bromazine indications/contra

Stem definitionDrug idCAS RN
404 118-23-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bromazine
  • bromanautine
  • bromodiphenhydramine
  • bromodiphenhydramine hydrochloride
  • bromodiphenhydramine HCl
  • Molecular weight: 334.26
  • Formula: C17H20BrNO
  • CLOGP: 4.32
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -4.99
  • ROTB: 6

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
April 28, 1954 FDA FOREST LABS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC R06AA01 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:37955 H1-receptor antagonist

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Cough indication 49727002
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Common cold indication 82272006 DOID:10459
Dependent drug abuse contraindication 6525002
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Epilepsy contraindication 84757009 DOID:1826
Kidney disease contraindication 90708001 DOID:2527
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009 DOID:2883
Lesion of brain contraindication 301766008
Primary adrenocortical insufficiency contraindication 373662000 DOID:13774
Operation on gastrointestinal tract contraindication 386621005
Pseudomembranous enterocolitis contraindication 397683000 DOID:0060185
Central nervous system depression contraindication 418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Acute exacerbation of asthma contraindication 708038006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.52 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 8.89 WOMBAT-PK CHEMBL

External reference:

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IDSource
4019640 VUID
N0000179056 NUI
C0054120 UMLSCUI
7132 IUPHAR_LIGAND_ID
D03166 KEGG_DRUG
202J683U97 UNII
1808-12-4 SECONDARY_CAS_RN
4019640 VANDF
N0000147733 NDFRT
N0000179056 NDFRT
d03575 MMSL
4301 MMSL
19759 RXNORM
387430000 SNOMEDCT_US
75501004 SNOMEDCT_US
004788 NDDF
2444 PUBCHEM_CID
CHEMBL1200967 ChEMBL_ID
CHEMBL1201245 ChEMBL_ID
C011410 MESH_SUPPLEMENTAL_RECORD_UI
DB01237 DRUGBANK_ID
336 INN_ID
CHEBI:59177 CHEBI

Pharmaceutical products:

None