nadide indications/contra

Stem definitionDrug idCAS RN
4140 53-84-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nicotinamide adenine
  • coenzyme I
  • nadide
  • nicotinamide adenine dinucleotide
  • NAD
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
  • Molecular weight: 663.43
  • Formula: C21H27N7O14P2
  • CLOGP: -7.80
  • LIPINSKI: 3
  • HAC: 21
  • HDO: 7
  • TPSA: 321.09
  • ALOGS: -2.52
  • ROTB: 11

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 25.68 0 4 5 7891 3377959

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.04 acidic
pKa2 2.08 acidic
pKa3 11.94 acidic
pKa4 12.72 acidic
pKa5 12.84 acidic
pKa6 13.47 acidic
pKa7 13.84 acidic
pKa8 3.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
N0000170823 NUI
C0027270 UMLSCUI
D00002 KEGG_DRUG
0U46U6E8UK UNII
2371 INN_ID
N0000170823 NDFRT
1044975 RXNORM
008958 NDDF
CHEMBL1234613 ChEMBL_ID
D009243 MESH_DESCRIPTOR_UI
5892 PUBCHEM_CID
CHEBI:15846 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Bonogen HUMAN OTC DRUG LABEL 3 50653-1001 SHAMPOO 0.30 g TOPICAL unapproved drug other 1 sections
Bonogen Plus HUMAN OTC DRUG LABEL 3 50653-2001 SHAMPOO 0.30 g TOPICAL unapproved drug other 1 sections
Born Hair HUMAN OTC DRUG LABEL 3 50653-4001 SHAMPOO 0.30 g TOPICAL unapproved drug other 7 sections