dexfosfoserine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives 4120 407-41-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phosphoserine
  • dexfosfoserine
  • fosforina
  • 3-O-Phosphoserine
  • L-Phosphoserine
  • seriphos
  • L-serine-O-phosphate
  • L-SOP
The phosphoric acid ester of serine.
  • Molecular weight: 185.07
  • Formula: C3H8NO6P
  • CLOGP: -4.46
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 130.08
  • ALOGS: -0.97
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:62089 glutamate synthase inhibitors
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77089 O-acetyl-L-homoserine sulfhydrolase inhibitor
CHEBI has role CHEBI:77090 L-serine-O-sulfate ammonia-lyase (pyruvate-forming) inhibitors
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.95 acidic
pKa2 1.56 acidic
pKa3 6.29 acidic
pKa4 9.68 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Metabotropic glutamate receptor 4 GPCR EC50 6 CHEMBL
Metabotropic glutamate receptor 7 GPCR AGONIST EC50 4.50 IUPHAR
Metabotropic glutamate receptor 6 GPCR AGONIST EC50 6.40 IUPHAR
Metabotropic glutamate receptor 8 GPCR AGONIST IC50 7.20 IUPHAR
Metabotropic glutamate receptor 4 GPCR EC50 5.40 CHEMBL
Metabotropic glutamate receptor 6 GPCR EC50 5.57 CHEMBL

External reference:

IDSource
C5418344 UMLSCUI
CHEBI:15811 CHEBI
SEP PDB_CHEM_ID
CHEMBL284377 ChEMBL_ID
DB04522 DRUGBANK_ID
6888 INN_ID
VI4F0K069V UNII
68841 PUBCHEM_CID
006741 NDDF
102750006 SNOMEDCT_US
D010768 MESH_DESCRIPTOR_UI
1411 IUPHAR_LIGAND_ID

Pharmaceutical products:

None