piperaquine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4193 | 4085-31-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The exact mechanism of action of piperaquine is unknown, but it likely mirrors that of chloroquine, a close structural analogue. Chloroquine binds to toxic haeme (derived from the patient’s haemoglobin) within the malaria parasite, preventing its detoxification via a polymerisation step.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 27, 2011 | EMA | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P01BF05 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS ANTIMALARIALS Artemisinin and derivatives, combinations |
| ATC | P01BF07 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS ANTIMALARIALS Artemisinin and derivatives, combinations |
| ATC | P01BX02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS ANTIMALARIALS Other antimalarials |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000962 | Antimalarials |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
| CHEBI has role | CHEBI:38068 | antimalarials |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Malaria | indication | 61462000 | DOID:12365 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.8 | Basic |
| pKa2 | 7.96 | Basic |
| pKa3 | 7.59 | Basic |
| pKa4 | 6.53 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| C0071105 | UMLSCUI |
| CHEBI:91231 | CHEBI |
| CHEMBL303933 | ChEMBL_ID |
| CHEMBL1652442 | ChEMBL_ID |
| DB13941 | DRUGBANK_ID |
| C034759 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10025 | IUPHAR_LIGAND_ID |
| 915967-82-7 | SECONDARY_CAS_RN |
| A0HV2Q956Y | UNII |
| 122262 | PUBCHEM_CID |
| 014245 | NDDF |
| 014246 | NDDF |
| 763289006 | SNOMEDCT_US |
| 895343007 | SNOMEDCT_US |
| CHEMBL539666 | ChEMBL_ID |
Pharmaceutical products:
None