minodronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
calcium metabolism regulator, pharmaceutical aid	4074	180064-38-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: minodronic acid minodronic acid hydrate recalbon minodronate YM-529 YM529	Molecular weight: 322.15 Formula: C9H12N2O7P2 CLOGP: -0.24 LIPINSKI: 0 HAC: 9 HDO: 5 TPSA: 152.59 ALOGS: -1.57 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

minodronic acid
minodronic acid hydrate
recalbon
minodronate
YM-529
YM529

Molecular weight: 322.15
Formula: C9H12N2O7P2
CLOGP: -0.24
LIPINSKI: 0
HAC: 9
HDO: 5
TPSA: 152.59
ALOGS: -1.57
ROTB: 4

Drug dosage:

None

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	0.01 %	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

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Approvals:

Date	Agency	Company	Orphan
July 11, 2011	PMDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	78.40	34.28	27	991	35096	63452908
Atypical femur fracture	73.07	34.28	17	1001	5355	63482649
Hepatic function abnormal	51.06	34.28	20	998	37122	63450882
Spinal compression fracture	48.07	34.28	15	1003	14268	63473736
Upper respiratory tract inflammation	39.72	34.28	9	1009	2514	63485490

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	84.28	32.42	31	1407	43195	79699755
Atypical femur fracture	66.45	32.42	16	1422	5173	79737777
Hepatic function abnormal	59.13	32.42	28	1410	73079	79669871
Spinal compression fracture	51.71	32.42	17	1421	16941	79726009
Upper respiratory tract inflammation	39.34	32.42	10	1428	4025	79738925
Interstitial lung disease	37.47	32.42	24	1414	112576	79630374

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Osteoporosis	indication	64859006	DOID:11476

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.11	acidic
pKa2	6.18	acidic
pKa3	7.16	acidic
pKa4	10.96	acidic
pKa5	11.56	acidic
pKa6	5.65	Basic

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Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Farnesyl pyrophosphate synthase	Enzyme	P14324	FPPS_HUMAN	IC50	8.52	CHEMBL
Geranylgeranyl pyrophosphate synthase	Enzyme	O95749	GGPPS_HUMAN	Ki	5.74	CHEMBL
Farnesyl diphosphate synthase	Enzyme		ISPA_ECOLI	IC50	5.96	CHEMBL
Geranylgeranyl pyrophosphate synthase	Enzyme		GGPPS_YEAST	Ki	6.89	CHEMBL

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External reference:

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ID	Source
M0N	PDB_CHEM_ID
130956	PUBCHEM_CID
3164	IUPHAR_LIGAND_ID
40SGR63TGL	UNII
7651	INN_ID
C087958	MESH_SUPPLEMENTAL_RECORD_UI
C2825721	UMLSCUI
CHEMBL319144	ChEMBL_ID
D09198	KEGG_DRUG
DB06548	DRUGBANK_ID

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Pharmaceutical products:

None