isoleucine indications/contra

Stem definitionDrug idCAS RN
4129 73-32-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isoleucine
  • L-isoleucine
An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
  • Molecular weight: 131.18
  • Formula: C6H13NO2
  • CLOGP: -1.76
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -0.06
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Parenteral nutrition associated liver disease 537.46 90.53 50 155 0 3385654

Pharmacologic Action:

None

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Classical phenylketonuria contraindication 7573000
Poisoning by digitalis glycoside contraindication 12876009
Sarcoidosis contraindication 31541009 DOID:13404
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Heart disease contraindication 56265001 DOID:114
Hypercalcemia contraindication 66931009 DOID:12678
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Kidney disease contraindication 90708001 DOID:2527
Kidney stone contraindication 95570007

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.51 acidic
pKa2 9.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
DB00167 DRUGBANK_ID
4018670 VUID
N0000146981 NUI
C0022192 UMLSCUI
3311 IUPHAR_LIGAND_ID
D00065 KEGG_DRUG
04Y7590D77 UNII
6164 INN_ID
6033 RXNORM
14971004 SNOMEDCT_US
412426002 SNOMEDCT_US
4018670 VANDF
NOCODE MMSL
N0000146981 NDFRT
N0000006312 NDFRT
003651 NDDF
CHEMBL1233584 ChEMBL_ID
D007532 MESH_DESCRIPTOR_UI
6306 PUBCHEM_CID
CHEBI:17191 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
NephrAmine HUMAN PRESCRIPTION DRUG LABEL 10 0264-1909 INJECTION, SOLUTION 0.56 g INTRAVENOUS NDA 13 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 0.21 g INTRAVENOUS NDA 13 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3200 SOLUTION 749 mg INTRAVENOUS ANDA 13 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3205 SOLUTION 749 mg INTRAVENOUS ANDA 13 sections
FreAmine III HUMAN PRESCRIPTION DRUG LABEL 16 0264-9010 INJECTION, SOLUTION 0.69 g INTRAVENOUS NDA 13 sections
FreAmine III HUMAN PRESCRIPTION DRUG LABEL 16 0264-9011 INJECTION, SOLUTION 0.69 g INTRAVENOUS NDA 13 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9341 SOLUTION 0.82 g INTRAVENOUS NDA 12 sections
FreAmine HBC HUMAN PRESCRIPTION DRUG LABEL 15 0264-9350 INJECTION, SOLUTION 0.76 g INTRAVENOUS NDA 13 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9361 SOLUTION 0.49 g INTRAVENOUS NDA 12 sections
HepatAmine HUMAN PRESCRIPTION DRUG LABEL 16 0264-9371 INJECTION, SOLUTION 0.90 g INTRAVENOUS NDA 13 sections
ProSol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0499 INJECTION, SOLUTION 1.08 g INTRAVENOUS NDA 12 sections
Clinisol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0502 INJECTION, SOLUTION 749 mg INTRAVENOUS ANDA 11 sections
Travasol HUMAN PRESCRIPTION DRUG LABEL 15 0338-0644 INJECTION 600 mg INTRAVENOUS NDA 15 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1083 INJECTION 165 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1089 INJECTION 255 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1091 INJECTION 255 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1093 INJECTION 255 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1095 INJECTION 255 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1099 INJECTION 300 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1101 INJECTION 300 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 15 0338-1103 INJECTION 300 mg INTRAVENOUS NDA 14 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1107 INJECTION 165 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1109 INJECTION 165 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1113 INJECTION 255 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1115 INJECTION 255 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1119 INJECTION 255 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1123 INJECTION 300 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1125 INJECTION 300 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1127 INJECTION 300 mg INTRAVENOUS NDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 0.82 g INTRAVENOUS ANDA 12 sections