bromazepam indications/contra

Stem definitionDrug idCAS RN
diazepam derivatives 399 1812-30-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bromazepam
  • durazanil
One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.
  • Molecular weight: 316.16
  • Formula: C14H10BrN3O
  • CLOGP: 1.70
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 54.35
  • ALOGS: -3.90
  • ROTB: 1

Drug dosage:

DoseUnitRoute
10 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1974 YEAR INTRODUCED

FDA Adverse Event Reporting System

scroll-->
MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 431.07 67.40 117 469 46937 3338336
Intentional overdose 412.37 67.40 91 495 15134 3370139
Overdose 282.97 67.40 79 507 33899 3351374
Suicide attempt 273.81 67.40 66 520 15781 3369492
Coma 240.91 67.40 57 529 12495 3372778
Sopor 202.34 67.40 40 546 3724 3381549
Drug abuse 153.01 67.40 43 543 18287 3366986
Somnolence 129.11 67.40 43 543 32161 3353112
Intentional self-injury 122.45 67.40 28 558 5157 3380116
Electrocardiogram QT prolonged 120.98 67.40 32 554 10763 3374510
Completed suicide 91.36 67.40 33 553 31081 3354192
Mydriasis 86.38 67.40 19 567 2915 3382358
Hypoglycaemia 81.28 67.40 25 561 14293 3370980
Hypotension 79.80 67.40 34 552 49480 3335793
Hyperchloraemia 77.12 67.40 11 575 132 3385141
Confusional state 67.49 67.40 28 558 37970 3347303

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC N05BA08 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.29 acidic
pKa2 3.26 Basic
pKa3 2.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel WOMBAT-PK

External reference:

scroll-->
IDSource
N0000166922 NUI
C0006213 UMLSCUI
D01245 KEGG_DRUG
CHEMBL277062 ChEMBL_ID
N0000166922 NDFRT
003512 NDDF
1749 RXNORM
387571009 SNOMEDCT_US
96234002 SNOMEDCT_US
2441 PUBCHEM_CID
D001960 MESH_DESCRIPTOR_UI
DB01558 DRUGBANK_ID
X015L14V0O UNII
2692 INN_ID
CHEBI:31302 CHEBI

Pharmaceutical products:

None