acetic acid indications/contra

Stem definitionDrug idCAS RN
4211 64-19-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetic acid
  • acetic acid, glacial
  • ethanoic acid
  • ethylic acid
  • vinegar acid
Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
  • Molecular weight: 60.05
  • Formula: C2H4O2
  • CLOGP: -0.19
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: 0.73
  • ROTB: 0

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
May 17, 1960 FDA HI TECH PHARMA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC G01AD02 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Organic acids
ATC S02AA10 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
MeSH PA D007202 Indicators and Reagents
CHEBI has role CHEBI:64049 food acidity regulator
CHEBI has role CHEBI:48356 protic solvent
CHEBI has role CHEBI:65256 antimicrobial food preservative

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009 DOID:9463
Herpes zoster auricularis contraindication 21954000 DOID:9210
Perforation of tympanic membrane contraindication 60442001
Herpes simplex contraindication 88594005 DOID:8566
Tuberculosis of ear contraindication 186269001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Infective otitis media contraindication 312218008
Porphyria contraindication 418470004 DOID:13268
Sensation Disturbance of Genitals contraindication
Otalgia off-label use 16001004
Impacted cerumen off-label use 18070006
Otitis Externa Seborrhea off-label use
Otitis Externa Eczema off-label use

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosine-protein kinase Fyn Kinase Kd 6.05 CHEMBL
Tyrosine-protein kinase Lck Kinase Kd 6.19 CHEMBL
Free fatty acid receptor 2 GPCR AGONIST EC50 4.60 IUPHAR

External reference:

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IDSource
1058 IUPHAR_LIGAND_ID
4018456 VUID
N0000146780 NUI
C0000983 UMLSCUI
D00010 KEGG_DRUG
CHEMBL539 ChEMBL_ID
d04228 MMSL
11539 MMSL
4017443 VANDF
4018456 VANDF
422082008 SNOMEDCT_US
N0000145831 NDFRT
N0000146780 NDFRT
N0000006517 NDFRT
002875 NDDF
822 MMSL
168 RXNORM
4122 MMSL
2869004 SNOMEDCT_US
9812 MMSL
002917 NDDF
326289007 SNOMEDCT_US
DB03166 DRUGBANK_ID
176 PUBCHEM_CID
Q40Q9N063P UNII
D019342 MESH_DESCRIPTOR_UI
CHEBI:15366 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0264-2304 IRRIGANT 0.25 g IRRIGATION NDA 13 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0338-0656 IRRIGANT 250 mg IRRIGATION NDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0409-6143 IRRIGANT 250 mg IRRIGATION NDA 12 sections
Acetasol HC HUMAN PRESCRIPTION DRUG LABEL 2 0472-0882 SOLUTION 2.41 g AURICULAR (OTIC) ANDA 10 sections
Fem pH HUMAN PRESCRIPTION DRUG LABEL 2 0813-0799 JELLY 0.01 g VAGINAL UNAPPROVED DRUG OTHER 12 sections
Borofair HUMAN PRESCRIPTION DRUG LABEL 1 0904-3524 SOLUTION/ DROPS 2 mg AURICULAR (OTIC) ANDA 13 sections
acetic acid HUMAN PRESCRIPTION DRUG LABEL 1 21695-222 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 24208-615 SOLUTION/ DROPS 2 mg AURICULAR (OTIC) ANDA 13 sections
Hydrocortisone and Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 2 45963-412 SOLUTION 2.41 g AURICULAR (OTIC) ANDA 11 sections
acetic acid HUMAN PRESCRIPTION DRUG LABEL 1 50090-0351 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50383-889 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
Hydrocortisone and Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 2 50383-901 SOLUTION 20.75 mg AURICULAR (OTIC) NDA 11 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50436-4600 SOLUTION 20 mg AURICULAR (OTIC) ANDA 10 sections
Hydrocortisone and Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 2 51672-3007 SOLUTION 20.80 mg AURICULAR (OTIC) ANDA 11 sections
RELEGARD HUMAN PRESCRIPTION DRUG LABEL 2 51674-0130 GEL 0.90 mg TOPICAL unapproved drug other 2 sections
acetic acid HUMAN PRESCRIPTION DRUG LABEL 1 55045-1243 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 11 sections
acetic acid HUMAN PRESCRIPTION DRUG LABEL 1 55700-424 SOLUTION 20.65 mg AURICULAR (OTIC) NDA 10 sections
ACETIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 60432-741 SOLUTION 20 mg AURICULAR (OTIC) ANDA 10 sections
Acetic Acid HUMAN PRESCRIPTION DRUG LABEL 1 68071-3304 SOLUTION 25 mg AURICULAR (OTIC) ANDA 11 sections