bromopride indications/contra

Stem definitionDrug idCAS RN
sulpiride derivatives 406 4093-35-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bromopride
  • emepride
  • Molecular weight: 344.25
  • Formula: C14H22BrN3O2
  • CLOGP: 2.43
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 67.59
  • ALOGS: -3.16
  • ROTB: 7

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1976 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A03FA04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives
MeSH PA D000932 Antiemetics
MeSH PA D001337 Autonomic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.06 acidic
pKa2 8.94 Basic
pKa3 0.89 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme IC50 4.17 WOMBAT-PK
D(2) dopamine receptor GPCR Ki 7.85 WOMBAT-PK

External reference:

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IDSource
C0054129 UMLSCUI
D07101 KEGG_DRUG
75473V2YZK UNII
3142 INN_ID
19768 RXNORM
005442 NDDF
CHEMBL399510 ChEMBL_ID
2446 PUBCHEM_CID
C013855 MESH_SUPPLEMENTAL_RECORD_UI
DB09018 DRUGBANK_ID

Pharmaceutical products:

None