vitamin A palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4197	79-81-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: vitamin A palmitate retinol palmitate retinyl palmitate	Molecular weight: 524.87 Formula: C36H60O2 CLOGP: 12 LIPINSKI: 2 HAC: 2 HDO: 0 TPSA: 26.30 ALOGS: -6.81 ROTB: 21 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

vitamin A palmitate
retinol palmitate
retinyl palmitate

Molecular weight: 524.87
Formula: C36H60O2
CLOGP: 12
LIPINSKI: 2
HAC: 2
HDO: 0
TPSA: 26.30
ALOGS: -6.81
ROTB: 21

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 18, 1949	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Presbyacusis	108.82	74.59	20	698	2845	63485459
Pleural thickening	108.69	74.59	20	698	2863	63485441
Blood magnesium increased	107.65	74.59	20	698	3018	63485286
Pleural fibrosis	104.98	74.59	20	698	3452	63484852
Deafness neurosensory	98.29	74.59	20	698	4835	63483469
Epigastric discomfort	91.63	74.59	20	698	6760	63481544
Cyst	77.07	74.59	20	698	14079	63474225

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypervitaminosis A	79.57	72.68	9	877	10	34956035

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypervitaminosis A	124.13	59.67	14	1518	24	79742832
Presbyacusis	76.08	59.67	16	1516	2644	79740212
Pleural thickening	74.26	59.67	16	1516	2966	79739890
Blood magnesium increased	71.68	59.67	16	1516	3490	79739366
Appendicolith	71.54	59.67	19	1513	8532	79734324
Pleural fibrosis	68.93	59.67	16	1516	4151	79738705
Blood phosphorus increased	67.96	59.67	19	1513	10328	79732528
Deafness neurosensory	60.91	59.67	16	1516	6882	79735974

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:76967	human xenobiotic metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
MeSH PA	D016588	Anticarcinogenic Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000975	Antioxidants
MeSH PA	D020011	Protective Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID
Vitamin deficiency	indication	85670002
Prevention of dental caries	indication	426482000
Dental fluorosis	contraindication	30265004

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Retinol-binding protein 4	Secreted	P02753	RET4_HUMAN	Kd	6.74	CHEMBL
Amyloid beta A4 protein	Unclassified	P05067	A4_HUMAN	IC50	6.75	CHEMBL
Alpha-synuclein	Transporter	P37840	SYUA_HUMAN	IC50	6.72	CHEMBL
Beta-lactoglobulin	Unclassified		LACB_BOVIN	Kd	7.44	CHEMBL

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External reference:

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ID	Source
RTL	PDB_CHEM_ID
001000	NDDF
001002	NDDF
11246	RXNORM
1D1K0N0VVC	UNII
2243	INN_ID
232172	MMSL
4017648	VANDF
4017669	VANDF
4020767	VUID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7862	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7862	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7874	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-7874	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9007	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9007	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9015	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins	HUMAN PRESCRIPTION DRUG LABEL	13	54643-9015	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	20 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	17 sections
Adult Infuvite Multiple Vitamins for Infusion	HUMAN PRESCRIPTION DRUG LABEL	13	54643-5649	INJECTION, SOLUTION	3300 [iU]	INTRAVENOUS	NDA	17 sections

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