doripenem 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| analogues of penicillanic acid antibiotics modified in the five-membered ring | 4149 | 148016-81-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.50 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.26 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.92 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.20 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 12, 2007 | FDA | SHIONOGI INC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01DH04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Carbapenems |
| FDA CS | M0024174 | Carbapenems |
| FDA EPC | N0000175496 | Penem Antibacterial |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pyelonephritis | indication | 45816000 | DOID:11400 |
| Abdominal abscess | indication | 75100008 | |
| Cholecystitis | indication | 76581006 | DOID:1949 |
| Infectious disease of abdomen | indication | 128070006 | |
| Complicated appendicitis | indication | 418171008 | |
| Complicated Urinary Tract Infections | indication | ||
| Impaired renal function disorder | contraindication | 197663003 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.79 | acidic |
| pKa2 | 8.53 | acidic |
| pKa3 | 11.22 | acidic |
| pKa4 | 9.17 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01836 | KEGG_DRUG |
| 4026738 | VANDF |
| C0389169 | UMLSCUI |
| CHEBI:135928 | CHEBI |
| O6P | PDB_CHEM_ID |
| CHEMBL491571 | ChEMBL_ID |
| CHEMBL1276416 | ChEMBL_ID |
| D000077726 | MESH_DESCRIPTOR_UI |
| DB06211 | DRUGBANK_ID |
| 12183 | IUPHAR_LIGAND_ID |
| 7975 | INN_ID |
| BHV525JOBH | UNII |
| 73303 | PUBCHEM_CID |
| 119771 | RXNORM |
| 121413 | MMSL |
| 24610 | MMSL |
| 246877 | MMSL |
| d07049 | MMSL |
| 012366 | NDDF |
| 428352004 | SNOMEDCT_US |
| 429369006 | SNOMEDCT_US |
Pharmaceutical products:
None