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lutein 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4145 | 127-40-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Fall | 24.17 | 18.98 | 49 | 2776 | 481761 | 90143861 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Appendicolith | 188.93 | 40.85 | 62 | 3461 | 13394 | 42604418 |
| Appendicitis | 166.69 | 40.85 | 63 | 3460 | 20550 | 42597262 |
| Blood phosphorus increased | 160.97 | 40.85 | 54 | 3469 | 12471 | 42605341 |
| Ventricular fibrillation | 140.32 | 40.85 | 62 | 3461 | 30061 | 42587751 |
| Cardiogenic shock | 121.22 | 40.85 | 59 | 3464 | 35581 | 42582231 |
| Myasthenia gravis | 118.48 | 40.85 | 46 | 3477 | 16091 | 42601721 |
| Stress | 106.42 | 40.85 | 58 | 3465 | 44154 | 42573658 |
| Ascites | 105.90 | 40.85 | 63 | 3460 | 56615 | 42561197 |
| Dry mouth | 103.48 | 40.85 | 55 | 3468 | 39824 | 42577988 |
| Blood uric acid increased | 102.48 | 40.85 | 41 | 3482 | 15506 | 42602306 |
| Abdominal distension | 97.07 | 40.85 | 65 | 3458 | 71670 | 42546142 |
| Blood cholesterol increased | 93.08 | 40.85 | 45 | 3478 | 26696 | 42591116 |
| Hyperphosphataemia | 91.66 | 40.85 | 36 | 3487 | 12968 | 42604844 |
| Incorrect route of product administration | 78.88 | 40.85 | 39 | 3484 | 24266 | 42593546 |
| Hypophosphataemia | 78.21 | 40.85 | 37 | 3486 | 20908 | 42596904 |
| Neuralgia | 76.89 | 40.85 | 39 | 3484 | 25608 | 42592204 |
| Multiple organ dysfunction syndrome | 69.15 | 40.85 | 60 | 3463 | 96975 | 42520837 |
| Hyponatraemia | 66.83 | 40.85 | 60 | 3463 | 101402 | 42516410 |
| Bacterial infection | 65.42 | 40.85 | 36 | 3487 | 27843 | 42589969 |
| Swelling | 65.34 | 40.85 | 46 | 3477 | 54839 | 42562973 |
| Constipation | 64.59 | 40.85 | 73 | 3450 | 162218 | 42455594 |
| Analgesic therapy | 60.19 | 40.85 | 22 | 3501 | 6502 | 42611310 |
| Sleep disorder therapy | 59.01 | 40.85 | 22 | 3501 | 6872 | 42610940 |
| Drug therapy | 56.96 | 40.85 | 21 | 3502 | 6359 | 42611453 |
| Thrombosis | 56.25 | 40.85 | 46 | 3477 | 68465 | 42549347 |
| Iron deficiency | 55.41 | 40.85 | 24 | 3499 | 11037 | 42606775 |
| Sleep disorder | 51.92 | 40.85 | 38 | 3485 | 48057 | 42569755 |
| General physical health deterioration | 51.76 | 40.85 | 63 | 3460 | 151183 | 42466629 |
| Diabetes mellitus | 50.70 | 40.85 | 41 | 3482 | 60046 | 42557766 |
| Somnolence | 48.63 | 40.85 | 59 | 3464 | 141046 | 42476766 |
| Sepsis | 45.25 | 40.85 | 68 | 3455 | 199266 | 42418546 |
| Chronic obstructive pulmonary disease | 44.83 | 40.85 | 39 | 3484 | 63075 | 42554737 |
| Bacteroides infection | 44.78 | 40.85 | 14 | 3509 | 2573 | 42615239 |
| Abdominal pain | 44.70 | 40.85 | 66 | 3457 | 190405 | 42427407 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Appendicolith | 219.89 | 22.84 | 63 | 5513 | 14192 | 110569531 |
| Appendicitis | 180.83 | 22.84 | 64 | 5512 | 28400 | 110555323 |
| Blood phosphorus increased | 177.15 | 22.84 | 55 | 5521 | 16285 | 110567438 |
| Ventricular fibrillation | 161.08 | 22.84 | 65 | 5511 | 41248 | 110542475 |
| Myasthenia gravis | 131.41 | 22.84 | 47 | 5529 | 21464 | 110562259 |
| Cardiogenic shock | 125.15 | 22.84 | 60 | 5516 | 57278 | 110526445 |
| Blood uric acid increased | 112.77 | 22.84 | 42 | 5534 | 21487 | 110562236 |
| Ascites | 108.40 | 22.84 | 64 | 5512 | 92744 | 110490979 |
| Hyperphosphataemia | 104.62 | 22.84 | 37 | 5539 | 16344 | 110567379 |
| Stress | 103.42 | 22.84 | 65 | 5511 | 105283 | 110478440 |
| Abdominal distension | 90.41 | 22.84 | 73 | 5503 | 175030 | 110408693 |
| Hypophosphataemia | 85.61 | 22.84 | 39 | 5537 | 33143 | 110550580 |
| Neuralgia | 77.19 | 22.84 | 41 | 5535 | 48437 | 110535286 |
| Multiple organ dysfunction syndrome | 73.56 | 22.84 | 61 | 5515 | 151649 | 110432074 |
| Bacterial infection | 73.48 | 22.84 | 39 | 5537 | 45997 | 110537726 |
| Analgesic therapy | 72.57 | 22.84 | 23 | 5553 | 7261 | 110576462 |
| Sleep disorder therapy | 71.99 | 22.84 | 23 | 5553 | 7448 | 110576275 |
| Drug therapy | 68.43 | 22.84 | 22 | 5554 | 7269 | 110576454 |
| Incorrect route of product administration | 66.54 | 22.84 | 41 | 5535 | 64020 | 110519703 |
| Thrombosis | 66.21 | 22.84 | 50 | 5526 | 108612 | 110475111 |
| Hyponatraemia | 65.47 | 22.84 | 67 | 5509 | 217586 | 110366137 |
| Iron deficiency | 58.23 | 22.84 | 25 | 5551 | 18451 | 110565272 |
| Dry mouth | 57.32 | 22.84 | 60 | 5516 | 199888 | 110383835 |
| Constipation | 54.57 | 22.84 | 78 | 5498 | 357708 | 110226015 |
| Diabetes mellitus | 52.43 | 22.84 | 42 | 5534 | 99339 | 110484384 |
| Chronic obstructive pulmonary disease | 51.03 | 22.84 | 43 | 5533 | 109115 | 110474608 |
| Bacteroides infection | 49.94 | 22.84 | 14 | 5562 | 2905 | 110580818 |
| Sepsis | 49.36 | 22.84 | 71 | 5505 | 327275 | 110256448 |
| Somnolence | 45.55 | 22.84 | 65 | 5511 | 297384 | 110286339 |
| Blood cholesterol increased | 41.80 | 22.84 | 49 | 5527 | 184736 | 110398987 |
| End stage renal disease | 39.44 | 22.84 | 20 | 5556 | 21453 | 110562270 |
| Aortic stenosis | 38.95 | 22.84 | 17 | 5559 | 13042 | 110570681 |
| Troponin increased | 35.94 | 22.84 | 21 | 5555 | 29745 | 110553978 |
| Activated partial thromboplastin time prolonged | 35.82 | 22.84 | 19 | 5557 | 22349 | 110561374 |
| Total lung capacity decreased | 30.49 | 22.84 | 12 | 5564 | 7102 | 110576621 |
| Gout | 29.55 | 22.84 | 20 | 5556 | 36546 | 110547177 |
| Lung opacity | 27.86 | 22.84 | 13 | 5563 | 11639 | 110572084 |
| Pulmonary embolism | 27.26 | 22.84 | 43 | 5533 | 214431 | 110369292 |
| Abdominal pain | 26.74 | 22.84 | 71 | 5505 | 512918 | 110070805 |
| General physical health deterioration | 26.50 | 22.84 | 63 | 5513 | 425232 | 110158491 |
| Anticoagulant therapy | 26.39 | 22.84 | 10 | 5566 | 5351 | 110578372 |
| Antacid therapy | 26.17 | 22.84 | 10 | 5566 | 5474 | 110578249 |
| Sleep disorder | 25.49 | 22.84 | 40 | 5536 | 198604 | 110385119 |
| Swelling | 22.94 | 22.84 | 53 | 5523 | 350988 | 110232735 |
| Hyperlipidaemia | 22.93 | 22.84 | 17 | 5559 | 35831 | 110547892 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:39456 | antiglaucoma drug |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:76924 | plant metabolite |
| CHEBI has role | CHEBI:77182 | food colouring |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tear film insufficiency | indication | 46152009 | |
| Age related macular degeneration | indication | 267718000 | DOID:10871 |
| Meibomian gland dysfunction | indication | 397549002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4024342 | VUID |
| N0000171226 | NUI |
| 4024342 | VANDF |
| C0043328 | UMLSCUI |
| CHEBI:28838 | CHEBI |
| LUT | PDB_CHEM_ID |
| CHEMBL173929 | ChEMBL_ID |
| D014975 | MESH_DESCRIPTOR_UI |
| DB00137 | DRUGBANK_ID |
| 13099 | IUPHAR_LIGAND_ID |
| X72A60C9MT | UNII |
| 5281243 | PUBCHEM_CID |
| 11359 | RXNORM |
| 117565 | MMSL |
| 24043 | MMSL |
| 399999 | MMSL |
| d06848 | MMSL |
| 008098 | NDDF |
| 009220 | NDDF |
| X72A60C9MT | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Strovite OneCaplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 5 mg | ORAL | unapproved drug other | 14 sections |
| Noon for Kids | HUMAN OTC DRUG LABEL | 1 | 82597-010 | POWDER | 10 mg | ORAL | unapproved drug other | 10 sections |
| Furryden Dental Easy Green | HUMAN OTC DRUG LABEL | 2 | 83332-401 | GUM, CHEWING | 0.01 g | ORAL | unapproved drug other | 11 sections |