bromhexine indications/contra

Stem definitionDrug idCAS RN
mucolytic, bromhexine derivatives 402 3572-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bromhexine
  • bromexine
  • bromhexine hydrochloride
  • bromhexine HCl
  • bromhexine monohydrochloride
A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
  • Molecular weight: 376.14
  • Formula: C14H20Br2N2
  • CLOGP: 4.88
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 29.26
  • ALOGS: -5.02
  • ROTB: 3

Drug dosage:

DoseUnitRoute
24 mg O
24 mg P

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC R05CB02 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Mucolytics
MeSH PA D005100 Expectorants
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:77034 mucolytic

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.16 Basic
pKa2 0.87 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.60 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 5.95 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.71 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 7.44 DRUG MATRIX

External reference:

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IDSource
N0000166541 NUI
C0006220 UMLSCUI
D01778 KEGG_DRUG
N0000166541 NDFRT
003678 NDDF
1753 RXNORM
708561003 SNOMEDCT_US
CHEMBL253376 ChEMBL_ID
2442 PUBCHEM_CID
CHEMBL1319139 ChEMBL_ID
D001964 MESH_DESCRIPTOR_UI
DB09019 DRUGBANK_ID
Q1J152VB1P UNII
2584 INN_ID
611-75-6 SECONDARY_CAS_RN
CHEBI:77032 CHEBI

Pharmaceutical products:

None