bucladesine indications/contra

Stem definitionDrug idCAS RN
415 362-74-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bucladesine
  • Dibutyryl cAMP
  • dbcAMP
  • Cyclic AMP dibutyrate
  • bucladesine sodium
  • bucladesine sodium salt
A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)
  • Molecular weight: 469.39
  • Formula: C18H24N5O8P
  • CLOGP: 0.74
  • LIPINSKI: 1
  • HAC: 13
  • HDO: 2
  • TPSA: 163.99
  • ALOGS: -2.46
  • ROTB: 8

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C01CE04 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Phosphodiesterase inhibitors
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:38147 cardiotonic drug

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.21 acidic
pKa2 12.91 acidic
pKa3 2.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
5485 IUPHAR_LIGAND_ID
D01238 KEGG_DRUG
4DZN2C97A7 UNII
16980-89-5 SECONDARY_CAS_RN
5288 INN_ID
N0000170821 NDFRT
CHEMBL485980 ChEMBL_ID
9687 PUBCHEM_CID
D003994 MESH_DESCRIPTOR_UI
CHEBI:50095 CHEBI

Pharmaceutical products:

None