All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

minodronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
calcium metabolism regulator, pharmaceutical aid	4074	180064-38-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: minodronic acid minodronic acid hydrate recalbon minodronate YM-529 YM529	Molecular weight: 322.15 Formula: C9H12N2O7P2 CLOGP: -0.24 LIPINSKI: 0 HAC: 9 HDO: 5 TPSA: 152.59 ALOGS: -1.57 ROTB: 4

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	0.01 %	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MTOR,NTRK1,NTRK2,PDK1,PDK2,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ULK1	50
kinase-selectivity-class	AURKA,AXL,BRAF,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,JAK2,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAPK7,PIK3CD,PIK3CG,PRKDC,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	25
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
July 11, 2011	PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	88.24	35.43	29	1186	39074	90588158
Atypical femur fracture	78.39	35.43	18	1197	6403	90620829
Hepatic function abnormal	57.31	35.43	22	1193	46266	90580966
Spinal compression fracture	54.14	35.43	16	1199	15162	90612070
Upper respiratory tract inflammation	40.81	35.43	9	1206	2663	90624569
Interstitial lung disease	40.61	35.43	20	1195	76385	90550847

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	92.54	30.85	33	1715	47984	110539567
Atypical femur fracture	70.78	30.85	17	1731	6202	110581349
Hepatic function abnormal	63.35	30.85	30	1718	89265	110498286
Spinal compression fracture	56.65	30.85	18	1730	18374	110569177
Interstitial lung disease	45.59	30.85	28	1720	139306	110448245
Upper respiratory tract inflammation	44.88	30.85	11	1737	4360	110583191

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Osteoporosis	indication	64859006	DOID:11476

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.11	acidic
pKa2	6.18	acidic
pKa3	7.16	acidic
pKa4	10.96	acidic
pKa5	11.56	acidic
pKa6	5.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Farnesyl pyrophosphate synthase	Enzyme	P14324	FPPS_HUMAN		IC50	8.52		CHEMBL
Geranylgeranyl pyrophosphate synthase	Enzyme	O95749	GGPPS_HUMAN		Ki	5.74		CHEMBL
Farnesyl diphosphate synthase	Enzyme		ISPA_ECOLI		IC50	5.96		CHEMBL
Geranylgeranyl pyrophosphate synthase	Enzyme		GGPPS_YEAST		Ki	6.89		CHEMBL

External reference:

ID	Source
D09198	KEGG_DRUG
C2825721	UMLSCUI
M0N	PDB_CHEM_ID
CHEMBL319144	ChEMBL_ID
DB06548	DRUGBANK_ID
130956	PUBCHEM_CID
3164	IUPHAR_LIGAND_ID
7651	INN_ID
40SGR63TGL	UNII
CHEBI:43806	CHEBI
C087958	MESH_SUPPLEMENTAL_RECORD_UI
40SGR63TGL	INXIGHT DRUGS

Pharmaceutical products:

None