potassium chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4199 7447-40-7

Description:

MoleculeDescription

Synonyms:

  • potassium chloride
A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
  • Molecular weight: 74.55
  • Formula: ClK
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 333.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 85 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Dec. 16, 1965 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 728.60 9.93 1183 181448 1043582 62262809
Hand deformity 431.66 9.93 5 182626 159452 63146939
Systemic lupus erythematosus 408.17 9.93 58 182573 208860 63097531
Contraindicated product administered 380.25 9.93 81 182550 217567 63088824
Hyperkalaemia 375.87 9.93 608 182023 53595 63252796
Hypokalaemia 366.32 9.93 876 181755 102928 63203463
Glossodynia 365.43 9.93 43 182588 178833 63127558
Cardiac failure congestive 354.54 9.93 806 181825 91627 63214764
Anti-cyclic citrullinated peptide antibody positive 317.45 9.93 3 182628 116209 63190182
Alopecia 312.83 9.93 306 182325 337230 62969161
Joint swelling 292.29 9.93 307 182324 327359 62979032
Pericarditis 270.26 9.93 31 182600 131548 63174843
Therapeutic product effect decreased 268.09 9.93 110 182521 193077 63113314
Arthropathy 267.46 9.93 173 182458 234619 63071772
Wound 264.94 9.93 71 182560 163192 63143199
Acute kidney injury 264.61 9.93 1472 181159 261943 63044448
Rheumatoid arthritis 261.70 9.93 208 182423 253611 63052780
Drug intolerance 250.50 9.93 312 182319 308349 62998042
Anaemia 239.33 9.93 1553 181078 291877 63014514
Maternal exposure during pregnancy 238.80 9.93 171 182460 219891 63086500
Atrial fibrillation 238.28 9.93 808 181823 115828 63190563
Pneumonia 225.62 9.93 2152 180479 454615 62851776
Abdominal discomfort 221.20 9.93 364 182267 320521 62985870
Discomfort 220.02 9.93 103 182528 167271 63139120
Duodenal ulcer perforation 218.97 9.93 7 182624 87202 63219189
Helicobacter infection 217.86 9.93 12 182619 92773 63213618
Oedema peripheral 201.55 9.93 1076 181555 188435 63117956
Dehydration 200.09 9.93 1007 181624 172347 63134044
Hypervolaemia 200.02 9.93 321 182310 28092 63278299
Blood potassium decreased 198.54 9.93 399 182232 41627 63264764
Lower respiratory tract infection 195.75 9.93 68 182563 132239 63174152
Musculoskeletal stiffness 189.31 9.93 152 182479 184466 63121925
Pulmonary hypertension 182.03 9.93 358 182273 36765 63269626
Infusion related reaction 182.03 9.93 265 182366 245256 63061135
Treatment failure 181.24 9.93 183 182448 198860 63107531
Synovitis 179.33 9.93 164 182467 186754 63119637
Off label use 175.99 9.93 1178 181453 673284 62633107
Plasma cell myeloma 175.75 9.93 346 182285 35559 63270832
Swelling 169.41 9.93 335 182296 275043 63031348
Drug hypersensitivity 157.94 9.93 419 182212 310268 62996123
Arthralgia 157.68 9.93 977 181654 568733 62737658
Product use issue 156.68 9.93 245 182386 220275 63086116
Hepatic enzyme increased 154.27 9.93 214 182417 202114 63104277
Pain 153.19 9.93 1379 181252 739249 62567142
Folliculitis 150.98 9.93 14 182617 70303 63236088
Pulmonary arterial hypertension 150.67 9.93 249 182382 22328 63284063
Diarrhoea 149.16 9.93 2884 179747 712482 62593909
Muscle injury 148.72 9.93 10 182621 65335 63241056
Gastrointestinal haemorrhage 146.48 9.93 540 182091 80636 63225755
Sepsis 140.60 9.93 836 181795 152287 63154104
Colitis microscopic 140.07 9.93 153 182478 9186 63297205
Exposure during pregnancy 138.18 9.93 146 182485 155401 63150990
Acute respiratory failure 138.01 9.93 306 182325 34179 63272212
Hypersensitivity 133.14 9.93 416 182215 292269 63014122
Right ventricular failure 131.81 9.93 202 182429 16986 63289405
Dyspnoea 127.98 9.93 2637 179994 658676 62647715
Hypotension 122.82 9.93 1261 181370 271343 63035048
Respiratory failure 117.62 9.93 592 182039 101266 63205125
Fluid retention 117.00 9.93 408 182223 59278 63247113
Rash 116.73 9.93 1042 181589 559829 62746562
Toxic anterior segment syndrome 115.92 9.93 69 182562 1702 63304689
Irritable bowel syndrome 114.11 9.93 47 182584 82365 63224026
Renal failure 113.57 9.93 651 181980 117001 63189390
Hypoxia 113.14 9.93 404 182227 59388 63247003
Hyponatraemia 106.59 9.93 617 182014 111283 63195108
Toxicity to various agents 106.45 9.93 360 182271 246890 63059501
Cardiac failure 104.96 9.93 521 182110 88621 63217770
Death 104.42 9.93 1583 181048 372798 62933593
Fall 100.73 9.93 1636 180995 390698 62915693
Impaired healing 97.07 9.93 91 182540 102451 63203940
International normalised ratio increased 95.92 9.93 323 182308 46102 63260289
Pneumonia aspiration 95.38 9.93 266 182365 34274 63272117
Pleural effusion 93.40 9.93 521 182110 92689 63213702
Psoriatic arthropathy 92.94 9.93 76 182555 91444 63214947
Product residue present 92.90 9.93 83 182548 3896 63302495
Asthenia 92.71 9.93 1584 181047 382020 62924371
Ill-defined disorder 90.60 9.93 62 182569 81693 63224698
Chronic obstructive pulmonary disease 90.52 9.93 389 182242 62297 63244094
Drug abuse 90.15 9.93 48 182583 72470 63233921
Bronchitis 84.92 9.93 633 181998 124302 63182089
Product use in unapproved indication 83.87 9.93 251 182380 178829 63127562
Device expulsion 83.59 9.93 4 182627 34918 63271473
Blister 83.15 9.93 154 182477 129660 63176731
Intentional product use issue 81.67 9.93 152 182479 127740 63178651
Deep vein thrombosis 77.79 9.93 459 182172 83341 63223050
Blood cholesterol increased 77.22 9.93 94 182537 93938 63212453
Liver injury 76.80 9.93 39 182592 60481 63245910
Cytokine release syndrome 76.24 9.93 143 182488 14171 63292220
Glaucoma 75.91 9.93 168 182463 18737 63287654
Urinary tract infection 66.79 9.93 1101 181530 263583 63042808
Diverticulitis 65.42 9.93 256 182375 39301 63267090
Electrolyte imbalance 64.96 9.93 164 182467 19912 63286479
Abortion spontaneous 63.59 9.93 28 182603 47167 63259224
Therapeutic product effect incomplete 63.16 9.93 169 182462 124887 63181504
Gastrooesophageal reflux disease 59.64 9.93 475 182156 95164 63211227
Nasopharyngitis 59.22 9.93 458 182173 253799 63052592
Injection site pain 57.17 9.93 187 182444 129613 63176778
Pulmonary oedema 57.14 9.93 310 182321 54563 63251828
Thrombocytopenia 56.39 9.93 674 181957 150483 63155908
Gastrointestinal disorder 55.80 9.93 192 182439 131047 63175344
Hip arthroplasty 55.69 9.93 34 182597 47612 63258779
Pulmonary embolism 53.97 9.93 543 182088 116141 63190250
Full blood count decreased 53.69 9.93 181 182450 25843 63280548
Completed suicide 53.60 9.93 226 182405 145447 63160944
Febrile neutropenia 52.30 9.93 546 182085 117903 63188488
Syncope 52.26 9.93 542 182089 116843 63189548
Dementia 52.14 9.93 145 182486 18649 63287742
Dyspnoea exertional 50.09 9.93 321 182310 59981 63246410
Haemoglobin decreased 50.08 9.93 639 181992 144846 63161545
Brain natriuretic peptide increased 49.80 9.93 68 182563 5145 63301246
Hypomagnesaemia 49.17 9.93 188 182443 28549 63277842
Platelet count decreased 47.43 9.93 527 182104 115595 63190796
Pancytopenia 47.22 9.93 456 182175 96477 63209914
C-reactive protein abnormal 47.13 9.93 38 182593 46058 63260333
Cardiac arrest 45.89 9.93 437 182194 92108 63214283
Constipation 45.86 9.93 905 181726 224038 63082353
Transfusion 45.82 9.93 121 182510 15096 63291295
Mobility decreased 45.17 9.93 187 182444 120972 63185419
Colitis 44.50 9.93 265 182366 48263 63258128
Clostridium difficile colitis 44.16 9.93 145 182486 20424 63285967
Atrial flutter 44.02 9.93 91 182540 9681 63296710
Sleep disorder 43.66 9.93 107 182524 81459 63224932
Fibromyalgia 43.44 9.93 105 182526 80315 63226076
Injection site swelling 42.94 9.93 44 182587 47528 63258863
Blood loss anaemia 41.94 9.93 85 182546 8916 63297475
Condition aggravated 41.83 9.93 861 181770 401356 62905035
Blood alkaline phosphatase increased 41.58 9.93 238 182393 42729 63263662
Injection site reaction 41.52 9.93 65 182566 58459 63247932
Metabolic encephalopathy 41.38 9.93 66 182565 5743 63300648
Infection 41.07 9.93 441 182190 228732 63077659
Mental status changes 40.75 9.93 223 182408 39376 63267015
Cor pulmonale 40.51 9.93 39 182592 2015 63304376
Oedema 39.84 9.93 443 182188 97179 63209212
Blood bilirubin increased 39.47 9.93 211 182420 36929 63269462
Stomatitis 39.16 9.93 236 182395 138489 63167902
Ascites 39.02 9.93 225 182406 40503 63265888
Arrhythmia 38.72 9.93 214 182417 37926 63268465
Knee arthroplasty 38.65 9.93 60 182571 54146 63252245
Haematoma 38.50 9.93 200 182431 34620 63271771
Rheumatoid nodule 37.95 9.93 3 182628 17152 63289239
Septic shock 37.81 9.93 324 182307 66305 63240086
Cerebrovascular accident 37.81 9.93 476 182155 107548 63198843
Neuropathy peripheral 37.73 9.93 496 182135 113171 63193220
Injection site bruising 37.56 9.93 39 182592 41871 63264520
Melaena 37.52 9.93 180 182451 30185 63276206
Suicide attempt 37.47 9.93 74 182557 60844 63245547
Respiratory distress 36.84 9.93 194 182437 33757 63272634
Cardiomegaly 36.77 9.93 123 182508 17491 63288900
Inflammation 36.58 9.93 118 182513 82155 63224236
Catheter management 36.46 9.93 44 182587 2943 63303448
Psoriasis 36.42 9.93 128 182503 86829 63219562
Type 2 diabetes mellitus 36.41 9.93 81 182550 63787 63242604
Encephalopathy 36.12 9.93 212 182419 38408 63267983
Injection site erythema 35.80 9.93 121 182510 83053 63223338
Urticaria 35.66 9.93 305 182326 165497 63140894
Coma 35.49 9.93 311 182320 64053 63242338
Joint range of motion decreased 35.38 9.93 25 182606 32403 63273988
Joint stiffness 35.28 9.93 41 182590 41828 63264563
Thrombosis 34.73 9.93 311 182320 64444 63241947
Oxygen consumption increased 34.62 9.93 49 182582 3835 63302556
Hyperaldosteronism 34.60 9.93 16 182615 230 63306161
Pregnancy 34.48 9.93 33 182598 36803 63269588
Decreased appetite 33.91 9.93 954 181677 250098 63056293
Grip strength decreased 33.73 9.93 11 182620 22276 63284115
Therapeutic response decreased 33.49 9.93 80 182551 61445 63244946
Intentional self-injury 33.42 9.93 16 182615 25671 63280720
Epistaxis 33.40 9.93 338 182293 72387 63234004
Cardiac failure acute 33.14 9.93 80 182551 9443 63296948
Blood urea increased 33.05 9.93 157 182474 26222 63280169
Multiple allergies 33.02 9.93 101 182530 13701 63292690
Peritonitis bacterial 32.80 9.93 54 182577 4825 63301566
Macular degeneration 32.69 9.93 148 182483 24228 63282163
White blood cell count decreased 32.61 9.93 572 182059 138532 63167859
Cellulitis 31.67 9.93 368 182263 81590 63224801
Hospice care 31.29 9.93 70 182561 7862 63298529
Cholestasis 31.12 9.93 167 182464 29267 63277124
Gout 30.71 9.93 96 182535 13175 63293216
Chest pain 30.38 9.93 825 181806 215134 63091257
Drug ineffective for unapproved indication 30.19 9.93 32 182599 34031 63272360
Accidental exposure to product 30.06 9.93 21 182610 27384 63279007
Hyperkaliuria 29.83 9.93 10 182621 56 63306335
Subileus 29.66 9.93 41 182590 3138 63303253
Disease progression 29.57 9.93 507 182124 122251 63184140
Suicidal ideation 29.54 9.93 87 182544 62334 63244057
Bradycardia 29.28 9.93 331 182300 72896 63233495
Acute motor-sensory axonal neuropathy 29.22 9.93 15 182616 274 63306117
Sedation complication 29.01 9.93 3 182628 13819 63292572
Wrong technique in product usage process 28.70 9.93 88 182543 62252 63244139
Endophthalmitis 28.65 9.93 43 182588 3549 63302842
Weight decreased 28.50 9.93 1018 181613 275780 63030611
Blood magnesium decreased 28.30 9.93 93 182538 13105 63293286
Loss of personal independence in daily activities 28.25 9.93 164 182467 97126 63209265
Sinusitis 27.92 9.93 471 182160 226182 63080209
Orthopnoea 27.85 9.93 58 182573 6203 63300188
Haemoptysis 27.71 9.93 159 182472 28567 63277824
Hypocalcaemia 27.69 9.93 171 182460 31542 63274849
Rectal haemorrhage 27.60 9.93 238 182393 48792 63257599
Hypercapnia 27.37 9.93 53 182578 5378 63301013
Skin reaction 26.94 9.93 99 182532 14750 63291641
Blood potassium abnormal 26.60 9.93 35 182596 2555 63303836
Generalised oedema 25.85 9.93 102 182529 15716 63290675
Inappropriate schedule of product administration 25.73 9.93 184 182447 103781 63202610
Electrocardiogram U wave present 25.68 9.93 10 182621 91 63306300
Hypernatraemia 25.50 9.93 63 182568 7546 63298845
Intentional overdose 25.47 9.93 118 182513 74034 63232357
Metabolic alkalosis 24.92 9.93 37 182594 3024 63303367
Headache 24.75 9.93 1531 181100 631710 62674681
Cardioactive drug level increased 24.59 9.93 31 182600 2169 63304222
Osteoarthritis 24.45 9.93 167 182464 95176 63211215
Tenosynovitis 24.33 9.93 5 182626 13790 63292601
Drug eruption 24.28 9.93 28 182603 28666 63277725
Adverse event 24.11 9.93 106 182525 67453 63238938
Red blood cell sedimentation rate increased 24.08 9.93 57 182574 43925 63262466
Acute left ventricular failure 23.84 9.93 22 182609 1077 63305314
Prothrombin time prolonged 23.83 9.93 71 182560 9493 63296898
Blood potassium increased 23.69 9.93 110 182521 18199 63288192
Toxic epidermal necrolysis 23.64 9.93 139 182492 25195 63281196
Blood creatinine increased 23.44 9.93 369 182262 87475 63218916
Left ventricular failure 23.35 9.93 51 182580 5636 63300755
Supraventricular tachycardia 23.30 9.93 92 182539 14179 63292212
Arthritis 23.27 9.93 217 182414 115704 63190687
Prescribed overdose 23.22 9.93 39 182592 34114 63272277
Haematocrit decreased 23.22 9.93 193 182438 39147 63267244
Malnutrition 22.90 9.93 96 182535 15202 63291189
Head injury 22.84 9.93 146 182485 27250 63279141
Live birth 22.80 9.93 24 182607 25606 63280785
Drug tolerance decreased 22.55 9.93 11 182620 17462 63288929
Immune effector cell-associated neurotoxicity syndrome 22.20 9.93 30 182601 2247 63304144
Foetal exposure during pregnancy 22.20 9.93 36 182595 31926 63274465
Gastritis 22.01 9.93 183 182448 37120 63269271
Adverse drug reaction 21.76 9.93 137 182494 79577 63226814
Calcium deficiency 21.69 9.93 21 182610 1093 63305298
Foot deformity 21.66 9.93 29 182602 27824 63278567
Blood pressure fluctuation 21.60 9.93 65 182566 46252 63260139
Pseudomonal bacteraemia 21.56 9.93 25 182606 1603 63304788
Troponin increased 21.41 9.93 71 182560 10050 63296341
Bezoar 21.16 9.93 24 182607 1502 63304889
Hyperthyroidism 21.13 9.93 91 182540 14582 63291809
Hepatotoxicity 21.09 9.93 47 182584 36994 63269397
Impaired work ability 21.08 9.93 12 182619 17463 63288928
Injury 20.98 9.93 124 182507 73123 63233268
Chronic kidney disease 20.84 9.93 211 182420 45187 63261204
Subdural haematoma 20.74 9.93 89 182542 14239 63292152
Body height decreased 20.70 9.93 70 182561 10008 63296383
Pneumothorax spontaneous 20.68 9.93 18 182613 816 63305575
Clostridium difficile infection 20.53 9.93 152 182479 29770 63276621
Cardiogenic shock 20.52 9.93 104 182527 17828 63288563
Therapy non-responder 20.44 9.93 131 182500 75770 63230621
Failure to thrive 20.43 9.93 56 182575 7142 63299249
Night sweats 20.34 9.93 72 182559 48742 63257649
Leukocytosis 20.28 9.93 136 182495 25799 63280592
Peripheral circulatory failure 20.27 9.93 19 182612 949 63305442
Serotonin syndrome 20.21 9.93 32 182599 28650 63277741
Disability 20.20 9.93 14 182617 18333 63288058
Facet joint syndrome 20.20 9.93 5 182626 12133 63294258
Electrocardiogram abnormal 19.97 9.93 65 182566 9114 63297277
Confusion postoperative 19.89 9.93 11 182620 235 63306156
Abdominal distension 19.87 9.93 355 182276 86260 63220131
Injection site pruritus 19.85 9.93 65 182566 45051 63261340
Blood glucose increased 19.83 9.93 345 182286 83411 63222980
Arteriosclerosis coronary artery 19.77 9.93 61 182570 8312 63298079
Lymphoedema 19.60 9.93 76 182555 11616 63294775
Thyroid disorder 19.55 9.93 91 182540 15071 63291320
Unevaluable event 19.52 9.93 230 182401 51156 63255235
Blood immunoglobulin M increased 19.40 9.93 20 182611 1123 63305268
Congenital osteodystrophy 19.34 9.93 6 182625 25 63306366
Hypophagia 19.33 9.93 155 182476 31104 63275287
Blood albumin decreased 19.32 9.93 89 182542 14677 63291714
Haemorrhage 19.30 9.93 264 182367 60758 63245633
Urine chloride decreased 19.29 9.93 8 182623 87 63306304
Tonsillar haemorrhage 19.28 9.93 11 182620 250 63306141
Pulmonary arterial pressure increased 19.25 9.93 36 182595 3559 63302832
Hypovolaemia 19.23 9.93 71 182560 10602 63295789
Nail dystrophy 19.07 9.93 19 182612 1024 63305367
Product selection error 19.05 9.93 8 182623 90 63306301
Aspartate aminotransferase increased 18.97 9.93 365 182266 89912 63216479
Vaginal flatulence 18.93 9.93 34 182597 3259 63303132
Oesophageal spasm 18.92 9.93 33 182598 3090 63303301
Obstructive airways disorder 18.84 9.93 19 182612 20680 63285711
Product compounding quality issue 18.80 9.93 6 182625 28 63306363
Oxygen saturation decreased 18.56 9.93 358 182273 88227 63218164
Oesophageal pain 18.51 9.93 36 182595 3665 63302726
Pulmonary fibrosis 18.46 9.93 56 182575 39753 63266638
Acne 18.37 9.93 24 182607 23269 63283122
Nodule 18.36 9.93 20 182611 21006 63285385
Arteriovenous malformation 18.20 9.93 21 182610 1339 63305052
Device difficult to use 18.19 9.93 7 182624 12789 63293602
Lower gastrointestinal haemorrhage 18.19 9.93 57 182574 7833 63298558
Coronary artery disease 18.13 9.93 157 182474 32220 63274171
Electrocardiogram T wave peaked 18.11 9.93 10 182621 213 63306178
Pericardial effusion 18.02 9.93 148 182483 29910 63276481
Blood immunoglobulin G increased 17.87 9.93 28 182603 2399 63303992
Alkalosis hypochloraemic 17.85 9.93 9 182622 158 63306233
Myocardial infarction 17.75 9.93 394 182237 99499 63206892
Laboratory test abnormal 17.50 9.93 135 182496 26777 63279614
Coagulopathy 17.45 9.93 110 182521 20434 63285957
Nodal arrhythmia 17.35 9.93 19 182612 1144 63305247
Device related infection 17.30 9.93 121 182510 23271 63283120
Bursitis 17.26 9.93 52 182579 36989 63269402
Prothrombin consumption time prolonged 17.15 9.93 6 182625 39 63306352
Blood immunoglobulin A decreased 17.07 9.93 20 182611 1297 63305094
Activated partial thromboplastin time prolonged 17.01 9.93 51 182580 6842 63299549
Anterior chamber inflammation 16.99 9.93 11 182620 316 63306075
Gastric polyps 16.88 9.93 33 182598 3372 63303019
Cholelithiasis 16.86 9.93 197 182434 43728 63262663
Vascular purpura 16.79 9.93 21 182610 1457 63304934
Presyncope 16.76 9.93 137 182494 27648 63278743
Schizophrenia 16.76 9.93 4 182627 9948 63296443
Bacteraemia 16.72 9.93 96 182535 17252 63289139
Blood chloride decreased 16.61 9.93 44 182587 5498 63300893
Chronic respiratory failure 16.53 9.93 24 182607 1923 63304468
Paracentesis 16.51 9.93 17 182614 953 63305438
Chronic sinusitis 16.50 9.93 77 182554 12766 63293625
Atelectasis 16.40 9.93 112 182519 21371 63285020
Altered visual depth perception 16.34 9.93 11 182620 338 63306053
Mental status changes postoperative 16.33 9.93 9 182622 191 63306200
Occult blood positive 16.32 9.93 34 182597 3636 63302755
Paraesthesia oral 16.29 9.93 103 182528 19153 63287238
Urosepsis 16.24 9.93 100 182531 18424 63287967
Cerebral haematoma 16.24 9.93 34 182597 3649 63302742
Ankylosing spondylitis 16.15 9.93 5 182626 10469 63295922
Blood pressure diastolic abnormal 16.14 9.93 11 182620 14531 63291860
Purging 16.08 9.93 6 182625 48 63306343
Mitral valve incompetence 16.08 9.93 104 182527 19490 63286901
Hypoalbuminaemia 16.07 9.93 72 182559 11733 63294658
Device related sepsis 16.01 9.93 36 182595 4058 63302333
Lung infiltration 15.93 9.93 83 182548 14380 63292011
Sinus node dysfunction 15.92 9.93 39 182592 4646 63301745
Emphysema 15.87 9.93 68 182563 10870 63295521
Hypophosphataemia 15.79 9.93 70 182561 11356 63295035
Lung perforation 15.77 9.93 7 182624 91 63306300
Catheter site infection 15.75 9.93 40 182591 4874 63301517
Cardiac disorder 15.72 9.93 219 182412 50597 63255794
Wrong patient received product 15.62 9.93 25 182606 2182 63304209
Polyuria 15.54 9.93 57 182574 8485 63297906
Lip dry 15.51 9.93 13 182618 15457 63290934
Chronic left ventricular failure 15.49 9.93 12 182619 461 63305930
Peptic ulcer 15.39 9.93 38 182593 4549 63301842
Neuroglycopenia 15.37 9.93 12 182619 466 63305925
Polyarthritis 15.37 9.93 5 182626 10141 63296250
Somnolence 15.25 9.93 644 181987 178041 63128350
Cerebral haemorrhage 15.17 9.93 145 182486 30584 63275807
Hypoglycaemia 15.16 9.93 250 182381 59815 63246576
Lupus-like syndrome 15.15 9.93 13 182618 15282 63291109
Adenocarcinoma 15.13 9.93 29 182602 2921 63303470
Blood cholesterol decreased 15.09 9.93 16 182615 928 63305463
Blood pressure diastolic increased 15.04 9.93 5 182626 10005 63296386
Hiatus hernia 14.98 9.93 110 182521 21484 63284907
Wrong strength 14.91 9.93 6 182625 60 63306331
Gestational diabetes 14.90 9.93 3 182628 8393 63297998
Small intestinal obstruction 14.85 9.93 97 182534 18240 63288151
Urine sodium decreased 14.80 9.93 8 182623 163 63306228
Muscle spasticity 14.71 9.93 25 182606 21769 63284622
Atrioventricular block first degree 14.49 9.93 50 182581 7223 63299168
Acute pulmonary oedema 14.47 9.93 54 182577 8104 63298287
Pulse absent 14.45 9.93 41 182590 5333 63301058
Congenital bowing of long bones 14.41 9.93 6 182625 66 63306325
Wheezing 14.40 9.93 191 182440 95404 63210987
Diverticulum intestinal haemorrhagic 14.37 9.93 20 182611 1541 63304850
Injection site rash 14.21 9.93 20 182611 18789 63287602
Subclavian vein thrombosis 14.19 9.93 22 182609 1868 63304523
Proctitis 14.14 9.93 41 182590 5400 63300991
Vascular encephalopathy 14.03 9.93 11 182620 430 63305961
Thyroxine decreased 14.03 9.93 13 182618 640 63305751
Hypercholesterolaemia 13.92 9.93 25 182606 21309 63285082
Ageusia 13.91 9.93 77 182554 13651 63292740
Enterococcus test positive 13.87 9.93 17 182614 1156 63305235
Hypoxic-ischaemic encephalopathy 13.84 9.93 35 182596 4252 63302139
Cataract operation 13.76 9.93 41 182590 5481 63300910
Blood pressure systolic abnormal 13.73 9.93 11 182620 13375 63293016
Pruritus 13.70 9.93 876 181755 360577 62945814
Creatinine renal clearance decreased 13.70 9.93 16 182615 16292 63290099
Muscle haemorrhage 13.62 9.93 29 182602 3150 63303241
Skin candida 13.47 9.93 20 182611 1635 63304756
Cataract operation complication 13.39 9.93 7 182624 133 63306258
Finger deformity 13.27 9.93 3 182628 7742 63298649
Cardiac amyloidosis 13.26 9.93 14 182617 808 63305583
Bone erosion 13.22 9.93 19 182612 17698 63288693
Drug resistance 13.14 9.93 29 182602 22904 63283487
Flail chest 13.12 9.93 6 182625 84 63306307
Micturition disorder 13.07 9.93 25 182606 2513 63303878
Blood glucose decreased 13.01 9.93 104 182527 20848 63285543
Right atrial pressure increased 12.89 9.93 7 182624 144 63306247
Blood calcium abnormal 12.81 9.93 17 182614 1251 63305140
Pseudomonal sepsis 12.80 9.93 24 182607 2377 63304014
Injection site warmth 12.67 9.93 15 182616 15180 63291211
Vascular device infection 12.64 9.93 48 182583 7264 63299127
Polyneuropathy 12.60 9.93 14 182617 14575 63291816
Tracheal obstruction 12.51 9.93 6 182625 94 63306297
Catheter site haemorrhage 12.50 9.93 28 182603 3147 63303244
Acute coronary syndrome 12.49 9.93 60 182571 10066 63296325
Incision site pain 12.44 9.93 16 182615 1142 63305249
Abortion induced 12.40 9.93 7 182624 10235 63296156
Neutropenia 12.39 9.93 619 182012 174386 63132005
Pneumonia bacterial 12.34 9.93 57 182574 9408 63296983
Hydronephrosis 12.31 9.93 62 182569 10600 63295791
Aortic valve disease 12.30 9.93 16 182615 1155 63305236
Mood swings 12.26 9.93 21 182610 18227 63288164
Blood sodium decreased 12.25 9.93 115 182516 24137 63282254
Hospitalisation 12.22 9.93 326 182305 84755 63221636
Dermatitis exfoliative 12.18 9.93 39 182592 5420 63300971
Transplant rejection 12.17 9.93 8 182623 10772 63295619
Scleroderma 12.17 9.93 39 182592 5423 63300968
Food allergy 12.16 9.93 9 182622 11392 63294999
Pulmonary arterial wedge pressure increased 12.12 9.93 9 182622 324 63306067
Depressed level of consciousness 12.11 9.93 117 182514 61961 63244430
Blood albumin abnormal 12.10 9.93 11 182620 528 63305863
Pain in jaw 12.09 9.93 184 182447 43312 63263079
Depressed mood 12.07 9.93 67 182564 40124 63266267
Thoracic operation 12.04 9.93 7 182624 165 63306226
Hyperglycaemia 11.99 9.93 178 182453 41689 63264702
Oxygen therapy 11.90 9.93 22 182609 2156 63304235
Acute myocardial infarction 11.85 9.93 143 182488 31981 63274410
Paralysis recurrent laryngeal nerve 11.85 9.93 5 182626 57 63306334
Fear of injection 11.83 9.93 3 182628 7161 63299230
Subclavian artery thrombosis 11.78 9.93 7 182624 172 63306219
Cystitis 11.78 9.93 223 182408 54768 63251623
Blood pressure systolic increased 11.66 9.93 84 182547 47313 63259078
Atrioventricular block second degree 11.66 9.93 31 182600 3883 63302508
Congestive hepatopathy 11.65 9.93 26 182605 2916 63303475
Retinal ischaemia 11.59 9.93 9 182622 347 63306044
Parkinsonism 11.56 9.93 60 182571 10379 63296012
Sedation 11.49 9.93 65 182566 38744 63267647
Poor peripheral circulation 11.48 9.93 30 182601 3719 63302672
Skin dystrophy 11.47 9.93 5 182626 62 63306329
Pneumonia klebsiella 11.46 9.93 23 182608 2396 63303995
Catheter site extravasation 11.39 9.93 9 182622 356 63306035
Uterine perforation 11.34 9.93 3 182628 6960 63299431
Alkalosis 11.26 9.93 9 182622 362 63306029
Demyelination 11.23 9.93 3 182628 6917 63299474
Dermatitis exfoliative generalised 11.19 9.93 30 182601 3777 63302614
Electrocardiogram U-wave abnormality 11.18 9.93 4 182627 28 63306363
Catheter placement 11.16 9.93 22 182609 2262 63304129
Sopor 11.14 9.93 30 182601 22134 63284257
Cardiovascular insufficiency 11.14 9.93 17 182614 1424 63304967
Movement disorder 11.13 9.93 29 182602 21632 63284759
Anterior chamber disorder 11.07 9.93 6 182625 123 63306268
Ovarian cyst 11.03 9.93 18 182613 15927 63290464
Disseminated intravascular coagulation 10.99 9.93 93 182538 18958 63287433
Ear pain 10.96 9.93 60 182571 36058 63270333
Toxic skin eruption 10.95 9.93 69 182562 12816 63293575
Red blood cell count decreased 10.94 9.93 171 182460 40474 63265917
Uveitis 10.89 9.93 12 182619 12541 63293850
Panniculitis 10.89 9.93 10 182621 11375 63295016
Sleep apnoea syndrome 10.89 9.93 130 182501 29003 63277388
Cardiorenal syndrome 10.86 9.93 13 182618 862 63305529
Oropharyngeal pain 10.77 9.93 199 182432 94288 63212103
Iron deficiency anaemia 10.75 9.93 96 182535 19873 63286518
Therapeutic response shortened 10.72 9.93 11 182620 11877 63294514
Sinoatrial block 10.71 9.93 13 182618 875 63305516
Haematemesis 10.63 9.93 134 182497 30278 63276113
Transient ischaemic attack 10.61 9.93 160 182471 37593 63268798
Cerebral ventricular rupture 10.57 9.93 7 182624 209 63306182
Haematotoxicity 10.53 9.93 7 182624 9369 63297022
Transplant evaluation 10.52 9.93 15 182616 1182 63305209
Serratia test positive 10.51 9.93 4 182627 34 63306357
Dry mouth 10.51 9.93 159 182472 77704 63228687
Faecaloma 10.49 9.93 48 182583 7893 63298498
Bronchiectasis 10.46 9.93 19 182612 16123 63290268
Asthma 10.45 9.93 283 182348 127278 63179113
Autoimmune disorder 10.45 9.93 21 182610 17156 63289235
Abdominal pain 10.44 9.93 980 181651 292476 63013915
Abortion incomplete complicated 10.43 9.93 3 182628 9 63306382
Bladder outlet obstruction 10.43 9.93 3 182628 9 63306382
Deposit eye 10.43 9.93 3 182628 9 63306382
Blood urea decreased 10.39 9.93 22 182609 2380 63304011
Blood magnesium abnormal 10.38 9.93 11 182620 638 63305753
Vascular pseudoaneurysm 10.34 9.93 17 182614 1517 63304874
Upper gastrointestinal haemorrhage 10.34 9.93 91 182540 18761 63287630
Pulmonary thrombosis 10.33 9.93 51 182580 8651 63297740
Pharyngitis 10.33 9.93 27 182604 20116 63286275
Polymyalgia rheumatica 10.27 9.93 29 182602 3762 63302629
Cardiac failure chronic 10.26 9.93 32 182599 4386 63302005
Cor pulmonale chronic 10.26 9.93 7 182624 220 63306171
Female genital tract fistula 10.21 9.93 46 182585 7513 63298878
Colour blindness 10.20 9.93 8 182623 313 63306078
Haemorrhagic arteriovenous malformation 10.15 9.93 6 182625 146 63306245
Staphylococcal infection 10.14 9.93 171 182460 41085 63265306
Neonatal infection 10.12 9.93 6 182625 147 63306244
Paratracheal lymphadenopathy 10.03 9.93 4 182627 39 63306352
Multiple drug therapy 9.98 9.93 28 182603 3618 63302773

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 367.51 10.29 526 107207 456225 34392973
Hypokalaemia 236.15 10.29 541 107192 57673 34791525
Hyperkalaemia 215.18 10.29 582 107151 68807 34780391
Drug abuse 194.92 10.29 35 107698 99061 34750137
Cardiac failure congestive 161.67 10.29 594 107139 82676 34766522
Cardiac failure 138.66 10.29 603 107130 90645 34758553
Toxicity to various agents 124.70 10.29 270 107463 200092 34649106
Acute kidney injury 120.18 10.29 1451 106282 303537 34545661
Off label use 116.93 10.29 786 106947 418738 34430460
Atrial fibrillation 116.78 10.29 710 107023 121683 34727515
Toxic anterior segment syndrome 115.20 10.29 61 107672 1108 34848090
Oedema peripheral 113.03 10.29 693 107040 119119 34730079
Hypotension 84.70 10.29 1049 106684 220600 34628598
Cardiogenic shock 83.14 10.29 224 107509 26394 34822804
Dyspnoea 82.62 10.29 1623 106110 375159 34474039
Dehydration 79.22 10.29 677 107056 129292 34719906
Treatment failure 76.99 10.29 24 107709 46673 34802525
Blood potassium decreased 75.34 10.29 169 107564 17746 34831452
Suicide attempt 70.30 10.29 17 107716 39099 34810099
International normalised ratio increased 69.71 10.29 310 107423 47017 34802181
Appendicolith 68.85 10.29 107 107626 8494 34840704
Therapeutic product effect incomplete 67.10 10.29 36 107697 50505 34798693
Hypervolaemia 65.76 10.29 170 107563 19539 34829659
Asthenia 64.31 10.29 1087 106646 244164 34605034
Ventricular fibrillation 63.65 10.29 185 107548 22769 34826429
Right ventricular failure 61.73 10.29 103 107630 8681 34840517
Pneumonia 56.48 10.29 1489 106244 361138 34488060
Ascites 56.20 10.29 288 107445 46283 34802915
Fluid retention 55.67 10.29 196 107537 26691 34822507
Abdominal distension 55.49 10.29 339 107394 58153 34791045
Anaemia 55.37 10.29 1018 106715 232317 34616881
Product use in unapproved indication 55.06 10.29 182 107551 117317 34731881
Rheumatoid arthritis 51.10 10.29 27 107706 38211 34810987
Pulmonary arterial hypertension 49.20 10.29 93 107640 8646 34840552
Cytokine release syndrome 48.42 10.29 168 107565 22709 34826489
Blood phosphorus increased 47.03 10.29 85 107648 7636 34841562
Pulmonary hypertension 45.46 10.29 155 107578 20769 34828429
Plasma cell myeloma 44.62 10.29 251 107482 41786 34807412
Intentional product use issue 42.86 10.29 74 107659 59742 34789456
Arthralgia 40.68 10.29 332 107401 169709 34679489
Acute respiratory failure 40.66 10.29 196 107537 30732 34818466
Spinal muscular atrophy 39.97 10.29 21 107712 375 34848823
Tachypnoea 39.91 10.29 136 107597 18216 34830982
Appendicitis 39.76 10.29 118 107615 14689 34834509
Sepsis 39.55 10.29 727 107006 165834 34683364
Toxic epidermal necrolysis 38.28 10.29 150 107583 21496 34827702
Foetal exposure during pregnancy 36.58 10.29 38 107695 38063 34811135
Incision site pain 36.24 10.29 36 107697 1802 34847396
Gastrointestinal haemorrhage 35.52 10.29 423 107310 88054 34761144
Chronic obstructive pulmonary disease 33.61 10.29 262 107471 48656 34800542
Injection site pain 33.03 10.29 43 107690 38962 34810236
Hyponatraemia 32.60 10.29 394 107339 82297 34766901
Ventricular tachycardia 32.49 10.29 165 107568 26414 34822784
Drug resistance 32.22 10.29 20 107713 25907 34823291
Suicidal ideation 31.72 10.29 47 107686 40341 34808857
Serotonin syndrome 31.52 10.29 11 107722 19922 34829276
Musculoskeletal stiffness 31.42 10.29 60 107673 46620 34802578
Blood lactic acid 31.14 10.29 17 107716 329 34848869
General physical health deterioration 30.47 10.29 560 107173 127709 34721489
Meningitis aseptic 29.94 10.29 43 107690 3181 34846017
Psoriasis 29.68 10.29 46 107687 38766 34810432
Alveolar lung disease 29.40 10.29 17 107716 369 34848829
Sedation 29.31 10.29 14 107719 20992 34828206
Headache 29.11 10.29 439 107294 200196 34649002
Oedema 28.72 10.29 240 107493 45501 34803697
Therapeutic product effect decreased 28.71 10.29 39 107694 34704 34814494
Drug interaction 27.99 10.29 509 107224 225437 34623761
Diaphragmatic spasm 27.05 10.29 11 107722 105 34849093
Intentional overdose 26.96 10.29 59 107674 43615 34805583
Intentional self-injury 26.75 10.29 5 107728 13766 34835432
Blood urea increased 26.30 10.29 172 107561 30192 34819006
Cardiorenal syndrome 26.12 10.29 20 107713 703 34848495
Stoma closure 25.92 10.29 14 107719 265 34848933
Fall 25.89 10.29 813 106920 202072 34647126
Faecal volume decreased 25.84 10.29 11 107722 119 34849079
Pneumococcal sepsis 25.69 10.29 24 107709 1113 34848085
Lower respiratory tract infection 25.65 10.29 36 107697 31601 34817597
Aggression 25.43 10.29 51 107682 38913 34810285
Motor neurone disease 24.84 10.29 17 107716 500 34848698
Drug ineffective for unapproved indication 24.69 10.29 22 107711 23693 34825505
Pulmonary interstitial emphysema syndrome 24.63 10.29 17 107716 507 34848691
Stress 23.95 10.29 168 107565 30179 34819019
Urticaria 23.77 10.29 105 107628 62272 34786926
Obstructive airways disorder 23.74 10.29 9 107724 15485 34833713
Mental status changes 23.47 10.29 199 107534 37884 34811314
Drug dependence 23.42 10.29 24 107709 24193 34825005
Cardiac failure chronic 23.29 10.29 65 107668 7814 34841384
Cytomegalovirus infection 22.97 10.29 28 107705 26107 34823091
Therapeutic response decreased 22.17 10.29 35 107698 29278 34819920
Blood creatinine increased 21.96 10.29 413 107320 94563 34754635
Increased bronchial secretion 21.90 10.29 28 107705 1853 34847345
Ventricular extrasystoles 21.87 10.29 84 107649 11924 34837274
Foetal disorder 21.74 10.29 19 107714 807 34848391
Hypomagnesaemia 21.57 10.29 128 107605 21723 34827475
Rectal haemorrhage 21.56 10.29 204 107529 40045 34809153
Inappropriate schedule of product administration 21.32 10.29 109 107624 62187 34787011
Peritoneal haematoma 21.23 10.29 8 107725 61 34849137
Loss of personal independence in daily activities 21.17 10.29 44 107689 33135 34816063
Haemoglobin decreased 21.06 10.29 504 107229 120268 34728930
Hypoxia 21.04 10.29 261 107472 54834 34794364
Oropharyngeal pain 21.04 10.29 49 107684 35436 34813762
Blood loss anaemia 20.78 10.29 64 107669 8130 34841068
Puncture site haematoma 20.77 10.29 10 107723 147 34849051
Glomerular filtration rate 20.47 10.29 9 107724 106 34849092
Cardiac output decreased 20.34 10.29 19 107714 881 34848317
Overdose 20.30 10.29 181 107552 90878 34758320
Cardiomyopathy 20.30 10.29 104 107629 16704 34832494
Cataract operation complication 20.24 10.29 10 107723 156 34849042
Product dose omission issue 20.18 10.29 254 107479 119457 34729741
Drug reaction with eosinophilia and systemic symptoms 20.05 10.29 45 107688 32967 34816231
Multiple organ dysfunction syndrome 19.84 10.29 339 107394 76227 34772971
Sputum increased 19.69 10.29 30 107703 2340 34846858
Scrotal oedema 19.42 10.29 26 107707 1800 34847398
Constipation 19.36 10.29 556 107177 136426 34712772
Joint swelling 19.26 10.29 107 107626 59783 34789415
Lymphadenectomy 19.25 10.29 13 107720 374 34848824
Product use issue 19.23 10.29 115 107618 63101 34786097
Insomnia 19.23 10.29 216 107517 103691 34745507
Disease complication 19.11 10.29 32 107701 2704 34846494
Product residue present 19.03 10.29 32 107701 2714 34846484
Atrial flutter 18.56 10.29 96 107637 15478 34833720
Exercise tolerance decreased 18.55 10.29 46 107687 5152 34844046
Lower respiratory tract infection bacterial 18.41 10.29 14 107719 487 34848711
Blood pressure fluctuation 18.29 10.29 31 107702 25218 34823980
Prothrombin time prolonged 18.13 10.29 67 107666 9339 34839859
Generalised oedema 18.04 10.29 81 107652 12327 34836871
Neutropenia neonatal 17.98 10.29 16 107717 696 34848502
N-terminal prohormone brain natriuretic peptide increased 17.97 10.29 31 107702 2684 34846514
Diarrhoea 17.96 10.29 1414 106319 388498 34460700
Right ventricular dysfunction 17.79 10.29 20 107713 1156 34848042
Therapy partial responder 17.63 10.29 4 107729 9612 34839586
Cardioactive drug level increased 17.58 10.29 24 107709 1693 34847505
Skin pressure mark 17.57 10.29 7 107726 63 34849135
Resuscitation 17.50 10.29 22 107711 1431 34847767
Dyspnoea exertional 17.39 10.29 207 107526 43072 34806126
Intentional product misuse 17.24 10.29 77 107656 45534 34803664
Sensory integrative dysfunction 17.15 10.29 6 107727 36 34849162
Blood bilirubin increased 17.11 10.29 187 107546 38109 34811089
Femoral artery aneurysm 16.97 10.29 9 107724 164 34849034
Atelectasis 16.96 10.29 103 107630 17624 34831574
Hepatotoxicity 16.87 10.29 25 107708 21460 34827738
Atrial enlargement 16.77 10.29 15 107718 657 34848541
Emotional disorder of childhood 16.74 10.29 6 107727 39 34849159
Angioedema 16.73 10.29 59 107674 37315 34811883
Psoriatic arthropathy 16.58 10.29 22 107711 19776 34829422
Bronchial disorder 16.51 10.29 21 107712 1382 34847816
Red blood cell sedimentation rate increased 16.42 10.29 4 107729 9158 34840040
Transient aphasia 16.41 10.29 12 107721 393 34848805
Lung infiltration 16.39 10.29 81 107652 12824 34836374
Heparin-induced thrombocytopenia 16.38 10.29 46 107687 5549 34843649
Cardiac disorder 16.34 10.29 204 107529 42922 34806276
Cerebellar ischaemia 16.18 10.29 8 107725 125 34849073
Cor pulmonale 16.12 10.29 16 107717 800 34848398
Hypoparathyroidism 16.09 10.29 14 107719 591 34848607
Arthropathy 16.08 10.29 37 107696 26870 34822328
Blood chloride decreased 16.06 10.29 36 107697 3777 34845421
Therapeutic product effect prolonged 16.01 10.29 10 107723 251 34848947
Psychotic disorder 15.96 10.29 32 107701 24420 34824778
Peri-implantitis 15.90 10.29 8 107725 130 34849068
Haematotoxicity 15.86 10.29 3 107730 8191 34841007
Congestive cardiomyopathy 15.76 10.29 55 107678 7455 34841743
Troponin T increased 15.60 10.29 27 107706 2344 34846854
Vascular purpura 15.47 10.29 23 107710 1755 34847443
Electrocardiogram T wave amplitude decreased 15.29 10.29 11 107722 351 34848847
Pulmonary oedema 15.18 10.29 218 107515 47311 34801887
Hypernatraemia 15.14 10.29 59 107674 8431 34840767
Respiratory failure 15.14 10.29 440 107293 108132 34741066
Erythema 15.10 10.29 188 107545 88592 34760606
Acquired haemophilia 14.98 10.29 17 107716 993 34848205
Injection site reaction 14.92 10.29 11 107722 13022 34836176
Supraventricular extrasystoles 14.64 10.29 33 107700 3475 34845723
Mobility decreased 14.55 10.29 46 107687 30082 34819116
Tendonitis 14.53 10.29 5 107728 9135 34840063
Chronic left ventricular failure 14.45 10.29 13 107720 574 34848624
Substance abuse 14.37 10.29 3 107730 7638 34841560
Cellulitis 14.28 10.29 236 107497 52715 34796483
Polyneuropathy 14.13 10.29 15 107718 14881 34834317
Lymphadenopathy 14.07 10.29 43 107690 28420 34820778
Wrong technique in product usage process 14.06 10.29 60 107673 35926 34813272
Dystonia 13.99 10.29 8 107725 10837 34838361
Hypovolaemia 13.97 10.29 61 107672 9173 34840025
Metabolic alkalosis 13.91 10.29 20 107713 1481 34847717
Drug eruption 13.90 10.29 25 107708 19873 34829325
Myasthenia gravis 13.85 10.29 50 107683 6890 34842308
Haematoma 13.82 10.29 130 107603 25475 34823723
Blood gases abnormal 13.82 10.29 10 107723 322 34848876
Completed suicide 13.80 10.29 216 107517 97952 34751246
Depressed mood 13.74 10.29 24 107709 19293 34829905
Therapeutic response shortened 13.73 10.29 3 107730 7401 34841797
Ischaemic cerebral infarction 13.64 10.29 18 107715 1229 34847969
Ischaemic cardiomyopathy 13.59 10.29 47 107686 6342 34842856
C-reactive protein abnormal 13.44 10.29 5 107728 8705 34840493
Rash 13.35 10.29 556 107177 222196 34627002
International normalised ratio fluctuation 13.34 10.29 18 107715 1256 34847942
Shoshin beriberi 13.26 10.29 6 107727 76 34849122
Type IIa hyperlipidaemia 13.20 10.29 8 107725 190 34849008
Hypophosphataemia 13.16 10.29 68 107665 10958 34838240
Cognitive disorder 13.04 10.29 45 107688 28648 34820550
Injection site swelling 12.85 10.29 10 107723 11517 34837681
N-terminal prohormone brain natriuretic peptide abnormal 12.80 10.29 8 107725 201 34848997
Right atrial pressure increased 12.72 10.29 6 107727 84 34849114
Blood uric acid increased 12.65 10.29 61 107672 9563 34839635
Pruritus 12.61 10.29 337 107396 141644 34707554
Body temperature decreased 12.51 10.29 13 107720 13021 34836177
Infusion related reaction 12.47 10.29 104 107629 52953 34796245
Endophthalmitis 12.47 10.29 31 107702 3477 34845721
Withdrawal syndrome 12.44 10.29 12 107721 12443 34836755
Red blood cells urine positive 12.43 10.29 21 107712 1788 34847410
Seizure 12.39 10.29 238 107495 104619 34744579
Respiratory distress 12.37 10.29 166 107567 35499 34813699
Alkalosis 12.31 10.29 7 107726 147 34849051
Catheter management 12.25 10.29 15 107718 950 34848248
Device related infection 12.21 10.29 93 107640 17144 34832054
Limited symptom panic attack 12.18 10.29 5 107728 49 34849149
Aspiration pleural cavity 12.17 10.29 14 107719 830 34848368
Drug intolerance 12.16 10.29 121 107612 59449 34789749
Hepatic cirrhosis 12.03 10.29 93 107640 17221 34831977
Poisoning 11.95 10.29 12 107721 12214 34836984
Drug-induced liver injury 11.93 10.29 47 107686 28785 34820413
Anaphylactic reaction 11.93 10.29 55 107678 32246 34816952
Glomerular filtration rate abnormal 11.91 10.29 14 107719 849 34848349
Blood albumin decreased 11.82 10.29 77 107656 13495 34835703
Oesophageal carcinoma 11.81 10.29 7 107726 9297 34839901
Cardiac failure acute 11.80 10.29 64 107669 10506 34838692
Pleural effusion 11.78 10.29 332 107401 81214 34767984
Clostridium difficile colitis 11.78 10.29 86 107647 15644 34833554
Sopor 11.76 10.29 12 107721 12124 34837074
Schizophrenia 11.75 10.29 6 107727 8660 34840538
Asthma 11.74 10.29 80 107653 42576 34806622
Bradycardia 11.73 10.29 310 107423 75108 34774090
Drug hypersensitivity 11.72 10.29 176 107557 80353 34768845
Blood pressure increased 11.67 10.29 196 107537 87906 34761292
Systemic infection 11.66 10.29 39 107694 5173 34844025
Anxiety 11.65 10.29 226 107507 99202 34749996
Hyperphosphataemia 11.57 10.29 35 107698 4402 34844796
Left ventricular dysfunction 11.45 10.29 61 107672 9946 34839252
Respiratory tract infection bacterial 11.34 10.29 20 107713 1762 34847436
Hepatic function abnormal 11.33 10.29 85 107648 44278 34804920
Blood pressure diastolic decreased 11.32 10.29 7 107726 9087 34840111
Drug level decreased 11.30 10.29 5 107728 7841 34841357
Renal atrophy 11.29 10.29 16 107717 1169 34848029
Hypersensitivity 11.23 10.29 127 107606 60908 34788290
Arthritis 11.20 10.29 54 107679 31292 34817906
Haematocrit decreased 11.19 10.29 150 107583 32066 34817132
Arrhythmia supraventricular 11.19 10.29 17 107716 1323 34847875
Pseudolymphoma 11.15 10.29 12 107721 660 34848538
Ileus 11.12 10.29 88 107645 16411 34832787
Pulmonary valve replacement 11.08 10.29 3 107730 6 34849192
Renal tubular acidosis 11.03 10.29 23 107710 2296 34846902
Gout 11.02 10.29 99 107634 19154 34830044
Depression 10.99 10.29 222 107511 96876 34752322
Accidental exposure to product 10.95 10.29 14 107719 12788 34836410
Product substitution issue 10.95 10.29 9 107724 10086 34839112
Mania 10.93 10.29 8 107725 9503 34839695
Shock haemorrhagic 10.88 10.29 66 107667 11288 34837910
Pathogen resistance 10.86 10.29 8 107725 9474 34839724
Coagulation factor VII level decreased 10.86 10.29 6 107727 119 34849079
Extrasystoles 10.77 10.29 31 107702 3792 34845406
Deep vein thrombosis 10.67 10.29 270 107463 64978 34784220
Body height decreased 10.67 10.29 31 107702 3812 34845386
Foetal malnutrition 10.67 10.29 5 107728 69 34849129
Cardiac pacemaker evaluation 10.64 10.29 6 107727 124 34849074
Nikolsky's sign 10.59 10.29 7 107726 194 34849004
Nephropathy toxic 10.53 10.29 14 107719 12574 34836624
Iron deficiency anaemia 10.51 10.29 61 107672 10268 34838930
Drug withdrawal syndrome 10.51 10.29 29 107704 19805 34829393
Lactobacillus test positive 10.45 10.29 4 107729 32 34849166
Stasis dermatitis 10.44 10.29 14 107719 971 34848227
Torsade de pointes 10.44 10.29 47 107686 7162 34842036
Chronic respiratory failure 10.37 10.29 17 107716 1412 34847786
Catheter site infection 10.36 10.29 24 107709 2573 34846625
Leukopenia 10.35 10.29 134 107599 62722 34786476
Cortical visual impairment 10.34 10.29 4 107729 33 34849165
Myelosuppression 10.33 10.29 28 107705 19237 34829961

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 820.92 9.55 1234 237514 1079679 78425961
Hyperkalaemia 574.70 9.55 1140 237608 113258 79392382
Hypokalaemia 533.36 9.55 1269 237479 142771 79362869
Cardiac failure congestive 387.16 9.55 1118 237630 141284 79364356
Acute kidney injury 340.87 9.55 2688 236060 516716 78988924
Atrial fibrillation 294.86 9.55 1274 237474 196612 79309028
Hand deformity 289.91 9.55 4 238744 103915 79401725
Pemphigus 281.53 9.55 3 238745 99579 79406061
Drug abuse 268.40 9.55 77 238671 162614 79343026
Oedema peripheral 250.68 9.55 1448 237300 250840 79254800
Joint swelling 245.34 9.55 302 238446 288344 79217296
Toxicity to various agents 240.79 9.55 569 238179 420971 79084669
Hypervolaemia 234.43 9.55 442 238306 42248 79463392
Off label use 233.74 9.55 1675 237073 905540 78600100
Anaemia 229.75 9.55 2185 236563 442830 79062810
Rheumatoid arthritis 229.60 9.55 173 238575 208297 79297343
Therapeutic product effect decreased 228.70 9.55 102 238646 163761 79341879
Systemic lupus erythematosus 219.88 9.55 47 238701 121102 79384538
Cardiac failure 217.74 9.55 980 237768 153862 79351778
Dehydration 214.51 9.55 1374 237374 246813 79258827
Pneumonia 204.57 9.55 2937 235811 657309 78848331
Arthropathy 201.48 9.55 142 238606 176969 79328671
Musculoskeletal stiffness 198.18 9.55 141 238607 174867 79330773
Contraindicated product administered 196.04 9.55 114 238634 157424 79348216
Toxic anterior segment syndrome 193.31 9.55 114 238634 2650 79502990
Blood potassium decreased 190.88 9.55 427 238321 46085 79459555
Pulmonary hypertension 187.98 9.55 433 238315 47647 79457993
Pericarditis 185.99 9.55 42 238706 104194 79401446
Arthralgia 176.46 9.55 998 237750 570805 78934835
Hypotension 175.40 9.55 2052 236696 438265 79067375
Lower respiratory tract infection 174.77 9.55 84 238664 129136 79376504
Dyspnoea 174.07 9.55 3561 235187 853464 78652176
Glossodynia 173.96 9.55 47 238701 103290 79402350
Drug intolerance 173.69 9.55 329 238419 263790 79241850
Right ventricular failure 171.71 9.55 276 238472 23221 79482419
Pulmonary arterial hypertension 171.26 9.55 306 238442 28060 79477580
Alopecia 170.56 9.55 268 238480 231087 79274553
Duodenal ulcer perforation 161.48 9.55 9 238739 66202 79439438
Sepsis 157.69 9.55 1360 237388 268068 79237572
Helicobacter infection 156.94 9.55 14 238734 69690 79435950
Treatment failure 155.97 9.55 168 238580 170318 79335322
Acute respiratory failure 154.50 9.55 460 238288 59081 79446559
Wound 147.49 9.55 82 238666 116097 79389543
International normalised ratio increased 146.19 9.55 571 238177 84150 79421490
Fluid retention 145.31 9.55 500 238248 69309 79436331
Maternal exposure during pregnancy 144.35 9.55 118 238630 136420 79369220
Gastrointestinal haemorrhage 140.17 9.55 838 237910 146881 79358759
Synovitis 139.59 9.55 147 238601 150587 79355053
Abdominal discomfort 130.90 9.55 354 238394 250373 79255267
Drug hypersensitivity 129.86 9.55 459 238289 298457 79207183
Plasma cell myeloma 128.38 9.55 401 238347 52858 79452782
Infusion related reaction 127.14 9.55 316 238432 229921 79275719
Product use in unapproved indication 125.86 9.55 360 238388 249999 79255641
Muscle injury 120.30 9.55 6 238742 48555 79457085
Cytokine release syndrome 120.14 9.55 305 238443 35693 79469947
Hyponatraemia 117.54 9.55 923 237825 176925 79328715
Colitis microscopic 114.43 9.55 151 238597 10617 79495023
Intentional product use issue 112.25 9.55 176 238572 151936 79353704
Discomfort 111.34 9.55 127 238621 125490 79380150
Hypoxia 107.90 9.55 601 238147 102642 79402998
Hypersensitivity 107.11 9.55 413 238335 261826 79243814
Chronic obstructive pulmonary disease 102.79 9.55 517 238231 84902 79420738
Folliculitis 101.46 9.55 21 238727 55359 79450281
Pain 100.88 9.55 1492 237256 702310 78803330
Hepatic enzyme increased 100.50 9.55 251 238497 182359 79323281
Asthenia 99.13 9.55 2113 236635 509576 78996064
Irritable bowel syndrome 98.02 9.55 32 238716 62209 79443431
Respiratory failure 95.89 9.55 894 237854 180017 79325623
Cardiogenic shock 95.01 9.55 309 238439 41605 79464035
Product use issue 94.58 9.55 317 238431 209505 79296135
Diarrhoea 92.73 9.55 3361 235387 877128 78628512
Therapeutic product effect incomplete 91.67 9.55 178 238570 141467 79364173
Ascites 91.38 9.55 458 238290 75104 79430536
Renal failure 88.60 9.55 956 237792 200012 79305628
Rash 85.96 9.55 1217 237531 577141 78928499
Injection site pain 85.92 9.55 161 238587 129677 79375963
Suicide attempt 83.57 9.55 75 238673 82857 79422783
Impaired healing 81.67 9.55 85 238663 87570 79418070
Exposure during pregnancy 81.48 9.55 110 238638 101022 79404618
Fall 79.88 9.55 1967 236781 485662 79019978
Psoriatic arthropathy 75.69 9.55 73 238675 77926 79427714
Pleural effusion 75.04 9.55 714 238034 144548 79361092
Glaucoma 73.98 9.55 175 238573 19586 79486054
Bronchitis 72.44 9.55 652 238096 129992 79375648
Appendicolith 70.22 9.55 106 238642 8445 79497195
Nasopharyngitis 68.26 9.55 462 238286 253419 79252221
Ventricular fibrillation 67.58 9.55 230 238518 31696 79473944
Completed suicide 64.70 9.55 450 238298 245317 79260323
Psoriasis 63.87 9.55 106 238642 89481 79416159
Ill-defined disorder 62.37 9.55 63 238685 65812 79439828
Inappropriate schedule of product administration 62.19 9.55 199 238549 133429 79372211
Oedema 61.87 9.55 588 238160 118992 79386648
Device expulsion 61.59 9.55 4 238744 25857 79479783
Death 61.50 9.55 2171 236577 564343 78941297
Dyspnoea exertional 61.44 9.55 459 238289 86614 79419026
Abdominal distension 60.25 9.55 585 238163 119065 79386575
Atrial flutter 59.85 9.55 171 238577 21454 79484186
Injection site swelling 57.34 9.55 35 238713 47097 79458543
Swelling 56.94 9.55 397 238351 216314 79289326
Therapeutic response decreased 56.65 9.55 70 238678 66783 79438857
Deep vein thrombosis 56.44 9.55 582 238166 120337 79385303
Drug ineffective for unapproved indication 55.74 9.55 43 238705 51195 79454445
Haemoglobin decreased 55.45 9.55 954 237794 221165 79284475
Hypomagnesaemia 55.06 9.55 282 238466 46629 79459011
Suicidal ideation 54.72 9.55 90 238658 76250 79429390
Electrolyte imbalance 53.13 9.55 208 238540 30673 79474967
Blister 52.79 9.55 182 238566 119294 79386346
Intentional self-injury 52.23 9.55 16 238732 32403 79473237
C-reactive protein abnormal 52.09 9.55 41 238707 48326 79457314
Pneumonia aspiration 51.85 9.55 361 238387 66606 79439034
Blood loss anaemia 51.38 9.55 131 238617 15367 79490273
Blood urea increased 50.94 9.55 284 238464 48506 79457134
Blood bilirubin increased 50.67 9.55 356 238392 65876 79439764
Toxic epidermal necrolysis 49.57 9.55 264 238484 44317 79461323
Pulmonary oedema 49.19 9.55 441 238307 87813 79417827
Mental status changes 48.96 9.55 356 238392 66603 79439037
Urticaria 48.78 9.55 339 238409 184862 79320778
Urinary tract infection 48.70 9.55 1120 237628 273392 79232248
Rectal haemorrhage 47.64 9.55 391 238357 75909 79429731
Haematoma 47.49 9.55 293 238455 51902 79453738
Blood pressure fluctuation 47.34 9.55 80 238668 67065 79438575
Mobility decreased 46.93 9.55 197 238551 121978 79383662
Injection site reaction 46.80 9.55 57 238691 54728 79450912
Injection site erythema 46.58 9.55 103 238645 78094 79427546
Thrombocytopenia 46.36 9.55 1080 237668 264179 79241461
Serotonin syndrome 46.23 9.55 40 238708 44987 79460653
Blood phosphorus increased 45.85 9.55 98 238650 10249 79495391
Incision site pain 45.47 9.55 49 238699 2781 79502859
Transfusion 45.44 9.55 154 238594 21176 79484464
Cor pulmonale 45.02 9.55 44 238704 2224 79503416
Syncope 44.87 9.55 771 237977 178678 79326962
Catheter management 44.66 9.55 55 238693 3608 79502032
Cardiac arrest 43.97 9.55 742 238006 171354 79334286
Injection site bruising 43.85 9.55 35 238713 40967 79464673
Generalised oedema 42.68 9.55 162 238586 23547 79482093
Diverticulitis 42.51 9.55 259 238489 45677 79459963
Ventricular tachycardia 42.39 9.55 242 238506 41693 79463947
Febrile neutropenia 42.37 9.55 947 237801 230052 79275588
Liver injury 42.22 9.55 65 238683 56549 79449091
Intentional overdose 41.85 9.55 169 238579 105791 79399849
Sleep disorder 40.97 9.55 126 238622 85551 79420089
Blood creatinine increased 40.88 9.55 672 238076 154385 79351255
Inflammation 40.62 9.55 144 238604 93609 79412031
Drug eruption 40.48 9.55 43 238705 43892 79461748
Respiratory distress 40.28 9.55 306 238442 58033 79447607
Spinal muscular atrophy 40.20 9.55 21 238727 382 79505258
Clostridium difficile colitis 39.95 9.55 197 238551 32086 79473554
Stomatitis 39.95 9.55 266 238482 146491 79359149
Tachypnoea 39.93 9.55 196 238552 31867 79473773
Appendicitis 39.87 9.55 145 238603 20649 79484991
Cardiac failure acute 39.74 9.55 136 238612 18793 79486847
Hospice care 39.27 9.55 92 238656 10232 79495408
Wrong technique in product usage process 38.73 9.55 104 238644 73771 79431869
Headache 38.19 9.55 1585 237163 652187 78853453
Infection 37.81 9.55 503 238245 241209 79264431
Constipation 37.72 9.55 1112 237636 281938 79223702
Obstructive airways disorder 37.38 9.55 24 238724 31435 79474205
Hepatotoxicity 37.31 9.55 60 238688 51292 79454348
Fibromyalgia 37.30 9.55 86 238662 64254 79441386
Gastrointestinal disorder 37.15 9.55 214 238534 121991 79383649
Oxygen consumption increased 37.08 9.55 59 238689 4920 79500720
Gastrooesophageal reflux disease 37.07 9.55 476 238272 103770 79401870
Brain natriuretic peptide increased 36.83 9.55 82 238666 8818 79496822
Cellulitis 36.71 9.55 493 238255 108567 79397073
Grip strength decreased 36.69 9.55 10 238738 21859 79483781
Arthritis 36.65 9.55 198 238550 114682 79390958
Osteoarthritis 36.57 9.55 136 238612 87173 79418467
Pulmonary embolism 36.45 9.55 719 238029 170935 79334705
Metabolic encephalopathy 36.43 9.55 83 238665 9064 79496576
Hip arthroplasty 36.42 9.55 32 238716 35724 79469916
Cardioactive drug level increased 36.34 9.55 50 238698 3659 79501981
Encephalopathy 36.14 9.55 334 238414 67063 79438577
Drug resistance 35.97 9.55 44 238704 42169 79463471
Sedation complication 35.67 9.55 3 238745 15666 79489974
Pregnancy 35.46 9.55 18 238730 26833 79478807
Tenosynovitis 35.34 9.55 3 238745 15551 79490089
Joint range of motion decreased 34.86 9.55 29 238719 33253 79472387
Platelet count decreased 34.74 9.55 795 237953 193869 79311771
Endophthalmitis 34.59 9.55 66 238682 6362 79499278
Arrhythmia 34.56 9.55 307 238441 60965 79444675
Abortion spontaneous 34.40 9.55 23 238725 29484 79476156
Loss of personal independence in daily activities 34.29 9.55 174 238574 102406 79403234
Full blood count decreased 34.15 9.55 165 238583 26654 79478986
Red blood cell sedimentation rate increased 34.02 9.55 53 238695 45889 79459751
Cataract operation complication 33.84 9.55 17 238731 284 79505356
Product residue present 33.65 9.55 47 238701 3489 79502151
Joint stiffness 33.30 9.55 44 238704 40786 79464854
Rheumatoid nodule 33.23 9.55 6 238742 17432 79488208
Accidental exposure to product 33.17 9.55 27 238721 31295 79474345
Metabolic alkalosis 33.16 9.55 53 238695 4436 79501204
Cholestasis 33.04 9.55 268 238480 51841 79453799
Septic shock 33.03 9.55 534 238214 122267 79383373
Cardiac failure chronic 32.73 9.55 90 238658 11045 79494595
Bradycardia 32.64 9.55 579 238169 134978 79370662
Sinusitis 32.35 9.55 402 238346 195099 79310541
Hypernatraemia 32.26 9.55 106 238642 14345 79491295
Vascular purpura 32.23 9.55 43 238705 3055 79502585
Sedation 32.03 9.55 67 238681 51828 79453812
Electrocardiogram abnormal 31.49 9.55 116 238632 16621 79489019
Depressed mood 31.28 9.55 61 238687 48419 79457221
Dementia 30.89 9.55 151 238597 24508 79481132
Multiple organ dysfunction syndrome 30.17 9.55 517 238231 119729 79385911
Asthma 30.06 9.55 259 238489 134836 79370804
Prothrombin time prolonged 30.03 9.55 115 238633 16784 79488856
Epistaxis 30.02 9.55 485 238263 111030 79394610
Cardiorenal syndrome 30.00 9.55 30 238718 1559 79504081
Oropharyngeal pain 29.86 9.55 198 238550 109155 79396485
Hyperaldosteronism 29.64 9.55 18 238730 442 79505198
Blood lactic acid 29.54 9.55 18 238730 445 79505195
Atelectasis 29.29 9.55 181 238567 32076 79473564
Malnutrition 29.06 9.55 139 238609 22363 79483277
Device related infection 29.02 9.55 189 238559 34105 79471535
Cardiomegaly 28.58 9.55 155 238593 26197 79479443
Knee arthroplasty 28.27 9.55 54 238694 43194 79462446
Cytomegalovirus infection 28.09 9.55 53 238695 42591 79463049
Blood alkaline phosphatase increased 28.08 9.55 303 238445 63361 79442279
Schizophrenia 27.98 9.55 6 238742 15434 79490206
Gout 27.81 9.55 147 238601 24602 79481038
Catheter site infection 27.44 9.55 62 238686 6733 79498907
Blood cholesterol increased 27.42 9.55 143 238605 83577 79422063
Lung infiltration 27.07 9.55 138 238610 22774 79482866
Melaena 26.95 9.55 290 238458 60600 79445040
Congestive cardiomyopathy 26.83 9.55 87 238661 11693 79493947
Adverse drug reaction 26.78 9.55 105 238643 66287 79439353
Diaphragmatic spasm 26.73 9.55 11 238737 112 79505528
Blood magnesium decreased 26.63 9.55 109 238639 16403 79489237
Immune effector cell-associated neurotoxicity syndrome 26.62 9.55 56 238692 5792 79499848
Colitis 26.60 9.55 336 238412 72971 79432669
Right ventricular dysfunction 26.54 9.55 36 238712 2599 79503041
Chronic left ventricular failure 26.38 9.55 23 238725 1003 79504637
Impaired work ability 26.28 9.55 13 238735 19668 79485972
Atrial enlargement 26.05 9.55 23 238725 1020 79504620
Alveolar lung disease 25.92 9.55 18 238730 559 79505081
Hyperkaliuria 25.91 9.55 12 238736 166 79505474
Cardiac disorder 25.85 9.55 306 238442 65451 79440189
Blood potassium increased 25.79 9.55 163 238585 29112 79476528
Left ventricular failure 25.77 9.55 75 238673 9506 79496134
Electrocardiogram U wave present 25.75 9.55 11 238737 124 79505516
Pancytopenia 25.68 9.55 664 238084 165081 79340559
Hypocalcaemia 25.56 9.55 245 238503 49679 79455961
Cerebrovascular accident 25.50 9.55 627 238121 154665 79350975
Exercise tolerance decreased 25.36 9.55 72 238676 8999 79496641
Therapeutic response shortened 25.25 9.55 8 238740 15855 79489785
Blood pressure diastolic abnormal 25.17 9.55 13 238735 19189 79486451
Lymphoedema 25.03 9.55 88 238660 12325 79493315
Stoma closure 24.96 9.55 14 238734 295 79505345
Unevaluable event 24.72 9.55 265 238483 55320 79450320
Chronic respiratory failure 24.16 9.55 37 238711 2985 79502655
Live birth 24.11 9.55 13 238735 18731 79486909
Blood pressure systolic increased 23.91 9.55 111 238637 66875 79438765
Ileus 23.75 9.55 147 238601 26064 79479576
Ankylosing spondylitis 23.69 9.55 4 238744 12201 79493439
Pneumococcal sepsis 23.64 9.55 27 238721 1635 79504005
Blood pressure systolic abnormal 23.63 9.55 11 238737 17236 79488404
Facet joint syndrome 23.57 9.55 3 238745 11299 79494341
Hypophosphataemia 23.57 9.55 120 238628 19793 79485847
Alkalosis hypochloraemic 23.29 9.55 16 238732 488 79505152
Acute motor-sensory axonal neuropathy 23.15 9.55 15 238733 414 79505226
Subdural haematoma 22.90 9.55 167 238581 31267 79474373
Increased bronchial secretion 22.84 9.55 38 238710 3289 79502351
Calcium deficiency 22.81 9.55 20 238728 879 79504761
Motor neurone disease 22.80 9.55 17 238731 591 79505049
Wheezing 22.80 9.55 231 238517 116433 79389207
Pulmonary interstitial emphysema syndrome 22.75 9.55 16 238732 507 79505133
Vaginal flatulence 22.70 9.55 33 238715 2542 79503098
Puncture site haematoma 22.43 9.55 11 238737 174 79505466
Paraesthesia 22.37 9.55 382 238366 175941 79329699
Skin pressure mark 22.28 9.55 9 238739 87 79505553
Chest pain 22.25 9.55 1046 237702 281258 79224382
Failure to thrive 22.21 9.55 82 238666 11762 79493878
Hypovolaemia 21.92 9.55 108 238640 17583 79488057
Disability 21.84 9.55 12 238736 17108 79488532
Faecal volume decreased 21.83 9.55 11 238737 185 79505455
Injection site pruritus 21.80 9.55 60 238688 42223 79463417
White blood cell count decreased 21.70 9.55 727 238021 187561 79318079
Foot deformity 21.69 9.55 24 238724 24050 79481590
Heparin-induced thrombocytopenia 21.60 9.55 71 238677 9611 79496029
Blood parathyroid hormone decreased 21.49 9.55 3 238745 10533 79495107
Activated partial thromboplastin time prolonged 21.44 9.55 92 238656 14136 79491504
Blood albumin decreased 21.37 9.55 135 238613 24108 79481532
Hypercapnia 21.27 9.55 67 238681 8868 79496772
Tendonitis 21.20 9.55 24 238724 23806 79481834
Urine chloride decreased 21.18 9.55 9 238739 100 79505540
Insomnia 20.95 9.55 566 238182 244604 79261036
Intentional product misuse 20.92 9.55 183 238565 94982 79410658
Haemoptysis 20.88 9.55 258 238490 55741 79449899
Oesophageal pain 20.68 9.55 42 238706 4237 79501403
Blood potassium abnormal 20.66 9.55 35 238713 3075 79502565
Night sweats 20.62 9.55 83 238665 52012 79453628
Haematocrit decreased 20.56 9.55 277 238471 61035 79444605
Right atrial pressure increased 20.31 9.55 12 238736 280 79505360
Pulmonary fibrosis 20.30 9.55 66 238682 44046 79461594
Macular degeneration 20.18 9.55 77 238671 11219 79494421
Supraventricular extrasystoles 20.07 9.55 56 238692 6931 79498709
Pulmonary arterial pressure increased 20.02 9.55 43 238705 4512 79501128
Subileus 20.01 9.55 49 238699 5605 79500035
Head injury 19.93 9.55 185 238563 37184 79468456
Transplant evaluation 19.92 9.55 25 238723 1672 79503968
N-terminal prohormone brain natriuretic peptide increased 19.89 9.55 44 238704 4711 79500929
Poisoning 19.83 9.55 28 238720 25244 79480396
Mitral valve incompetence 19.81 9.55 150 238598 28415 79477225
Aggression 19.66 9.55 82 238666 50876 79454764
Electrocardiogram T wave amplitude decreased 19.66 9.55 17 238731 733 79504907
Dystonia 19.65 9.55 21 238727 21378 79484262
Haematotoxicity 19.62 9.55 11 238737 15508 79490132
Acne 19.53 9.55 32 238716 27158 79478482
Ischaemic cardiomyopathy 19.52 9.55 59 238689 7636 79498004
Depressed level of consciousness 19.46 9.55 190 238558 96462 79409178
Thrombosis 19.46 9.55 357 238391 83743 79421897
Blood glucose increased 19.40 9.55 466 238282 114509 79391131
Lip dry 19.39 9.55 11 238737 15407 79490233
Bacteraemia 19.31 9.55 166 238582 32658 79472982
Oesophageal spasm 19.23 9.55 36 238712 3420 79502220
Alkalosis 19.22 9.55 15 238733 559 79505081
Arteriovenous malformation 19.18 9.55 25 238723 1736 79503904
Blood chloride decreased 19.18 9.55 61 238687 8116 79497524
Mania 19.01 9.55 16 238732 18244 79487396
Psychotic disorder 19.01 9.55 62 238686 41340 79464300
Nail dystrophy 18.90 9.55 19 238729 994 79504646
Blood pressure diastolic increased 18.83 9.55 10 238738 14532 79491108
Movement disorder 18.74 9.55 33 238715 27226 79478414
Pruritus 18.72 9.55 978 237770 393670 79111970
Polyneuropathy 18.71 9.55 27 238721 24124 79481516
Body temperature decreased 18.60 9.55 43 238705 32102 79473538
Peritonitis bacterial 18.58 9.55 67 238681 9500 79496140
Overdose 18.53 9.55 415 238333 183791 79321849
Acute left ventricular failure 18.49 9.55 25 238723 1799 79503841
Femoral artery aneurysm 18.39 9.55 10 238738 198 79505442
Arrhythmia supraventricular 18.37 9.55 27 238721 2100 79503540
Blood pressure increased 18.30 9.55 487 238261 210873 79294767
Small intestinal obstruction 18.24 9.55 142 238606 27130 79478510
Ventricular extrasystoles 18.16 9.55 111 238637 19593 79486047
Hypoglycaemia 18.14 9.55 415 238333 101179 79404461
Scrotal oedema 18.05 9.55 23 238725 1562 79504078
Paranoia 17.92 9.55 19 238729 19413 79486227
Glomerular filtration rate 17.88 9.55 9 238739 151 79505489
Urine sodium decreased 17.87 9.55 11 238737 277 79505363
Shock haemorrhagic 17.86 9.55 112 238636 19948 79485692
Disease progression 17.86 9.55 698 238050 183664 79321976
Confusion postoperative 17.78 9.55 10 238738 212 79505428
Mood swings 17.71 9.55 20 238728 19860 79485780
Electrocardiogram T wave peaked 17.66 9.55 18 238730 957 79504683
Muscle spasticity 17.65 9.55 23 238725 21452 79484188
Lung perforation 17.64 9.55 8 238740 105 79505535
Multiple allergies 17.62 9.55 70 238678 10390 79495250
Lower gastrointestinal haemorrhage 17.59 9.55 95 238653 16030 79489610
Neuroleptic malignant syndrome 17.50 9.55 35 238713 27524 79478116
Pickwickian syndrome 17.36 9.55 13 238735 455 79505185
Substance abuse 17.31 9.55 5 238743 10521 79495119
Resuscitation 17.24 9.55 28 238720 2376 79503264
Blood pressure diastolic decreased 17.02 9.55 41 238707 30175 79475465
Peripheral circulatory failure 16.95 9.55 19 238729 1127 79504513
Aspartate aminotransferase increased 16.92 9.55 539 238209 138102 79367538
Sopor 16.90 9.55 47 238701 32963 79472677
Multiple-drug resistance 16.85 9.55 3 238745 8805 79496835
Asphyxia 16.81 9.55 7 238741 11713 79493927
COVID-19 16.79 9.55 352 238396 157322 79348318
Prothrombin consumption time prolonged 16.78 9.55 6 238742 40 79505600
Purging 16.78 9.55 6 238742 40 79505600
Cardiomyopathy 16.65 9.55 145 238603 28629 79477011
Cerebral haematoma 16.62 9.55 57 238691 7885 79497755
Nodule 16.57 9.55 27 238721 22967 79482673
Post procedural complication 16.45 9.55 125 238623 23704 79481936
Throat tightness 16.42 9.55 37 238711 27870 79477770
Therapy non-responder 16.33 9.55 187 238561 92118 79413522
Hypochloraemia 16.30 9.55 28 238720 2487 79503153
Iron deficiency anaemia 16.25 9.55 132 238616 25540 79480100
Post transplant lymphoproliferative disorder 16.20 9.55 7 238741 11457 79494183
Leukocytosis 16.11 9.55 200 238548 43255 79462385
Pulmonary arterial wedge pressure increased 16.04 9.55 13 238735 512 79505128
Pneumonia staphylococcal 15.95 9.55 41 238707 4833 79500807
Coeliac disease 15.93 9.55 7 238741 11344 79494296
Blood phosphorus decreased 15.87 9.55 50 238698 6618 79499022
Prescribed overdose 15.87 9.55 59 238689 37824 79467816
Enterococcus test positive 15.76 9.55 25 238723 2079 79503561
Throat irritation 15.73 9.55 66 238682 40880 79464760
Coagulopathy 15.71 9.55 171 238577 35835 79469805
Pain in jaw 15.67 9.55 209 238539 45942 79459698
Catheterisation cardiac 15.56 9.55 45 238703 5683 79499957
Product substitution issue 15.35 9.55 23 238725 20233 79485407
Oesophageal carcinoma 15.29 9.55 7 238741 11077 79494563
International normalised ratio decreased 15.24 9.55 56 238692 8014 79497626
Angioedema 15.08 9.55 150 238598 75885 79429755
Hyperthyroidism 15.05 9.55 116 238632 22093 79483547
Flail chest 15.04 9.55 7 238741 98 79505542
Injection site rash 15.00 9.55 19 238729 17935 79487705
Exostosis 14.97 9.55 17 238731 16841 79488799
Pulse absent 14.97 9.55 65 238683 10038 79495602
Dyskinesia 14.93 9.55 76 238672 44697 79460943
Gastric polyps 14.92 9.55 34 238714 3713 79501927
Transient aphasia 14.91 9.55 12 238736 468 79505172
Torsade de pointes 14.88 9.55 104 238644 19208 79486432
Hypoalbuminaemia 14.86 9.55 112 238636 21185 79484455
Neuroglycopenia 14.82 9.55 12 238736 472 79505168
Product storage error 14.81 9.55 16 238732 16210 79489430
Transplant rejection 14.80 9.55 22 238726 19415 79486225
Bone erosion 14.79 9.55 19 238729 17828 79487812
Aspiration pleural cavity 14.66 9.55 21 238727 1596 79504044
Drug-induced liver injury 14.59 9.55 127 238621 65990 79439650
Bronchiectasis 14.59 9.55 28 238720 22358 79483282
Dry eye 14.52 9.55 59 238689 36872 79468768
Paracentesis 14.51 9.55 19 238729 1326 79504314
Cardioversion 14.45 9.55 24 238724 2074 79503566
Cor pulmonale chronic 14.44 9.55 10 238738 309 79505331
Chronic sinusitis 14.38 9.55 77 238671 12949 79492691
Hepatocellular injury 14.34 9.55 211 238537 47382 79458258
Chronic kidney disease 14.33 9.55 278 238470 65876 79439764
Orthopnoea 14.32 9.55 64 238684 10009 79495631
Blood immunoglobulin M increased 14.27 9.55 19 238729 1347 79504293
Abdominal pain 14.27 9.55 1353 237395 388216 79117424
Cognitive disorder 14.27 9.55 137 238611 69789 79435851
Thrombotic microangiopathy 14.24 9.55 24 238724 20145 79485495
Proctitis 14.20 9.55 47 238701 6385 79499255
Injection site warmth 14.20 9.55 14 238734 14793 79490847
Cardiovascular insufficiency 14.10 9.55 29 238719 2952 79502688
Cardiac output decreased 13.99 9.55 22 238726 1816 79503824
Cardiac amyloidosis 13.97 9.55 22 238726 1818 79503822
Pericardial effusion 13.93 9.55 205 238543 46032 79459608
Mental status changes postoperative 13.92 9.55 8 238740 177 79505463
Anhedonia 13.78 9.55 84 238664 14814 79490826
Acute pulmonary oedema 13.65 9.55 81 238667 14149 79491491
Bursitis 13.63 9.55 58 238690 35786 79469854
Disease complication 13.62 9.55 39 238709 4898 79500742
Congestive hepatopathy 13.61 9.55 37 238711 4510 79501130
Decubitus ulcer 13.60 9.55 87 238661 15600 79490040
Anaphylactic reaction 13.54 9.55 173 238575 83570 79422070
Type IIa hyperlipidaemia 13.53 9.55 9 238739 260 79505380
Middle insomnia 13.43 9.55 17 238731 16052 79489588
Shoshin beriberi 13.42 9.55 6 238742 76 79505564
Thyroid disorder 13.42 9.55 80 238668 13999 79491641
Pneumothorax spontaneous 13.35 9.55 19 238729 1435 79504205
Finger deformity 13.35 9.55 3 238745 7471 79498169
Cardiac pacemaker evaluation 13.27 9.55 7 238741 130 79505510
Skin reaction 13.26 9.55 88 238660 15980 79489660
Occult blood positive 13.20 9.55 48 238700 6835 79498805
Nightmare 13.11 9.55 37 238711 25824 79479816
Cholelithiasis 13.05 9.55 226 238522 52438 79453202
Adenocarcinoma 13.04 9.55 33 238715 3853 79501787
Catheter placement 12.99 9.55 28 238720 2946 79502694
Troponin T increased 12.98 9.55 31 238717 3491 79502149
Peritoneal haematoma 12.94 9.55 8 238740 203 79505437
Device issue 12.86 9.55 40 238708 27068 79478572
Spinal cord paralysis 12.85 9.55 7 238741 139 79505501
Influenza like illness 12.79 9.55 145 238603 71562 79434078
Blood albumin abnormal 12.76 9.55 13 238735 691 79504949
Drug tolerance decreased 12.76 9.55 12 238736 12966 79492674
Peri-implantitis 12.74 9.55 8 238740 209 79505431
Supraventricular tachycardia 12.74 9.55 108 238640 21162 79484478
Right ventricular systolic pressure increased 12.63 9.55 15 238733 947 79504693
Extrapyramidal disorder 12.60 9.55 31 238717 22648 79482992
Altered visual depth perception 12.49 9.55 10 238738 387 79505253
Device difficult to use 12.44 9.55 13 238735 13372 79492268
Thoracic operation 12.41 9.55 8 238740 219 79505421
Ischaemic cerebral infarction 12.39 9.55 25 238723 2510 79503130
Device use error 12.39 9.55 3 238745 7098 79498542
Lymphadenectomy 12.38 9.55 17 238731 1242 79504398
Cardiac pacemaker insertion 12.37 9.55 42 238706 5780 79499860
Limited symptom panic attack 12.32 9.55 5 238743 49 79505591
Sleep apnoea syndrome 12.31 9.55 165 238583 36313 79469327
Migraine 12.27 9.55 186 238562 87307 79418333
Skin disorder 12.26 9.55 56 238692 33887 79471753
Coagulation factor VII level decreased 12.25 9.55 8 238740 224 79505416
Pantoea agglomerans infection 12.17 9.55 6 238742 96 79505544
Anterior chamber disorder 12.17 9.55 7 238741 155 79505485
Hyperglycaemia 12.15 9.55 286 238462 70049 79435591
Sleep disorder due to a general medical condition 12.04 9.55 15 238733 14262 79491378
Catheter culture positive 12.03 9.55 8 238740 231 79505409
Condition aggravated 12.02 9.55 1315 237433 499809 79005831
Respiratory tract infection bacterial 12.02 9.55 22 238726 2055 79503585
Electrocardiogram QT prolonged 11.99 9.55 355 238393 90031 79415609
Deposit eye 11.98 9.55 5 238743 53 79505587
Skin candida 11.94 9.55 22 238726 2065 79503575
Injection site haemorrhage 11.94 9.55 43 238705 27827 79477813
Vasculitis 11.94 9.55 37 238711 25065 79480575
Scleroderma 11.93 9.55 40 238708 5470 79500170
Blood immunoglobulin A decreased 11.91 9.55 18 238730 1435 79504205
Right ventricular dilatation 11.91 9.55 21 238727 1905 79503735
Hyperbilirubinaemia 11.90 9.55 119 238629 24399 79481241
Food allergy 11.88 9.55 9 238739 10815 79494825
Drug reaction with eosinophilia and systemic symptoms 11.82 9.55 129 238619 64115 79441525
Female genital tract fistula 11.74 9.55 42 238706 5933 79499707
Aortic stenosis 11.71 9.55 49 238699 7446 79498194
Familial periodic paralysis 11.67 9.55 7 238741 168 79505472
Type 2 diabetes mellitus 11.62 9.55 112 238636 57010 79448630
Glomerular filtration rate abnormal 11.55 9.55 19 238729 1629 79504011
Drug interaction 11.53 9.55 1078 237670 414105 79091535
Panniculitis 11.52 9.55 12 238736 12359 79493281
Blood sodium decreased 11.46 9.55 151 238597 33104 79472536
HLA-B*27 positive 11.44 9.55 6 238742 110 79505530
Renal atrophy 11.42 9.55 20 238728 1805 79503835
Sputum increased 11.36 9.55 35 238713 4578 79501062
Lung consolidation 11.36 9.55 55 238693 8892 79496748
Hypophagia 11.35 9.55 195 238553 45172 79460468
Pharyngitis 11.35 9.55 32 238716 22343 79483297
Injection site urticaria 11.32 9.55 13 238735 12813 79492827
Cortical visual impairment 11.28 9.55 4 238744 26 79505614
Gastritis erosive 11.23 9.55 63 238685 10784 79494856
Catheter site extravasation 11.22 9.55 10 238738 449 79505191
Pseudomonal bacteraemia 11.22 9.55 27 238721 3055 79502585
Extrasystoles 11.20 9.55 48 238700 7371 79498269
Lip swelling 11.20 9.55 74 238674 40837 79464803
Myasthenia gravis 11.16 9.55 61 238687 10338 79495302
Drug chemical incompatibility 11.16 9.55 6 238742 116 79505524
Enterococcal sepsis 11.15 9.55 25 238723 2701 79502939
Lower respiratory tract infection bacterial 11.09 9.55 14 238734 942 79504698
Electrocardiogram ST segment abnormal 11.08 9.55 18 238730 1527 79504113
Adverse event 11.04 9.55 121 238627 60093 79445547
N-terminal prohormone brain natriuretic peptide abnormal 11.01 9.55 8 238740 267 79505373
Uveitis 11.01 9.55 21 238727 16809 79488831
General physical health deterioration 10.99 9.55 962 237786 274276 79231364
Renin decreased 10.98 9.55 6 238742 120 79505520
Emphysema 10.97 9.55 85 238663 16215 79489425
Arteriosclerosis coronary artery 10.95 9.55 91 238657 17725 79487915
Clostridium difficile infection 10.87 9.55 184 238564 42501 79463139
Cardioactive drug level decreased 10.81 9.55 7 238741 193 79505447
Haemorrhage 10.79 9.55 353 238395 90765 79414875
Paradoxical drug reaction 10.78 9.55 4 238744 7181 79498459
Device related sepsis 10.71 9.55 42 238706 6198 79499442
Oral herpes 10.70 9.55 44 238704 27410 79478230
Acute hepatic failure 10.68 9.55 50 238698 30063 79475577
Cataract operation 10.66 9.55 37 238711 5148 79500492
Tachycardia 10.64 9.55 642 238106 177126 79328514
Iatrogenic infection 10.62 9.55 5 238743 72 79505568
Bladder cancer 10.60 9.55 27 238721 19499 79486141
Abortion induced 10.60 9.55 4 238744 7105 79498535
Sexual dysfunction 10.56 9.55 5 238743 7758 79497882
Basal cell carcinoma 10.54 9.55 67 238681 37308 79468332
Creatinine renal clearance decreased 10.53 9.55 26 238722 18976 79486664
Diuretic therapy 10.53 9.55 7 238741 202 79505438
Hyperlipidaemia 10.51 9.55 122 238626 25971 79479669
Withdrawal syndrome 10.49 9.55 43 238705 26811 79478829
Skin dystrophy 10.49 9.55 5 238743 74 79505566
Irritability 10.48 9.55 76 238672 41068 79464572
Endometrial disorder 10.47 9.55 11 238737 606 79505034
Euphoric mood 10.47 9.55 5 238743 7721 79497919
Atrioventricular block 10.46 9.55 75 238673 13966 79491674
Lactobacillus test positive 10.46 9.55 4 238744 33 79505607
Tonsillar haemorrhage 10.44 9.55 8 238740 290 79505350
Oesophagitis 10.43 9.55 115 238633 24174 79481466
Hernia 10.42 9.55 87 238661 16972 79488668
Vascular encephalopathy 10.39 9.55 11 238737 612 79505028
Bronchial disorder 10.37 9.55 23 238725 2466 79503174
Body height decreased 10.36 9.55 52 238696 8528 79497112
Uterine perforation 10.35 9.55 3 238745 6300 79499340
Tracheal obstruction 10.35 9.55 7 238741 208 79505432
Syringe issue 10.34 9.55 3 238745 6295 79499345
Gestational diabetes 10.33 9.55 3 238745 6290 79499350
Abortion incomplete complicated 10.31 9.55 3 238745 9 79505631
Ejection fraction decreased 10.30 9.55 153 238595 34424 79471216
Ear pain 10.29 9.55 57 238691 32812 79472828
Heart transplant 10.28 9.55 17 238731 1464 79504176
Ageusia 10.25 9.55 85 238663 16547 79489093
Coma 10.20 9.55 383 238365 100266 79405374
Psychomotor hyperactivity 10.19 9.55 22 238726 16827 79488813
Premature delivery 10.19 9.55 36 238712 23431 79482209
Photosensitivity reaction 10.15 9.55 31 238717 21096 79484544
Catheter site haemorrhage 10.08 9.55 36 238712 5081 79500559
Petechiae 10.07 9.55 100 238648 20465 79485175
Atrioventricular block first degree 10.06 9.55 68 238680 12423 79493217
Incorrect dose administered 10.04 9.55 165 238583 76465 79429175
International normalised ratio abnormal 10.04 9.55 39 238709 5729 79499911
Road traffic accident 10.03 9.55 83 238665 43581 79462059
Osmotic demyelination syndrome 10.01 9.55 17 238731 1496 79504144
Blood aldosterone increased 9.98 9.55 7 238741 221 79505419
Ovarian cyst 9.95 9.55 14 238734 12641 79492999
Photophobia 9.95 9.55 30 238718 20498 79485142
Adenocarcinoma pancreas 9.88 9.55 20 238728 2013 79503627
Catheter removal 9.85 9.55 11 238737 650 79504990
Herpes zoster 9.85 9.55 208 238540 92875 79412765
Autoimmune disorder 9.79 9.55 22 238726 16590 79489050
Abdominal pain upper 9.79 9.55 559 238189 223260 79282380
Catheter site scab 9.79 9.55 7 238741 228 79505412
Blood pressure decreased 9.72 9.55 377 238371 99089 79406551
Oxygen therapy 9.68 9.55 24 238724 2766 79502874
Carbon dioxide increased 9.68 9.55 21 238727 2219 79503421
Neuromyopathy 9.65 9.55 17 238731 1541 79504099
Hypercholesterolaemia 9.65 9.55 36 238712 23059 79482581
Cardiac operation 9.65 9.55 35 238713 4977 79500663
Blood cholesterol decreased 9.64 9.55 18 238730 1707 79503933
Blood immunoglobulin G increased 9.63 9.55 25 238723 2964 79502676
Radiculopathy 9.63 9.55 52 238696 8772 79496868
Hypertrophy 9.61 9.55 12 238736 798 79504842
Troponin increased 9.61 9.55 94 238654 19161 79486479
Electrocardiogram U-wave abnormality 9.57 9.55 5 238743 91 79505549
Hypertransaminasaemia 9.57 9.55 13 238735 11911 79493729
Exposure to toxic agent 9.57 9.55 8 238740 9150 79496490
Mitral valve disease 9.55 9.55 26 238722 3171 79502469

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A12BA01 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
POTASSIUM
Potassium
ATC A12BA51 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
POTASSIUM
Potassium
ATC B05XA01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Electrolyte solutions
CHEBI has role CHEBI:33287 fertilizers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Hypokalemia indication 43339004
Incomplete passage of stool indication 249515001
Hypokalemia Prevention indication
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Urinary tract obstruction contraindication 7163005 DOID:5200
Poisoning by digitalis glycoside contraindication 12876009
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Primary hyperoxaluria contraindication 17901006 DOID:2977
Myocardial infarction contraindication 22298006 DOID:5844
Acute vomiting contraindication 23971007
Ventricular tachycardia contraindication 25569003
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Acute epiglottitis contraindication 29608009 DOID:9398
Sarcoidosis contraindication 31541009 DOID:11335
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Toxic colitis contraindication 42359007
Achalasia of esophagus contraindication 45564002 DOID:9164
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Acidosis contraindication 51387008
Gastrointestinal perforation contraindication 51875005
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Perforation of intestine contraindication 56905009 DOID:2074
Peptic reflux disease contraindication 57643001
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Ulcerative colitis contraindication 64766004 DOID:8577
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Hypercalcemia contraindication 66931009 DOID:12678
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Incontinence of feces contraindication 72042002
Arteriosclerotic vascular disease contraindication 72092001
Appendicitis contraindication 74400008 DOID:8337
Hyperchloremia contraindication 74450001
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Third degree burn injury contraindication 80247002
Intestinal obstruction contraindication 81060008 DOID:8437
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Hiatal hernia contraindication 84089009 DOID:12642
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Myocardial dysfunction contraindication 233928007
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
At risk for aspiration contraindication 371736008
Primary adrenocortical insufficiency contraindication 373662000
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastric ulcer contraindication 397825006 DOID:10808
Hemochromatosis contraindication 399187006 DOID:2352
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Unconscious contraindication 418107008
Hypertensive urgency contraindication 443482000
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Esophageal Compression contraindication
Predisposition to Nausea and Vomiting contraindication
Suppression of the Gag Reflex contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10792306 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 11529368 March 9, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9592252 Aug. 11, 2032 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 10918723 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM PLENVU SALIX N209381 May 4, 2018 RX FOR SOLUTION ORAL 9326969 Sept. 10, 2033 FOR CLEANSING OF THE COLON IN PREPARATION FOR COLONOSCOPY IN ADULTS
0.225GM;0.188GM;1.479GM SUTAB BRAINTREE LABS N213135 Nov. 10, 2020 RX TABLET ORAL 11033498 Aug. 4, 2037 GASTROINTESTINAL TABLETS INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY
0.225GM;0.188GM;1.479GM SUTAB BRAINTREE LABS N213135 Nov. 10, 2020 RX TABLET ORAL 11382864 Aug. 4, 2037 GASTROINTESTINAL TABLETS INDICATED FOR CLEANSING THE COLON IN PREPARATION FOR COLONOSCOPY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.225GM;0.188GM;1.479GM SUTAB BRAINTREE LABS N213135 Nov. 10, 2020 RX TABLET ORAL Nov. 10, 2023 NEW PRODUCT
0.9GM/BOT;178.7GM/BOT;1.12GM/BOT;0.5GM/BOT;7.3GM/BOT SUFLAVE BRAINTREE LABS N215344 June 15, 2023 RX FOR SOLUTION ORAL June 15, 2026 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Carbonic anhydrase 4 Enzyme Ki 4.05 CHEMBL

External reference:

IDSource
4020361 VUID
N0000148186 NUI
D02060 KEGG_DRUG
4017447 VANDF
4020073 VANDF
4020361 VANDF
C0032825 UMLSCUI
CHEBI:32588 CHEBI
CHEMBL1200731 ChEMBL_ID
D011189 MESH_DESCRIPTOR_UI
DB00761 DRUGBANK_ID
660YQ98I10 UNII
4873 PUBCHEM_CID
8591 RXNORM
5326 MMSL
7330 MMSL
d00345 MMSL
000767 NDDF
007231 NDDF
420155008 SNOMEDCT_US
8631001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-0795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-1795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
BSS HUMAN PRESCRIPTION DRUG LABEL 6 0065-1795 SOLUTION 0.75 mg OPHTHALMIC NDA 9 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3023 TABLET, FILM COATED, EXTENDED RELEASE 1500 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3023 TABLET, FILM COATED, EXTENDED RELEASE 1500 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3058 TABLET, FILM COATED, EXTENDED RELEASE 600 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3058 TABLET, FILM COATED, EXTENDED RELEASE 600 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3278 TABLET, FILM COATED, EXTENDED RELEASE 750 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-3278 TABLET, FILM COATED, EXTENDED RELEASE 750 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-7804 TABLET, FILM COATED, EXTENDED RELEASE 750 mg ORAL NDA 24 sections
K-Tab HUMAN PRESCRIPTION DRUG LABEL 1 0074-7804 TABLET, FILM COATED, EXTENDED RELEASE 750 mg ORAL NDA 24 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0466 SOLUTION 3 g ORAL UNAPPROVED DRUG OTHER 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0841 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0841 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0948 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0948 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-1680 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-1680 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-1896 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-1896 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-2520 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-2520 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-2847 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-2847 SOLUTION 40 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-4948 SOLUTION 20 meq ORAL ANDA 21 sections
Potassium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-4948 SOLUTION 20 meq ORAL ANDA 21 sections
KLOR-CON HUMAN PRESCRIPTION DRUG LABEL 1 0245-0360 POWDER, FOR SOLUTION 1.50 g ORAL ANDA 21 sections