All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

isoleucine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	4129	73-32-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: isoleucine L-isoleucine	An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels. Molecular weight: 131.18 Formula: C6H13NO2 CLOGP: -1.76 LIPINSKI: 0 HAC: 3 HDO: 2 TPSA: 63.32 ALOGS: -0.06 ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PLK1,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70	45
kinase-selectivity-class	ACVR2B,AXL,BRAF,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,TEK,TGFBR1	10
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Foetal growth restriction	90.44	76.71	15	121	9365	90618946

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:75771	mouse metabolite
CHEBI has role	CHEBI:75772	<em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role	CHEBI:76924	plant metabolite
CHEBI has role	CHEBI:76971	<em>Escherichia coli</em> metabolite
CHEBI has role	CHEBI:77746	human metabolite
CHEBI has role	CHEBI:84735	algal metabolite
CHEBI has role	CHEBI:83056	<em>Daphnia magna</em> metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Classical phenylketonuria	contraindication	7573000
Poisoning by digitalis glycoside	contraindication	12876009
Sarcoidosis	contraindication	31541009	DOID:11335
End stage renal disease	contraindication	46177005	DOID:784
Humoral hypercalcemia of malignancy	contraindication	47709007
Heart disease	contraindication	56265001	DOID:114
Hypercalcemia	contraindication	66931009	DOID:12678
Ventricular fibrillation	contraindication	71908006
Hypercalciuria	contraindication	71938000
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.51	acidic
pKa2	9.83	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4018670	VUID
N0000146981	NUI
D00065	KEGG_DRUG
4018670	VANDF
C0022192	UMLSCUI
CHEBI:17191	CHEBI
ILE	PDB_CHEM_ID
CHEMBL1233584	ChEMBL_ID
D007532	MESH_DESCRIPTOR_UI
DB00167	DRUGBANK_ID
6164	INN_ID
04Y7590D77	UNII
6306	PUBCHEM_CID
6033	RXNORM
40034	MMSL
NOCODE	MMSL
003651	NDDF
14971004	SNOMEDCT_US
412426002	SNOMEDCT_US
3311	IUPHAR_LIGAND_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TrophAmine	HUMAN PRESCRIPTION DRUG LABEL	20	0264-1933	SOLUTION	0.82 g	INTRAVENOUS	NDA	23 sections
Plenamine	HUMAN PRESCRIPTION DRUG LABEL	17	0264-4500	SOLUTION	749 mg	INTRAVENOUS	ANDA	20 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0180	INJECTION	480 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0184	INJECTION	480 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0188	INJECTION	480 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0194	INJECTION	480 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-0198	INJECTION	360 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	20	0338-0202	INJECTION	480 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	20	0338-0206	INJECTION	480 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	20	0338-0210	INJECTION	480 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	20	0338-0214	INJECTION	480 mg	INTRAVENOUS	NDA	20 sections
ProSol	HUMAN PRESCRIPTION DRUG LABEL	17	0338-0499	INJECTION, SOLUTION	1.08 g	INTRAVENOUS	NDA	21 sections
Clinisol	HUMAN PRESCRIPTION DRUG LABEL	17	0338-0502	INJECTION, SOLUTION	749 mg	INTRAVENOUS	ANDA	18 sections
Travasol	HUMAN PRESCRIPTION DRUG LABEL	15	0338-0644	INJECTION	600 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1089	INJECTION	255 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1091	INJECTION	255 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1099	INJECTION	300 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1101	INJECTION	300 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1113	INJECTION	255 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1115	INJECTION	255 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1123	INJECTION	300 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1125	INJECTION	300 mg	INTRAVENOUS	NDA	20 sections
Premasol - sulfite-free (Amino Acid)	HUMAN PRESCRIPTION DRUG LABEL	19	0338-1130	INJECTION, SOLUTION	0.82 g	INTRAVENOUS	ANDA	15 sections
Premasol - sulfite-free (Amino Acid)	HUMAN PRESCRIPTION DRUG LABEL	19	0338-1131	INJECTION, SOLUTION	0.49 g	INTRAVENOUS	ANDA	15 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1133	INJECTION	255 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1134	INJECTION	255 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1137	INJECTION	300 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX	HUMAN PRESCRIPTION DRUG LABEL	16	0338-1138	INJECTION	300 mg	INTRAVENOUS	NDA	21 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1142	INJECTION	165 mg	INTRAVENOUS	NDA	20 sections
CLINIMIX E	HUMAN PRESCRIPTION DRUG LABEL	21	0338-1144	INJECTION	255 mg	INTRAVENOUS	NDA	20 sections