permethrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4152	52645-53-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: permethrin	A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES. Molecular weight: 391.29 Formula: C21H20Cl2O3 CLOGP: 7.31 LIPINSKI: 1 HAC: 3 HDO: 0 TPSA: 35.53 ALOGS: -6.75 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

permethrin

A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.

Molecular weight: 391.29
Formula: C21H20Cl2O3
CLOGP: 7.31
LIPINSKI: 1
HAC: 3
HDO: 0
TPSA: 35.53
ALOGS: -6.75
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
March 31, 1986	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pregnancy with injectable contraceptive	52.42	35.43	7	650	133	63488232
Acarodermatitis	38.11	35.43	7	650	1076	63487289

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Ejaculation failure	54.97	40.23	8	128	801	34955994

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pregnancy with injectable contraceptive	55.13	30.47	7	681	107	79743593
Ejaculation failure	54.77	30.47	8	680	357	79743343
Acarodermatitis	44.04	30.47	8	680	1390	79742310

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	P03AC04	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Pyrethrines, incl. synthetic compounds
ATC	P03AC54	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS ECTOPARASITICIDES, INCL. SCABICIDES Pyrethrines, incl. synthetic compounds
CHEBI has role	CHEBI:33286	agricultural chemicals
CHEBI has role	CHEBI:38956	ectoparasiticides
CHEBI has role	CHEBI:39116	pyrethroid ester insecticides
CHEBI has role	CHEBI:73333	scabicides
FDA CS	M0018228	Pyrethrins
FDA EPC	N0000175847	Pyrethroid
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D007306	Insecticides

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Pediculosis corporis	indication	25188002	DOID:5513
Infestation by Phthirus pubis	indication	71011005	DOID:13760
Pediculosis capitis	indication	81000006	DOID:5501
Infestation by Sarcoptes scabiei var hominis	indication	128869009	DOID:8295
Pediculosis Prevention	indication
Bronchospasm	contraindication	4386001

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

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Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel protein	Ion channel		Q2VKV7_SARSC	BLOCKER				CHEMBL	CHEMBL

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External reference:

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ID	Source
003009	NDDF
1887004	SNOMEDCT_US
33199	RXNORM
4018775	VUID
4018775	VANDF
40326	PUBCHEM_CID
410457007	SNOMEDCT_US
41581	MMSL
509F88P9SZ	UNII
5260	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
good neighbor pharmacy lice treatment	HUMAN OTC DRUG LABEL	1	46122-108	LOTION	1 mg	TOPICAL	ANDA	16 sections
good sense lice killing creme rinse	HUMAN OTC DRUG LABEL	1	0113-1910	LOTION	1 mg	TOPICAL	ANDA	16 sections
good sense lice killing creme rinse	HUMAN OTC DRUG LABEL	1	0113-1910	LOTION	1 mg	TOPICAL	ANDA	16 sections
health mart lice treatment	HUMAN OTC DRUG LABEL	1	62011-0255	LOTION	1 mg	TOPICAL	ANDA	16 sections
lice treatment	HUMAN OTC DRUG LABEL	1	0363-0955	LOTION	1 mg	TOPICAL	ANDA	16 sections
lice treatment	HUMAN OTC DRUG LABEL	1	0363-0955	LOTION	1 mg	TOPICAL	ANDA	16 sections
lice treatment	HUMAN OTC DRUG LABEL	1	11822-0549	LOTION	1 mg	TOPICAL	ANDA	16 sections
Lice Treatment	HUMAN OTC DRUG LABEL	1	42254-065	LOTION	1 mg	TOPICAL	ANDA	16 sections
Lice Treatment	HUMAN OTC DRUG LABEL	1	59779-769	LOTION	1 mg	TOPICAL	ANDA	16 sections
Nix	HUMAN OTC DRUG LABEL	1	63736-024	SHAMPOO	1 g	TOPICAL	NDA	32 sections

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