testosterone propionate Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
androgens/anabolic steroids 4146 57-85-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • virormone
  • testosterone propionate
An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.
  • Molecular weight: 344.50
  • Formula: C22H32O3
  • CLOGP: 4.88
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -4.84
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
May 2, 1974 FDA WATSON LABS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Deficiency of testosterone biosynthesis indication 38825009
Male hypogonadism indication 48723006
Undescended testicle indication 204878001 DOID:11383
Delayed puberty indication 400003000
Klinefelter's syndrome, XXY indication 405769009
Hormone receptor positive malignant neoplasm of breast indication 417181009
LHRH Deficiency indication
Gynecomastia contraindication 4754008 DOID:12698
Hypercholesterolemia contraindication 13644009
Humoral hypercalcemia of malignancy contraindication 47709007
Chronic heart failure contraindication 48447003
Heart disease contraindication 56265001 DOID:114
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Kidney disease contraindication 90708001 DOID:557
Neoplasm of prostate contraindication 126906006 DOID:10283
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Obesity contraindication 414916001 DOID:9970
Breast Carcinoma in Males contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Androgen receptor Nuclear hormone receptor AGONIST Ki 9.60 CHEMBL CHEMBL
Steroid 17-alpha-hydroxylase/17,20 lyase Enzyme IC50 7.25 CHEMBL
Androgen receptor Transcription factor IC50 5.72 CHEMBL

External reference:

IDSource
4017481 VUID
N0000145869 NUI
C0039607 UMLSCUI
D00959 KEGG_DRUG
3050 MMSL
10382 RXNORM
96338002 SNOMEDCT_US
5555 MMSL
4017481 VANDF
001248 NDDF
CHEMBL1170 ChEMBL_ID
DB01420 DRUGBANK_ID
CHEBI:9466 CHEBI
WI93Z9138A UNII
D043343 MESH_DESCRIPTOR_UI
5995 PUBCHEM_CID
7100 IUPHAR_LIGAND_ID
DB00624 DRUGBANK_ID

Pharmaceutical products:

None