zinostatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
enzyme inhibitors 4108 9014-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zinostatin
  • holoneocarzinostatin
  • neocarcinostatin
  • vinostatin
  • neocarzinostatin
An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.
  • Molecular weight: 659.64
  • Formula: C35H33NO12
  • CLOGP: 4.72
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 4
  • TPSA: 174.77
  • ALOGS: -4.39
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003603 Cytotoxins
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D009676 Noxae
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.11 acidic
pKa2 12.97 acidic
pKa3 6.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02046 KEGG_DRUG
C0027597 UMLSCUI
CHEMBL3989835 ChEMBL_ID
D009353 MESH_DESCRIPTOR_UI
4458 INN_ID
PP082U6W1L UNII
CHR PDB_CHEM_ID
CHEMBL454708 ChEMBL_ID
DB04408 DRUGBANK_ID
57125363 PUBCHEM_CID

Pharmaceutical products:

None