nadide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4140 53-84-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nicotinamide adenine
  • coenzyme I
  • nadide
  • nicotinamide adenine dinucleotide
  • NAD
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
  • Molecular weight: 663.43
  • Formula: C21H27N7O14P2
  • CLOGP: -7
  • LIPINSKI: 3
  • HAC: 21
  • HDO: 7
  • TPSA: 321.09
  • ALOGS: -2.52
  • ROTB: 11

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatocellular carcinoma 26.66 24.88 3 3 2191 63486825

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:78675 fundamental metabolites
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.04 acidic
pKa2 2.08 acidic
pKa3 11.94 acidic
pKa4 12.72 acidic
pKa5 12.84 acidic
pKa6 13.47 acidic
pKa7 13.84 acidic
pKa8 3.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
0U46U6E8UK UNII
N0000170823 NUI
D00002 KEGG_DRUG
C0027270 UMLSCUI
CHEBI:44215 CHEBI
NAD PDB_CHEM_ID
CHEMBL1234613 ChEMBL_ID
5892 PUBCHEM_CID
DB14128 DRUGBANK_ID
2371 INN_ID
2451 IUPHAR_LIGAND_ID
1044975 RXNORM
008958 NDDF
D009243 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Bonogenhair care shampoo HUMAN OTC DRUG LABEL 4 50653-1001 SHAMPOO 0.30 g TOPICAL unapproved drug other 4 sections
Bonogen Plushair care shampoo HUMAN OTC DRUG LABEL 4 50653-2001 SHAMPOO 0.30 g TOPICAL unapproved drug other 4 sections
Born Hair HUMAN OTC DRUG LABEL 4 50653-4001 SHAMPOO 0.30 g TOPICAL unapproved drug other 7 sections