buclizine indications/contra

Stem definitionDrug idCAS RN
diphenylmethyl piperazine derivatives 416 82-95-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • buclizine
  • buclifen
  • histabuticine
  • histabutizine
  • histabutyzine
  • hitabutyzyne
  • buclizine hydrochloride
  • buclizine HCl
  • Molecular weight: 433.04
  • Formula: C28H33ClN2
  • CLOGP: 8.06
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -6.25
  • ROTB: 6

Drug dosage:

DoseUnitRoute
50 mg O

Approvals:

DateAgencyCompanyOrphan
None FDA STUART PHARMS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC R06AE01 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Piperazine derivatives
ATC R06AE51 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Piperazine derivatives
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:48873 cholinergic antagonist
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:36333 local anaesthetic
CHEBI has role CHEBI:35488 central nervous system depressant

Drug Use (View source of the data)

scroll-->
DiseaseRelationSNOMED_IDDOID
Motion sickness indication 37031009 DOID:2951

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.15 Basic
pKa2 3.15 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

scroll-->
IDSource
DB00354 DRUGBANK_ID
4019642 VUID
N0000147735 NUI
C0164386 UMLSCUI
7134 IUPHAR_LIGAND_ID
D02089 KEGG_DRUG
0C94V6X681 UNII
291 INN_ID
129-74-8 SECONDARY_CAS_RN
4019642 VANDF
N0000005980 NDFRT
N0000147735 NDFRT
59636 RXNORM
387344005 SNOMEDCT_US
61623002 SNOMEDCT_US
004801 NDDF
6729 PUBCHEM_CID
CHEMBL1200403 ChEMBL_ID
CHEMBL1201271 ChEMBL_ID
C046894 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:3205 CHEBI

Pharmaceutical products:

None