 10.38 12 86057 280 42534986
Pruritus 24.36 10.38 525 85544 188246 42347020
Unmasking of previously unidentified disease 24.22 10.38 20 86049 1209 42534057
Antacid therapy 24.11 10.38 38 86031 4679 42530587
Blood pressure diastolic decreased 24.09 10.38 60 86009 10315 42524951
Idiopathic intracranial hypertension 24.06 10.38 17 86052 813 42534453
Klebsiella infection 23.69 10.38 63 86006 11269 42523997
Weight increased 23.63 10.38 327 85742 107656 42427610
White blood cell count increased 23.58 10.38 34 86035 45053 42490213
Haemorrhoids 23.47 10.38 82 85987 17015 42518251
Haemoglobin decreased 23.33 10.38 164 85905 132307 42402959
Hyperphosphataemia 22.97 10.38 68 86001 12936 42522330
Extrapyramidal disorder 22.94 10.38 3 86066 16409 42518857
Myasthenia gravis 22.68 10.38 78 85991 16059 42519207
Pneumonia 22.53 10.38 665 85404 421484 42113782
Activated partial thromboplastin time prolonged 22.46 10.38 77 85992 15826 42519440
Wrong technique in product usage process 22.44 10.38 32 86037 42603 42492663
Anticoagulant therapy 22.44 10.38 36 86033 4499 42530767
Electrocardiogram QT prolonged 22.38 10.38 39 86030 47906 42487360
Inflammatory marker increased 22.35 10.38 45 86024 6711 42528555
Sepsis 22.19 10.38 543 85526 198791 42336475
Skin lesion 22.09 10.38 111 85958 27063 42508203
Chest pain 22.07 10.38 178 85891 139352 42395914
Medication error 21.93 10.38 128 85941 33026 42502240
Drug therapy 21.71 10.38 43 86026 6337 42528929
Lower respiratory tract infection 21.63 10.38 150 85919 41056 42494210
Aggression 21.46 10.38 35 86034 44128 42491138
Arthritis 21.42 10.38 152 85917 41913 42493353
Tinnitus 21.31 10.38 115 85954 28823 42506443
Angina pectoris 21.26 10.38 21 86048 32875 42502391
Decreased appetite 21.18 10.38 269 85800 192868 42342398
Anal fissure 21.17 10.38 38 86031 5201 42530065
Cushingoid 20.96 10.38 30 86039 3392 42531874
Anaphylactic reaction 20.92 10.38 153 85916 42590 42492676
Psychotic disorder 20.84 10.38 17 86052 29191 42506075
Delirium 20.83 10.38 47 86022 52472 42482794
Intentional self-injury 20.73 10.38 3 86066 15199 42520067
Papule 20.72 10.38 40 86029 5786 42529480
Pyrexia 20.48 10.38 982 85087 393060 42142206
Blood glucose increased 20.46 10.38 78 85991 73621 42461645
Coma 20.38 10.38 49 86020 53505 42481761
Dry skin 20.32 10.38 167 85902 48171 42487095
Weight fluctuation 20.12 10.38 40 86029 5911 42529355
Syncope 20.08 10.38 118 85951 99288 42435978
Palpitations 20.03 10.38 173 85896 50624 42484642
Bacterial infection 20.00 10.38 110 85959 27769 42507497
Hyponatraemic seizure 19.96 10.38 9 86060 177 42535089
Meningitis tuberculous 19.90 10.38 14 86055 665 42534601
Proctitis 19.89 10.38 27 86042 2906 42532360
Disease progression 19.75 10.38 190 85879 143466 42391800
Hydrocephalus 19.54 10.38 40 86029 6038 42529228
Periorbital infection 19.38 10.38 9 86060 190 42535076
Skin plaque 19.34 10.38 39 86030 5824 42529442
Urticaria 19.05 10.38 231 85838 73805 42461461
Growth retardation 18.99 10.38 24 86045 2408 42532858
Hepatic cirrhosis 18.96 10.38 8 86061 19694 42515572
Dizziness 18.96 10.38 372 85697 248882 42286384
Shared psychotic disorder 18.89 10.38 5 86064 16 42535250
Leukaemia recurrent 18.75 10.38 21 86048 1855 42533411
Preterm premature rupture of membranes 18.74 10.38 7 86062 83 42535183
Blood calcium increased 18.70 10.38 48 86021 8406 42526860
Pituitary tumour recurrent 18.30 10.38 7 86062 89 42535177
Immunosuppressant drug level increased 18.26 10.38 45 86024 7686 42527580
Splenic peliosis 18.23 10.38 5 86064 19 42535247
Hyperkalaemia 18.18 10.38 92 85977 80366 42454900
Toxic epidermal necrolysis 18.16 10.38 104 85965 26646 42508620
Renal disorder 18.16 10.38 19 86050 28961 42506305
Primary adrenal insufficiency 18.16 10.38 10 86059 306 42534960
Stomatococcal infection 18.11 10.38 9 86060 222 42535044
Lung consolidation 18.08 10.38 41 86028 6636 42528630
Blood phosphorus increased 18.00 10.38 61 86008 12464 42522802
Meningitis candida 17.95 10.38 8 86061 153 42535113
Skin papilloma 17.86 10.38 25 86044 2769 42532497
C-reactive protein increased 17.82 10.38 67 86002 63493 42471773
Posturing 17.81 10.38 12 86057 531 42534735
Unevaluable event 17.79 10.38 26 86043 34262 42501004
Body height below normal 17.71 10.38 9 86060 233 42535033
Neutrophil count decreased 17.68 10.38 67 86002 63348 42471918
Product quality issue 17.63 10.38 7 86062 17875 42517391
Insulin-like growth factor increased 17.59 10.38 19 86050 1612 42533654
Neurotoxicity 17.42 10.38 94 85975 23557 42511709
Superior sagittal sinus thrombosis 17.39 10.38 10 86059 333 42534933
Macule 17.37 10.38 21 86048 2014 42533252
Chronic kidney disease 17.36 10.38 44 86025 47197 42488069
Arteriosclerosis coronary artery 17.32 10.38 8 86061 18669 42516597
Insomnia 17.29 10.38 154 85915 118099 42417167
Lacrimal duct neoplasm 17.13 10.38 5 86064 25 42535241
Mantle cell lymphoma stage III 17.13 10.38 5 86064 25 42535241
Therapy cessation 17.12 10.38 10 86059 20440 42514826
Perineal pain 17.09 10.38 15 86054 986 42534280
Cardio-respiratory arrest 16.97 10.38 61 86008 58575 42476691
Loss of consciousness 16.91 10.38 113 85956 92241 42443025
Neoplasm recurrence 16.86 10.38 24 86045 2700 42532566
Haematuria 16.81 10.38 60 86009 57739 42477527
Feeling abnormal 16.81 10.38 78 85991 69708 42465558
Feeling cold 16.76 10.38 61 86008 12912 42522354
Blood thyroid stimulating hormone decreased 16.69 10.38 22 86047 2301 42532965
Cognitive disorder 16.68 10.38 27 86042 34145 42501121
Anal fistula 16.66 10.38 38 86031 6175 42529091
Adrenocorticotropic hormone deficiency 16.63 10.38 17 86052 1353 42533913
Cardiac failure congestive 16.56 10.38 103 85966 85499 42449767
Bladder cancer 16.28 10.38 7 86062 17040 42518226
Arteriosclerosis 16.23 10.38 8 86061 17981 42517285
Thrombotic microangiopathy 16.23 10.38 66 86003 14716 42520550
Encephalitis cytomegalovirus 16.19 10.38 16 86053 1223 42534043
Tooth injury 16.06 10.38 16 86053 1235 42534031
Neuroleptic malignant syndrome 15.95 10.38 12 86057 21460 42513806
Apnoeic attack 15.95 10.38 11 86058 506 42534760
Rales 15.93 10.38 55 86014 11345 42523921
Blood creatine phosphokinase increased 15.56 10.38 48 86021 48290 42486976
Incorrect route of product administration 15.53 10.38 93 85976 24212 42511054
Colitis 15.52 10.38 153 85916 46419 42488847
Accident 15.51 10.38 38 86031 6465 42528801
Fluid retention 15.42 10.38 25 86044 31594 42503672
Drug-induced liver injury 15.38 10.38 34 86035 38239 42497027
Diarrhoea 15.27 10.38 768 85301 460081 42075185
Rheumatoid arthritis 15.24 10.38 40 86029 42400 42492866
Mineralocorticoid deficiency 15.07 10.38 4 86065 13 42535253
Multiple sclerosis relapse 15.05 10.38 5 86064 14259 42521007
Otitis media acute 15.05 10.38 12 86057 690 42534576
Perioral dermatitis 15.04 10.38 8 86061 228 42535038
Lip swelling 14.91 10.38 77 85992 18976 42516290
Respiratory depression 14.73 10.38 10 86059 18858 42516408
Appendicolith 14.71 10.38 60 86009 13396 42521870
Subdural haematoma 14.69 10.38 15 86054 23123 42512143
Optic nerve disorder 14.67 10.38 12 86057 716 42534550
Dermatitis 14.64 10.38 55 86014 11820 42523446
17-hydroxyprogesterone increased 14.63 10.38 4 86065 15 42535251
Therapy interrupted 14.61 10.38 14 86055 22236 42513030
Vertigo 14.61 10.38 119 85950 34228 42501038
Blood corticotrophin increased 14.61 10.38 7 86062 159 42535107
Disturbance in sexual arousal 14.53 10.38 7 86062 161 42535105
Cardiogenic shock 14.37 10.38 122 85947 35518 42499748
Product prescribing error 14.34 10.38 19 86050 26093 42509173
Iron deficiency 14.28 10.38 52 86017 11009 42524257
Injection site pain 14.28 10.38 64 86005 57734 42477532
Staphylococcal sepsis 14.19 10.38 53 86016 11361 42523905
Optic nerve operation 14.09 10.38 10 86059 482 42534784
Hallucination, visual 14.07 10.38 13 86056 21007 42514259
Cryptococcal fungaemia 14.03 10.38 7 86062 174 42535092
Serotonin syndrome 14.00 10.38 19 86050 25826 42509440
Dysarthria 13.93 10.38 38 86031 39769 42495497
Pituitary infarction 13.87 10.38 4 86065 19 42535247
Allergic eosinophilia 13.80 10.38 5 86064 54 42535212
Lymphocytic hypophysitis 13.80 10.38 9 86060 377 42534889
Skin fissures 13.80 10.38 47 86022 9629 42525637
Respiratory distress 13.75 10.38 137 85932 41683 42493583
Tracheal injury 13.72 10.38 5 86064 55 42535211
Perineal infection 13.67 10.38 11 86058 641 42534625
Adrenal insufficiency neonatal 13.55 10.38 3 86066 3 42535263
Skin candida 13.54 10.38 11 86058 650 42534616
Lichenification 13.52 10.38 10 86059 514 42534752
Job dissatisfaction 13.47 10.38 7 86062 190 42535076
Pleuritic pain 13.46 10.38 38 86031 7039 42528227
Leukopenia 13.41 10.38 92 85977 74654 42460612
Varicella zoster virus infection 13.36 10.38 21 86048 2580 42532686
Diarrhoea haemorrhagic 13.33 10.38 40 86029 7667 42527599
Total lung capacity decreased 13.30 10.38 25 86044 3545 42531721
Appendicitis 13.25 10.38 79 85990 20534 42514732
Hyperbilirubinaemia 13.21 10.38 79 85990 20556 42514710
Agitation 13.17 10.38 76 85993 64238 42471028
Drug specific antibody 13.13 10.38 9 86060 410 42534856
Glucocorticoid deficiency 13.12 10.38 10 86059 538 42534728
Cerebral infarction 13.10 10.38 27 86042 31142 42504124
Eczema herpeticum 13.06 10.38 8 86061 300 42534966
Thyroxine free decreased 13.01 10.38 8 86061 302 42534964
Pharyngitis streptococcal 12.93 10.38 26 86043 3874 42531392
Bronchial haemorrhage 12.93 10.38 11 86058 693 42534573
Epiphysiolysis 12.91 10.38 6 86063 127 42535139
Hallucination, auditory 12.83 10.38 7 86062 14857 42520409
Blood luteinising hormone decreased 12.82 10.38 6 86063 129 42535137
Hepatic function abnormal 12.80 10.38 57 86012 51510 42483756
Underdose 12.79 10.38 9 86060 16657 42518609
Memory impairment 12.78 10.38 55 86014 50167 42485099
Seborrhoeic dermatitis 12.72 10.38 18 86051 2014 42533252
Anhidrosis 12.66 10.38 7 86062 216 42535050
Functional gastrointestinal disorder 12.66 10.38 20 86049 2468 42532798
Pneumonia aspiration 12.64 10.38 55 86014 50023 42485243
Lung neoplasm malignant 12.63 10.38 12 86057 19135 42516131
Fluid replacement 12.62 10.38 8 86061 319 42534947
Vasospasm 12.53 10.38 10 86059 576 42534690
Crohn's disease 12.52 10.38 22 86047 2962 42532304
Nightmare 12.51 10.38 90 85979 24922 42510344
Gastric ulcer perforation 12.50 10.38 13 86056 1056 42534210
Herpes simplex 12.43 10.38 37 86032 7058 42528208
Parakeratosis 12.34 10.38 7 86062 227 42535039
Blood androstenedione increased 12.34 10.38 3 86066 6 42535260
Congenital adrenal gland hypoplasia 12.34 10.38 3 86066 6 42535260
Arrhythmia 12.30 10.38 41 86028 40276 42494990
Dyspnoea exertional 12.11 10.38 56 86013 50092 42485174
Angina unstable 12.10 10.38 4 86065 11444 42523822
Dermatitis diaper 12.06 10.38 8 86061 345 42534921
Morganella infection 12.05 10.38 10 86059 609 42534657
Dacryocanaliculitis 12.02 10.38 3 86066 7 42535259
Type 1 diabetes mellitus 11.98 10.38 31 86038 5456 42529810
Disseminated cryptococcosis 11.97 10.38 17 86052 1908 42533358
Anxiety 11.93 10.38 168 85901 118392 42416874
Depressed level of consciousness 11.92 10.38 53 86016 47917 42487349
Dystrophic calcification 11.89 10.38 4 86065 34 42535232
Drug ineffective for unapproved indication 11.85 10.38 144 85925 46019 42489247
Renal injury 11.79 10.38 5 86064 12275 42522991
Blood growth hormone decreased 11.79 10.38 4 86065 35 42535231
Vomiting projectile 11.78 10.38 11 86058 784 42534482
Substance-induced psychotic disorder 11.73 10.38 21 86048 2868 42532398
Peripheral swelling 11.73 10.38 121 85948 90149 42445117
Tendon disorder 11.73 10.38 23 86046 3366 42531900
Rhabdomyolysis 11.66 10.38 101 85968 77918 42457348
Myelitis transverse 11.66 10.38 14 86055 1333 42533933
Refeeding syndrome 11.60 10.38 5 86064 88 42535178
Prothrombin level abnormal 11.60 10.38 5 86064 88 42535178
Leptotrichia infection 11.60 10.38 5 86064 88 42535178
Systemic candida 11.56 10.38 30 86039 5289 42529977
Paranoia 11.54 10.38 7 86062 14019 42521247
Aphthous ulcer 11.53 10.38 32 86037 5869 42529397
Melaena 11.41 10.38 40 86029 38706 42496560
Thyrotoxic crisis 11.33 10.38 11 86058 823 42534443
Nausea 11.32 10.38 671 85398 396128 42139138
Hypokinesia 11.25 10.38 3 86066 9868 42525398
Dysgeusia 11.24 10.38 112 85957 34077 42501189
Hypernatraemia 11.18 10.38 45 86024 9987 42525279
Intentional product misuse to child 11.14 10.38 4 86065 42 42535224
Device dislocation 11.13 10.38 38 86031 7793 42527473
Human herpes virus 6 serology positive 11.12 10.38 6 86063 176 42535090
Epstein-Barr viraemia 11.09 10.38 18 86051 2271 42532995
Candida infection 10.95 10.38 78 85991 21532 42513734
Diabetes mellitus inadequate control 10.93 10.38 9 86060 15381 42519885
Anaplastic astrocytoma 10.92 10.38 5 86064 102 42535164
Blood uric acid increased 10.92 10.38 61 86008 15486 42519780
Feeling hot 10.89 10.38 83 85986 23399 42511867
Neurogenic bowel 10.88 10.38 6 86063 184 42535082
Arthralgia 10.73 10.38 512 85557 204726 42330540
Weight decreased 10.71 10.38 518 85551 207430 42327836
Graft complication 10.67 10.38 10 86059 716 42534550
Addison's disease 10.63 10.38 3 86066 13 42535253
Platelet transfusion 10.59 10.38 15 86054 1679 42533587
Skin hyperpigmentation 10.58 10.38 25 86044 4156 42531110
Ulcer 10.56 10.38 63 86006 16378 42518888
Tumour lysis syndrome 10.55 10.38 79 85990 22152 42513114
Pharyngeal paraesthesia 10.53 10.38 11 86058 898 42534368
Bradycardia 10.53 10.38 116 85953 85368 42449898
Rash pruritic 10.53 10.38 109 85960 33494 42501772
Radial pulse abnormal 10.52 10.38 4 86065 50 42535216
Arm amputation 10.50 10.38 5 86064 112 42535154
Subcutaneous emphysema 10.49 10.38 15 86054 1694 42533572
Renal tubular necrosis 10.45 10.38 13 86056 18341 42516925
Pituitary tumour 10.42 10.38 9 86060 579 42534687

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional product use issue 800.40 10.01 2059 325640 245847 110015753
Systemic lupus erythematosus 684.60 10.01 1976 325723 252362 110009238
Completed suicide 653.83 10.01 13 327686 242368 110019232
Infusion related reaction 653.43 10.01 2543 325156 378619 109882981
Pericarditis 635.28 10.01 1749 325950 217365 110044235
Wound 631.46 10.01 1822 325877 232615 110028985
Pemphigus 631.31 10.01 1722 325977 212848 110048752
Duodenal ulcer perforation 626.88 10.01 1527 326172 176173 110085427
Toxicity to various agents 622.16 10.01 324 327375 480231 109781369
Glossodynia 616.97 10.01 1745 325954 220259 110041341
Anti-cyclic citrullinated peptide antibody positive 572.14 10.01 1497 326202 180487 110081113
Helicobacter infection 570.65 10.01 1495 326204 180382 110081218
Hand deformity 567.11 10.01 1676 326023 216830 110044770
Rheumatic fever 553.46 10.01 1162 326537 121417 110140183
Rheumatoid factor positive 544.07 10.01 1204 326495 130436 110131164
Death 458.26 10.01 859 326840 698010 109563590
Type 2 diabetes mellitus 457.43 10.01 1357 326342 175875 110085725
Drug abuse 447.36 10.01 18 327681 177393 110084207
Discomfort 436.85 10.01 1515 326184 213192 110048408
Synovitis 410.76 10.01 1755 325944 272337 109989263
Blister 408.80 10.01 1541 326158 225835 110035765
Adrenocortical insufficiency acute 404.47 10.01 217 327482 4223 110257377
Fall 401.44 10.01 735 326964 602747 109658853
Swollen joint count increased 391.51 10.01 805 326894 82856 110178744
Drug interaction 379.37 10.01 559 327140 499624 109761976
Maternal exposure during pregnancy 374.95 10.01 1623 326076 253260 110008340
Folliculitis 359.38 10.01 1204 326495 166449 110095151
Swelling 353.68 10.01 2007 325692 349034 109912566
Blood cholesterol increased 353.59 10.01 1278 326421 183507 110078093
Psoriatic arthropathy 341.66 10.01 1319 326380 195442 110066158
Hepatic enzyme increased 330.73 10.01 1846 325853 319046 109942554
Irritable bowel syndrome 330.68 10.01 1155 326544 163060 110098540
Fibromyalgia 326.95 10.01 1182 326517 169727 110091873
Arthropathy 322.63 10.01 1693 326006 285829 109975771
Facet joint syndrome 319.02 10.01 811 326888 96017 110165583
Acute kidney injury 310.49 10.01 913 326786 634517 109627083
Abdominal discomfort 310.33 10.01 2114 325585 391744 109869856
Condition aggravated 308.46 10.01 3430 324269 731406 109530194
Deep vein thrombosis postoperative 307.98 10.01 596 327103 58695 110202905
Injury 298.53 10.01 1177 326522 176088 110085512
Alopecia 289.23 10.01 1961 325738 362792 109898808
Muscle injury 286.62 10.01 994 326705 139813 110121787
Lip dry 278.99 10.01 788 326911 99295 110162305
Ill-defined disorder 277.59 10.01 1058 326641 155795 110105805
Adrenal insufficiency 277.30 10.01 471 327228 41919 110219681
Liver injury 265.71 10.01 1014 326685 149399 110112201
Joint range of motion decreased 263.73 10.01 878 326821 120954 110140646
Sleep disorder due to general medical condition, insomnia type 263.09 10.01 799 326900 104844 110156756
Grip strength decreased 257.35 10.01 665 327034 79509 110182091
Lower respiratory tract infection 256.00 10.01 1407 326292 241699 110019901
Impaired healing 254.30 10.01 1206 326493 195511 110066089
Anaemia 249.43 10.01 811 326888 546275 109715325
Breast cancer stage III 235.42 10.01 638 327061 78479 110183121
Autoimmune disorder 235.24 10.01 567 327132 64916 110196684
C-reactive protein abnormal 232.91 10.01 879 326820 128816 110132784
Live birth 230.95 10.01 584 327115 68900 110192700
Adjustment disorder with depressed mood 228.98 10.01 442 327257 43441 110218159
Blood pressure fluctuation 227.28 10.01 608 327091 74216 110187384
Hypersensitivity 222.50 10.01 1996 325703 402002 109859598
Myocardial infarction 222.10 10.01 148 327551 191935 110069665
Intentional overdose 221.97 10.01 59 327640 132442 110129158
Product use issue 218.01 10.01 1626 326073 310069 109951531
Peripheral venous disease 209.24 10.01 636 327063 83481 110178119
Lower limb fracture 206.80 10.01 590 327109 74758 110186842
Atrial fibrillation 199.14 10.01 232 327467 229410 110032190
Dislocation of vertebra 198.98 10.01 416 327283 43305 110218295
Inappropriate schedule of product administration 196.81 10.01 1152 326547 202485 110059115
Sleep disorder 193.43 10.01 1126 326573 197518 110064082
Platelet count decreased 189.08 10.01 243 327456 230200 110031400
Road traffic accident 188.78 10.01 723 326976 106675 110154925
Bursitis 188.33 10.01 824 326875 129094 110132506
Exposure during pregnancy 184.97 10.01 982 326717 166442 110095158
Interstitial lung disease 184.42 10.01 91 327608 139243 110122357
Hypercholesterolaemia 183.70 10.01 640 327059 90197 110171403
Stomatitis 182.31 10.01 1398 326301 268844 109992756
Cardiac failure 177.75 10.01 176 327523 187450 110074150
Wound infection 177.50 10.01 659 327040 95806 110165794
Product dose omission issue 176.74 10.01 436 327263 321346 109940254
Frequent bowel movements 175.89 10.01 538 327161 70852 110190748
White blood cell count decreased 175.00 10.01 255 327444 229135 110032465
Hip arthroplasty 173.01 10.01 457 327242 55356 110206244
Off label use 172.76 10.01 5731 321968 1494454 108767146
Steroid withdrawal syndrome 167.84 10.01 73 327626 872 110260728
Prescribed overdose 165.92 10.01 604 327095 86977 110174623
Gait inability 163.21 10.01 818 326881 135558 110126042
Suicide attempt 162.25 10.01 52 327647 103342 110158258
Dry mouth 161.87 10.01 1081 326618 198867 110062733
Sciatica 161.55 10.01 621 327078 91778 110169822
Colitis ulcerative 159.85 10.01 549 327150 76814 110184786
Renal impairment 156.35 10.01 197 327502 188248 110073352
Contraindicated product administered 155.70 10.01 1263 326436 247004 110014596
Urticaria 153.32 10.01 1531 326168 317326 109944274
Drug level below therapeutic 153.17 10.01 181 327518 11492 110250108
Overdose 153.12 10.01 287 327412 233507 110028093
Wheezing 151.81 10.01 1283 326416 253947 110007653
Sedation 149.62 10.01 16 327683 69667 110191933
Haemoglobin decreased 148.65 10.01 322 327377 248405 110013195
Malignant neoplasm progression 148.50 10.01 179 327520 174388 110087212
Cardiac failure congestive 148.44 10.01 137 327562 150863 110110737
Lupus vulgaris 145.64 10.01 315 327384 33568 110228032
Craniopharyngioma 145.00 10.01 51 327648 326 110261274
Coma 144.26 10.01 85 327614 117784 110143816
Gastrointestinal haemorrhage 143.71 10.01 167 327532 165351 110096249
Mobility decreased 143.06 10.01 1197 326502 236225 110025375
Syncope 141.30 10.01 239 327460 202297 110059303
X-ray abnormal 140.07 10.01 333 327366 37784 110223816
Drug intolerance 139.62 10.01 1828 325871 404684 109856916
Neutropenia 139.48 10.01 603 327096 374017 109887583
Onychomycosis 137.69 10.01 333 327366 38198 110223402
Injection site pain 137.45 10.01 196 327503 177726 110083874
Musculoskeletal stiffness 136.65 10.01 1348 326351 278474 109983126
Night sweats 132.02 10.01 762 326937 133221 110128379
Weight increased 131.40 10.01 1856 325843 417788 109843812
Onychomadesis 126.68 10.01 359 327340 45304 110216296
Treatment failure 126.47 10.01 1317 326382 275917 109985683
Gastrointestinal disorder 125.23 10.01 1180 326519 240772 110020828
Renal failure 124.36 10.01 307 327392 226267 110035333
Secondary immunodeficiency 123.55 10.01 106 327593 4570 110257030
Obesity 122.54 10.01 661 327038 112690 110148910
Migraine 121.32 10.01 898 326801 170754 110090846
Disease progression 120.82 10.01 348 327351 243686 110017914
Knee arthroplasty 119.72 10.01 444 327255 64504 110197096
Joint swelling 115.99 10.01 1900 325799 440945 109820655
Dehydration 115.31 10.01 432 327267 279079 109982521
Therapeutic product effect decreased 114.93 10.01 1168 326531 243148 110018452
C-reactive protein 113.64 10.01 267 327432 30064 110231536
Rash 112.55 10.01 3206 324493 817758 109443842
Adverse event 110.58 10.01 624 327075 108185 110153415
Cognitive disorder 110.10 10.01 61 327638 87450 110174150
Nausea 108.60 10.01 2811 324888 1232879 109028721
Myelosuppression 108.60 10.01 73 327626 94267 110167333
Wrong technique in product usage process 108.29 10.01 62 327637 87286 110174314
Electrocardiogram QT prolonged 108.10 10.01 98 327601 108862 110152738
Retinitis 107.71 10.01 272 327427 32055 110229545
Urinary tract infection 107.41 10.01 549 327150 325733 109935867
Steroid dependence 107.30 10.01 129 327570 8340 110253260
Product label confusion 106.97 10.01 219 327480 22458 110239142
Depressed level of consciousness 106.69 10.01 105 327594 112173 110149427
General physical health deterioration 105.61 10.01 1809 325890 423486 109838114
Balance disorder 102.91 10.01 116 327583 116444 110145156
Adverse drug reaction 101.16 10.01 596 327103 104963 110156637
Blepharospasm 100.28 10.01 374 327325 54477 110207123
Diabetes insipidus 99.97 10.01 110 327589 6460 110255140
Osteoarthritis 99.69 10.01 901 326798 181722 110079878
Dyspepsia 99.11 10.01 932 326767 190033 110071567
Suicidal ideation 98.67 10.01 80 327619 93857 110167743
Pneumonia 98.34 10.01 1919 325780 874795 109386805
Hallucination 97.37 10.01 94 327605 101338 110160262
Anti-cyclic citrullinated peptide antibody 96.78 10.01 195 327504 19769 110241831
Neutrophil count decreased 96.63 10.01 130 327569 120811 110140789
Cardio-respiratory arrest 96.16 10.01 121 327578 115715 110145885
Blood creatinine increased 95.58 10.01 254 327445 182635 110078965
Blood glucose increased 95.52 10.01 153 327546 132343 110129257
Contusion 94.15 10.01 1082 326617 232279 110029321
Hypoaesthesia 94.00 10.01 1379 326320 312844 109948756
Injection site erythema 93.07 10.01 85 327614 94091 110167509
Myalgia 91.51 10.01 344 327355 222037 110039563
Inflammation 91.42 10.01 925 326774 192313 110069287
Hypotension 91.40 10.01 1052 326647 522797 109738803
Multiple sclerosis relapse 90.78 10.01 19 327680 50221 110211379
Leukopenia 90.22 10.01 191 327508 148600 110113000
Lupus-like syndrome 90.02 10.01 296 327403 40496 110221104
Breast cancer stage II 88.78 10.01 228 327471 27147 110234453
Alanine aminotransferase increased 88.09 10.01 266 327433 183507 110078093
Haematuria 88.04 10.01 70 327629 82935 110178665
Feeling abnormal 86.31 10.01 262 327437 180449 110081151
Cough 85.70 10.01 914 326785 460727 109800873
Hepatic function abnormal 85.42 10.01 83 327616 89212 110172388
Bradycardia 85.10 10.01 211 327488 155306 110106294
Lung disorder 84.28 10.01 860 326839 179187 110082413
Prescribed underdose 82.27 10.01 397 327302 64777 110196823
Loss of consciousness 81.85 10.01 302 327397 196004 110065596
Pulmonary fibrosis 81.51 10.01 550 327149 101492 110160108
Agitation 81.06 10.01 131 327568 112920 110148680
Respiratory arrest 80.32 10.01 36 327663 58263 110203337
Hyperkalaemia 80.10 10.01 177 327522 135619 110125981
Thrombocytopenia 79.65 10.01 656 327043 348229 109913371
Intentional self-injury 79.32 10.01 9 327690 37420 110224180
Pituitary tumour benign 78.21 10.01 66 327633 2781 110258819
Cerebrovascular accident 78.16 10.01 275 327424 181009 110080591
Incorrect route of product administration 77.84 10.01 386 327313 63675 110197925
Dysarthria 77.26 10.01 81 327618 84040 110177560
Aspartate aminotransferase increased 77.01 10.01 231 327468 159705 110101895
Oedema 76.97 10.01 956 326743 209020 110052580
Porphyria acute 76.63 10.01 171 327528 18609 110242991
Secondary adrenocortical insufficiency 75.86 10.01 79 327620 4355 110257245
Device expulsion 75.03 10.01 4 327695 30887 110230713
Exostosis 73.96 10.01 301 327398 45655 110215945
Maternal exposure timing unspecified 73.37 10.01 180 327519 20833 110240767
Aplastic anaemia 73.26 10.01 197 327502 24111 110237489
Nail disorder 73.19 10.01 353 327346 57582 110204018
Poisoning 73.18 10.01 3 327696 29102 110232498
Tremor 73.09 10.01 329 327370 201903 110059697
Chronic kidney disease 72.87 10.01 71 327628 76220 110185380
Human bocavirus infection 72.75 10.01 44 327655 1084 110260516
Hyperhidrosis 72.41 10.01 297 327402 187001 110074599
Blood creatine phosphokinase increased 72.16 10.01 66 327633 73011 110188589
Arrhythmia 72.14 10.01 60 327639 69515 110192085
Catarrh 71.34 10.01 98 327601 7237 110254363
Cardiac disorder 70.56 10.01 73 327626 76207 110185393
Febrile bone marrow aplasia 70.12 10.01 158 327541 17307 110244293
Unevaluable event 69.28 10.01 45 327654 59182 110202418
Burns second degree 68.80 10.01 99 327600 7634 110253966
Cerebral infarction 68.36 10.01 34 327665 51804 110209796
Diarrhoea 67.15 10.01 2729 324970 1136776 109124824
Melaena 66.83 10.01 63 327636 68694 110192906
Angina pectoris 66.74 10.01 52 327647 62243 110199357
Therapy interrupted 66.73 10.01 32 327667 49790 110211810
Serotonin syndrome 66.44 10.01 47 327652 59106 110202494
Therapy cessation 66.17 10.01 25 327674 44832 110216768
Cataract 66.00 10.01 83 327616 79402 110182198
Somnolence 65.31 10.01 565 327134 296884 109964716
Osteonecrosis of jaw 64.06 10.01 31 327668 47986 110213614
Leukoencephalopathy 63.90 10.01 105 327594 9090 110252510
Faecal calprotectin increased 62.70 10.01 88 327611 6631 110254969
Product use in unapproved indication 62.20 10.01 1751 325948 445626 109815974
International normalised ratio increased 61.78 10.01 101 327598 86671 110174929
Dyspnoea exertional 61.07 10.01 136 327563 103924 110157676
Herpes zoster 60.90 10.01 145 327554 108234 110153366
Ulcer haemorrhage 60.22 10.01 175 327524 22396 110239204
Epistaxis 60.14 10.01 192 327507 130180 110131420
Upper gastrointestinal haemorrhage 60.06 10.01 37 327662 50059 110211541
Walking aid user 59.92 10.01 187 327512 24888 110236712
Injection site swelling 59.60 10.01 57 327642 61733 110199867
Orthostatic hypotension 59.49 10.01 65 327634 66184 110195416
Adverse reaction 59.36 10.01 208 327491 29386 110232214
Body temperature fluctuation 58.85 10.01 64 327635 3709 110257891
Mycobacterium chelonae infection 58.71 10.01 58 327641 3002 110258598
Cardiac arrest 58.68 10.01 342 327357 196411 110065189
Dyskinesia 57.62 10.01 41 327658 51405 110210195
Drug level decreased 57.60 10.01 152 327547 18396 110243204
Coeliac disease 57.36 10.01 267 327432 42920 110218680
Neuroleptic malignant syndrome 57.34 10.01 15 327684 34044 110227556
Laryngitis 56.92 10.01 263 327436 42148 110219452
Lung neoplasm malignant 56.79 10.01 15 327684 33827 110227773
Finger deformity 56.67 10.01 221 327478 32871 110228729
Adrenal suppression 56.49 10.01 44 327655 1652 110259948
Constipation 56.10 10.01 735 326964 357051 109904549
Product prescribing error 56.07 10.01 42 327657 51289 110210311
Accidental exposure to product 55.82 10.01 40 327659 49968 110211632
Normal newborn 55.78 10.01 167 327532 21729 110239871
Back pain 55.69 10.01 769 326930 370227 109891373
Diverticulitis 55.68 10.01 46 327653 53476 110208124
Heart rate irregular 55.56 10.01 225 327474 34049 110227551
Hypertension 55.48 10.01 1938 325761 508146 109753454
Norovirus test positive 55.36 10.01 35 327664 935 110260665
Rhabdomyolysis 54.36 10.01 179 327520 120222 110141378
Taste disorder 54.36 10.01 356 327343 65031 110196569
Dysphagia 54.23 10.01 252 327447 153348 110108252
Poisoning deliberate 54.15 10.01 7 327692 26324 110235276
Urinary retention 53.56 10.01 77 327622 69606 110191994
Renal disorder 53.39 10.01 41 327658 49438 110212162
Back injury 52.97 10.01 279 327420 47120 110214480
Epilepsy 52.93 10.01 491 327208 99718 110161882
Drug specific antibody present 52.90 10.01 92 327607 8342 110253258
Liver function test abnormal 52.20 10.01 77 327622 68873 110192727
Bacterial infection 52.15 10.01 272 327427 45764 110215836
Amnesia 51.97 10.01 509 327190 104899 110156701
Full blood count abnormal 51.44 10.01 54 327645 55998 110205602
Pleural effusion 51.35 10.01 312 327387 177397 110084203
Blood alkaline phosphatase increased 51.03 10.01 82 327617 70853 110190747
Bronchitis 50.63 10.01 266 327433 156766 110104834
Metastases to bone 50.61 10.01 15 327684 31357 110230243
Parkinsonism 50.55 10.01 4 327695 22183 110239417
Coronary artery disease 50.52 10.01 84 327615 71606 110189994
Aggression 50.03 10.01 61 327638 59149 110202451
Pregnancy 49.99 10.01 290 327409 50777 110210823
Seizure 49.94 10.01 417 327282 220768 110040832
Dermatitis atopic 49.93 10.01 178 327521 25363 110236237
Eczema 49.79 10.01 376 327323 71917 110189683
Acute myocardial infarction 48.74 10.01 110 327589 83667 110177933
Mental status changes 48.44 10.01 95 327604 76027 110185573
Hyperadrenocorticism 48.10 10.01 27 327672 576 110261024
Extrapyramidal disorder 48.06 10.01 13 327686 28854 110232746
Metabolic acidosis 48.05 10.01 144 327555 99600 110162000
Psychotic disorder 47.96 10.01 48 327651 50889 110210711
Subdural haematoma 47.93 10.01 24 327675 36430 110225170
Cholelithiasis 47.84 10.01 71 327628 63351 110198249
Dyspnoea 47.73 10.01 2739 324960 1104133 109157467
Liver disorder 47.62 10.01 637 327062 141606 110119994
Anal fissure 47.28 10.01 96 327603 9785 110251815
Influenza 47.25 10.01 300 327399 168801 110092799
Respiratory depression 46.93 10.01 18 327681 31983 110229617
Human herpesvirus 6 infection 46.89 10.01 76 327623 6505 110255095
Hypopnoea 46.86 10.01 104 327595 11276 110250324
Drug eruption 46.70 10.01 54 327645 53605 110207995
Pulmonary arterial hypertension 46.64 10.01 19 327680 32549 110229051
Musculoskeletal pain 46.61 10.01 782 326917 182241 110079359
Vision blurred 46.54 10.01 210 327489 128812 110132788
Prostate cancer 46.25 10.01 27 327672 37614 110223986
Jaundice 45.98 10.01 65 327634 59171 110202429
Aphasia 45.53 10.01 65 327634 58932 110202668
Metastases to liver 45.48 10.01 24 327675 35362 110226238
Blood potassium decreased 45.46 10.01 56 327643 54058 110207542
Sinusitis 45.41 10.01 1176 326523 295512 109966088
Bladder cancer 45.29 10.01 4 327695 20288 110241312
Hypomagnesaemia 45.13 10.01 68 327631 60302 110201298
Cystitis bacterial 45.01 10.01 34 327665 1219 110260381
Cerebral haemorrhage 44.97 10.01 77 327622 64891 110196709
Therapy non-responder 44.90 10.01 685 327014 156622 110104978
Red blood cell sedimentation rate abnormal 44.84 10.01 9 327690 24500 110237100
Drug withdrawal syndrome 44.39 10.01 29 327670 38025 110223575
Blood bilirubin increased 44.00 10.01 100 327599 75872 110185728
Asthenia 43.97 10.01 1634 326065 687365 109574235
Device difficult to use 43.96 10.01 3 327696 18802 110242798
Pneumonia aspiration 43.82 10.01 111 327588 81122 110180478
Nasopharyngitis 43.52 10.01 1501 326198 392860 109868740
Bone erosion 43.24 10.01 260 327439 46111 110215489
Transient ischaemic attack 43.23 10.01 77 327622 63905 110197695
Hypopituitarism 43.22 10.01 59 327640 4331 110257269
Blood urea increased 42.96 10.01 60 327639 54897 110206703
Rheumatoid nodule 42.71 10.01 5 327694 20291 110241309
Medication error 42.66 10.01 489 327210 104877 110156723
Cortisol decreased 42.32 10.01 47 327652 2789 110258811
Mitral valve incompetence 42.25 10.01 23 327676 33306 110228294
Thymus hypoplasia 42.06 10.01 37 327662 1650 110259950
Gingival pain 41.98 10.01 122 327577 15614 110245986
Skin ulcer 41.75 10.01 78 327621 63567 110198033
Pancytopenia 41.73 10.01 408 327291 209205 110052395
Hypofibrinogenaemia 41.70 10.01 44 327655 2463 110259137
Rectal haemorrhage 41.51 10.01 540 327159 119293 110142307
Pulmonary hypertension 41.48 10.01 62 327637 55158 110206442
Chronic sinusitis 40.92 10.01 165 327534 24919 110236681
Drug resistance 40.71 10.01 65 327634 56309 110205291
Poor venous access 40.56 10.01 162 327537 24360 110237240
Red blood cell count decreased 40.47 10.01 84 327615 65839 110195761
Breast cancer 40.25 10.01 33 327666 38509 110223091
Diabetes mellitus inadequate control 40.06 10.01 19 327680 29756 110231844
Injection site bruising 40.04 10.01 56 327643 51207 110210393
Lactic acidosis 39.85 10.01 141 327558 92670 110168930
Haematoma 39.85 10.01 70 327629 58406 110203194
Plasma cell myeloma 39.65 10.01 79 327620 62857 110198743
Femur fracture 39.52 10.01 44 327655 44425 110217175
Abdominal pain upper 39.32 10.01 1332 326367 347779 109913821
Respiratory tract infection 39.30 10.01 97 327602 71520 110190080
Altered state of consciousness 39.25 10.01 69 327630 57557 110204043
Blood potassium increased 39.25 10.01 25 327674 33224 110228376
Seronegative arthritis 38.92 10.01 106 327593 13071 110248529
Eosinophilia 38.89 10.01 70 327629 57866 110203734
Hepatotoxicity 38.74 10.01 81 327618 63319 110198281
Pruritus 38.68 10.01 2100 325599 579460 109682140
Restlessness 38.65 10.01 67 327632 56192 110205408
Lymphoid tissue hypoplasia 38.51 10.01 35 327664 1630 110259970
Hallucination, auditory 38.45 10.01 15 327684 26382 110235218
Intentional product misuse 38.05 10.01 234 327465 132670 110128930
Myelodysplastic syndrome 38.03 10.01 33 327666 37451 110224149
Schizophrenia 37.93 10.01 9 327690 21817 110239783
Dysphonia 37.75 10.01 108 327591 75821 110185779
Pseudostroke 37.40 10.01 16 327683 183 110261417
Sinus congestion 37.21 10.01 22 327677 30437 110231163
Chronic obstructive pulmonary disease 36.83 10.01 182 327517 108976 110152624
Agranulocytosis 36.82 10.01 80 327619 61680 110199920
Drug dependence 36.76 10.01 57 327642 49963 110211637
Anal inflammation 36.62 10.01 41 327658 2455 110259145
Rib fracture 36.41 10.01 28 327671 33742 110227858
Strongyloidiasis 36.10 10.01 58 327641 4928 110256672
Lymphocyte count decreased 35.94 10.01 72 327627 57171 110204429
Blood calcium decreased 35.83 10.01 32 327667 35813 110225787
Pituitary haemorrhage 35.62 10.01 18 327681 308 110261292
Confusional state 35.36 10.01 1713 325986 466967 109794633
Hypophysitis 35.18 10.01 60 327639 5355 110256245
Angioedema 35.12 10.01 161 327538 98339 110163261
Parosmia 34.98 10.01 102 327597 13078 110248522
Blood pressure systolic abnormal 34.78 10.01 15 327684 24835 110236765
Tendonitis 34.55 10.01 17 327682 26066 110235534
Pulmonary oedema 34.44 10.01 167 327532 100492 110161108
Drug use disorder 34.43 10.01 6 327693 18068 110243532
Respiratory disorder 34.36 10.01 343 327356 71039 110190561
Abnormal behaviour 34.29 10.01 39 327660 39000 110222600
Memory impairment 34.12 10.01 794 326905 196150 110065450
Pneumoretroperitoneum 33.92 10.01 15 327684 187 110261413
Female genital tract fistula 33.91 10.01 117 327582 16402 110245198
Therapeutic response shortened 33.65 10.01 175 327524 29408 110232192
Unmasking of previously unidentified disease 33.61 10.01 42 327657 2826 110258774
Toxic skin eruption 33.43 10.01 20 327679 27495 110234105
Ischaemic stroke 33.31 10.01 44 327655 41219 110220381
Hypocalcaemia 33.22 10.01 92 327607 65274 110196326
Pseudomonal sepsis 33.20 10.01 79 327620 8967 110252633
Overlap syndrome 33.12 10.01 79 327620 8980 110252620
Heart rate decreased 33.02 10.01 383 327316 82373 110179227
Thrombosis 32.86 10.01 188 327511 108474 110153126
Muscle rigidity 32.85 10.01 15 327684 24016 110237584
Miosis 32.85 10.01 12 327687 21971 110239629
Joint dislocation 32.71 10.01 193 327506 33997 110227603
Hypothalamic pituitary adrenal axis suppression 32.55 10.01 22 327677 660 110260940
Impaired quality of life 32.39 10.01 175 327524 29842 110231758
Angina unstable 32.31 10.01 5 327694 16427 110245173
Affect lability 31.77 10.01 8 327691 18629 110242971
Haematemesis 31.70 10.01 81 327618 59027 110202573
Foot deformity 31.63 10.01 249 327450 48231 110213369
Gastric ulcer 31.61 10.01 43 327656 39784 110221816
Nodule 31.59 10.01 30 327669 32601 110228999
Metastases to central nervous system 31.57 10.01 14 327685 22803 110238797
Hypogonadism 31.41 10.01 34 327665 1960 110259640
Right ventricular failure 31.35 10.01 19 327680 25935 110235665
Atrioventricular block 31.29 10.01 6 327693 16871 110244729
COVID-19 31.25 10.01 524 327175 244536 110017064
Soft tissue mass 31.18 10.01 30 327669 1503 110260097
Coordination abnormal 31.13 10.01 18 327681 25210 110236390
Blood pressure diastolic abnormal 31.04 10.01 19 327680 25796 110235804
Hepatic steatosis 31.02 10.01 61 327638 48770 110212830
Hip fracture 31.00 10.01 35 327664 35116 110226484
Diffuse large B-cell lymphoma 30.90 10.01 5 327694 15893 110245707
Salpingo-oophorectomy unilateral 30.85 10.01 23 327676 808 110260792
Infection 30.80 10.01 1340 326359 360860 109900740
Haematotoxicity 30.68 10.01 12 327687 21070 110240530
Disability 30.47 10.01 173 327526 30050 110231550
Ventricular tachycardia 30.46 10.01 64 327635 49945 110211655
Neuropathy peripheral 30.43 10.01 362 327337 178915 110082685
Neoplasm recurrence 30.15 10.01 55 327644 5177 110256423
Rhinovirus infection 30.11 10.01 90 327609 11699 110249901
Renal injury 30.09 10.01 9 327690 18704 110242896
Cardiac failure chronic 30.09 10.01 3 327696 13808 110247792
Panniculitis 30.06 10.01 5 327694 15577 110246023
Haematocrit decreased 30.05 10.01 98 327601 66019 110195581
Ear infection 29.98 10.01 301 327398 62431 110199169
Hemiplegia 29.95 10.01 15 327684 22767 110238833
Haemorrhage 29.94 10.01 189 327510 106503 110155097
Palmar-plantar erythrodysaesthesia syndrome 29.91 10.01 47 327652 40978 110220622
Hospitalisation 29.78 10.01 274 327425 142219 110119381
Therapy partial responder 29.43 10.01 40 327659 37021 110224579
Fear 29.41 10.01 16 327683 23177 110238423
Perfume sensitivity 29.37 10.01 25 327674 1066 110260534
Full blood count decreased 29.37 10.01 31 327668 32068 110229532
Bone disorder 29.33 10.01 13 327686 21179 110240421
Symptom masked 29.30 10.01 32 327667 1863 110259737
Basal cell carcinoma 29.23 10.01 56 327643 45214 110216386
Proctalgia 29.22 10.01 96 327603 13126 110248474
Neoplasm progression 29.18 10.01 96 327603 64499 110197101
Eating disorder 29.14 10.01 29 327670 30829 110230771
Perioral dermatitis 29.13 10.01 21 327678 700 110260900
Parainfluenzae virus infection 29.02 10.01 64 327635 6910 110254690
Atrial flutter 28.97 10.01 18 327681 24244 110237356
Eczema herpeticum 28.90 10.01 18 327681 468 110261132
Kounis syndrome 28.87 10.01 58 327641 5867 110255733
Hepatic cirrhosis 28.80 10.01 317 327382 67309 110194291
Fluid retention 28.60 10.01 163 327536 94144 110167456
Mydriasis 28.51 10.01 15 327684 22142 110239458
Pituitary tumour recurrent 28.51 10.01 13 327686 175 110261425
Grip strength 28.47 10.01 75 327624 9066 110252534
Enterobacter infection 28.45 10.01 57 327642 5754 110255846
Depressed mood 28.42 10.01 89 327610 60720 110200880
Shared psychotic disorder 28.29 10.01 9 327690 40 110261560
Faecaloma 28.28 10.01 5 327694 14903 110246697
Subcutaneous drug absorption impaired 28.23 10.01 67 327632 7592 110254008
Ear pain 28.20 10.01 261 327438 52965 110208635
Drug reaction with eosinophilia and systemic symptoms 28.20 10.01 136 327563 81959 110179641
Hypercalcaemia 28.18 10.01 60 327639 46597 110215003
Proteinuria 28.09 10.01 47 327652 39971 110221629
Disorientation 27.97 10.01 111 327588 70560 110191040
Paraesthesia 27.90 10.01 1042 326657 275479 109986121
Gamma-glutamyltransferase increased 27.77 10.01 91 327608 61218 110200382
Hemiparesis 27.75 10.01 55 327644 43848 110217752
Creatinine renal clearance decreased 27.73 10.01 15 327684 21800 110239800
Metastases to lung 27.69 10.01 17 327682 23046 110238554
Paranoia 27.56 10.01 16 327683 22358 110239242
Insulin-like growth factor decreased 27.42 10.01 19 327680 594 110261006
Urinary incontinence 27.29 10.01 65 327634 48522 110213078
Vaginal haemorrhage 26.77 10.01 21 327678 25053 110236547
Pollakiuria 26.55 10.01 57 327642 44138 110217462
Breast cancer female 26.42 10.01 3 327696 12465 110249135
Arteriosclerosis 26.12 10.01 21 327678 24746 110236854
Viraemia 26.06 10.01 45 327654 4057 110257543
SARS-CoV-2 test negative 25.98 10.01 32 327667 2121 110259479
Growth retardation 25.87 10.01 35 327664 2547 110259053
Multimorbidity 25.86 10.01 27 327672 1493 110260107
Hypoxia 25.81 10.01 252 327447 129263 110132337
Hyperaesthesia 25.74 10.01 6 327693 14721 110246879
Osteomyelitis 25.68 10.01 43 327656 36557 110225043
Oesophageal perforation 25.63 10.01 28 327671 1631 110259969
Acute myeloid leukaemia 25.62 10.01 46 327653 38064 110223536
Vaginal discharge 25.48 10.01 113 327586 17795 110243805
Head injury 25.42 10.01 56 327643 42961 110218639
Drug tolerance decreased 25.41 10.01 154 327545 27386 110234214
Thermophobia 25.39 10.01 9 327690 59 110261541
Renal cyst 25.38 10.01 11 327688 18161 110243439
Motor dysfunction 25.36 10.01 21 327678 24385 110237215
Glomerular filtration rate decreased 25.35 10.01 29 327670 28927 110232673
Purpura 25.32 10.01 21 327678 24367 110237233
Sinus disorder 25.31 10.01 36 327663 32692 110228908
Meningitis candida 25.23 10.01 13 327686 232 110261368
Intervertebral disc degeneration 25.17 10.01 11 327688 18074 110243526
Delirium 25.14 10.01 550 327149 134475 110127125
Cerebellar tumour 25.10 10.01 12 327687 181 110261419
Urticaria thermal 25.03 10.01 17 327682 514 110261086
Surgery 25.01 10.01 53 327646 41230 110220370
Glycosylated haemoglobin increased 24.94 10.01 20 327679 23599 110238001
Swollen joint count 24.84 10.01 69 327630 8605 110252995
Limb injury 24.79 10.01 46 327653 37590 110224010
Rhinitis allergic 24.79 10.01 11 327688 17911 110243689
Device issue 24.77 10.01 40 327659 34495 110227105
Bone marrow failure 24.75 10.01 88 327611 57760 110203840
Natural killer-cell leukaemia 24.74 10.01 10 327689 98 110261502
Sedation complication 24.74 10.01 14 327685 19841 110241759
Dystonia 24.66 10.01 24 327675 25781 110235819
Hypophagia 24.61 10.01 77 327622 52549 110209051
Eye injury 24.54 10.01 64 327635 7691 110253909
Hepatocellular injury 24.47 10.01 73 327626 50569 110211031
Erythema nodosum 24.30 10.01 58 327641 6595 110255005
Gangrene 24.28 10.01 9 327690 16332 110245268
Psychomotor hyperactivity 24.27 10.01 15 327684 20262 110241338
Abscess bacterial 24.27 10.01 21 327678 916 110260684
Proctitis 24.23 10.01 107 327592 16820 110244780
Deafness 24.21 10.01 26 327673 26683 110234917
Gastritis 24.12 10.01 80 327619 53619 110207981
Apathy 24.03 10.01 9 327690 16230 110245370
Pulmonary congestion 24.01 10.01 34 327665 30932 110230668
General symptom 24.00 10.01 69 327630 8777 110252823
Hallucination, visual 23.86 10.01 51 327648 39554 110222046
Cerebral candidiasis 23.86 10.01 9 327690 72 110261528
Dysstasia 23.85 10.01 38 327661 32948 110228652
Atrioventricular block complete 23.84 10.01 15 327684 20067 110241533
Weight fluctuation 23.82 10.01 129 327570 22016 110239584
Complication associated with device 23.82 10.01 15 327684 20058 110241542
Leukocytosis 23.63 10.01 81 327618 53747 110207853
Febrile neutropenia 23.49 10.01 1156 326543 315611 109945989
Platelet count increased 23.46 10.01 26 327673 26308 110235292
Product storage error 23.45 10.01 18 327681 21710 110239890
Transplant rejection 23.30 10.01 23 327676 24544 110237056
Neutrophil count increased 23.14 10.01 42 327657 34610 110226990
Lymphadenopathy 22.96 10.01 104 327595 63731 110197869
Bone pain 22.90 10.01 107 327592 65026 110196574
Drug level above therapeutic 22.86 10.01 81 327618 11507 110250093
Generalised tonic-clonic seizure 22.85 10.01 84 327615 54596 110207004
Delusion 22.81 10.01 22 327677 23733 110237867
Hypervolaemia 22.69 10.01 73 327626 49387 110212213
Pulmonary alveolar haemorrhage 22.64 10.01 16 327683 20134 110241466
Injection site pruritus 22.59 10.01 77 327622 51181 110210419
Granulocytopenia 22.58 10.01 5 327694 12710 110248890
Mental disorder 22.51 10.01 51 327648 38740 110222860
Osteoporosis 22.40 10.01 373 327326 86779 110174821
Blood corticotrophin increased 22.33 10.01 13 327686 298 110261302
Injection site mass 22.26 10.01 24 327675 24589 110237011
Acute generalised exanthematous pustulosis 22.07 10.01 19 327680 21645 110239955
Splenomegaly 22.03 10.01 24 327675 24474 110237126
Myoclonus 22.03 10.01 40 327659 32958 110228642
Rash vesicular 22.03 10.01 94 327605 14558 110247042
Normal tension glaucoma 22.01 10.01 8 327691 57 110261543
Foetal death 21.96 10.01 10 327689 16035 110245565
Analgesic therapy 21.92 10.01 59 327640 7225 110254375
Dyslipidaemia 21.77 10.01 10 327689 15955 110245645
Death neonatal 21.67 10.01 26 327673 1677 110259923
Carpal tunnel syndrome 21.64 10.01 21 327678 22589 110239011
Spinal stenosis 21.59 10.01 15 327684 19041 110242559
Haemorrhagic stroke 21.51 10.01 7 327692 13782 110247818
Normochromic normocytic anaemia 21.51 10.01 6 327693 13051 110248549
Visual acuity reduced 21.48 10.01 39 327660 32134 110229466
Renal cancer 21.45 10.01 6 327693 13028 110248572
Neoplasm malignant 21.42 10.01 49 327650 37094 110224506
Tooth disorder 21.33 10.01 34 327665 29475 110232125
Injection site haemorrhage 21.20 10.01 41 327658 32987 110228613
Renal tubular necrosis 21.20 10.01 36 327663 30439 110231161
Palpitations 21.10 10.01 338 327361 158874 110102726
Exposure to toxic agent 21.01 10.01 6 327693 12852 110248748
Atrioventricular block first degree 20.86 10.01 8 327691 14217 110247383
Rotator cuff syndrome 20.70 10.01 12 327687 16782 110244818
Blood lactate dehydrogenase increased 20.64 10.01 65 327634 44269 110217331
Pituitary infarction 20.59 10.01 8 327691 70 110261530
Allergy test positive 20.56 10.01 19 327680 904 110260696
Mental impairment 20.56 10.01 22 327677 22617 110238983
Stenotrophomonas bacteraemia 20.50 10.01 12 327687 278 110261322
Spondylitis 20.46 10.01 77 327622 11261 110250339
Femoral neck fracture 20.29 10.01 6 327693 12561 110249039
Liver function test increased 20.26 10.01 372 327327 88176 110173424
Feeling hot 20.24 10.01 381 327318 90725 110170875
Gastric cancer 20.23 10.01 4 327695 11004 110250596
Blindness 20.14 10.01 49 327650 36310 110225290
Cardiac failure acute 20.13 10.01 25 327674 24053 110237547
Gastric disorder 20.06 10.01 43 327656 33314 110228286
Hepatic encephalopathy 20.01 10.01 33 327666 28223 110233377
Nephrotic syndrome 19.92 10.01 8 327691 13823 110247777
Bronchiectasis 19.87 10.01 180 327519 36313 110225287
Insulin-like growth factor increased 19.85 10.01 29 327670 2267 110259333
COVID-19 pneumonia 19.84 10.01 51 327648 37092 110224508
Urosepsis 19.76 10.01 38 327661 30637 110230963
Therapy change 19.75 10.01 3 327696 9994 110251606
Productive cough 19.70 10.01 230 327469 114075 110147525
Hepatitis acute 19.68 10.01 16 327683 18750 110242850
Geotrichum infection 19.68 10.01 21 327678 1191 110260409
Eosinophil count increased 19.65 10.01 20 327679 21038 110240562
Tenosynovitis 19.55 10.01 12 327687 16271 110245329
Musculoskeletal disorder 19.52 10.01 23 327676 22641 110238959
Nerve injury 19.46 10.01 4 327695 10709 110250891
Thyrotoxic crisis 19.45 10.01 27 327672 2013 110259587
Torsade de pointes 19.39 10.01 23 327676 22577 110239023
Vasculitis 19.36 10.01 49 327650 35824 110225776
Influenza like illness 19.35 10.01 168 327531 88244 110173356
Dissociation 19.34 10.01 3 327696 9839 110251761
Injection site warmth 19.32 10.01 14 327685 17391 110244209
Cellulitis 19.31 10.01 260 327439 125756 110135844
Cholestasis 19.30 10.01 112 327587 64406 110197194
Respiratory tract congestion 19.21 10.01 39 327660 30818 110230782
Congenital hiatus hernia 19.14 10.01 51 327648 6208 110255392
Vaginal flatulence 19.11 10.01 79 327620 12065 110249535
Abnormal dreams 19.05 10.01 7 327692 12773 110248827
Anhidrosis 19.03 10.01 13 327686 397 110261203
Hypokinesia 18.95 10.01 22 327677 21804 110239796
Arterial occlusive disease 18.78 10.01 11 327688 15297 110246303
Hypoglycaemia 18.73 10.01 237 327462 115867 110145733
Thirst 18.72 10.01 22 327677 21685 110239915
Cardiomyopathy 18.71 10.01 45 327654 33480 110228120
Akathisia 18.69 10.01 14 327685 17099 110244501
Carotid artery occlusion 18.61 10.01 3 327696 9562 110252038
Blood glucose decreased 18.59 10.01 37 327662 29451 110232149
Thyrotoxic periodic paralysis 18.57 10.01 10 327689 196 110261404
Coronary artery occlusion 18.42 10.01 12 327687 15760 110245840
Diplopia 18.42 10.01 63 327636 41831 110219769
Speech disorder 18.36 10.01 107 327592 61462 110200138
Glucocorticoid deficiency 18.35 10.01 20 327679 1162 110260438
Gingival bleeding 18.33 10.01 19 327680 19820 110241780
Dysuria 18.32 10.01 104 327595 60127 110201473
Rhinitis 18.28 10.01 122 327577 22423 110239177
Coronary artery stenosis 18.17 10.01 9 327690 13749 110247851
Sleep disorder therapy 18.11 10.01 56 327643 7415 110254185
Pneumatosis intestinalis 18.02 10.01 61 327638 8468 110253132
Cystitis 18.01 10.01 118 327581 65918 110195682
Hypertriglyceridaemia 17.99 10.01 95 327604 16059 110245541
Blood corticotrophin decreased 17.98 10.01 17 327682 833 110260767
Tongue disorder 17.93 10.01 10 327689 14288 110247312
Hyperemesis gravidarum 17.78 10.01 14 327685 534 110261066
Ligament sprain 17.74 10.01 13 327686 16055 110245545
Muscle twitching 17.66 10.01 39 327660 29896 110231704
Fracture 17.50 10.01 29 327670 24759 110236841
Synovial cyst 17.49 10.01 6 327693 11424 110250176
Colorectal cancer 17.42 10.01 3 327696 9111 110252489
Ventricular extrasystoles 17.41 10.01 25 327674 22616 110238984
Epstein-Barr viraemia 17.40 10.01 35 327664 3544 110258056
Acute hepatic failure 17.31 10.01 53 327646 36415 110225185
Dementia 17.30 10.01 43 327656 31630 110229970
Colon cancer 17.27 10.01 14 327685 16429 110245171
Pustular psoriasis 17.25 10.01 83 327616 13522 110248078
Toxic encephalopathy 17.20 10.01 12 327687 15202 110246398
Electrocardiogram abnormal 17.19 10.01 18 327681 18691 110242909
Systemic infection 17.16 10.01 4 327695 9815 110251785
Polyneuropathy 17.06 10.01 44 327655 31968 110229632
Renal function test abnormal 16.97 10.01 3 327696 8943 110252657
Ventricular hypokinesia 16.96 10.01 6 327693 11208 110250392
Hepatitis C 16.95 10.01 8 327691 12565 110249035
Breast cancer metastatic 16.88 10.01 6 327693 11175 110250425
Peritoneal tuberculosis 16.87 10.01 14 327685 576 110261024
Spinal osteoarthritis 16.83 10.01 21 327678 20162 110241438
Lymphoma 16.81 10.01 21 327678 20150 110241450
Metastases to lymph nodes 16.81 10.01 12 327687 15020 110246580
Mucosal inflammation 16.76 10.01 388 327311 95753 110165847
Hepatic failure 16.70 10.01 127 327572 68612 110192988
Rheumatoid arthritis 16.59 10.01 722 326977 298891 109962709
Movement disorder 16.51 10.01 54 327645 36350 110225250
Hypothalamo-pituitary disorder 16.50 10.01 30 327669 2816 110258784
Shock haemorrhagic 16.49 10.01 35 327664 27212 110234388
Squamous cell carcinoma of skin 16.44 10.01 16 327683 17187 110244413
Mastocytosis 16.39 10.01 16 327683 816 110260784
Splenic peliosis 16.34 10.01 5 327694 19 110261581
Pulmonary function test decreased 16.33 10.01 3 327696 8697 110252903
Tardive dyskinesia 16.32 10.01 10 327689 13569 110248031
Hyperreflexia 16.31 10.01 4 327695 9481 110252119
Aortic arteriosclerosis 16.29 10.01 6 327693 10932 110250668
Epidural lipomatosis 16.29 10.01 25 327674 2042 110259558
Musculoskeletal discomfort 16.20 10.01 28 327671 23510 110238090
Primary adrenal insufficiency 16.19 10.01 14 327685 610 110260990
Antacid therapy 16.08 10.01 44 327655 5440 110256160
Intracranial infection 16.07 10.01 11 327688 337 110261263
Personality disorder 16.07 10.01 9 327690 12828 110248772
Alcohol poisoning 16.07 10.01 61 327638 8959 110252641
Blood pressure systolic decreased 16.01 10.01 10 327689 13431 110248169
Internal haemorrhage 15.91 10.01 5 327694 10066 110251534
Jaundice cholestatic 15.89 10.01 12 327687 14596 110247004
Sexual dysfunction 15.88 10.01 3 327696 8527 110253073
Hypertensive crisis 15.87 10.01 30 327669 24342 110237258
Mineralocorticoid deficiency 15.76 10.01 5 327694 22 110261578
Carotid artery stenosis 15.75 10.01 4 327695 9259 110252341
Fistula 15.71 10.01 88 327611 15211 110246389
Polyp 15.69 10.01 5 327694 9975 110251625
Eosinophilic granulomatosis with polyangiitis 15.69 10.01 6 327693 10680 110250920
Product administration error 15.67 10.01 57 327642 37160 110224440
Flushing 15.67 10.01 414 327285 104322 110157278
Anger 15.62 10.01 20 327679 18987 110242613
Squamous cell carcinoma 15.62 10.01 19 327680 18444 110243156
Ecchymosis 15.58 10.01 17 327682 17321 110244279
Localised infection 15.56 10.01 70 327629 42978 110218622
Multiple sclerosis 15.56 10.01 33 327666 25665 110235935
Duodenal ulcer 15.56 10.01 21 327678 19493 110242107
Hepatocellular carcinoma 15.44 10.01 5 327694 9875 110251725
Hypoacusis 15.41 10.01 53 327646 35138 110226462
Herpes simplex oesophagitis 15.37 10.01 12 327687 452 110261148
Food allergy 15.37 10.01 22 327677 19926 110241674
Peritonitis bacterial 15.32 10.01 6 327693 10527 110251073
Anosmia 15.25 10.01 9 327690 12463 110249137
Haemolytic anaemia 15.22 10.01 24 327675 20896 110240704
Pancreatic carcinoma 15.20 10.01 13 327686 14859 110246741
Hepatic cancer 15.19 10.01 7 327692 11149 110250451
Joint effusion 15.19 10.01 24 327675 20881 110240719
Pulmonary embolism 15.16 10.01 502 327197 213972 110047628
Anhedonia 15.15 10.01 14 327685 15414 110246186
Skin toxicity 15.13 10.01 8 327691 11775 110249825
Electrocardiogram QRS complex prolonged 15.08 10.01 10 327689 13011 110248589
Dry eye 15.06 10.01 100 327599 55693 110205907
Faeces discoloured 14.96 10.01 51 327648 33897 110227703
Sinusitis fungal 14.93 10.01 28 327671 2692 110258908
Pelvic fracture 14.93 10.01 12 327687 14142 110247458
Hypothyroidism 14.88 10.01 141 327558 72758 110188842
Gastroenteritis norovirus 14.87 10.01 33 327666 3578 110258022
Diabetic ketoacidosis 14.84 10.01 69 327630 41989 110219611
Vitamin D deficiency 14.75 10.01 20 327679 18532 110243068
Immunodeficiency 14.74 10.01 62 327637 38776 110222824
Nephropathy 14.73 10.01 11 327688 13456 110248144
Anticoagulant therapy 14.72 10.01 42 327657 5319 110256281
Pain in jaw 14.70 10.01 90 327609 51087 110210513
Supraventricular extrasystoles 14.69 10.01 3 327696 8070 110253530
Sensory disturbance 14.68 10.01 18 327681 17411 110244189
Complication of device insertion 14.67 10.01 4 327695 8834 110252766
Hypersomnia 14.63 10.01 39 327660 28022 110233578
Syringe issue 14.57 10.01 5 327694 9520 110252080
Dizziness 14.57 10.01 1829 325870 696364 109565236
Respiratory failure 14.52 10.01 507 327192 214825 110046775
Burning sensation 14.50 10.01 133 327566 69079 110192521
Weaning failure 14.49 10.01 15 327684 821 110260779
Protein urine present 14.45 10.01 8 327691 11476 110250124
Product quality issue 14.43 10.01 315 327384 76984 110184616
Deformity 14.43 10.01 6 327693 10154 110251446
Device related bacteraemia 14.39 10.01 18 327681 1212 110260388
Multiple-drug resistance 14.24 10.01 11 327688 13224 110248376
Mood altered 14.19 10.01 26 327673 21349 110240251
Portal hypertension 14.17 10.01 4 327695 8633 110252967
Bone density decreased 14.12 10.01 16 327683 16026 110245574
Abortion spontaneous 14.11 10.01 53 327646 34229 110227371
Pneumonia bacterial 14.07 10.01 36 327663 26225 110235375
Petechiae 14.07 10.01 30 327669 23287 110238313
Intervertebral disc protrusion 14.06 10.01 39 327660 27659 110233941
Presyncope 14.02 10.01 86 327613 48801 110212799
Sinus tachycardia 13.98 10.01 76 327623 44417 110217183
Peripheral arterial occlusive disease 13.98 10.01 5 327694 9275 110252325
Red blood cell sedimentation rate increased 13.96 10.01 317 327382 77985 110183615
Excessive eye blinking 13.88 10.01 22 327677 1848 110259752
Upper-airway cough syndrome 13.75 10.01 16 327683 15841 110245759
Myelopathy 13.71 10.01 42 327657 5534 110256066
Salivary hypersecretion 13.63 10.01 19 327680 17402 110244198
Pneumonitis 13.58 10.01 153 327546 76378 110185222
Radiculopathy 13.55 10.01 101 327598 19235 110242365
Encephalitis cytomegalovirus 13.53 10.01 22 327677 1888 110259712
Subarachnoid haemorrhage 13.51 10.01 44 327655 29658 110231942
Electrolyte imbalance 13.51 10.01 60 327639 36968 110224632
Diaphragm muscle weakness 13.27 10.01 8 327691 196 110261404
Withdrawal syndrome 13.25 10.01 48 327651 31332 110230268
Spinal fusion surgery 13.20 10.01 58 327641 9098 110252502
Concussion 13.18 10.01 9 327690 11529 110250071
Respiratory moniliasis 13.17 10.01 11 327688 457 110261143
Product monitoring error 13.12 10.01 5 327694 8922 110252678
Post procedural haemorrhage 13.08 10.01 16 327683 15496 110246104
Actinomycotic sepsis 13.05 10.01 8 327691 202 110261398
Cerebral vasoconstriction 13.04 10.01 19 327680 1482 110260118
Nephropathy toxic 12.99 10.01 40 327659 27438 110234162
Sputum discoloured 12.99 10.01 41 327658 27904 110233696
Hypernatraemia 12.99 10.01 94 327605 17739 110243861
Growth hormone deficiency 12.98 10.01 11 327688 466 110261134
Sickle cell anaemia with crisis 12.98 10.01 6 327693 9539 110252061
Acute coronary syndrome 12.92 10.01 31 327668 23081 110238519
Haemoptysis 12.91 10.01 142 327557 71212 110190388
Stomatococcal infection 12.78 10.01 10 327689 378 110261222
Morganella infection 12.78 10.01 18 327681 1361 110260239
Transaminases increased 12.77 10.01 123 327576 63267 110198333
Hyperpyrexia 12.76 10.01 4 327695 8065 110253535
Antithrombin III 12.76 10.01 6 327693 87 110261513
Ataxia 12.75 10.01 46 327653 30062 110231538
Drug therapy 12.73 10.01 49 327650 7242 110254358
Heavy menstrual bleeding 12.66 10.01 18 327681 16347 110245253
Multiple drug therapy 12.62 10.01 4 327695 8010 110253590
Performance status decreased 12.62 10.01 3 327696 7263 110254337
Lethargy 12.61 10.01 198 327501 93378 110168222
Disturbance in attention 12.61 10.01 120 327579 61875 110199725
Septic shock 12.54 10.01 579 327120 156949 110104651
Transplant failure 12.53 10.01 41 327658 5594 110256006
Lymphoproliferative disorder 12.50 10.01 3 327696 7215 110254385
Pyelonephritis 12.49 10.01 36 327663 25214 110236386
Drug-induced liver injury 12.47 10.01 454 327245 119613 110141987
Anal fistula 12.46 10.01 54 327645 8419 110253181
Bradypnoea 12.46 10.01 5 327694 8644 110252956
Tendon rupture 12.43 10.01 14 327685 14064 110247536
Eye haemorrhage 12.39 10.01 10 327689 11764 110249836
Dizziness postural 12.39 10.01 15 327684 14594 110247006
Mouth haemorrhage 12.37 10.01 13 327686 13475 110248125
Large intestine polyp 12.32 10.01 16 327683 15101 110246499
Amenorrhoea 12.25 10.01 6 327693 9225 110252375
Hereditary angioedema 12.23 10.01 3 327696 7111 110254489
Limb discomfort 12.18 10.01 71 327628 40783 110220817
Anaphylactic shock 12.16 10.01 96 327603 51450 110210150
Cortisol increased 12.13 10.01 12 327687 622 110260978
Atrial tachycardia 12.13 10.01 6 327693 9172 110252428
Paradoxical drug reaction 12.12 10.01 7 327692 9810 110251790
Small intestine gangrene 12.11 10.01 5 327694 52 110261548
Herpes zoster infection neurological 12.09 10.01 11 327688 513 110261087
Psychomotor retardation 12.08 10.01 4 327695 7788 110253812
Mass 12.06 10.01 25 327674 19605 110241995
Haematochezia 12.04 10.01 437 327262 115087 110146513
Initial insomnia 12.01 10.01 8 327691 10381 110251219
Eye pain 11.97 10.01 93 327606 50006 110211594
Decreased activity 11.96 10.01 9 327690 10965 110250635
17-hydroxyprogesterone increased 11.94 10.01 3 327696 4 110261596
Diabetic neuropathy 11.94 10.01 3 327696 6996 110254604
Device use error 11.92 10.01 6 327693 9083 110252517
Coma scale abnormal 11.92 10.01 7 327692 9719 110251881
Peptic ulcer haemorrhage 11.90 10.01 16 327683 1157 110260443
Blood creatine increased 11.86 10.01 10 327689 11511 110250089
Granulicatella infection 11.85 10.01 7 327692 165 110261435
Blood glucose fluctuation 11.85 10.01 4 327695 7694 110253906
Malaise 11.83 10.01 2211 325488 669608 109591992
Sinus node dysfunction 11.83 10.01 6 327693 9041 110252559
Chorioretinopathy 11.83 10.01 23 327676 2272 110259328
Device dislocation 11.79 10.01 51 327648 31653 110229947
Varicose vein 11.79 10.01 3 327696 6937 110254663
Therapeutic response unexpected 11.79 10.01 34 327665 23809 110237791
Intermenstrual bleeding 11.78 10.01 3 327696 6931 110254669
Chromaturia 11.69 10.01 46 327653 29314 110232286
Sarcoidosis 11.67 10.01 12 327687 12567 110249033
Hypomania 11.61 10.01 8 327691 10202 110251398
Musculoskeletal chest pain 11.61 10.01 45 327654 28802 110232798
Pulmonary mass 11.56 10.01 64 327635 37237 110224363
Bradykinesia 11.56 10.01 9 327690 10779 110250821
Vaccination site inflammation 11.55 10.01 5 327694 59 110261541
Prostatic specific antigen increased 11.54 10.01 12 327687 12499 110249101
Nasal oedema 11.54 10.01 3 327696 6836 110254764
Clostridium difficile colitis 11.48 10.01 188 327511 43590 110218010
International normalised ratio decreased 11.48 10.01 5 327694 8231 110253369
Autoimmune nephritis 11.44 10.01 13 327686 791 110260809
Adrenocorticotropic hormone deficiency 11.41 10.01 22 327677 2160 110259440
Polyomavirus-associated nephropathy 11.40 10.01 5 327694 8196 110253404
Decubitus ulcer 11.39 10.01 23 327676 18213 110243387
Cortisol abnormal 11.36 10.01 6 327693 113 110261487
Sleep disorder due to general medical condition, hypersomnia type 11.35 10.01 21 327678 1998 110259602
Ventricular arrhythmia 11.35 10.01 8 327691 10079 110251521
Obstructive airways disorder 11.34 10.01 85 327614 46064 110215536
Emotional disorder 11.32 10.01 19 327680 16141 110245459
Chronic graft versus host disease 11.31 10.01 7 327692 9450 110252150
Lymphocytic hypophysitis 11.24 10.01 12 327687 681 110260919
Blood glucose abnormal 11.24 10.01 13 327686 12903 110248697
Blood albumin decreased 11.22 10.01 43 327656 27609 110233991
Vulval haemorrhage 11.19 10.01 4 327695 27 110261573
Superinfection 11.12 10.01 40 327659 5723 110255877
Bradyphrenia 11.10 10.01 11 327688 11717 110249883
Hypocholesterolaemia 11.09 10.01 43 327656 6378 110255222
Blood pressure abnormal 11.07 10.01 32 327667 22392 110239208
Infant irritability 11.06 10.01 4 327695 28 110261572
Multiple allergies 11.04 10.01 12 327687 12251 110249349
Alanine aminotransferase abnormal 11.04 10.01 7 327692 9327 110252273
Nocturia 10.98 10.01 21 327678 16969 110244631
Blood urine present 10.97 10.01 36 327663 24209 110237391
Dental caries 10.96 10.01 13 327686 12760 110248840
Haemarthrosis 10.95 10.01 4 327695 7325 110254275
Sulphaemoglobinaemia 10.90 10.01 11 327688 584 110261016
SARS-CoV-2 test positive 10.89 10.01 21 327678 16914 110244686
Hypokalaemia 10.87 10.01 436 327263 182012 110079588
Pharyngitis 10.86 10.01 38 327661 25060 110236540
Irritability 10.84 10.01 90 327609 47719 110213881
Genital haemorrhage 10.77 10.01 4 327695 7248 110254352
Peripheral vascular disorder 10.75 10.01 6 327693 8570 110253030
Aortic valve incompetence 10.74 10.01 10 327689 10971 110250629
Pruritus genital 10.74 10.01 3 327696 6519 110255081
Allergic eosinophilia 10.73 10.01 5 327694 71 110261529
Pseudohypoaldosteronism 10.73 10.01 5 327694 71 110261529
No adverse event 10.72 10.01 154 327545 73685 110187915
Pericardial effusion 10.70 10.01 113 327586 57104 110204496
Embolism venous 10.68 10.01 36 327663 4987 110256613
Optic nerve operation 10.68 10.01 10 327689 484 110261116
Adrenal atrophy 10.66 10.01 5 327694 72 110261528
Exercise tolerance decreased 10.66 10.01 12 327687 12055 110249545
Progressive multifocal leukoencephalopathy 10.65 10.01 38 327661 24918 110236682
Hepatic cytolysis 10.60 10.01 108 327591 54945 110206655
Hepatic lesion 10.57 10.01 6 327693 8487 110253113
Wheelchair user 10.56 10.01 5 327694 7837 110253763
B-cell lymphoma 10.53 10.01 4 327695 7150 110254450
Kidney transplant rejection 10.50 10.01 12 327687 11975 110249625
Ischaemia 10.49 10.01 7 327692 9076 110252524
Mucosal hyperaemia 10.48 10.01 5 327694 75 110261525
Ageusia 10.47 10.01 27 327672 19618 110241982
Skin haemorrhage 10.47 10.01 38 327661 24789 110236811
Skin necrosis 10.40 10.01 31 327668 21481 110240119
Intracardiac thrombus 10.35 10.01 32 327667 4236 110257364
Cryptococcal fungaemia 10.35 10.01 8 327691 297 110261303
Viral upper respiratory tract infection 10.34 10.01 9 327690 10199 110251401
Sensory loss 10.32 10.01 31 327668 21426 110240174
Cerebral microangiopathy 10.31 10.01 9 327690 397 110261203
Atelectasis 10.31 10.01 65 327634 36647 110224953
Aortic valve stenosis 10.31 10.01 3 327696 6347 110255253
Cardiac murmur 10.28 10.01 115 327584 24513 110237087
Hepatitis cholestatic 10.27 10.01 23 327676 17543 110244057
Hyperuricaemia 10.26 10.01 17 327682 14514 110247086
Cardiac tamponade 10.25 10.01 11 327688 11296 110250304
Brain injury 10.25 10.01 15 327684 13461 110248139
Hot flush 10.21 10.01 136 327563 65900 110195700
Adrenal gland cancer metastatic 10.19 10.01 4 327695 36 110261564
Blood sodium decreased 10.18 10.01 69 327630 38250 110223350
Multiple fractures 10.18 10.01 7 327692 8933 110252667
Extrasystoles 10.17 10.01 6 327693 8312 110253288
Upper limb fracture 10.17 10.01 30 327669 20858 110240742
Airway peak pressure increased 10.16 10.01 11 327688 634 110260966
Bile duct stone 10.16 10.01 3 327696 6286 110255314
Lung adenocarcinoma 10.15 10.01 8 327691 9523 110252077
Small intestinal obstruction 10.13 10.01 55 327644 32158 110229442
Basilar artery aneurysm 10.10 10.01 4 327695 37 110261563
Retinal haemorrhage 10.09 10.01 8 327691 9493 110252107
Refusal of treatment by patient 10.07 10.01 8 327691 9486 110252114
Blood pressure systolic increased 10.07 10.01 179 327520 82812 110178788
Leukaemia recurrent 10.07 10.01 26 327673 3105 110258495
Asthma 10.06 10.01 867 326832 249424 110012176
Brain natriuretic peptide increased 10.06 10.01 11 327688 11198 110250402
Lymphoedema 10.05 10.01 18 327681 14911 110246689
Increased tendency to bruise 10.05 10.01 12 327687 11746 110249854
Sinus bradycardia 10.03 10.01 49 327650 29434 110232166

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Aspergillus infection 61.59 44.16 17 223 66 113647
Drug-induced liver injury 58.79 44.16 16 224 58 113655

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:88188 allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cerebral edema indication 2032001
Keratitis indication 5888003 DOID:4677
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Hemorrhoids indication 70153002 DOID:9746
Transfusion reaction due to serum protein reaction indication 72284000
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Autoimmune disease indication 85828009
Corneal abrasion indication 85848002
Infection by larvae of Trichinella spiralis indication 88264003
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Transplanted organ rejection indication 213148006
Adrenogenital disorder indication 267395000 DOID:0050811
Eruption of skin indication 271807003 DOID:0050486
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Inflammatory dermatosis indication 703938007
Transfusion Reaction Urticaria indication
Erythroblastic Anemia indication
Synovitis due to Osteoarthritis indication
Systemic Dermatomyositis indication
Respiratory distress syndrome in the newborn off-label use 46775006
Lichen simplex chronicus off-label use 53891004
Congenital hypoplastic anemia off-label use 88854002 DOID:1339
Pruritus of genital organs off-label use 267802000
Itching of skin off-label use 418363000
Neonatal Bronchopulmonary Dysplasia off-label use
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Bacterial septicemia contraindication 10001005 DOID:0040085
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Measles contraindication 14189004 DOID:8622
Esophagitis contraindication 16761005 DOID:11963
Mood swings contraindication 18963009
Cirrhosis of liver contraindication 19943007 DOID:5082
Glaucoma contraindication 23986001 DOID:1686
Abscess of intestine contraindication 24557004
Acute tuberculosis contraindication 25629007
Shock contraindication 27942005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Severe myopia contraindication 34187009
Hyperthyroidism contraindication 34486009 DOID:7998
Gastrointestinal fistula contraindication 37831005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Duodenal ulcer disease contraindication 51868009 DOID:1724
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Krukenberg spindle contraindication 85430004
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Disorder of mucous membrane contraindication 95351003
Bilateral cataracts contraindication 95722004
Open wound contraindication 125643001
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Heart block contraindication 233916004
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Telangiectasia disorder contraindication 247479008
Diverticulitis of gastrointestinal tract contraindication 271366000
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Vaccinia keratitis contraindication 397552005
Gastric ulcer contraindication 397825006 DOID:10808
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Denuded skin contraindication 418242004
Exposure to varicella contraindication 444453009




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Acute otitis externa Indication
Cats Chronic otitis externa Indication
Cats Ear canker Indication
Cats Inflammatory conditions of the external ear canal Indication
Cats Allergy Indication
Cats Infectious skin conditions Indication
Cats Traumatic skin conditions Indication
Cats Prevention of bacterial infections in superficial wounds Indication
Cats Prevention of bacterial infections in cuts Indication
Cats Prevention of bacterial infections in abrasions Indication
Cats Allergic dermatoses Indication
Cats Infections associated with minor burns and wounds Indication
Cats Nonspecific pruritus Indication
Dogs Acute otitis externa Indication
Dogs Chronic otitis externa Indication
Dogs Ear canker Indication
Dogs Inflammatory conditions of the external ear canal Indication
Dogs Allergy Indication
Dogs Infectious skin conditions Indication
Dogs Traumatic skin conditions Indication
Dogs Prevention of bacterial infections in superficial wounds Indication
Dogs Prevention of bacterial infections in cuts Indication
Dogs Prevention of bacterial infections in abrasions Indication
Dogs Allergic dermatoses Indication
Dogs Infections associated with minor burns and wounds Indication
Dogs Nonspecific pruritus Indication
Horses No Use Class Stated Or Implied Indication

🐶 Veterinary products

ProductApplicantIngredients
Neo-Cortef with Tetracaine Zoetis Inc. 3
Kymar Ointment Improved Intervet Inc. 4
Kanfosone Ointment Zoetis Inc. 3
Amphoderm Ointment Zoetis Inc. 3
Bacitracin-Neomycin-Polymyxin with Hydrocortisone Acetate Ophthalmic Ointment, Vetropolycin HC Ophthalmic Ointment Dechra, Ltd. 4
Forte Topical Ointment Zoetis Inc. 4
Neo-Cortef Sterile Ointment Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL
Corticosteroid-binding globulin Secreted Ki 7.55 CHEMBL

External reference:

IDSource
4017942 VUID
N0000179154 NUI
D00165 KEGG_DRUG
4017941 VANDF
4017942 VANDF
C0063077 UMLSCUI
CHEBI:17609 CHEBI
CHEMBL1091 ChEMBL_ID
DB14539 DRUGBANK_ID
C021650 MESH_SUPPLEMENTAL_RECORD_UI
3X7931PO74 UNII
5744 PUBCHEM_CID
DB00741 DRUGBANK_ID
27197 RXNORM
2500 MMSL
2749 MMSL
4837 MMSL
4838 MMSL
d00254 MMSL
002147 NDDF
002148 NDDF
16602005 SNOMEDCT_US
396458002 SNOMEDCT_US
56423005 SNOMEDCT_US
79380007 SNOMEDCT_US
C0020268 UMLSCUI
5754 PUBCHEM_CID
38 INN_ID
D006854 MESH_DESCRIPTOR_UI
CHEBI:17650 CHEBI
3X7931PO74 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PROCTOFOAMHC HUMAN PRESCRIPTION DRUG LABEL 2 0037-6822 AEROSOL, FOAM 100 mg TOPICAL ANDA 22 sections
EPIFOAM HUMAN PRESCRIPTION DRUG LABEL 2 0037-6824 AEROSOL, FOAM 100 mg TOPICAL ANDA 20 sections
Cortifoam HUMAN PRESCRIPTION DRUG LABEL 1 0037-6830 AEROSOL, FOAM 1500 mg TOPICAL NDA 21 sections
Walgreens Eczema Relief HUMAN OTC DRUG LABEL 1 0363-0357 CREAM 10 mg TOPICAL OTC Monograph Drug 14 sections
Hydrocortisone HUMAN OTC DRUG LABEL 1 0363-0972 CREAM 1 g TOPICAL OTC Monograph Drug 15 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0574-7090 SUPPOSITORY 25 mg RECTAL Unapproved drug other 14 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0574-7093 SUPPOSITORY 30 mg RECTAL Unapproved drug other 14 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0493 SUPPOSITORY 30 mg RECTAL unapproved drug other 14 sections
ANUCORT-HC HUMAN PRESCRIPTION DRUG LABEL 1 0713-0503 SUPPOSITORY 25 mg RECTAL unapproved drug other 14 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7340 SUPPOSITORY 25 mg RECTAL Unapproved drug other 14 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 10135-751 SUPPOSITORY 25 mg RECTAL unapproved drug other 12 sections
Vagisil Anti-Itch Creme Maximum Strength Sensitive Skin Formula HUMAN OTC DRUG LABEL 1 11509-5101 CREAM 280 mg TOPICAL OTC MONOGRAPH NOT FINAL 11 sections
Hydrocortisone HUMAN OTC DRUG LABEL 1 11822-2069 CREAM 1 g TOPICAL OTC Monograph Drug 15 sections
Lidocaine Hydrochloride and Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 13925-160 CREAM 5 mg TOPICAL unapproved drug other 19 sections
Lidocaine Hydrochloride and Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 13925-163 CREAM 10 mg RECTAL unapproved drug other 22 sections
Lidocaine Hydrochloride and Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 13925-164 GEL 25 mg RECTAL unapproved drug other 20 sections
Lidocaine Hydrochloride and Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 2 13925-165 CREAM 5 mg RECTAL unapproved drug other 22 sections
NuCort HUMAN PRESCRIPTION DRUG LABEL 1 15014-185 LOTION 20 mg TOPICAL unapproved drug other 20 sections
Hemmorex-HC HUMAN PRESCRIPTION DRUG LABEL 1 16477-201 SUPPOSITORY 25 mg RECTAL unapproved drug other 14 sections
Hemmorex-HC HUMAN PRESCRIPTION DRUG LABEL 1 16477-202 SUPPOSITORY 30 mg RECTAL unapproved drug other 15 sections
Hydrocortisone Acetate Human Prescription Drug Label 1 16571-164 SUPPOSITORY 30 mg RECTAL unapproved drug other 13 sections
Hydrocortisone Acetate Human Prescription Drug Label 1 16571-676 SUPPOSITORY 25 mg RECTAL UNAPPROVED DRUG OTHER 13 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 21695-731 SUPPOSITORY 30 mg RECTAL Unapproved drug other 12 sections
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc with Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 4 21695-736 OINTMENT 10 mg OPHTHALMIC ANDA 18 sections
ProctofoamHC HUMAN PRESCRIPTION DRUG LABEL 2 21695-982 AEROSOL, FOAM 100 mg TOPICAL ANDA 23 sections
LIDOCAINE HYDROCHLORIDE, HYDROCORTISONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 2 24470-964 GEL 25 mg RECTAL unapproved drug other 10 sections
LIDOCAINE HYDROCHLORIDE, HYDROCORTISONE ACETATE HUMAN PRESCRIPTION DRUG LABEL 2 24470-965 CREAM 5 mg RECTAL unapproved drug other 10 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 24689-102 SUPPOSITORY 25 mg RECTAL unapproved drug other 16 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 24689-103 SUPPOSITORY 30 mg RECTAL unapproved drug other 16 sections
Hydrocortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 39328-029 SUPPOSITORY 25 mg RECTAL UNAPPROVED DRUG OTHER 14 sections