budipine indications/contra

Stem definitionDrug idCAS RN
tricyclic compounds 420 57982-78-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • budipine
  • Molecular weight: 293.45
  • Formula: C21H27N
  • CLOGP: 5.58
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -5.36
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC N04BX03 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
DOPAMINERGIC AGENTS
Other dopaminergic agents
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.07 CHEMBL
Glutamate [NMDA] receptor Ion channel Ki 4.93 CHEMBL

External reference:

scroll-->
IDSource
C0054202 UMLSCUI
D07306 KEGG_DRUG
68778 PUBCHEM_CID
19832 RXNORM
007104 NDDF
CHEMBL334491 ChEMBL_ID
L9026OPI2Z UNII
4037 INN_ID
C026710 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None