lercanidipine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 4157 100427-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lercanidipine hydrochloride
  • lercanidipine
  • masnidipine
  • zanidip
  • lercanidipine HCl
  • Molecular weight: 611.74
  • Formula: C36H41N3O6
  • CLOGP: 8
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -6.59
  • ROTB: 14

Drug dosage:

DoseUnitRoute
10 mg O

Approvals:

None

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypotension 311.09 44.31 109 984 67291 4570608
Orthostatic hypotension 281.07 44.31 62 1031 6812 4631087
Acute kidney injury 276.00 44.31 101 992 70330 4567569
Fall 273.22 44.31 103 990 77943 4559956
Hypertension 225.17 44.31 80 1013 50718 4587181
Hyponatraemia 185.34 44.31 58 1035 24672 4613227
Overdose 179.08 44.31 65 1028 43494 4594405
Confusional state 132.76 44.31 54 1039 48780 4589119
Bradycardia 128.33 44.31 43 1050 22526 4615373
Syncope 111.86 44.31 43 1050 33352 4604547
Oedema peripheral 109.11 44.31 45 1048 41927 4595972
Anuria 108.86 44.31 26 1067 3989 4633910
Interstitial lung disease 106.60 44.31 36 1057 19249 4618650
Labile hypertension 97.93 44.31 14 1079 115 4637784
Hypokalaemia 91.87 44.31 32 1061 18728 4619171
Hyperkalaemia 89.18 44.31 30 1063 15807 4622092
Respiratory alkalosis 81.89 44.31 15 1078 628 4637271
Cholestasis 77.98 44.31 23 1070 7897 4630002
Presyncope 76.41 44.31 22 1071 6942 4630957
Renin increased 75.26 44.31 11 1082 107 4637792
Drug interaction 73.12 44.31 39 1054 64469 4573430
Pemphigoid 73.08 44.31 17 1076 2319 4635580
Supine hypertension 70.86 44.31 10 1083 74 4637825
Tinnitus 70.52 44.31 22 1071 9111 4628788
Dizziness 69.62 44.31 44 1049 99827 4538072
Somnolence 68.77 44.31 33 1060 43627 4594272
Vasoplegia syndrome 68.72 44.31 12 1081 381 4637518
Myalgia 66.88 44.31 32 1061 42016 4595883
Epileptic encephalopathy 60.44 44.31 8 1085 34 4637865
Labelled drug-drug interaction medication error 57.97 44.31 15 1078 3173 4634726
Metabolic acidosis 56.15 44.31 20 1073 12420 4625479
Electrocardiogram QT prolonged 55.74 44.31 21 1072 15274 4622625
Cough 55.67 44.31 31 1062 55556 4582343
Intermittent claudication 54.38 44.31 11 1082 778 4637121
Coma 52.97 44.31 21 1072 17498 4620401
Photosensitivity reaction 52.43 44.31 15 1078 4611 4633288
Dyspnoea 52.14 44.31 42 1051 138943 4498956
Hypoglycaemia 51.96 44.31 21 1072 18388 4619511
Renal artery stenosis 51.81 44.31 10 1083 555 4637344
Blood triglycerides increased 50.35 44.31 15 1078 5310 4632589
Cell death 48.47 44.31 10 1083 780 4637119
Poisoning deliberate 47.79 44.31 12 1081 2250 4635649
Shock 46.62 44.31 16 1077 8900 4628999
Agitation 46.42 44.31 21 1072 24179 4613720
Dehydration 46.20 44.31 25 1068 42265 4595634
Medication error 46.09 44.31 18 1075 14398 4623501
Cardiac arrest 45.40 44.31 23 1070 33984 4603915
Chest pain 44.60 44.31 26 1067 50674 4587225

Pharmacologic Action:

SourceCodeDescription
ATC C08CA13 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C09BB02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09DB08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.96 Basic
pKa2 2.09 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
C0595331 UMLSCUI
D01849 KEGG_DRUG
356862006 SNOMEDCT_US
007361 NDDF
135056 RXNORM
395986007 SNOMEDCT_US
CHEMBL250270 ChEMBL_ID
DB00528 DRUGBANK_ID
OA8TFX68PE UNII
132866-11-6 SECONDARY_CAS_RN
6971 INN_ID
CHEBI:135930 CHEBI
CHEMBL2106419 ChEMBL_ID
65866 PUBCHEM_CID
C060343 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None